!Source "The Drug Repurposing Hub, Broad Institute" !URL http://www.broadinstitute.org/repurposing !File_date 8/18/2025 !Table_name drug_information !API_available We suggest using the available data API and/or custom web export function for additional annotation fields and database source information. !Disclaimer For research use only. Do not use the Repurposing Hub to make clinical treatment decisions. BROAD DOES NOT GUARANTEE OR WARRANT THE ACCURACY OF THE DATA WITHIN THE REPURPOSING HUB. RELIANCE ON THE REPURPOSING HUB IS AT THE USER'S SOLE RISK. !Restrictions The Drug Repurposing Hub data is provided for non-commercial use only. !Citation "Please cite usage as: Corsello SM, et al. Nature Medicine. 2017 Apr 7;23(4):405-408. doi: 10.1038/nm.4306." !Contact repurposing@broadinstitute.org pert_iname clinical_phase moa target disease_area indication 10058-F4 Preclinical c-Myc inhibitor 10-deacetylbaccatin Preclinical antitumor agent 10-DEBC Preclinical AKT inhibitor PIM1 10-hydroxycamptothecin Preclinical topoisomerase inhibitor TOP1 "1,12-Besm" Phase 2 polyamine biosynthesis inhibitor "1-(1,2-diphenylethyl)piperidine-(+/-)" Preclinical glutamate receptor antagonist "1,2,3,4,5,6-hexabromocyclohexane" Preclinical JAK inhibitor JAK2 1-(2-chloro-5-methylphenoxy)-3-(isopropylamino)-2-propanol Preclinical 12-O-tetradecanoylphorbol-13-acetate Phase 2 PKC activator CD4 | KCNT2 | TRPV4 "1,3-dipropyl-8-phenylxanthine" Preclinical adenosine receptor antagonist 1400W Preclinical nitric oxide synthase inhibitor NOS1 | NOS2 | NOS3 "1-(4-(((2s,4r)-2-((1h-1,2,4-triazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl)methoxy)phenyl)-4-isopropylpiperazine" Launched sterol demethylase inhibitor infectious disease vulvovaginal candidiasis "1,4-butanediol" Phase 1 benzodiazepine receptor agonist | gamma hydroxybutyric acid agonist MAN1B1 | PLA2G2A | PLA2G2E "1,5-dicaffeoylquinic-acid" Phase 1 "16,16-dimethylprostaglandin-e2" Phase 2 prostanoid receptor agonist HPGD "17,21-dihydroxypregn-4-ene-3,20-dione" Launched glucocorticoid receptor agonist NR3C1 "gastroenterology, rheumatology, dermatology" "ulcerative colitis, rheumatoid arthritis, psoriasis, joint inflammation, eczema" 17-hydroxyprogesterone-caproate Launched progesterone receptor agonist AR | CYP1A2 | CYP2B6 | CYP3A5 | ESR1 | ESR2 | NR1H4 | NR1I2 | NR3C1 | PGR obstetrics/gynecology spontaneous preterm birth 17-PA Preclinical glucocorticoid receptor agonist 1-acetyl-4-methylpiperazine Preclinical acetylcholine receptor agonist 1-azakenpaullone Preclinical glycogen synthase kinase inhibitor CCNB1 | CDK1 | CDK5 | GSK3B 1-deoxymannojirimycin Preclinical alpha mannosidase inhibitor MAN2A1 1E-1-(2-hydroxy-5-methylphenyl)-1-dodecanone-oxime Preclinical 1-EBIO Preclinical potassium channel activator KCNN1 | KCNN2 | KCNN3 | KCNN4 1-ethyl-2-pyrrolidone Preclinical transdermal absorption-enhancing compound "1h,1'h-2,2'-bibenzo[d]imidazole" Phase 2 dna inhibitor 1-hexadecanal Preclinical sphingosine 1-phosphate receptor substrate DBI | RHO 1-hexadecanol Launched dermatology cosmetic 1-naphthyl-PP1 Preclinical SRC inhibitor EPHB4 | SRC 1-octacosanol Phase 2 1-octanol Phase 2 GJA1 | GJA10 | GJA3 | GJA4 | GJA5 | GJA8 | GJA9 | GJB1 | GJB2 | GJB3 | GJB4 | GJB5 | GJB6 | GJB7 | GJC1 | GJC2 | GJC3 | GJD2 | GJD3 | GJD4 | GJE1 1-phenylbiguanide Preclinical serotonin receptor agonist HTR3A | HTR3B "1S,2R-phenylpropanolamine" Withdrawn adrenergic receptor agonist "1-((Z)-3-chloroallyl)-1,3,5,7-tetraazaadamantan-1-ium" Preclinical GRIN1 20-HETE Preclinical ion channel antagonist KCNMA1 20-hydroxyecdysone Phase 2 ecdysone receptor modulator 2-[1-(4-piperonyl)piperazinyl]benzothiazole Preclinical serotonin receptor agonist HTR4 2-(1-adamantylamino)benzoic-acid Preclinical 2-((2-ethoxyphenoxy)(phenyl)methyl)morpholine methanesulfonate "2-(((((((2r,3s,4r,5r)-5-(4-amino-2-oxopyrimidin-1(2h)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(hydroxy)phosphoryl)oxy)oxidophosphoryl)oxy)-n,n,n-trimethylethan-1-aminium" "2,3-cis/exo-camphanediol" Phase 1 "2,3-cis/exo-pinanediol" Phase 1 "2,3-DCPE" Preclinical BCL-XL downregulator BCL2L1 2-(3-mercaptopropyl)pentanedioic-acid Phase 1 glutamate carboxypeptidase inhibitor FOLH1 "2,4-dihydroxypyrimidine-5-carboxylic acid" Preclinical "2,4-dinitrochlorobenzene" Phase 2 thioredoxin inhibitor TXN "2,4-dinitrophenol" Preclinical ATP synthase inhibitor APP | TTR "2,5-furandimethanol" Phase 2 hemoglobin modulator HBB "2,6-dimethylpiperidine" Preclinical 2-amino-2-(4-hydroxyphenyl)acetic acid 2-amino-4-(methylselanyl)butanoic acid 2-aminobenzenesulfonamide Preclinical carbonic anhydrase inhibitor CA12 | CA14 | CA2 | CA6 | CA9 2-APB Preclinical "1,4,5-trisphosphate inhibitor" ITPR1 | TRPC1 | TRPC3 | TRPC4 | TRPC5 | TRPC6 | TRPC7 | TRPM2 | TRPM3 | TRPM6 | TRPV1 | TRPV6 2-BFI Preclinical imidazoline receptor ligand ADRA2A | ADRA2B | ADRA2C | MAOA | MAOB 2-chloroadenosine Preclinical adenosine receptor agonist ADORA1 | ADORA2A | ADORA2B "2-(chloromethyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one" Preclinical 2-chloro-N6-cyclopentyladenosine Preclinical adenosine receptor agonist ADORA1 | ADORA2A | ADORA2B | ADORA3 2-chloropyrazine Preclinical 2-CMDO Preclinical dopamine receptor antagonist DRD2 | DRD4 2'-C-methylguanosine Preclinical HCV inhibitor 2-deoxy-2-([methyl(nitroso)carbamoyl]amino)hexose Preclinical endocrinology | oncology hypoglycemia | pancreatic cancer 2-deoxyglucose Phase 2 glycolysis inhibitor SLC2A1 | SLC2A2 | SLC2A3 | SLC2A4 2-ethoxybenzoic-acid Phase 1 analgesic agent PTGS1 | PTGS2 "2-ethyl-1,3-hexanediol" Preclinical 2-fluoro-2-deoxy-D-galactose Phase 1 LCT 2-fluorofucose Phase 1 "2-hydroxy-4-((E)-3-(4-hydroxyphenyl)acryloyl)-2-((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)-6-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)cyclohexane-1,3,5-trione" Preclinical 2-hydroxyethyl-salicylate Launched neurology/psychiatry pain relief 2-hydroxyflutamide Phase 2 androgen receptor antagonist AR 2-hydroxysaclofen Preclinical GABA receptor antagonist GABBR1 | GABBR2 2-iminobiotin Phase 2 nitric oxide synthase inhibitor NOS1 | NOS2 2-iodohippuric-acid Preclinical 2-iodomelatonin Preclinical melatonin receptor agonist MTNR1A | MTNR1B | NQO2 2-isopropyl-5-methylcyclohexanol 2'-MeCCPA Preclinical adenosine receptor agonist ADORA1 2-methoxyestradiol Phase 2 hypoxia inducible factor inhibitor CASP3 | COMT | CYP19A1 | CYP1A1 | CYP1B1 | HIF1A | TNFRSF10B | TUBB 2-methyl-5-hydroxytryptamine Preclinical serotonin receptor agonist HTR1B | HTR1D | HTR1E | HTR1F | HTR3A | HTR3B | HTR6 2-methyl-5-nitrophenol Preclinical 2-methylimidazole Preclinical cholesterol inhibitor 2-octyldodecan-1-ol Preclinical 2-oleoylglycerol Phase 1 glucose dependent insulinotropic receptor ligand GPR119 2-oxoglutaric-acid Preclinical OXGR1 2-oxopropanoate Preclinical pyruvate dehydrogenase kinase inhibitor ABAT 2-phenylmelatonin Preclinical melatonin receptor agonist MTNR1A | MTNR1B 2-PMDQ Preclinical adrenergic receptor antagonist ADRA1A 2-pyridylethylamine Preclinical histamine receptor agonist HRH1 "((2r,3s,4r,5r)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2h)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyltriphosphoric acid" (2s)-2-amino-5-({(1r)-2-[(carboxymethyl)amino]-1-[(nitrososulfanyl)methyl]-2-oxoethyl}amino)-5-oxopentanoic acid Phase 1 nitric oxide stimulant PTPN1 "[(2s,3s,5s,8r,9s,10s,13s,14s,16s,17r)-17-acetoxy-2,16-bis(4,4-dimethylpiperazin-4-ium-1-yl)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-3-yl] acetate" 2-TEDC Preclinical lipoxygenase inhibitor ALOX12 2-thiouracil Preclinical "3,3'-dichlorobenzaldazine" Preclinical glutamate receptor modulator GRM5 "3,3'-diindolylmethane" Phase 3 "CHK inhibitor | cytochrome P450 activator | indoleamine 2,3-dioxygenase inhibitor" AHR | AR | CYP1A2 | GUSB | HIF1A | IDO1 | IFNG | PI3 "3,4-DCPG-(+/-)" Preclinical glutamate receptor agonist GRM8 "3,4-DCPG-(R)" Preclinical glutamate receptor antagonist "3,4-DCPG-(S)" Preclinical glutamate receptor agonist GRM8 3-(4-methylbenzylidene)camphor Launched endocrine disruptor dermatology sunscreen lotion "3,4-methylenedioxy-beta-nitrostyrene" Preclinical SRC inhibitor | SYK inhibitor SRC | SYK "3,5-DHPG-(S)" Preclinical glutamate receptor agonist GRM1 3-alpha-bis-(4-fluorophenyl)-methoxytropane Preclinical dopamine uptake inhibitor CHRM1 | SLC6A2 | SLC6A3 | SLC6A4 3-alpha-bis(4-fluorophenyl)methoxytropane hydrochloride Preclinical dopamine reuptake inhibitor 3-alpha-hydroxy-5-beta-androstan-17-one Preclinical HSD17B11 | IGHG2 | SULT2A1 3-amino-benzamide Phase 2 PARP inhibitor PARP1 3-anilinopropan-1-ol Preclinical 3-AQC Preclinical serotonin receptor agonist HTR3A 3-benzoyl-n-(1-phenylethyl)thiazolidine-4-carboxamide 3-bromo-7-nitroindazole Preclinical nitric oxide synthase inhibitor NOS1 | NOS2 | NOS3 3-bromocamphor Launched 3-bromopyruvate Preclinical hexokinase inhibitor HK2 3-carboxy-4-hydroxyphenylglycine-(R) Preclinical glutamate receptor antagonist GRIN1 | GRIN2A | GRIN2B | GRIN2C 3-carboxy-4-hydroxyphenylglycine-(S) Preclinical glutamate receptor antagonist GRM1 | GRM5 3-cpmt Preclinical dopamine reuptake inhibitor 3-CPMT Preclinical dopamine reuptake inhibitor 3-deazaadenosine Phase 2 adenosylhomocysteinase inhibitor AHCY 3-deazaadenosine (hydrochloride) Phase 2 adenosylhomocysteinase inhibitor AHCY Immunology rheumatoid arthritis 3-deazaneplanocin-A Preclinical histone lysine methyltransferase inhibitor AHCY | EZH2 3-deazauridine Preclinical cytidine deaminase inhibitor "3-ethyl-7-hydroxy-2,8,12,16-tetramethyl-5,13-dioxo-10-(2-oxoethyl)-4,17-dioxabicyclo[14.1.0]heptadec-14-en-9-yl 3,4,6-trideoxy-3-(dimethylamino)hexopyranoside" 3'-fluorobenzylspiperone Preclinical dopamine receptor ligand DRD2 3-hydroxy-3-phenylpentanamide Phase 1 GABA receptor modulator 3-indolebutyric-acid Preclinical B2M | HLA-A | TRAC | TRBC1 3-MATIDA Preclinical glutamate receptor antagonist GRM1 3-methyladenine Preclinical PI3K inhibitor PI3 3-methyl-GABA Preclinical GABA aminotransferase activator ABAT 3-MPPI Preclinical adrenergic receptor ligand ADRA1A 3PO Preclinical phosphofructokinase inhibitor PFKFB3 4-(3-phosphonopropyl)-2-piperazinecarboxylic acid "4,4'-DDT" Preclinical 4-(4-fluorobenzoyl)-1-(4-phenylbutyl)-piperidine Preclinical serotonin receptor antagonist HTR2A "4,4-pentamethylenepiperidine" Preclinical M2 channel blocker "4,5,6,7-tetrabromobenzotriazole" Preclinical casein kinase inhibitor AKT1 | CHEK1 | CSNK2A1 | CSNK2A2 | CSNK2B | GSK3B | LCK | MAP2K1 | MAPK1 | MAPK11 | MAPK12 | MAPK14 | MAPK8 | PRKCA | ROCK1 | RPS6KB1 | SGK1 "4,6-diamino-3-hydroxy-2-(pentofuranosyloxy)cyclohexyl 2,6-diamino-2,6-dideoxyhexopyranoside" "4-acetyl-1,1-dimethylpiperazinium" Preclinical acetylcholine receptor agonist 4-aminohippuric-acid Launched SLC22A6 nephrology renal diagnostic agent 4-(aminomethyl)benzoic-acid Preclinical hemostatic agent 4BP-TQS Preclinical nicotinic receptor agonist CHRNA7 4-carboxy-3-hydroxyphenylglycine-(RS) Preclinical glutamate receptor agonist | glutamate receptor antagonist GRM1 | GRM2 4-carboxy-3-hydroxyphenylglycine-(S) Preclinical glutamate receptor agonist | glutamate receptor antagonist GRM1 | GRM2 4-chlorophenylguanidine Preclinical urokinase inhibitor PLAUR 4-CMTB Preclinical free fatty acid receptor agonist FFAR2 4-cpa Preclinical pesticide DPP9 4-DAMP Preclinical cholinergic receptor antagonist CHRM1 | CHRM2 | CHRM3 | CHRM4 | CHRM5 4E1RCat Preclinical protein synthesis inhibitor EIF4E | EIF4G1 4EGI-1 Preclinical protein synthesis inhibitor EIF4E 4-galactosyllactose Preclinical 4-HQN Preclinical PARP inhibitor PARP1 4-hydroxy-phenazone Preclinical 4-IBP Preclinical sigma receptor agonist SIGMAR1 4-iodo-6-phenylpyrimidine Preclinical macrophage migration inhibiting factor inhibitor MIF 4-iodo-L-phenylalanine Preclinical DPP4 4-methylgenistein Preclinical protein tyrosine kinase inhibitor AR | CYP19A1 | ESRRA | ESRRB | ESRRG | FASN | PPARA | PPARG | SRD5A1 | SRD5A2 4-methylhistamine Preclinical histamine receptor agonist HRH4 4-mu-8C Preclinical IRE1 inhibitor ERN1 4-phenolsulfonic-acid Preclinical "4-phenyl-1,2,3,4-tetrahydroisoquinoline" Preclinical dopamine release inhibitor 4-PPBP Preclinical sigma receptor ligand SIGMAR1 4-P-PDOT Preclinical melatonin receptor antagonist MTNR1A | MTNR1B 4-propylbenzoic-acid Preclinical 4-pyrimidinecarbonitrile Preclinical "(4s,4ar,5s,5ar,6s,12as)-4-(dimethylamino)-5,6,10,12a-tetrahydroxy-6-methyl-1,3,11,12-tetraoxo-1,2,3,4,4a,5,5a,6,11,11a,12,12a-dodecahydro-2-naphthacenecarboxamide hydrate" 4SC-202 Phase 1 HDAC inhibitor HDAC1 4-tert-butylphenol Preclinical 5-[({[1-(2-chloroethyl)-2-oxohydrazino]carbonyl}amino)methyl]-2-methyl-4-pyrimidinamine hydrochloride "5-(4chlorophenyl)-4-ethyl-2,4-dihydro-3H-1,2,4-triazol-3-one" Preclinical "5,7-dichlorokynurenic-acid" Preclinical glutamate receptor antagonist GLRA2 | GRIN1 | GRIN2A | GRIN2B | GRIN2C | GRIN2D "5-amino-3-D-ribofuranosylthiazolo[4,5-d]pyrimidin-2,7(3H,6H)-dione" Preclinical TLR7 5-aminolevulinic-acid Launched oxidizing agent ALAD dermatology | oncology actinic keratosis (AK) | glioma 5-BDBD Preclinical purinergic receptor antagonist P2RX4 5-carboxamidotryptamine Preclinical serotonin receptor agonist HTR1A | HTR1B | HTR1D | HTR1E | HTR1F | HTR2A | HTR2B | HTR2C | HTR5A | HTR6 | HTR7 5'-chloro-5'-deoxy-ENBA-(+/-) Preclinical adenosine receptor agonist ADORA1 | ADORA2A | ADORA2B | ADORA3 5-fluoro-3-pyridyl-methanol Preclinical 5-fluoropyrimidine Phase 3 kinase inhibitor ALK 5-fluorouracil Launched thymidylate synthase inhibitor CD44 | DPYD | TYMS oncology | oncology | oncology | oncology breast cancer | colorectal cancer | gastric adenocarcinoma | pancreatic cancer 5-FP Phase 1 thymidylate synthase inhibitor TYMS 5-HMF Phase 2 5-hydroxydecanoic-acid Preclinical 5-hydroxyectoine Preclinical 5-hydroxymethyl-tolterodine Phase 1 acetylcholine receptor antagonist CHRM3 5-hydroxytryptophan Launched neurotransmitter SLC36A1 | SLC36A2 neurology/psychiatry insomnia 5-iodo-A-85380 Phase 2 acetylcholine receptor agonist 5-methylfurmethiodide Preclinical acetylcholine receptor agonist CHRM1 | CHRM2 | CHRM3 | CHRM4 5-methylhydantoin-(D) Preclinical 5-methylhydantoin-(L) Preclinical 5-octanoylsalicylic-acid Preclinical protein kinase activator PRKAA1 | PRKAA2 "(5z,8z,11z,14z,17z)-methyl icosa-5,8,11,14,17-pentaenoate" "6,7-dehydro-17-acetoxy-progesterone" Preclinical steroidal progestin 6-aminochrysene Phase 2 transferase inhibitor 6-aminopenicillanic-acid Preclinical 6-benzylaminopurine Preclinical purinergic receptor activator 6-chloromelatonin Preclinical melatonin receptor agonist MTNR1A | MTNR1B 6-diazo-5-oxo-l-nor-leucine Phase 2 glutaminase inhibitor GGT1 | GLS hematologic malignancy burkitt's lymphoma 6-diazo-5-oxo-L-norleucine Preclinical glutamate receptor antagonist | glutaminase inhibitor GLS 6-iodo-nordihydrocapsaicin Preclinical TRPV antagonist TRPV1 6-thio-2'-deoxyguanosine Preclinical telomerase inhibitor TERT oncology non-small cell lung cancer (nsclc) "7,8,9,10-tetrahydroazepino[2,1-b]quinazolin-12(6H)-one" Preclinical 7-aminocephalosporanic-acid Preclinical beta lactamase inhibitor 7-chlorokynurenic-acid Preclinical glutamate receptor antagonist GRIN1 | GRIN2A | GRIN2B | GRIN2C 7-hydroxy-DPAT Preclinical dopamine receptor agonist DRD2 | DRD3 7-hydroxy-PIPAT Preclinical dopamine receptor ligand DRD3 7-hydroxystaurosporine Phase 2 CDK inhibitor | CHK inhibitor | PKC inhibitor AKT1 | CDK1 | CDK2 | CDK4 | CDK6 | CHEK1 | CHEK2 | GSK3B | LCK | MAPK14 | MARK1 | MARK3 | PDPK1 | PRKCA | PRKCB | PRKCD | PRKCE | PRKCG 7-keto-DHEA Launched steroid 7-methoxytacrine Phase 2 acetylcholinesterase inhibitor ACHE 7-methylxanthine Phase 2 adenosine receptor antagonist 7-nitroindazole Preclinical nitric oxide synthase inhibitor NOS1 | NOS2 | NOS3 7-((r)-2-amino-2-phenylacetamido)-3-chloro-8-oxo-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid hydrate 80841-78-7 Preclinical 8-bromo-cAMP Preclinical PKA activator 8-bromo-cGMP Preclinical PKA activator PRKG1 8-hydroxy-DPAT Preclinical serotonin receptor agonist HTR5A | HTR7 8-hydroxy-PIPAT Preclinical dopamine receptor ligand DRD2 | DRD3 8-M-PDOT Preclinical melatonin receptor agonist MTNR1A | MTNR1B 9-aminoacridine Preclinical 9-aminocamptothecin Phase 2 topoisomerase inhibitor TOP1 9-anthracenecarboxylic-acid Preclinical ANO1 | CLCN1 9-ing-41 Phase 2 gsk3b inhibitor GSK3B | MARK2 hematologic malignancy myelofibrosis A0001 Phase 2 A-1070722 Preclinical glycogen synthase kinase inhibitor GSK3A | GSK3B | PTGER2 A-1120 Preclinical retinoid receptor ligand RBP4 A12B4C3 Preclinical polynucleotide kinase/phosphatase inhibitor PNKP A205804 Preclinical ICAM1 expression inhibitor ICAM1 | SELE A-317491 Preclinical purinergic receptor antagonist P2RX3 A-33903 Phase 2 A-366 Preclinical histone lysine methyltransferase inhibitor EHMT1 | EHMT2 A-381393 Preclinical dopamine receptor antagonist DRD4 A-412997 Preclinical dopamine receptor agonist DRD4 A-438079 Preclinical purinergic receptor antagonist P2RX7 A-485 Preclinical histone acetyltransferase inhibitor CREBBP | EP300 A-582941 Preclinical nicotinic receptor agonist CHRNA7 A61603 Preclinical adrenergic receptor agonist ADRA1A A-61603 Preclinical adrenergic receptor agonist ADRA1A | ADRA1B | ADRA1D A66 Preclinical PI3K inhibitor PIK3CA A-674563 Preclinical AKT inhibitor AKT1 | PKIA | PRKACA A-7 Preclinical calmodulin antagonist A740003 Preclinical purinergic receptor antagonist P2RX7 A-769662 Preclinical AMPK activator A77636 Preclinical dopamine receptor agonist CALY | DRD1 A-784168 Preclinical transient receptor potential channel antagonist TRPV1 A-803467 Preclinical sodium channel blocker SCN10A A-804598 Preclinical purinergic receptor antagonist P2RX7 A-839977 Preclinical purinergic receptor antagonist IL1B | P2RX7 A-867744 Preclinical acetylcholine receptor allosteric modulator CHRNA3 | CHRNA4 | CHRNA7 A-887826 Preclinical sodium channel blocker SCN10A A922500 Preclinical diacylglycerol O acyltransferase inhibitor DGAT1 A-922500 Preclinical diacylglycerol O acyltransferase inhibitor DGAT1 A-939572 Preclinical stearoyl-CoA desaturase inhibitor SCD A-967079 Preclinical transient receptor potential channel antagonist TRPA1 A-987306 Preclinical histamine receptor antagonist ADORA1 | AVPR1A | CCR1 | CHRM1 | CHRM2 | CHRM3 | CHRM4 | DRD3 | HRH4 | HTR1A | HTR1B | HTR2A | HTR2B | HTR3A | TACR2 AA-29504 Preclinical GABA receptor positive allosteric modulator GABRA1 | GABRA4 | GABRB3 AAI101 Phase 3 lactamase inhibitor LACTB AB-423 Preclinical HBV capsid assembly inhibitor ab-680 Phase 1 cd antagonist NT5E oncology pancreatic cancer ab928 Phase 2 adenosine receptor antagonist ADORA2A | ADORA2B oncology non-small cell lung cancer (nsclc) abacavir Launched nucleoside reverse transcriptase inhibitor infectious disease human immunodeficiency virus (HIV-1) abafungin Phase 3 sterol methyltransferase inhibitor abamectin Launched benzodiazepine receptor agonist GABBR1 | GABBR2 infectious disease gastrointestinal parasites abamectin (avermectin b1a shown) Launched benzodiazepine receptor agonist GABBR1 | GABBR2 infectious disease gastrointestinal parasites abametapir Phase 3 metalloproteinase inhibitor MMP2 | MMP8 | MMP9 abarelix Phase 3 gonadotropin releasing factor hormone receptor antagonist GNRH1 | GNRHR ABBV-744 Phase 1 bromodomain inhibitor BRD2 ABC-294640 Phase 2 sphingosine kinase inhibitor SPHK2 abc294640 hcl Phase 2 sphingosine kinase inhibitor SPHK2 abemaciclib Launched CDK inhibitor CDK4 | CDK6 oncology breast cancer abiraterone Launched androgen biosynthesis inhibitor CYP11B1 | CYP17A1 oncology prostate cancer abiraterone-acetate Launched androgen biosynthesis inhibitor CYP17A1 | CYP2C19 | CYP2C8 | CYP3A5 oncology prostate cancer ABT-072 Phase 2 RNA polymerase inhibitor NS5B ABT-202 Phase 1 acetylcholine receptor agonist ABT-239 Phase 1 histamine receptor antagonist HRH1 | HRH2 | HRH3 abt 418 Preclinical abt-418 (hydrochloride) Preclinical nicotinic receptor agonist CHRNA4 | CHRNA7 | HTR3A neurology/psychiatry alzheimer's disease ABT-491 Phase 1 platelet activating factor receptor antagonist PTAFR ABT-639 Phase 2 calcium channel blocker CACNA1G | CACNA1H | CACNA1I ABT-702 Preclinical adenosine kinase inhibitor ADK ABT-724 Phase 2 dopamine receptor agonist DRD4 ABT-737 Phase 1/Phase 2 BCL inhibitor BCL2 | BCL2L1 | BCL2L2 ABT-751 Phase 2 tubulin polymerization inhibitor TUBB ABX-1431 Phase 2 monoacylglycerol lipase inhibitor MGLL ABX464 Phase 2 antiviral AC-186 Preclinical estrogen receptor agonist ESR2 AC1NDSS5 Phase 1 AC260584 Preclinical cholinergic receptor agonist CHRM1 AC-261066 Preclinical retinoid receptor agonist RARB AC-264613 Preclinical PAR agonist F2RL1 AC-55541 Preclinical PARP inhibitor F2RL1 | PARP2 AC-55649 Preclinical retinoid receptor agonist RARA | RARB AC-710 Preclinical PDGFR tyrosine kinase receptor inhibitor CSF1R | FLT3 | KIT | PDGFRA | PDGFRB AC-7954-(+/-) Preclinical urotensin receptor agonist UTS2R acadesine Phase 3 AMPK activator acalabrutinib Launched Bruton's tyrosine kinase (BTK) inhibitor BTK hematologic malignancy mantle cell lymphoma (MCL) acalisib Phase 1 PI3K inhibitor PIK3CB | PIK3CD acamprosate Launched glutamate receptor antagonist GABRA1 | GABRA2 | GABRA3 | GABRA4 | GABRA5 | GABRA6 | GABRB1 | GABRB2 | GABRB3 | GABRD | GABRE | GABRG1 | GABRG2 | GABRG3 | GABRP | GABRQ | GRIN1 | GRIN2A | GRIN2B | GRIN2C | GRIN2D | GRIN3A | GRIN3B | GRM5 neurology/psychiatry abstinence from alcohol acarbose Launched glucosidase inhibitor AMY2A | GAA | MGAM endocrinology diabetes mellitus ACDPP Preclinical glutamate receptor antagonist GRM5 acebilustat Phase 2 leukotriene inhibitor LTA4H acebutolol Launched adrenergic receptor antagonist ADRB1 cardiology | cardiology hypertension | ventricular arrhythmias acebutolol hydrochloride Launched adrenergic receptor antagonist CES2 Cardiology angina pectoris acecainide Phase 3 polarization inhibitor SCN5A aceclidine Launched acetylcholine receptor agonist CHRM1 | CHRM2 | CHRM3 | CHRM4 | CHRM5 ophthalmology glaucoma aceclidine hcl Launched acetylcholine receptor agonist CHRM1 | CHRM2 | CHRM3 | CHRM4 | CHRM5 ophthalmology glaucoma aceclofenac Launched prostanoid receptor antagonist PTGS2 rheumatology | rheumatology | rheumatology | rheumatology | rheumatology | rheumatology ankylosing spondylitis | ischiadynia | lumbago | osteoarthritis | periarthritis | rheumatoid arthritis acedapsone Launched infectious disease leprosy acedoben Phase 2 acefylline Launched adenosine receptor agonist ADORA1 pulmonary asthma aceglutamide Launched gastroenterology peptic ulcer disease (PUD) acelarin Phase 2/Phase 3 anticancer agent acemetacin Launched cyclooxygenase inhibitor PTGS1 | PTGS2 rheumatology osteoarthritis aceneuramic-acid Phase 3 CES1 | SELE | SELP acenocoumarol Launched vitamin K antagonist VKORC1 hematology deep vein thrombosis (DVT) acepromazine Launched dopamine receptor antagonist ADRA1A | ADRA1B | DRD1 | DRD2 | HTR1A | HTR2A neurology/psychiatry sedative acesulfame-potassium Phase 3 acetanilide Preclinical hydrogen peroxide decomposition inhibitor acetarsol Launched gastroenterology diarrhea acetazolamide Launched carbonic anhydrase inhibitor AQP1 | CA1 | CA12 | CA13 | CA14 | CA2 | CA3 | CA4 | CA6 | CA7 ophthalmology glaucoma acetohexamide Launched ATP channel blocker ABCC8 | KCNJ1 | KCNJ10 | KCNJ11 endocrinology diabetes mellitus acetohydroxamic-acid Launched urease inhibitor MMP12 infectious disease urinary tract infections acetophenazine Launched dopamine receptor antagonist DRD1 | DRD2 neurology/psychiatry psychosis acetriazoic-acid Preclinical acetyl-11-keto-beta-boswellic-acid Phase 2 lipoxygenase inhibitor ABCB1 | ALOX5 | HSD11B1 | HSD11B2 acetylcholine Launched acetylcholine receptor agonist ACHE | CHRM1 | CHRM2 | CHRM3 | CHRM4 | CHRM5 | CHRNA2 gastroenterology | neurology/psychiatry | neurology/psychiatry | neurology/psychiatry | pulmonary chest congestion | drowsiness | fatigue | headache | indigestion acetylcysteine Launched mucolytic agent ACY1 | CHUK | GRIN1 | GRIN2A | GRIN2B | GRIN2D | GRIN3A | GSS | IKBKB | RELA | SLC7A11 gastroenterology | gastroenterology acetaminophen overdose | hepatic injury acetyl-farnesyl-cysteine Launched methyltransferase inhibitor PPARG dermatology acne vulgaris (AV) acetyl-l-leucine Launched neurology/psychiatry vertigo acetylsalicylsalicylic-acid Preclinical cyclooxygenase inhibitor acetylspiramycin Preclinical other antibiotic acexamic-acid Launched 5 alpha reductase inhibitor GAST | SRD5A1 dermatology wound healing acifran Phase 3 cholesterol inhibitor HCAR2 | HCAR3 acipimox Launched cholesterol inhibitor HCAR2 endocrinology hyperlipidemia acitazanolast Launched mediator release inhibitor allergy allergic rhinitis acitretin Launched retinoid receptor agonist RARA | RARB | RARG | RBP1 | RXRA | RXRB | RXRG | STAT3 dermatology psoriasis acivicin Phase 2 gamma glutamyltransferase inhibitor CAD | CTPS1 | GGT1 aclarubicin Launched topoisomerase inhibitor TOP1 | TOP2A hematologic malignancy acute myeloid leukemia (AML) aclidinium Launched acetylcholine receptor antagonist CHRM1 | CHRM2 | CHRM3 | CHRM4 | CHRM5 pulmonary | pulmonary | pulmonary bronchitis | chronic obstructive pulmonary disease (COPD) | emphysema acolbifene Phase 3 estrogen receptor antagonist ESR1 | ESR2 acotiamide Launched acetylcholinesterase inhibitor ACHE | CHRM1 | CHRM2 gastroenterology dyspepsia acoziborole Preclinical antitrypanosomal ACPC Phase 1 glutamate receptor antagonist acriflavine Launched hypoxia inducible factor inhibitor HIF1A infectious disease fungal infection acriflavinium Launched hypoxia inducible factor inhibitor HIF1A infectious disease fungal infection acrisorcin Launched other antifungal infectious disease fungal infection acrivastine Launched histamine receptor antagonist HRH1 allergy allergic rhinitis acrizanib Phase 2 vegfr inhibitor ophthalmology macular degeneration acrylate Phase 3 mucus protecting agent ACT-132577 Launched endothelin receptor antagonist EDNRA | EDNRB pulmonary pulmonary arterial hypertension (PAH) ACT-462206 Phase 1 orexin receptor antagonist HCRTR1 | HCRTR2 act-709478 Phase 2 calcium channel blocker CACNA1G neurology/psychiatry epilepsy actarit Launched interleukin receptor agonist rheumatology rheumatoid arthritis ACTB-1003 Phase 1 FGFR inhibitor | VEGFR inhibitor FGF2 | KDR | RPS6KA1 | RPS6KB1 | TEK actinomycin d Launched rna polymerase inhibitor oncology "wilm's tumor, ewing's sarcoma, rhabdomyosarcoma, testicular carcinoma" actinomycin-d Launched RNA polymerase inhibitor oncology | oncology | oncology | oncology Ewing's sarcoma | rhabdomyosarcoma | testicular carcinoma | Wilm's tumor actinonin Preclinical infectious disease gram-negative bacterial infections actinoquinol Preclinical acumapimod Phase 1 p38 MAPK inhibitor MAPK14 ACY-1215 Phase 1/Phase 2 HDAC inhibitor HDAC1 | HDAC2 | HDAC3 | HDAC6 | HDAC8 acyclovir Launched DNA polymerase inhibitor PNP infectious disease | infectious disease | infectious disease chicken pox | genitial herpes | shingles AD-5467 Phase 2 aldose reductase inhibitor AKR1B1 adapalene Launched retinoid receptor agonist RARA | RARB | RARG | RXRA | RXRB | RXRG dermatology acne vulgaris (AV) adaprev Phase 3 TGF beta receptor inhibitor AKR1B1 | GPI | HK1 | M6PR | PYGM | TGFB1 adaptavir Phase 2 CC chemokine receptor antagonist CCR5 adarotene Phase 1 retinoid receptor agonist RARA | RARB | RARG adatanserin Phase 2 serotonin receptor agonist | serotonin receptor antagonist HTR1A | HTR2A adavivint Phase 1 WNT pathway inhibitor ADD-233089 Phase 1 benzodiazepine receptor agonist adefovir Launched DNA polymerase inhibitor infectious disease hepatitis B adefovir-dipivoxil Launched DNA polymerase inhibitor infectious disease hepatitis B adelmidrol Launched anti-inflammatory agent dermatology dermatitis ademetionine Launched methyltransferase stimulant | phosphodiesterase inhibitor PDE4B neurology/psychiatry | neurology/psychiatry attention-deficit/hyperactivity disorder (ADHD) | depression adenine Preclinical protein synthesis stimulant ACACB | ACP1 | APRT | MTAP | PECR | SRPK2 adenosine Launched adenosine receptor agonist ADORA1 | ADORA2A | ADORA2B | ADORA3 | PI4K2A | PI4K2B | TRPM4 cardiology Wolff-Parkinson-White Syndrome (WPW) adenosine 5-monophosphate Launched adenosine receptor agonist ACSL1 | ACSS1 | ACSS2 | ADCY1 | ADK | CREB1 | FBP1 | HINT1 | PDE4B | PDE4D | PIM1 | PRKAA1 | PRKAB1 | PRKAB2 | PYGL | TRPM4 adenosine-phosphate Launched adenosine receptor agonist ACSL1 | ACSS1 | ACSS2 | ADCY1 | ADK | CREB1 | FBP1 | HINT1 | PDE4B | PDE4D | PIM1 | PRKAA1 | PRKAB1 | PRKAB2 | PYGL | TRPM4 adenosine-triphosphate Phase 2 adenosine receptor agonist ABCA1 | ABCB1 | ABCB11 | ABCC2 | ABCC8 | ABCC9 | ABCG1 | ABL1 | ABL2 | ACSL1 | ACSS1 | ACSS2 | ACVR1 | ACVR1B | ACVRL1 | ADCY1 | ADRBK1 | ADRBK2 | AFG3L2 | AKT1 | ALK | AMHR2 | APAF1 | ARAF | ASNA1 | ASNS | ASS1 | CDK15 | GPR17 | ITPR1 | NAE1 | NT5C2 | P2RY1 | P2RY11 | P2RY13 | P2RY2 | P2RY4 | PRKAA1 | RYR1 | RYR2 | RYR3 | SLC25A4 | TNK2 | TRPM4 | TRPM7 adiphenine Launched acetylcholine receptor antagonist CHRNA1 neurology/psychiatry spasms adipic-acid Preclinical solute carrier family member inhibitor SLC22A6 adiporon Preclinical adiponectin receptor agonist ADIPOR1 | ADIPOR2 ADL5859 Phase 2 opioid receptor agonist OPRD1 adomeglivant Preclinical glucagon receptor antagonist GCGR adoprazine Phase 2 dopamine receptor antagonist | serotonin receptor agonist DRD2 | HTR1A adrafinil Launched adrenergic receptor agonist neurology/psychiatry fatigue adrenalone Launched adrenergic receptor agonist ADRA1A hematology hemorrhage adrenosterone Preclinical 11-beta hydroxysteroid dehydrogenase inhibitor HSD11B1 | HSD11B2 adriforant (hydrochloride) Phase 2 histamine receptor antagonist HRH4 dermatology dermatitis ADX-10059 Phase 2 glutamate receptor negative allosteric modulator GRM5 ADX-47273 Preclinical glutamate receptor modulator GRM5 AEE788 Phase 1/Phase 2 EGFR inhibitor | VEGFR inhibitor EGFR | ERBB2 | ERBB4 | FGFR2 | FGFR3 | FLT1 | KDR AEG3482 Preclinical HSP inducer AF38469 Preclinical sortilin inhibitor SORT1 afalanine Phase 3 dopamine receptor agonist DRD2 | SLC6A3 afamelanotide Launched melanocyte-stimulating hormone mimetic | melatonin receptor agonist MC1R | MC3R | MC4R | MC5R dermatology erythropoietic protoporphyria (epp) afatinib Launched EGFR inhibitor EGFR | ERBB2 | ERBB4 oncology non-small cell lung cancer (NSCLC) afimoxifene Phase 2 estrogen receptor antagonist CYP3A5 | ESR1 | ESR2 | ESRRG | PLD1 | PRKCD | PRKCE | PRKCQ | PRKCZ afloqualone Launched acetylcholine receptor antagonist neurology/psychiatry sedative AFN-1252 Phase 2 FABI inhibitor afobazole Launched anxiolytic neurology/psychiatry anxiety afoxolaner Launched gaba receptor antagonist GABRA1 infectious disease flea control AG-1024 Preclinical insulin growth factor receptor inhibitor EGFR | IGF1R AG-14361 Preclinical PARP inhibitor PARP1 AG-490 Preclinical EGFR inhibitor | JAK inhibitor EGFR | JAK2 | JAK3 | STAT3 AG-555 Preclinical tyrosine kinase inhibitor CDK2 AG-556 Preclinical tyrosine kinase inhibitor AGI-5198 Preclinical isocitrate dehydrogenase inhibitor IDH1 AGI-6780 Preclinical isocitrate dehydrogenase inhibitor IDH2 AGM-1470 Phase 2 cell cycle inhibitor METAP2 agmatine Phase 3 nitric oxide synthase inhibitor ADRA2C | ASIC3 | CACNA1B | CHRNA1 | GRIN1 | KCNJ1 | NISCH | PCSK1 | PCSK6 AGN-192403 Preclinical imidazoline receptor ligand NISCH AGN-194310 Phase 3 retinoid receptor antagonist RXRA | RXRB | RXRG AGN-195183 Phase 1/Phase 2 retinoid receptor agonist RARA agomelatine Launched melatonin receptor agonist | serotonin receptor antagonist CYP1A2 | CYP2C19 | HTR2A | HTR2B | HTR2C | MTNR1A | MTNR1B neurology/psychiatry depression AGP-103 Launched membrane permeability inhibitor AH11110 Preclinical adrenergic receptor ligand ADRA1B AH6809 Preclinical prostanoid receptor antagonist PTGDR | PTGER1 | PTGER2 | PTGER3 AH-7614 Preclinical free fatty acid receptor antagonist FFAR4 AI-10-49 Preclinical core binding factor inhibitor CBFB AIM-100 Preclinical tyrosine kinase inhibitor TNK2 AJ76-(+) Preclinical dopamine receptor antagonist DRD2 | DRD3 | DRD4 ajmaline Launched sodium channel blocker KCNH2 | KCNQ1 "cardiology | cardiology, Tachycardias | Tachycardias" "atrial fibrillation (af) | Wolff-Parkinson-White Syndrome (WPW) | wolff-parkinson-white syndrome (wpw), atrial fibrillation (af)" AK-7 Preclinical SIRT inhibitor SIRT2 AKBA Phase 3 lipoxygenase inhibitor ALOX5 aklomide Launched infectious disease coccidiosis AL-8697 Preclinical p38 MAPK inhibitor MAPK14 | RET | TNF alacepril Launched angiotensin converting enzyme inhibitor ACE cardiology hypertension alafosfalin Phase 1 bacterial cell wall synthesis inhibitor alagebrium Phase 2/Phase 3 glycosylation inhibitor alanine Launched alanosine Phase 2 antimetabolite alantolactone Preclinical apoptosis stimulant | STAT inhibitor ACHE | STAT3 alaproclate Phase 2 serotonin receptor antagonist SLC6A4 alarelin Launched gonadotropin releasing factor hormone receptor antagonist GNRH1 albendazole Launched tubulin polymerization inhibitor CYP1A2 | CYP2J2 | TUBA1A | TUBB | TUBB4B infectious disease | infectious disease cystic hydatid disease | parenchymal neurocysticercosis albendazole-oxide Launched anthelmintic agent infectious disease | infectious disease cystic hydatid disease | parenchymal neurocysticercosis albuterol Launched adrenergic receptor agonist ADRB2 pulmonary asthma alcaftadine Launched histamine receptor antagonist HRH1 allergy allergic conjunctivitis alclofenac Launched cyclooxygenase inhibitor PTGS1 | PTGS2 rheumatology rheumatoid arthritis alclometasone dipropionate Launched glucocorticoid receptor agonist NR3C1 Dermatology corticosteroid-responsive dermatoses alclometasone-dipropionate Launched glucocorticoid receptor agonist CYP3A4 | NR3C1 | SERPINA6 dermatology corticosteroid-responsive dermatoses alcuronium Launched muscle relaxant CHRM1 | CHRM2 | CHRM3 | CHRM4 | CHRNA7 neurology/psychiatry muscle relaxant alda-1 Preclinical aldehyde dehydrogenase activator ALDH2 aldose reductase-in-1 Phase 3 aldose reductase inhibitor AKR1B1 cardiology cardiomyopathy aldoxorubicin Phase 3 topoisomerase inhibitor TOP2A alectinib Launched ALK tyrosine kinase receptor inhibitor ALK | MET oncology non-small cell lung cancer (NSCLC) aleglitazar Phase 3 ppar receptor agonist PPARA | PPARG endocrinology diabetes mellitus alendronate Launched bone resorption inhibitor ATP6V1A | FDPS | PTPN4 | PTPRE | PTPRS orthopedics osteoporosis alexidine Preclinical phosphatidylglycerophosphatase inhibitor CXCR4 | PTPMT1 alfacalcidol Launched vitamin D receptor agonist CYP27B1 | VDR endocrinology vitamin D deficiency alfadolone-acetate Phase 2 benzodiazepine receptor agonist alflutinib Phase 2 protein tyrosine kinase inhibitor EGFR oncology non-small cell lung cancer (nsclc) alfuzosin Launched adrenergic receptor antagonist ADRA1A | ADRA1B | ADRA1D | SCN10A | SCN11A | SCN1A | SCN2A | SCN3A | SCN4A | SCN5A | SCN7A | SCN8A | SCN9A urology benign prostatic hyperplasia (BPH) algestone acetophenide Launched endocrinology contraceptive algestone-acetophenide Launched endocrinology contraceptive alibendol Launched antispasmodic gastroenterology bile stimulation alicapistat Phase 1 calpain inhibitor CAPN1 | CAPN2 neurology/psychiatry alzheimer's disease alimemazine Launched histamine receptor agonist | histamine receptor antagonist HRH1 allergy | neurology/psychiatry | neurology/psychiatry | pulmonary cough suppressant | itching | sedative | urticaria alinidine Phase 3 bradycardic effect HCN1 | HCN2 | HCN3 | HCN4 alisertib Phase 3 Aurora kinase inhibitor AURKA aliskiren-hemifumarate Launched renin inhibitor REN cardiology hypertension alisporivir Phase 3 cyclophilin inhibitor PPIA alizapride Launched dopamine receptor antagonist DRD2 gastroenterology nausea alizapride hcl Launched dopamine receptor antagonist gastroenterology nausea alizarin Preclinical alk2-in-1 Phase 1 alk inihibitor ALK oncology glioma allantoin Launched cosmetic dermatology skin protectant allicin Phase 2 cytokine production inhibitor CTSB | CTSL | TRPA1 | TRPV1 allopurinol Launched xanthine oxidase inhibitor XDH rheumatology | urology gout | kidney stones allopurinol-riboside Phase 2 "anti-leishmanial agent | anti-leishmanial agent, phosphorylase inhibitor | phosphorylase inhibitor" PNP allylestrenol Launched steroidal progestin ESR1 | PGR | SLC6A9 obstetrics/gynecology premature labor allylisothiocyanate Preclinical TRPV agonist TRPA1 allylthiourea Preclinical nitrification inhibitor alminoprofen Preclinical cyclooxygenase inhibitor PTGS1 | PTGS2 cardiology edema almitrine Launched neurotransmitter agonist ATP1A1 pulmonary chronic obstructive pulmonary disease (COPD) almonertinib Phase 2 egfr inhibitor EGFR oncology non-small cell lung cancer (nsclc) almorexant Phase 3 orexin receptor antagonist HCRTR1 | HCRTR2 almotriptan Launched serotonin receptor agonist HTR1B | HTR1D | HTR1F neurology/psychiatry migraine headache aloe-emodin Preclinical anticancer agent CASP3 | CASP8 alofanib Phase 1 fgfr inhibitor FGFR2 oncology ovarian cancer alogliptin Launched dipeptidyl peptidase inhibitor DPP4 endocrinology diabetes mellitus alogliptin benzoate Launched dipeptidyl peptidase inhibitor DPP4 endocrinology diabetes mellitus aloin Preclinical angiogenesis inhibitor aloperine Preclinical alosetron Withdrawn serotonin receptor antagonist HTR3A alovudine Phase 2 DNA synthesis marker aloxistatin Phase 3 protease inhibitor CTSB | CTSG | CTSH | CTSL alpelisib Launched PI3K inhibitor PIK3CA | PIK3CB | PIK3CD | PIK3CG oncology breast cancer alpha-asarone Preclinical cytochrome P450 inhibitor | HMGCR inhibitor ACHE | HMGCR alpha-D-glucopyranose Preclinical alpha-glucosyl-hesperidin Preclinical antioxidant alpha-linolenic-acid Phase 3 omega 3 fatty acid stimulant ELOVL4 | FADS1 | FADS2 | FFAR1 | FFAR4 | PTGS2 | SLC8A1 | TRPV1 alpha-methylhistamine-dihydrobromide-(R)-(-) Preclinical histamine receptor agonist HRH3 alpha-methylhistamine-dihydrobromide-(S)-(+) Preclinical histamine receptor agonist HRH3 alpha-methylserotonin Preclinical serotonin receptor agonist HTR1D | HTR1E | HTR1F | HTR2A | HTR2B | HTR2C | HTR4 alpha-tochopherol Launched antioxidant endocrinology vitamin E deficiency alpha-tochopheryl-acetate Launched antioxidant endocrinology vitamin E deficiency alpidem Withdrawn benzodiazepine receptor agonist GABRA1 alprenolol Launched adrenergic receptor antagonist ADRB1 | ADRB2 cardiology angina pectoris alprostadil Launched prostanoid receptor agonist CATSPER1 | CATSPER2 | CATSPER3 | CATSPER4 | PTGDR | PTGER1 | PTGER2 | PTGER4 | PTGIR cardiology congenital heart defects alrestatin Preclinical aldose reductase inhibitor AKR1B1 ALS-8112 Phase 1 ALS-8176 Phase 1 RNA polymerase inhibitor altanserin Phase 2 serotonin receptor antagonist HTR2A | HTR2C althiazide Launched diuretic cardiology hypertension altinicline Phase 2 nicotinic receptor agonist CHRNA4 | CHRNB2 altiratinib Phase 1 MET inhibitor | VEGFR inhibitor KDR | MET | TEK altrenogest Launched progestogen hormone PGR endocrinology estrus altretamine Launched DNA synthesis inhibitor oncology ovarian cancer alverine Launched muscle relaxant HTR1A gastroenterology | gastroenterology diverticular disease | irritable bowel syndrome alvespimycin Phase 2 HSP inhibitor HSP90AA1 alvimopan Launched opioid receptor antagonist OPRD1 | OPRK1 | OPRM1 gastroenterology postoperative ileus alvocidib Phase 2 CDK inhibitor BCL2 | BIRC5 | CCNT1 | CDK1 | CDK2 | CDK4 | CDK5 | CDK6 | CDK7 | CDK8 | CDK9 | EGFR | MCL1 | PYGM | XIAP ALX-40-4C Preclinical CC chemokine receptor antagonist CXCR4 ALX-5407 Phase 1 glycine transporter inhibitor SLC6A9 AM095 Preclinical lysophosphatidic acid receptor antagonist LPAR1 AM-1241 Preclinical cannabinoid receptor agonist CNR1 | CNR2 AM211 Preclinical prostaglandin inhibitor PTGDR2 AM-24 Phase 2 lipoxygenase inhibitor ALOX5 | SELL AM-251 Preclinical cannabinoid receptor antagonist CNR1 | GPR18 | GPR55 AM-281 Preclinical cannabinoid receptor antagonist CNR1 | CNR2 | GPR55 AM-404 Preclinical cyclooxygenase inhibitor | FAAH inhibitor | TRPV antagonist CNR1 | CNR2 | FAAH | TRPV1 AM-580 Preclinical retinoid receptor agonist RARA AM-630 Preclinical cannabinoid receptor antagonist CNR1 | CNR2 AM679 Preclinical cannabinoid receptor agonist | lipoxygenase inhibitor ALOX5AP | CNR1 | CNR2 AM-92016 Preclinical potassium channel blocker GRIN1 | GRIN2B amantadine Launched glutamate receptor antagonist DRD2 | GRIN1 | GRIN2A | GRIN2B | GRIN2C | GRIN2D | GRIN3A infectious disease | neurology/psychiatry influenza A virus infection | Parkinson's Disease ambazone Phase 1 DNA damage inducer ambenonium Launched cholinesterase inhibitor ACHE neurology/psychiatry myasthenia gravis ambrisentan Launched endothelin receptor antagonist CYP2C19 | CYP3A4 | CYP3A5 | EDNRA | EDNRB | SLCO1B3 pulmonary pulmonary arterial hypertension (PAH) ambroxol Launched sodium channel blocker CYP3A4 | GBA pulmonary bronchitis amcasertib Phase 2 kinase inhibitor amcenestrant Phase 3 ESR1 oncology breast cancer amcinonide Launched glucocorticoid receptor agonist NR3C1 dermatology | Dermatology corticosteroid-responsive dermatoses | dermatitis AMD11070 Phase 3 CC chemokine receptor antagonist CCR5 | CXCR4 AMD-3465 Preclinical CC chemokine receptor antagonist CXCR4 amdinocillin Launched bacterial cell wall synthesis inhibitor infectious disease | infectious disease gram-negative bacterial infections | urinary tract infections ameltolide Preclinical anticonvulsant amenamevir Phase 1 helicase primase inhibitor ametantrone Preclinical anticancer agent TOP2A amezinium Launched adrenergic receptor agonist ADRB2 cardiology hypotension amfebutamone hcl Launched dopamine reuptake inhibitor SLC6A2 | SLC6A3 neurology/psychiatry depression amfenac Launched cyclooxygenase inhibitor PTGS1 | PTGS2 neurology/psychiatry pain relief amflutizole Phase 2 xanthine oxidase inhibitor XDH AMG-176 Phase 1 MCL1 inhibitor MCL1 AMG-208 Phase 1 tyrosine kinase inhibitor MET AMG-232 Phase 2 MDM inhibitor MDM2 AMG319 Phase 2 PI3K inhibitor PIK3CD AMG-319 Phase 2 PI3K inhibitor PIK3CD amg 333 Phase 1 transient receptor potential channel antagonist TRPM8 neurology/psychiatry migraine headache AMG-337 Phase 2 MET inhibitor MET AMG458 Preclinical MET inhibitor MET AMG-487 Phase 2 CC chemokine receptor antagonist CXCR3 AMG-487-(+/-) Phase 2 CC chemokine receptor antagonist CXCR3 AMG-510 Phase 1/Phase 2 K-Ras inhibitor KRAS AMG-517 Phase 1 TRPV antagonist TRPV1 AMG-548 Phase 1 MAP kinase inhibitor MAPK11 | MAPK12 | MAPK13 | MAPK14 | TNF AMG-837 Phase 1 free fatty acid receptor agonist FFAR1 AMG900 Phase 1 Aurora kinase inhibitor AURKA | AURKB | AURKC AMG-925 Phase 1 CDK inhibitor | FLT3 inhibitor CDK4 | CDK6 | FLT3 AMG-9810 Preclinical TRPV antagonist TRPV1 AMG-PERK-44 Preclinical PERK inhibitor EIF2AK4 AMI-1 Preclinical protein arginine N-methyltransferase inhibitor PRMT1 amibegron Phase 3 adrenergic receptor agonist ADRB3 amidopyrine Launched analgesic agent dermatology dermatitis herpetiformis (DH) amifampridine Launched potassium channel blocker neurology/psychiatry Lambert-Eaton myasthenic syndrome (LEMS) amiflamine Phase 1 monoamine oxidase inhibitor MAOA | MAOB | SLC6A2 amifostine Launched reducing agent ALPPL2 | ENPP1 nephrology renal toxicity amikacin Launched bacterial 30S ribosomal subunit inhibitor infectious disease gram-negative bacterial infections amiloride Launched sodium channel blocker AOC1 | ASIC1 | ASIC2 | ASIC3 | PKD2 | PKD2L1 | PLAU | SCNN1A | SCNN1B | SCNN1D | SCNN1G | SLC9A1 | TRPC7 | TRPV2 cardiology | cardiology congestive heart failure | hypertension amineptine Withdrawn dopamine receptor agonist SLC6A2 | SLC6A4 aminocaproic-acid Launched plasminogen activator inhibitor LPA | PLAT | PLG hematology fibrinolytic bleeding aminoglutethimide Launched glucocorticoid receptor antagonist CYP11A1 | CYP19A1 | NR3C1 endocrinology | oncology breast cancer | Cushing's syndrome aminoguanidine Phase 3 nitric oxide synthase inhibitor AKR1B1 | NOS2 | TIMP3 aminohydroxybutyric-acid Launched neurology/psychiatry epilepsy aminolevulinic-acid-benzyl-ester Phase 1 aminomethyltransferase Preclinical nitric oxide synthase inhibitor NOS2 aminopentamide Launched acetylcholine receptor antagonist CHRM1 gastroenterology | gastroenterology | gastroenterology acute abdominal visceral spasm | hypertrophic gastritis (GHG) | nausea aminophylline Launched adenosine receptor antagonist ADORA1 | ADORA2A | ADORA2B | ADORA3 | HDAC2 | PDE3A | PDE3B | PDE4A | PDE4B | PDE4C | PDE4D | PDE5A pulmonary | pulmonary | pulmonary asthma | bronchitis | emphysema aminopterin Phase 3 dihydrofolate reductase inhibitor DHFR | SLC46A1 aminopurvalanol-a Preclinical CDK inhibitor | tyrosine kinase inhibitor CDK1 | CDK2 | CDK5 aminosalicylate Launched cyclooxygenase inhibitor ALOX5 | CHUK | PLA2G2E | PTGS1 | PTGS2 gastroenterology | gastroenterology inflammatory bowel disease | ulcerative colitis aminothiadiazole Phase 2 inosine monophosphate dehydrogenase inhibitor ADORA3 | IMPDH1 aminothiazole Preclinical cyclin D inhibitor NOS2 amiodarone Launched potassium channel blocker ADRB1 | CACNA1H | CACNA2D2 | CHRM3 | CYP2C8 | KCNA7 | KCNH2 | SCN5A cardiology ventricular arrhythmias amiprilose Phase 3 CD antagonist amiselimod Phase 2 sphingosine 1-phosphate receptor modulator S1PR1 amisulpride Launched dopamine receptor antagonist DRD2 | DRD3 neurology/psychiatry | neurology/psychiatry | neurology/psychiatry bipolar disorder | psychosis | schizophrenia amitifadine Phase 3 serotonin transporter (SERT) inhibitor SLC6A2 | SLC6A3 | SLC6A4 amitraz Launched adrenergic receptor agonist ADRA1A | ADRA2A infectious disease generalized demodicosis amitriptyline Launched norepinephrine inhibitor | norepinephrine reuptake inhibitor | serotonin–norepinephrine reuptake inhibitor (SNRI) | serotonin receptor antagonist ADRA1A | ADRA1B | ADRA1D | ADRA2A | ADRB1 | ADRB2 | ADRB3 | CHRM1 | CHRM2 | CHRM3 | CHRM4 | CHRM5 | CYP2C19 | CYP3A5 | HRH1 | HRH2 | HRH4 | HTR1A | HTR1B | HTR1D | HTR2A | HTR2C | HTR6 | HTR7 | KCNA1 | KCND2 | KCND3 | KCNQ2 | KCNQ3 | NTRK1 | NTRK2 | OPRD1 | OPRK1 | OPRM1 | SCN4A | SIGMAR1 | SLC6A2 | SLC6A4 neurology/psychiatry depression amlexanox Launched histamine receptor modulator FGF1 | IL3 | PDE4A | PDE4B | PDE4C | PDE4D | S100A12 | S100A13 allergy | dental | ophthalmology | pulmonary allergic rhinitis | aphthous ulcers | asthma | conjunctivitis amlodipine Launched calcium channel blocker ABCG2 | CACNA1C | CACNA1D | CACNA1F | CACNA1S | CACNA2D1 cardiology | cardiology | cardiology | cardiology chronic stable angina | coronary artery disease (CAD) | hypertension | vasospastic angina amlodipine besylate (norvasc) Launched calcium channel blocker CACNA1C | CACNA1D | CACNA1F | CACNA1S | CACNA2D1 cardiology "hypertension, chronic stable angina, vasospastic angina, coronary artery disease (cad)" ammonium glycyrrhizinate Launched thrombin inhibitor HSD11B1 | HSD11B2 | SLCO1B1 | SLCO1B3 dermatology cosmetic ammonium-glycyrrhizinate Launched thrombin inhibitor F2 | HSD11B1 | HSD11B2 | SLCO1B1 | SLCO1B3 dermatology cosmetic ammonium-lactate Launched HCAR1 dermatology | dermatology ichthyosis vulgaris | xerosis cutis ammonium-perfluorocaprylate Phase 1 Pim kinase inhibitor PIM1 AMN-082 Preclinical glutamate receptor modulator GRM7 amodiaquine Launched histamine receptor agonist CYP2C8 | HNMT infectious disease malaria amonafide Phase 3 topoisomerase inhibitor TOP2A | TOP2B amorolfine Launched membrane integrity inhibitor infectious disease onychomycosis amoxapine Launched norepinephrine reputake inhibitor ADRA1A | ADRA1B | ADRA1D | ADRA2A | ADRA2B | ADRA2C | CHRM1 | CHRM2 | CHRM3 | CHRM4 | CHRM5 | DRD1 | DRD2 | DRD3 | DRD4 | DRD5 | GABRA1 | GABRA2 | GABRA3 | GABRA4 | GABRA5 | GABRA6 | GABRB1 | GABRB2 | GABRB3 | GABRD | GABRE | GABRG1 | GABRG2 | GABRG3 | GABRP | GABRQ | HRH1 | HRH4 | HTR1A | HTR1B | HTR2A | HTR2B | HTR2C | HTR3A | HTR6 | HTR7 | SLC6A2 | SLC6A3 | SLC6A4 neurology/psychiatry depression amoxicillin Launched penicillin binding protein inhibitor CYP2C19 | SLC15A1 | SLC15A2 | SLC22A6 gastroenterology | infectious disease | infectious disease | infectious disease | infectious disease | infectious disease | infectious disease duodenal ulcer disease | ear infections | genitourinary tract infections | gonorrhea | respiratory tract infections | skin infections | throat infections ampalex Phase 2 glutamate receptor agonist GRIA1 | GRIA2 | GRIA3 | GRIA4 AMPA-(RS) Preclinical glutamate receptor agonist GRIN1 AMPA-(S) Preclinical glutamate receptor agonist GRIA2 | GRIN1 amperozide Launched dopamine receptor antagonist DRD2 | FAAH | HTR2A neurology/psychiatry psychosis amphotericin-b Launched membrane permeability enhancer infectious disease fungal infection ampicillin Launched bacterial cell wall synthesis inhibitor infectious disease | infectious disease | infectious disease | infectious disease | infectious disease | infectious disease bacterial septicemia | endocarditis | gastrointestinal infections | meningitis | respiratory tract infections | urinary tract infections ampiroxicam Launched cyclooxygenase inhibitor PTGS1 | PTGS2 neurology/psychiatry pain relief amprenavir Launched HIV protease inhibitor infectious disease human immunodeficiency virus (HIV-1) amprolium Launched thiamine uptake blocker infectious disease coccidiosis ampyrone Preclinical cyclooxygenase inhibitor amrinone Launched phosphodiesterase inhibitor PDE3A | PDE3B | PDE4B | TNF cardiology congestive heart failure amrubicin Launched topoisomerase inhibitor TOP2A | TOP2B oncology small cell lung cancer amsacrine Launched topoisomerase inhibitor KCNH2 | TOP2A hematologic malignancy acute lymphoblastic leukemia (ALL) amthamine Preclinical histamine receptor agonist HRH2 amtolmetin-guacil Launched cyclooxygenase inhibitor PTGS1 | PTGS2 rheumatology | rheumatology osteoarthritis | rheumatoid arthritis amuvatinib Phase 2 FLT3 inhibitor | KIT inhibitor | PDGFR tyrosine kinase receptor inhibitor | RAD51 inhibitor | RET tyrosine kinase inhibitor AXL | FLT3 | KIT | MET | MST1R | PDGFRA | RAD51 | RET amxt-1501 tetrahydrochloride Phase 1 ornithine decarboxylase inhibitor ODC1 | TPO oncology neuroblastoma amygdalin Phase 2 caspase activator CASP3 amyleine Preclinical local anesthetic amylene-hydrate Preclinical local anesthetic amylmetacresol is a component of strepsis mixture Launched sodium channel blocker SCN2A otolaryngology sore throat amyl-nitrite Preclinical atrial natriuretic peptide receptor agonist amyloid p-in-1 Phase 1 beta amyloid inhibitor APP neurology/psychiatry alzheimer's disease AMZ30 Preclinical protein phosphatase inhibitor AN2718 Phase 1 leucyl-tRNA synthetase inhibitor ANA-12 Preclinical tropomyosin receptor kinase inhibitor NTRK2 anabasine Preclinical acetylcholine receptor agonist anacetrapib Phase 3 cholesteryl ester transfer protein inhibitor CETP anacetrapib (mk-0859) Phase 3 cholesteryl ester transfer protein inhibitor CETP anagliptin Launched dipeptidyl peptidase inhibitor DPP4 | SLC22A8 endocrinology diabetes mellitus anagrelide Launched phosphodiesterase inhibitor PDE3A hematologic malignancy | hematology myeloproliferative neoplasms | thrombocythemia anamorelin Phase 3 growth hormone secretagogue receptor agonist GHSR anandamide Phase 2 cannabinoid receptor agonist CACNA1G | CACNA1H | CACNA1I | CNR1 | CNR2 | GLRA1 | GPR18 | GPR55 | KCNA2 | KCND3 | KCNK3 | KCNK9 | TRPM8 | TRPV1 anastrozole Launched aromatase inhibitor CYP19A1 oncology breast cancer andarine Phase 1 androgen receptor modulator AR andrographolide Phase 2 tumor necrosis factor production inhibitor IL1B | IL6 | NFKB1 | NFKB2 | TNF androstenone Preclinical steroid androsterone Preclinical androgen receptor agonist anecortave-acetate Launched angiogenesis inhibitor ophthalmology macular degeneration anethole Launched glutathione transferase stimulant anethole-trithione Launched glutathione transferase stimulant dental xerostomia anguidine Preclinical apoptosis stimulant | protein synthesis inhibitor SLC5A1 Endocrinology diabetes mellitus anidulafungin Launched "fungal 1,3-beta-D-glucan synthase inhibitor" infectious disease | infectious disease | infectious disease candidemia | esophageal candidiasis | fungal infection aniracetam Launched glutamate receptor agonist DRD2 | GRIA1 | GRIA2 | GRIA3 | GRIA4 | HTR2A anisindione Launched vitamin K antagonist GGCX hematology deep vein thrombosis (DVT) anisodamine Phase 3 lipid peroxidase inhibitor ADRA1A | TNF anisomycin Preclinical DNA synthesis inhibitor NHP2L1 | RPL10L | RPL11 | RPL13A | RPL15 | RPL19 | RPL23 | RPL23A | RPL26L1 | RPL3 | RPL37 | RPL8 | RSL24D1 anisotropine Launched acetylcholine receptor antagonist gastroenterology peptic ulcer disease (PUD) anisotropine methylbromide Launched acetylcholine receptor antagonist gastroenterology peptic ulcer disease (pud) anlotinib Launched PDGFR tyrosine kinase receptor inhibitor | VEGFR inhibitor KDR | PDGFRB anpirtoline Phase 1 serotonin receptor agonist HTR1B | HTR3A ANR-94 Preclinical adenosine receptor antagonist ADORA2A ansamitocin-p-3 Preclinical apoptosis stimulant ansofaxine Phase 3 ansofaxine hydrochloride Phase 3 dopamine-norepinephrine reuptake inhibitor ADRA1A | DRD2 | HTR2A neurology/psychiatry depression antagonist-g Phase 1 neuropeptide receptor antagonist MAPK8 antalarmin Preclinical corticotropin releasing factor receptor antagonist CRHR1 antazoline Launched antihistamine HRH1 ophthalmology | otolaryngology conjunctivitis | nasal congestion anthralin Launched DNA synthesis inhibitor dermatology psoriasis anthraquinone Preclinical CDC inhibitor CDC25B antimonyl Phase 1 antimony-potassium Phase 2 antimony potassium tartrate trihydrate Phase 2 antimycin-A Preclinical ATP synthase inhibitor CYCS antineoplaston a10 Phase 2 p53 activator DPM1 | LGALS1 oncology brainstem glioma antioxine Launched AP-18 Preclinical transient receptor potential channel antagonist TRPA1 AP1903 Phase 1/Phase 2 MTOR AP26113 Phase 2 ALK tyrosine kinase receptor inhibitor ALK | EGFR apabetalone Phase 3 apolipoprotein expression enhancer APOA1 | BRD3 | BRD4 apafant Phase 3 platelet activating factor receptor antagonist PTAFR apalutamide Launched androgen receptor antagonist AR oncology prostate cancer apararenone Preclinical mineralocorticoid receptor antagonist NR3C2 apatinib Phase 3 RET tyrosine kinase inhibitor CSK | CYP3A5 | KDR | KIT | RET APC-100 Phase 1/Phase 2 androgen receptor antagonist | anti-inflammatory agent AR APcK-110 Preclinical KIT inhibitor KIT | STAT3 APD597 Phase 1 glucose dependent insulinotropic receptor agonist GPR119 APD668 Phase 1 glucose dependent insulinotropic receptor agonist GPR119 aphidicolin Phase 1 RNA synthesis inhibitor API-001 Phase 2 sigma receptor antagonist SIGMAR1 API-1 Preclinical AKT inhibitor AKT1 | AKT2 | AKT3 apigenin Preclinical casein kinase inhibitor | cell proliferation inhibitor AKR1B1 | AR | CDK6 | CFTR | CYP19A1 | CYP1A2 | CYP1B1 | HSD17B1 | MAOA | ODC1 | XDH apixaban Launched coagulation factor inhibitor CYP2C19 | CYP2C8 | CYP2J2 | F10 cardiology | hematology | hematology | hematology | neurology/psychiatry atrial fibrillation (AF) | deep vein thrombosis (DVT) | pulmonary embolism (PE) | stroke | systemic embolism apocynin Phase 1 NADPH oxidase inhibitor NOX3 | NOX4 apomorphine hydrochloride Launched dopamine receptor agonist ADRA2A | ADRA2B | ADRA2C | CALY | DRD1 | DRD2 | DRD3 | DRD4 | DRD5 | HTR1A | HTR1B | HTR1D | HTR2A | HTR2B | HTR2C | HTR5A neurology/psychiatry parkinson's disease apoptosis-activator-II Preclinical carboxylesterase inhibitor BCHE | CES1 APR-246 Phase 3 p53 activator TP53 apraclonidine Launched adrenergic receptor agonist ADRA1A | ADRA2A | ADRA2B | ADRA2C ophthalmology | ophthalmology glaucoma | intraocular pressure apramycin Launched bacterial 30S ribosomal subunit inhibitor infectious disease gram-negative bacterial infections apramycin sulfate Launched bacterial 30s ribosomal subunit inhibitor infectious disease gram-negative bacterial infections apratastat Phase 2 matrix metalloprotease inhibitor | tumor necrosis factor production inhibitor ADAM17 | MMP1 | MMP13 | MMP9 apremilast Launched phosphodiesterase inhibitor PDE4A | PDE4B | PDE4C | PDE4D | TNF | TNFRSF1A dermatology | rheumatology psoriasis | psoriatic arthritis aprepitant Launched tachykinin antagonist CYP2C19 | TACR1 gastroenterology | gastroenterology nausea | vomiting apricitabine Phase 3 nucleoside reverse transcriptase inhibitor aprindine Launched voltage-gated sodium channel blocker CALM1 | SCN5A cardiology cardiac arrythmia apronal Preclinical cytochrome P450 modulator CYB5A | CYB5R1 | POR aptiganel Phase 3 glutamate receptor antagonist GRIN1 APTO-253 Phase 1 krüppel-like factor expression enhancer KLF4 APY0201 Preclinical phosphoinositide dependent kinase inhibitor IL12A | IL12B | PIKFYVE APY-29 Preclinical serine/threonine kinase inhibitor ERN1 apyramide Preclinical cyclooxygenase inhibitor PTGS1 | PTGS2 AQ-13 Phase 2 antimalarial agent AQ-RA741 Preclinical acetylcholine receptor antagonist CHRM2 AQW-051 Preclinical nicotinic receptor agonist CHRNA7 AR-12 Phase 1 phosphoinositide dependent kinase inhibitor PDPK1 ar-13324 m1 metabolite Phase 1 protein kinase c inhibitor PRKCA | ROCK1 ophthalmology macular degeneration AR-42 Phase 1 HDAC inhibitor AKT1 | HDAC1 | HDAC2 ar-9281 Phase 2 epoxide hydolase inhibitor EPHX2 cardiology hypertension AR-A014418 Preclinical glycogen synthase kinase inhibitor GSK3B arachidonic-acid Phase 1 cytochrome P450 inhibitor CLCN2 | CYP2J2 | CYP4F2 | KCNJ4 | KCNK10 | KCNK18 | KCNK2 | PRKCZ | PTGS1 | TRPC6 | TRPM2 aramchol Phase 2/Phase 3 stearoyl-CoA desaturase inhibitor SCD aranidipine Preclinical l-type calcium channel blocker CACNA1C cardiology hypertension arbidol Launched cytochrome P450 inhibitor CYP2C19 | CYP2E1 | CYP3A4 | CYP3A5 infectious disease influenza A virus infection arbutamine Withdrawn adrenergic receptor agonist ADRB1 | ADRB2 | ADRB3 cardiology coronary artery disease (cad) arbutin Phase 2/Phase 3 melanin inhibitor TYR AR-C155858 Preclinical monocarboxylate transporter inhibitor SLC16A1 | SLC16A7 ARC-239 Preclinical adrenergic receptor antagonist ADRA2A | ADRA2B | ADRA2C arctigenin Preclinical MEK inhibitor ADIPOR1 | AHR | CHUK | MAP2K1 arcyriaflavin-a Preclinical CDK inhibitor CCND1 | CCNE1 | CDK2 | CDK4 ardeparin Withdrawn thrombin inhibitor SERPIND1 arecaidine-but-2-ynyl-ester Preclinical acetylcholine receptor agonist CHRM2 arecaidine-propargyl-ester Preclinical acetylcholine receptor agonist CHRM1 | CHRM2 | CHRM3 | CHRM4 arecoline Phase 1 acetylcholine receptor agonist CHRM1 | CHRM2 | CHRM3 | CHRM4 argatroban Launched thrombin inhibitor CYP3A5 | F2 hematology heparin-induced thrombocytopenia (HIT) argireline Phase 3 neurotransmitter release inhibitor arglabin Launched farnesyltransferase inhibitor FNTA | NFKB1 arimoclomol Phase 3 superoxide dismutase inhibitor HSPA1A | SOD1 neurology/psychiatry amyotrophic lateral sclerosis (als) aripiprazole Launched serotonin receptor agonist | serotonin receptor antagonist ADRA1A | ADRA1B | ADRA2A | ADRA2B | ADRA2C | CHRM1 | CHRM2 | CHRM3 | CHRM4 | CHRM5 | DRD1 | DRD2 | DRD3 | DRD4 | DRD5 | HRH1 | HTR1A | HTR1B | HTR1D | HTR1E | HTR2A | HTR2C | HTR3A | HTR6 | HTR7 neurology/psychiatry | neurology/psychiatry | neurology/psychiatry bipolar disorder | depression | schizophrenia aripiprazole-lauroxil Launched serotonin receptor agonist DRD2 | HTR1A | HTR2A neurology/psychiatry schizophrenia arofylline Phase 3 phosphodiesterase inhibitor PDE4A | PDE4B | PDE4C | PDE4D arotinolol Launched adrenergic receptor antagonist ADRB1 | ADRB2 | ADRB3 cardiology | neurology/psychiatry hypertension | tremors ARQ-092 Phase 1 AKT inhibitor AKT2 ARQ-621 Phase 1 kinesin-like spindle protein inhibitor KIF11 ARRY-334543 Phase 2/Phase 3 EGFR inhibitor EGFR | ERBB2 | ERBB4 arsanilic-acid Phase 1 LYZ arsenic-trioxide Launched apoptosis stimulant AKT1 | CCND1 | IKBKB | JUN | MAPK1 | MAPK3 | TXNRD1 gastroenterology diarrhea arsenic trioxide diethanolamine salt Launched apoptosis stimulant AKT1 | CCND1 | IKBKB | JUN | MAPK1 | MAPK3 | TXNRD1 gastroenterology diarrhea artelinic acid Preclinical antimalarial agent infectious disease malaria artemether Launched antimalarial agent ATP1A1 | CYP2B6 | CYP2C19 | CYP3A5 infectious disease malaria artemisinin Launched DNA synthesis inhibitor CYP2B6 infectious disease malaria artemotil Launched infectious disease malaria artesunate Launched DNA synthesis inhibitor infectious disease malaria articaine Launched local anesthetic neurology/psychiatry local anesthetic arundic-acid Phase 2/Phase 3 astrocyte modulating agent APP | PTGS2 | S100B ARV-825 Preclinical bromodomain inhibitor BRD4 AS-1269574 Preclinical glucose dependent insulinotropic receptor agonist GPR119 AS-1892802 Preclinical rho associated kinase inhibitor ROCK1 AS-1949490 Preclinical SHIP2 phosphatase inhibitor INPP5D AS-2034178 Preclinical free fatty acid receptor agonist FFAR1 | INS AS-2444697 Preclinical interleukin inhibitor IRAK4 AS-252424 Preclinical PI3K inhibitor PIK3CG AS-604850 Preclinical PI3K inhibitor PIK3CA | PIK3CG AS-703026 Phase 2 MEK inhibitor MAP2K1 | MAP2K2 AS-77 Phase 1 potassium channel blocker KCNA3 | KCNA5 | KCNN4 ASA-404 Phase 3 angiogenesis inhibitor asapiprant Preclinical prostaglandin inhibitor PTGDR asaraldehyde Preclinical cyclooxygenase inhibitor PTGS2 asciminib Phase 2 Bcr-Abl kinase inhibitor ABL1 | BCR ASC-J9 Phase 2 androgen receptor enhancer AR ascomycin Preclinical calcineurin inhibitor FKBP1A ascorbic-acid Launched antioxidant AKR1B1 | SLC23A1 | SLC23A2 endocrinology scurvy asenapine Launched dopamine receptor antagonist | serotonin receptor antagonist DRD1 | DRD2 | HRH1 | HTR1A | HTR1B | HTR1D | HTR1E | HTR2A neurology/psychiatry | neurology/psychiatry bipolar disorder | schizophrenia asenapine maleate Launched "dopamine receptor antagonist, serotonin receptor antagonist" DRD2 | HRH1 | HTR1A | HTR1B | HTR1D | HTR1E | HTR2A neurology/psychiatry "schizophrenia, bipolar disorder" asiatic-acid Preclinical apoptosis stimulant PYGM asimadoline Phase 3 opioid receptor agonist OPRK1 asivatrep Phase 3 transient receptor potential channel antagonist TRPV1 ASP-2535 Phase 1 glycine transporter inhibitor SLC6A9 ASP3026 Phase 1 ALK tyrosine kinase receptor inhibitor ALK asp5878 Phase 1 fgfr inhibitor FGFR3 ASP-6537 Preclinical cyclooxygenase inhibitor PTGS1 ASP-9521 Preclinical aldo-keto reductase inhibitor AKR1C3 aspartame Launched TAS1R2 | TRPV1 aspirin Launched cyclooxygenase inhibitor AKR1C1 | ASIC3 | EDNRA | HSPA5 | IKBKB | NFKB1 | NFKB2 | NFKBIA | PRKAA1 | PRKAA2 | PRKAB1 | PRKAB2 | PRKAG1 | PRKAG2 | PRKAG3 | PTGS1 | PTGS2 | RPS6KA3 | TP53 dental | endocrinology | neurology/psychiatry | neurology/psychiatry fever | headache | muscle pain | toothache AST-1306 Phase 1 EGFR inhibitor EGFR | ERBB2 | ERBB4 astaxanthin Launched antioxidant astemizole Withdrawn histamine receptor antagonist CYP2J2 | CYP3A5 | HRH1 | KCNH1 | KCNH2 astilbin Preclinical "nuclear factor erythroid derived, like (NRF2) activator" AKR1B1 | GABPA astragaloside-a Preclinical anti-inflammatory agent ASTX660 Phase 1/Phase 2 apoptosis inhibitor BIRC2 | XIAP asunaprevir Phase 3 HCV inhibitor asymmetrical-dimethylarginine Phase 1 nitric oxide synthase inhibitor NOS2 | NOS3 AT-1015 Preclinical serotonin receptor antagonist HTR2A AT13148 Phase 1 protein kinase inhibitor AKT1 | AKT2 | AKT3 | ROCK1 | ROCK2 | SGK3 AT13387 Phase 2 HSP inhibitor HSP90AA1 AT-406 Phase 1 IAP antagonist BIRC2 | BIRC3 | XIAP AT-7519 Phase 2 CDK inhibitor CDK1 | CDK2 | CDK4 | CDK5 | CDK6 | CDK9 AT7867 Preclinical AKT inhibitor AKT2 | GSK3B | PKIA | PRKACA | ROCK2 AT-9283 Phase 2 Aurora kinase inhibitor | JAK inhibitor ABL1 | AURKA | AURKB | BCR | FLT3 | JAK2 | JAK3 | RPS6KA6 | STK17A ataluren Launched CFTR channel agonist | dystrophin stimulant CFTR | DMD | F8 | F9 genetics | pulmonary cystic fibrosis | duchenne muscular dystrophy (DMD) atamparib Phase 1 parp inhibitor TIPARP oncology carcinoid tumors atazanavir Launched HIV protease inhibitor infectious disease human immunodeficiency virus (HIV-1) ATB-346 Phase 2 cyclooxygenase inhibitor PTGER2 atenolol-(-) Launched adrenergic receptor antagonist cardiology hypertension atenolol-(+/-) Launched adrenergic receptor antagonist ADRB1 | ADRB2 | LTF | PLA2G2E cardiology | cardiology angina pectoris | hypertension atenolol-(+) Preclinical adrenergic receptor antagonist ADRB1 atglistatin Preclinical adipose triglyceride lipase inhibitor aticaprant Phase 2 opioid receptor antagonist OPRK1 atipamezole Launched adrenergic receptor antagonist neurology/psychiatry reverse sedative atiprimod Phase 2 JAK inhibitor | STAT inhibitor CASP3 | CASP9 | IL6 | JAK2 | STAT3 atizoram Phase 2 phosphodiesterase inhibitor PDE4A | PDE4B | PDE4C | PDE4D atm-3507 tropomyosin receptor kinase inhibitor TPM3 oncology ovarian cancer ATN-161 Phase 2 integrin antagonist ITGA5 | ITGAV | ITGB1 | ITGB3 | ITGB5 atomoxetine Launched norepinephrine transporter inhibitor GRIN1 | GRIN2A | GRIN2B | GRIN2C | GRIN2D | GRIN3A | GRIN3B | SLC6A2 | SLC6A3 | SLC6A4 neurology/psychiatry attention-deficit/hyperactivity disorder (ADHD) atorvastatin Launched HMGCR inhibitor AHR | CYP3A5 | DPP4 | FASLG | HMGCR cardiology | neurology/psychiatry heart attack | stroke atosiban Launched oxytocin receptor antagonist AVPR1A | AVPR1B | AVPR2 | OXT | OXTR Birth | cardiology | cardiology | endocrinology | neurology/psychiatry angina pectoris | hyperlipidemia | myocardial infarction | premature labor | stroke atovaquone Launched mitochondrial electron transport inhibitor infectious disease pneumonia atp Phase 3 purinergic receptor activator Cardiology cardiac arrythmia ATPA Preclinical glutamate receptor agonist GRIK1 atractylenolide-i Preclinical JAK inhibitor JAK2 | STAT3 atracurium Launched acetylcholine receptor antagonist critical care | neurology/psychiatry endotracheal intubation | muscle relaxant atracurium besylate Launched acetylcholine receptor antagonist "critical care, neurology/psychiatry" "endotracheal intubation, muscle relaxant" atrasentan Phase 3 endothelin receptor antagonist EDNRA atr inhibitor 2 Phase 2 atr kinase inhibitor ATR oncology ovarian cancer atropine Launched acetylcholine receptor antagonist CHRM1 | CHRM2 | CHRM3 ophthalmology | ophthalmology | ophthalmology amblyopia | cycloplegia | mydriasis atropine-oxide Preclinical acetylcholine receptor antagonist CHRM1 | CHRM2 | CHRM3 | CHRM4 | CHRM5 atuveciclib Phase 1 CDK9 inhibitor CCNT1 | CDK9 auranofin Launched NFkB pathway inhibitor IKBKB | PRDX5 | TRPA1 | TXNRD1 | TXNRD2 rheumatology rheumatoid arthritis aurora-a-inhibitor-i Preclinical Aurora kinase inhibitor AURKA aurothioglucose Launched PKC inhibitor PRKCI rheumatology rheumatoid arthritis AUT-1 Preclinical potassium channel activator KCNC1 | KCNC2 autotaxin-modulator-1 Preclinical autotaxin inhibitor ENPP2 AV-412 Phase 1 protein tyrosine kinase inhibitor EGFR | ERBB2 AV-608 Phase 2 tachykinin antagonist TACR1 avacopan Phase 2 complement inhibitor C5AR1 | C5AR2 avadomide Phase 2 antitumor agent avagacestat Phase 2 gamma secretase inhibitor PSEN1 avanafil Launched phosphodiesterase inhibitor PDE5A urology erectile dysfunction avapritinib Launched KIT inhibitor KIT avasimibe Phase 3 ACAT inhibitor ABCB1 | CES1 | SOAT1 avatrombopag Launched thrombopoietin receptor agonist MPL hematology thrombocytopenia AVE-0991 Preclinical angiotensin receptor agonist MRGPRX1 AVE-3085 Preclinical nitric oxide synthase stimulant AVex-73 Preclinical sigma receptor agonist CHRM2 | CHRM3 | SIGMAR1 avibactam Launched beta lactamase inhibitor infectious disease | infectious disease | infectious disease intra-abdominal infections | pyelonephritis | urinary tract infections avilamycin Launched other antibiotic infectious disease gram-positive bacterial infections avitinib Phase 2 EGFR inhibitor EGFR AVL-292 Phase 2 Bruton's tyrosine kinase (BTK) inhibitor BTK | EGFR | ITK | JAK3 | YES1 AVN-492 Preclinical serotonin receptor antagonist HTR6 AVN-944 Phase 2 inosine monophosphate dehydrogenase inhibitor IMPDH1 | IMPDH2 avobenzone Launched topical sunscreen agent dermatology | dermatology cosmetic | sunscreen lotion avoralstat Phase 3 kallikrein inhibitor KLK1 | KLKB1 avridine Preclinical immunostimulant AX-024 Preclinical cytokine production inhibitor axitinib Launched PDGFR tyrosine kinase receptor inhibitor | VEGFR inhibitor CSF1 | CYP2C19 | CYP3A5 | FLT1 | FLT4 | KDR | KIT | PDGFRB | PLK4 oncology renal cell carcinoma (RCC) AY-9944 Preclinical hedgehog pathway modulator AZ-10417808 Preclinical caspase inhibitor CASP3 AZ-10606120 Preclinical purinergic receptor antagonist P2RX7 AZ-12080282 Preclinical hedgehog pathway inhibitor DHH | IHH AZ191 Preclinical DYRK inhibitor DYRK1A | DYRK1B AZ20 Preclinical ATR kinase inhibitor ATR | MTOR AZ3146 Preclinical monopolar spindle 1 kinase inhibitor AZ505 Preclinical histone lysine methyltransferase inhibitor SMYD2 AZ5104 Preclinical EGFR inhibitor EGFR AZ-628 Preclinical RAF inhibitor BRAF | RAF1 AZ-7371 Preclinical antibacterial AZ7550 Phase 1 insulin growth factor receptor inhibitor IGF1R AZ960 Preclinical JAK inhibitor JAK2 | JAK3 azacitidine Launched DNA methyltransferase inhibitor DNMT1 | DNMT3A hematologic malignancy | hematologic malignancy | hematology anemia | chronic myelomonocytic leukemia (CMMoL) | myelodysplastic diseases (MDS) azacyclonol Preclinical histamine receptor antagonist HRH1 azaguanine-8 Preclinical purine antagonist PNP azalomycin-B Preclinical bacterial 50S ribosomal subunit inhibitor azaperone Launched dopamine receptor antagonist DRD2 | DRD3 neurology/psychiatry sedative azapropazone Withdrawn cyclooxygenase inhibitor PTGS1 | PTGS2 | XDH azaserine Preclinical purine antagonist azasetron Launched serotonin receptor antagonist HTR3A | HTR3B infectious disease genitial herpes azatadine Launched histamine receptor antagonist HRH1 allergy allergic rhinitis azathioprine Launched dehydrogenase inhibitor HPRT1 | IMPDH1 | PPAT rheumatology | transplant renal homotransplantation | rheumatoid arthritis AZD0156 Phase 1 ATM kinase inhibitor ATM azd-0364 Preclinical erk1 and erk2 phosphorylation inhibitor MAPK1 oncology non-small cell lung cancer (nsclc) AZD1080 Phase 1 glycogen synthase kinase inhibitor GSK3A | GSK3B AZD1208 Phase 1 Pim kinase inhibitor PIM1 | PIM2 | PIM3 AZD1283 Preclinical purinergic receptor antagonist P2RY12 AZD1390 Phase 1 ATM kinase inhibitor ATM AZD1446 Phase 2 acetylcholine receptor agonist CHRNA4 | CHRNB2 AZD1480 Phase 1 JAK inhibitor JAK1 | JAK2 | JAK3 azd1940 Preclinical cannabinoid receptor agonist CNR1 | CNR2 neurology/psychiatry acute pain AZD1981 Phase 2 CRTH receptor antagonist PTGDR2 AZD2014 Phase 2 mTOR inhibitor MTOR azd2098 Preclinical ccr antagonist CCR4 pulmonary asthma AZD2461 Phase 1 PARP inhibitor AZD2858 Preclinical glycogen synthase kinase inhibitor GSK3A | GSK3B AZD3264 Preclinical IKK inhibitor IKBKB AZD3463 Preclinical ALK tyrosine kinase receptor inhibitor | insulin growth factor receptor inhibitor ALK | IGF1R AZD3514 Phase 1 androgen receptor modulator AR AZD3759 Phase 2/Phase 3 EGFR inhibitor EGFR AZD3839 Phase 1 beta-secretase inhibitor BACE1 AZD3965 Phase 1 monocarboxylate transporter inhibitor SLC16A1 | SLC16A7 AZD3988 Preclinical diacylglycerol kinase inhibitor DGAT1 azd-4017 Phase 2 11-beta hydroxysteroid dehydrogenase inhibitor GGT1 | HSD11B1 endocrinology obesity AZD4282 Phase 1 glutamate receptor antagonist AGXT | AGXT2 | ALAS1 | ALAS2 | BAAT | GARS | GATM | GCAT | GCSH | GLDC | GLRA1 | GLRA2 | GLRA3 | GLRB | GLYAT | GLYATL1 | GLYATL2 | GNMT | GPR18 | GPRC6A | GRIN1 | GRIN2A | GRIN2B | GRIN2C | GRIN2D | GRIN3B | GSS | PIPOX | SHMT1 | SHMT2 | SLC32A1 | SLC36A1 | SLC6A5 | SLC6A9 AZD4547 Phase 2/Phase 3 FGFR inhibitor FGF2 | FGFR1 | FGFR2 | FGFR3 | FGFR4 | IGF1R | KDR AZD4573 Phase 1 CDK9 inhibitor CDK9 AZD4635 Phase 1/Phase 2 adenosine receptor antagonist ADORA2A AZD5069 Phase 2 CC chemokine receptor antagonist CXCR2 AZD5153 Phase 1 bromodomain inhibitor BRD4 | E2F | MTOR | MYC AZD5363 Phase 3 AKT inhibitor AKT1 | AKT2 | AKT3 azd5423 Phase 2 glucocorticoid receptor modulator BGLAP | NR3C1 pulmonary chronic obstructive pulmonary disease (copd) AZD5438 Phase 1 CDK inhibitor CCNB1 | CCNE1 | CDK1 | CDK2 | KCNH2 AZD5582 Preclinical XIAP inhibitor BIRC2 | BIRC3 | XIAP AZD5991 Phase 1 MCL1 inhibitor MCL1 AZD6482 Phase 1 PI3K inhibitor PIK3CA | PIK3CB | PIK3CD | PIK3CG AZD6738 Phase 2 ATR kinase inhibitor ATR AZD6765 Phase 2 glutamate receptor antagonist GRIN1 AZD7545 Phase 1 pyruvate dehydrogenase kinase inhibitor PDK1 | PDK2 AZD7594 Phase 2 glucocorticoid receptor modulator NR3C1 azd-7648 Phase 1/Phase 2 dna protein kinase inhibitor PRKDC oncology melanoma AZD7687 Phase 1 diacylglycerol O acyltransferase inhibitor DGAT1 AZD7762 Phase 1 CHK inhibitor CHEK1 | CHEK2 AZD7986 Phase 1 dipeptidyl peptidase inhibitor CTSC AZD8055 Phase 1 mTOR inhibitor MTOR AZD8186 Phase 1 PI3K inhibitor PIK3CB | PIK3CD azd8329 Phase 1 11-beta hydroxysteroid dehydrogenase inhibitor HSD11B1 endocrinology obesity AZD8330 Phase 1 MEK inhibitor MAP3K1 AZD8797 Preclinical CC chemokine receptor antagonist CX3CR1 | CXCR1 | CXCR2 AZD8835 Phase 1 PI3K inhibitor PIK3CA | PIK3CD AZD8931 Phase 2 EGFR inhibitor EGFR | ERBB2 | ERBB3 AZD9056 Phase 2 purinergic receptor antagonist P2RX7 AZD9272 Preclinical glutamate receptor antagonist GRM5 AZD9496 Phase 1 estrogen receptor agonist ESR1 AZD9668 Phase 2 elastase inhibitor ELANE azelaic-acid Launched tyrosinase inhibitor AKR1D1 | SRD5A2 | TXNRD1 | TXNRD2 | TYR dermatology rosacea azelastine Launched histamine receptor antagonist CYP2C19 | HRH1 ophthalmology conjunctivitis azeliragon Phase 3 RAGE receptor antagonist AGER azelnidipine Launched calcium channel blocker CACNA1C cardiology hypertension azilsartan Launched angiotensin receptor antagonist AGTR1 | AGTR2 | INS cardiology hypertension azilsartan-medoxomil Launched angiotensin receptor antagonist AGTR1 | AGTR2 | INS cardiology hypertension azimilide Phase 3 potassium channel blocker KCNA5 | KCNH2 | KCNQ1 azithromycin Launched bacterial 50S ribosomal subunit inhibitor MLNR infectious disease | infectious disease pelvic inflammatory disease | pneumonia azlocillin Launched bacterial cell wall synthesis inhibitor infectious disease | infectious disease gram-negative bacterial infections | gram-positive bacterial infections azlocillin sodium salt Launched bacterial cell wall synthesis inhibitor infectious disease "gram-positive bacterial infections, gram-negative bacterial infections" AZM-475271 Preclinical SRC inhibitor SRC azodicarbonamide Phase 2 DNA synthesis inhibitor azomycin-(2-nitroimidazole) Preclinical protein synthesis inhibitor azosemide Launched electrolyte reabsorption inhibitor SLC12A1 | SLC12A2 cardiology edema aztreonam Launched bacterial cell wall synthesis inhibitor infectious disease | infectious disease | infectious disease | infectious disease | infectious disease | infectious disease bacterial septicemia | gynecologic infections | intra-abdominal infections | respiratory tract infections | skin infections | urinary tract infections azvudine (hydrochloride) Phase 3 nucleoside reverse transcriptase inhibitor infectious disease human immunodeficiency virus (hiv-1) bacampicillin Launched bacterial cell wall synthesis inhibitor infectious disease | infectious disease gram-negative bacterial infections | gram-positive bacterial infections bacitracin Launched bacterial cell wall synthesis inhibitor IDE infectious disease first-aid antibiotic bacitracin zinc Launched bacterial cell wall synthesis inhibitor infectious disease first-aid antibiotic bacitracin (zinc) Launched bacterial cell wall synthesis inhibitor infectious disease first-aid antibiotic bacitracin-zinc Launched bacterial cell wall synthesis inhibitor infectious disease first-aid antibiotic baclofen Launched benzodiazepine receptor agonist GABBR1 | GABBR2 | KCTD12 | KCTD16 | KCTD8 neurology/psychiatry | neurology/psychiatry multiple sclerosis | spasms BADGE Preclinical PPAR receptor antagonist PPARG bafetinib Phase 2 Bcr-Abl kinase inhibitor | LYN tyrosine kinase inhibitor ABL1 | BCR | FYN | LYN bafilomycin-a1 Preclinical ATPase inhibitor ATP2A1 | ATP6V1A BAG-956 Preclinical phosphoinositide dependent kinase inhibitor PDPK1 | PIK3CG baicalein Preclinical lipoxygenase inhibitor ALOX12 | ALOX5 | GLO1 | PREP | SELL | SELP | TNF | XDH baicalin Launched beta glucuronidase inhibitor GUSB | PREP neurology/psychiatry anxiety bakuchiol Phase 2 DNA polymerase inhibitor HIF1A balaglitazone Phase 3 insulin sensitizer | PPAR receptor partial agonist INS | PPARG balapiravir Phase 2 RNA polymerase inhibitor balicatib Phase 2 cathepsin inhibitor CTSK balofloxacin Launched bacterial DNA gyrase inhibitor infectious disease gram-negative bacterial infections balovaptan Phase 3 vasopressin receptor antagonist AVPR1A | AVPR2 | HTR2B | OXTR baloxavir Phase 3 endonuclease inhibitor baloxavir-marboxil Launched endonuclease inhibitor infectious disease influenza A virus infection balsalazide Launched cyclooxygenase inhibitor ALOX5 | PPARG | PTGS1 | PTGS2 gastroenterology ulcerative colitis balsalazide disodium Launched cyclooxygenase inhibitor ALOX5 | PPARG | PTGS1 | PTGS2 gastroenterology ulcerative colitis BAM7 Preclinical BAX activator BAX bamaquimast Preclinical proton pump inhibitor bambuterol Launched adrenergic receptor agonist ADRB2 | BCHE | CYP2D6 pulmonary asthma BAN-ORL-24 Preclinical nociceptin/orphanin FQ receptor antagonist OPRL1 banoxantrone Phase 1/Phase 2 topoisomerase inhibitor TOP2A | TOP2B barasertib Phase 2/Phase 3 Aurora kinase inhibitor AURKA | AURKB barasertib-HQPA Phase 2/Phase 3 Aurora kinase inhibitor AURKB | AURKC bardoxolone Phase 1 "nuclear factor erythroid derived, like (NRF2) activator" NFE2L2 | NOS2 | PPARG bardoxolone-methyl Phase 3 "nuclear factor erythroid derived, like (NRF2) activator" BCL2 | CHUK | GSR | HMOX1 | HMOX2 | NFE2L2 | PPARG | STAT3 baricitinib Launched JAK inhibitor JAK1 | JAK2 rheumatology rheumatoid arthritis barium-6-O-phosphonato-D-glucose Preclinical TGFB1 | TGFBR2 barnidipine Launched calcium channel blocker cardiology hypertension basic-fuchsin Preclinical basimglurant Phase 2 glutamate receptor antagonist GRM5 basmisanil Phase 2 GABA receptor inverse agonist GABRA1 | GABRA5 batabulin Phase 1 tubulin polymerisation inhibitor TUBB oncology breast cancer batefenterol Phase 2 acetylcholine receptor antagonist | adrenergic receptor agonist ADRB2 | CHRM1 | CHRM2 | CHRM3 | CHRM4 | CHRM5 batimastat Phase 3 matrix metalloprotease inhibitor ADAM28 | ADAMTS5 | MMP1 | MMP12 | MMP16 | MMP2 | MMP8 bavisant Phase 2 histamine receptor antagonist HRH3 BAX-channel-blocker Preclinical cytochrome C release inhibitor BAX BAY1125976 Phase 1 AKT inhibitor AKT1 | AKT2 BAY-11-7082 Preclinical NFkB pathway inhibitor RELA BAY-11-7085 Preclinical NFkB pathway inhibitor NFKBIA BAY1217389 Phase 1 kinase inhibitor TTK BAY-1251152 Phase 1 CDK9 inhibitor CDK9 BAY-1436032 Phase 1 isocitrate dehydrogenase inhibitor IDH1 BAY-1895344 Phase 1 ATR kinase inhibitor ATR BAY-2402234 Phase 1 dihydroorotate dehydrogenase inhibitor DHODH bay 2416964 Phase 1 antitumor agent AHR oncology non-small cell lung cancer (nsclc) BAY-41-2272 Preclinical guanylyl cyclase activator GUCY1A3 | GUCY1B3 BAY-60-6583 Preclinical adenosine receptor agonist ADORA1 | ADORA2A | ADORA2B | ADORA3 BAY-60-7550 Preclinical phosphodiesterase inhibitor PDE2A BAY-61-3606 Preclinical SYK inhibitor SYK BAY-8002 Preclinical monocarboxylate transporter inhibitor SLC16A1 BAY-85-8050 Phase 1 bay-85-8501 Phase 2 elastase inhibitor ELANE BAY-87-2243 Phase 1 hypoxia inducible factor inhibitor HIF1A BAY-K-8644-(+/-) Preclinical L-type calcium channel blocker BAY-K-8644-(s)-(-) Preclinical L-type calcium channel activator CACNA1C BAY-W-9798 Phase 2 antioxidant BAZ2-ICR Preclinical bromodomain inhibitor ZNF215 bazedoxifene Launched selective estrogen receptor modulator (SERM) ESR1 | ESR2 endocrinology | orthopedics menopause | osteoporosis BC-11 Preclinical urokinase inhibitor PLAU BCI-540 Phase 2 glutamate receptor agonist BCTC Preclinical TRPV antagonist TRPM8 | TRPV1 BCX-1470 Phase 1 complement inhibitor | serine protease inhibitor CFD BD-1008 Preclinical sigma receptor antagonist BD-1047 Preclinical adrenergic receptor antagonist SIGMAR1 BD-1063 Preclinical sigma receptor antagonist SIGMAR1 BE-2254 Phase 2 adrenergic receptor antagonist ADRA1A BEBT-908 Preclinical PI3K inhibitor PIK3CA beclabuvir Phase 2 antiviral beclamide Launched anticonvulsant neurology/psychiatry | neurology/psychiatry sedative | seizures beclomethasone Launched glucocorticoid receptor agonist NR3C1 | SERPINA6 allergy allergic rhinitis beclomethasone-dipropionate Launched glucocorticoid receptor agonist CYP3A5 | GPR97 | NR3C1 allergy allergic rhinitis bedaquiline Launched ATPase inhibitor infectious disease tuberculosis befuraline Phase 2 begacestat Phase 1 gamma secretase inhibitor PSEN1 bekanamycin Launched bacterial 30S ribosomal subunit inhibitor infectious disease gram-negative bacterial infections belinostat Launched HDAC inhibitor HDAC1 | HDAC10 | HDAC11 | HDAC2 | HDAC3 | HDAC4 | HDAC5 | HDAC6 | HDAC7 | HDAC8 | HDAC9 hematologic malignancy peripheral T-cell lymphoma (PTCL) belizatinib Preclinical receptor tyrosine protein kinase inhibitor ALK | NTRK1 | NTRK2 | NTRK3 belotecan Phase 3 topoisomerase inhibitor TOP1 belvarafenib Phase 1 raf inhibitor ARAF | BRAF | NRAS oncology melanoma belzutifan Launched hif modulator EPAS1 oncology renal cell carcinoma (rcc) bemegride Launched chemoreceptor agonist GABRA1 critical care poison antidote bemesetron Phase 3 serotonin receptor antagonist HTR3A | HTR3B bemotrizinol Launched dermatology sunscreen lotion bempedoic-acid Launched AMPK inhibitor ACLY benactyzine Preclinical butyrylcholinesterase inhibitor BCHE benaxibine Phase 1 benazepril Launched angiotensin converting enzyme inhibitor ACE cardiology hypertension bendamustine Launched DNA inhibitor hematologic malignancy | hematologic malignancy chronic lymphocytic leukemia (CLL) | non-Hodgkin lymphoma (NHL) bendazac Launched cyclooxygenase inhibitor PTGS1 | PTGS2 neurology/psychiatry | rheumatology joint pain | muscle pain bendazol Launched nitric oxide synthase stimulant NOS1 | NOS2 bendroflumethiazide Launched sodium/potassium/chloride transporter inhibitor SLC12A1 | SLC12A3 cardiology hypertension benethamine Preclinical benfluorex Withdrawn gluconeogenesis inhibitor HMGCR benfluorex hydrochloride gluconeogenesis inhibitor HMGCR benfluralin Phase 3 CYP1A1 | CYP1A2 | CYP2B6 | CYP3A4 | ESR1 | MMP1 | SULT2A1 | UGT1A1 benfotiamine Launched antioxidant AGER rheumatology lumbago benidipine Launched calcium channel blocker CACNA1C | CACNA1G | CYP3A5 cardiology hypertension benperidol Launched dopamine receptor antagonist DRD2 neurology/psychiatry schizophrenia benproperine Launched antitussive SCN5A pulmonary cough suppressant benserazide Launched DOPA decarboxylase inhibitor DDC neurology/psychiatry Parkinson's Disease bentiromide Launched HPN gastroenterology pancreas diagnostic agent benurestat Phase 1 urease inhibitor benzalkonium Launched cationic surfactant dermatology | dermatology abrasions | superficial cuts benzamil Phase 2 sodium channel blocker ASIC1 | PKD2L1 | SCNN1A | SCNN1B | SCNN1D | SCNN1G | SLC8A1 benzbromarone Launched chloride channel blocker ABCC1 | SLC22A12 rheumatology gout "benzenemethanol,-2,5-dimethyl-[[(1-methylethyl)amino]methyl]" Preclinical benzethonium Launched sodium channel blocker SCN10A | SCN9A infectious disease first-aid antiseptic benznidazole Launched DNA synthesis inhibitor infectious disease Chagas disease benzocaine Launched sodium channel blocker SCN10A | SCN9A infectious disease first-aid antiseptic benzoclidine Preclinical benzo[d]thiazole-2(3H)-thione Phase 1 benzofenac Phase 1 benzoic-acid Launched food preservative DAO | HRSP12 | PRDX5 | RAB9A infectious disease tinea pedis benzoin Preclinical CES1 benzonatate Launched local anesthetic SCN5A pulmonary cough suppressant benzoquinonium-dibromide Preclinical cholinergic receptor antagonist CHRNA1 benzotript Phase 1 CCK receptor antagonist CCKAR | CCKBR benzoxiquine Preclinical antiinfective drug benzoylpas Preclinical benzoyl-peroxide Launched oxidizing agent dermatology acne vulgaris (AV) benzquinamide Withdrawn dopamine receptor agonist DRD2 | PTGS2 gastroenterology nausea benzthiazide Launched carbonic anhydrase inhibitor CA2 cardiology | cardiology edema | hypertension benztropine mesylate Launched acetylcholine receptor antagonist CHRM1 | HRH1 | SLC6A3 neurology/psychiatry "extrapyramidal symptoms (eps), parkinson's disease" benztropine-mesylate Launched acetylcholine receptor antagonist CHRM1 | HRH1 | SLC6A3 neurology/psychiatry | neurology/psychiatry extrapyramidal symptoms (EPS) | Parkinson's Disease benzydamine Launched prostanoid receptor antagonist dental | otolaryngology mouth inflammation | throat inflammation benzyl-alcohol Launched local anesthetic infectious disease virus herpes simplex (HSV) benzyl-benzoate Launched lipase inhibitor LIPE allergy sweet itch benzyldimethylhexadecylammonium Preclinical cationic surfactant benzyldimethyloctylammonium Preclinical benzyl-isothiocyanate Preclinical methylazoxymethanol acetate inhibitor benzylpenicillin Launched penicillin binding protein inhibitor infectious disease | infectious disease | infectious disease | infectious disease | infectious disease | infectious disease bacterial septicemia | celluitis | endocarditis | meningitis | pneumonia | syphilis bephenium-hydroxynaphthoate Launched anthelmintic agent infectious disease ascariasis bepotastine Launched histamine receptor antagonist HRH1 ophthalmology conjunctivitis bepridil Launched calcium channel blocker CACNA1C | KCNQ4 | SCN5A cardiology angina pectoris berberine Launched LDL receptor activator ACHE | CYP2C19 | CYP2E1 | LDLR | PTPN1 bergapten Phase 3 bergenin Preclinical interleukin inhibitor IL1B | PTPN1 | TNF besifloxacin Launched bacterial DNA gyrase inhibitor ophthalmology conjunctivitis besifovir Phase 3 antiviral GPT infectious disease hepatitis b beta-amyloid-synthesis-inhibitor Preclinical beta amyloid synthesis inhibitor APP beta-carotene Launched beta-CCB Launched benzodiazepine receptor ligand GABRA1 | GABRG2 beta-elemene Launched apoptosis stimulant MMP2 | MMP9 beta-funaltrexamine Preclinical opioid receptor antagonist OPRD1 | OPRK1 | OPRM1 beta-glycerophosphoric-acid Preclinical betahistine Launched histamine receptor agonist | histamine receptor antagonist HRH1 | HRH3 neurology/psychiatry Meniere's disease beta-hydroxy-beta-methylbutyrate Launched protein synthesis stimulant MTOR beta-hydroxybutyrate Phase 1 HCAR2 betaine Launched nitric oxide donor metabolism homocystinuria beta-lapachone Phase 2 topoisomerase inhibitor E2F1 | IDO1 | TDO2 | TOP1 betamethasone glucocorticoid receptor agonist NR3C1 dermatology corticosteroid-responsive dermatoses betamethasone acetate Launched glucocorticoid receptor agonist NR3C1 dermatology corticosteroid-responsive dermatoses betamethasone-acetate Launched glucocorticoid receptor agonist NR3C1 dermatology corticosteroid-responsive dermatoses betamethasone-butyrate-propionate Launched rheumatology rheumatoid arthritis betamethasone-dipropionate Launched anti-inflammatory agent NR3C1 dermatology corticosteroid-responsive dermatoses betamethasone-phosphate Launched rheumatology rheumatoid arthritis betamethasone sodium phosphate betamethasone-valerate Launched glucocorticoid receptor agonist NR3C1 dermatology corticosteroid-responsive dermatoses betamipron Launched panipenem uptake inhibitor nephrology renal toxicity beta-naphthol Preclinical betaxolol Launched adrenergic receptor antagonist ADRB1 | ADRB2 ophthalmology | ophthalmology | ophthalmology glaucoma | intraocular pressure | ocular hypertension betaxolol hydrochloride Launched adrenergic receptor antagonist ADRB1 | ADRB2 ophthalmology "intraocular pressure, glaucoma, ocular hypertension" betazole Launched histamine receptor agonist HRH2 gastroenterology gastric hypersecretion diagnostic BET-BAY-002 Preclinical bromodomain inhibitor BRD4 bethanechol Launched acetylcholine receptor agonist CHRM1 | CHRM2 | CHRM3 | CHRM4 urology urinary retention bethanechol chloride BETP Preclinical GLP receptor positive allosteric modulator GCG | GLP1R | INS betrixaban Launched coagulation factor inhibitor F10 | KCNH2 hematology deep vein thrombosis (DVT) betulinic-acid Phase 1/Phase 2 apoptosis stimulant | NFkB pathway inhibitor CASP3 | CASP8 | GPBAR1 | TOP1 bevantolol Launched adrenergic receptor antagonist ADRB1 cardiology | cardiology angina pectoris | hypertension bevenopran Phase 1 opioid receptor antagonist OPRM1 bevirimat-dimeglumine Phase 2 HIV capsid assembly inhibitor bexagliflozin Phase 3 solute carrier family member inhibitor SLC5A2 bexarotene Launched retinoid receptor agonist ABCA1 | CYP2C8 | CYP3A4 | RXRA | RXRB | RXRG hematologic malignancy cutaneous T-cell lymphoma (CTCL) bezafibrate Launched PPAR receptor agonist HSD11B1 | LPL | PPARA | PPARD | PPARG cardiology cholesterol BFH772 Phase 2 VEGFR inhibitor KDR BGP-15 Phase 2 PARP inhibitor PARP1 | PARP2 | PARP3 | PARP4 BGT226 Phase 1/Phase 2 PI3K inhibitor MTOR | PIK3CA | PIK3CB | PIK3CG BHQ Preclinical ATPase inhibitor ATP2A1 BI-224436 Phase 1 HIV integrase inhibitor BI-2536 Phase 2 PLK inhibitor BRD4 | PLK1 | PLK2 | PLK3 BI-409306 Phase 1 phosphodiesterase inhibitor PDE9A BI-78D3 Preclinical JNK inhibitor MAPK8 BI-847325 Phase 1 Aurora kinase inhibitor | MEK inhibitor AURKA | AURKB | AURKC | MAP2K1 | MAP2K2 BIA-10-2474 Preclinical Fatty acid hydrolase inhibitor FAAH biapenem Launched bacterial cell wall synthesis inhibitor infectious disease | infectious disease | infectious disease bacterial septicemia | pneumonia | urinary tract infections BIBN4096 Phase 2 calcitonin antagonist CALCA | CALCRL | RAMP1 BIBR-1532 Preclinical telomerase inhibitor TERT BIBU-1361 Preclinical EGFR inhibitor EGFR BIBX-1382 Phase 1 EGFR inhibitor EGFR | ERBB2 bicalutamide Launched androgen receptor antagonist AR | CYP2C19 oncology prostate cancer bicifadine Phase 3 dopamine reuptake inhibitor | serotonin receptor antagonist SLC6A2 | SLC6A4 bictegravir Launched HIV integrase inhibitor infectious disease human immunodeficiency virus (HIV-1) bicuculline-(+) Preclinical GABA receptor antagonist GABRA1 | GABRA2 | GABRA3 | GABRA4 | GABRA5 | GABRA6 | KCNN1 bicuculline methochloride Preclinical gaba receptor antagonist epilepsy bicuculline-methochloride-(-) Preclinical GABA receptor antagonist bicyclol Launched NFkB pathway inhibitor HSPA1A | HSPB1 infectious disease | infectious disease hepatitis B | hepatitis C BI-D1870 Preclinical ribosomal protein inhibitor RPS6KA1 | RPS6KA2 | RPS6KA3 | RPS6KA6 bifemelane Launched acetylcholine release enhancer MAOA | MAOB | SLC6A2 neurology/psychiatry | ophthalmology glaucoma | senile dementia bifendate Launched infectious disease | infectious disease hepatitis B | hepatitis C bifonazole Launched sterol demethylase inhibitor infectious disease | infectious disease tinea cruris | tinea pedis BIIB021 Phase 2 HSP inhibitor AOX1 | HSP90AA1 biib068 Phase 1 bruton's tyrosine kinase (btk) inhibitor BTK bilastine Launched histamine receptor antagonist HRH1 ophthalmology conjunctivitis bilobalide Preclinical GABA receptor modulator GLRA1 | GLRA2 | GLRB | HTR3A | HTR3B bimatoprost Launched prostanoid receptor agonist AKR1C3 | PTGER1 | PTGER3 | PTGFR ophthalmology | ophthalmology | ophthalmology | ophthalmology "glaucoma | intraocular pressure | intraocular pressure, glaucoma, ocular hypertension | ocular hypertension" bimosiamose Phase 2 p selectin inhibitor ICAM1 | SELE | SELP pulmonary chronic obstructive pulmonary disease (copd) BIMU-8 Preclinical serotonin receptor agonist HTR4 BINA Preclinical glutamate receptor positive allosteric modulator GRM2 bindarit Phase 2 NFkB pathway inhibitor CCL2 | CCL7 | CCL8 binimetinib Launched MEK inhibitor IL1R2 | IL6R | MAP2K1 | MAP2K2 | TNFRSF1A oncology melanoma BIO-1211 Phase 2 integrin antagonist ITGA4 | ITGB1 BIO-5192 Preclinical integrin inhibitor ITGA4 | ITGB1 biotin Launched vitamin B ACACA | ACACB | HLCS | MCCC1 | MCCC2 | PC | PCCA | PCCB | SLC5A6 bipenamol Phase 2 dipeptidyl peptidase inhibitor CTSC biperiden Launched acetylcholine receptor antagonist CHRM1 | CHRM2 | CHRM3 | CHRM4 | CHRM5 neurology/psychiatry Parkinson's Disease biperiden hcl Launched acetylcholine receptor antagonist CHRM1 | CHRM2 | CHRM3 | CHRM4 | CHRM5 neurology/psychiatry parkinson's disease birinapant Phase 2 XIAP inhibitor BIRC2 | BIRC3 | XIAP BIRT-377 Preclinical lymphocyte function-associated antigen negative modulator ICAM1 bisacodyl Launched laxative gastroenterology constipation bisantrene Phase 2 topoisomerase inhibitor TOP2A | TOP2B bisindolylmaleimide-IX Preclinical PKC inhibitor AKT1 | GSK3B | LCK | LRRK2 | MAPK1 | MAPK11 | MAPK12 | MAPK14 | MAPK8 | PRKCA | ROCK1 | RPS6KB1 | SIRT1 | SIRT2 bis(maltolato)oxovanadium(IV) Phase 2 tyrosine phosphatase inhibitor PTPN1 bismuth(III)-trifluoromethanesulfonate Preclinical direct substitution catalyst bismuth-oxalate Preclinical bismuth subcitrate potassium Launched gastroenterology duodenal ulcer disease bismuth-subcitrate-potassium Launched gastroenterology duodenal ulcer disease bismuth-subgallate Launched nitric oxide synthase inhibitor NOS1 gastroenterology internal deoderant bismuth-subsalicylate Launched antacid gastroenterology diarrhea bisoctrizole Phase 2 bisoprolol Launched adrenergic receptor antagonist ADRB1 cardiology hypertension bisphenol-A Phase 1 synthetic estrogen AR | ESR1 | ESR2 | ESRRG | PPARG bithionol Withdrawn autotaxin inhibitor ESR1 | ESR2 | MCL1 bitopertin Phase 3 glycine transporter inhibitor SLC6A5 | SLC6A9 bitoscanate Preclinical anthelmintic agent bivalirudin Launched thrombin inhibitor F2 cardiology angina pectoris BIX-01294 Preclinical histone lysine methyltransferase inhibitor EHMT1 | EHMT2 BIX-02188 Preclinical MEK inhibitor MAP2K5 BIX-02189 Preclinical MEK inhibitor MAP2K5 | MAPK7 BL-5583 Preclinical hypercalcaemic agent blebbistatin-(-) Preclinical ATPase inhibitor blebbistatin-(+/-) Preclinical ATPase inhibitor MYH14 | MYH2 bleomycetin Launched EGFR expression inhibitor bleomycin Launched dna damage inducer | DNA synthesis inhibitor hematologic malignancy | hematologic malignancy | oncology | oncology | Oncology | pulmonary Hodgkin's lymphoma | non-Hodgkin lymphoma (NHL) | pancreatic cancer | pleural effusion | squamous cell carcinoma | testicular carcinoma bleomycin sulfate Launched dna synthesis inhibitor "hematologic malignancy, pulmonary, oncology" "non-hodgkin lymphoma (nhl), hodgkin's lymphoma, pleural effusion, testicular carcinoma, squamous cell carcinoma" bleomycin (sulfate) blonanserin Launched dopamine receptor antagonist | serotonin receptor antagonist DRD2 | HTR2A neurology/psychiatry schizophrenia BLU9931 Preclinical FGFR inhibitor FGFR4 BLZ945 Phase 1/Phase 2 CSF1R inhibitor CSF1R BML-190 Preclinical cannabinoid receptor inverse agonist CNR2 BML-284 Preclinical WNT agonist BMS-182874 Phase 2 endothelin receptor antagonist EDNRA BMS-191011 Preclinical potassium channel activator KCNMA1 BMS-191095 Phase 1 KATP activator | potassium channel agonist BMS-207940 Preclinical endothelin receptor antagonist EDNRA | EDNRB BMS-214662 Phase 1 farnesyltransferase inhibitor FNTA | FNTB BMS-265246 Preclinical CDK inhibitor CCNE1 | CDK1 | CDK2 BMS-299897 Phase 1 gamma secretase inhibitor BMS-309403 Preclinical fatty acid binding protein inhibitor FABP4 BMS-345541 Preclinical IKK inhibitor CHUK | IKBKB BMS-387032 Phase 1 CDK inhibitor | cell cycle inhibitor | MCL1 inhibitor CDK2 | CDK7 | CDK9 | MCL1 BMS-470539 Preclinical melanocortin receptor agonist MC1R BMS-536924 Preclinical IGF-1 inhibitor AKT1 | CCNE1 | CDK2 | CYP3A4 | ERBB2 | IGF1R | INSR | KDR | LCK | MAPK1 | MET | PDGFRA | PDGFRB BMS-566419 Preclinical inosine monophosphate dehydrogenase inhibitor IMPDH1 | IMPDH2 BMS-582949 Phase 2 p38 MAPK inhibitor MAPK14 | TNF BMS-587101 Phase 2 integrin antagonist ICAM1 | ITGAL | ITGB2 BMS-599626 Phase 1 EGFR inhibitor | protein tyrosine kinase inhibitor EGFR | ERBB2 | ERBB3 | ERBB4 BMS-626529 Phase 3 HIV attachment inhibitor BMS-626531 Phase 1 p38 MAPK inhibitor MAPK14 | TNF BMS-649 Preclinical retinoid receptor agonist ABCA1 | RXRA BMS-688521 Preclinical ICAM1 antagonist | leukocyte function-associated antigen receptor antagonist ICAM1 BMS-690514 Phase 2 EGFR inhibitor | VEGFR inhibitor EGFR | ERBB2 | ERBB4 | FLT1 | FLT3 | FLT4 | KDR BMS-707035 Phase 2 HIV integrase inhibitor BMS-754807 Phase 2 IGF-1 inhibitor AKT1 | IGF1R BMS-770767 Phase 2 11-beta-HSD1 inhibitor HSD11B1 BMS-777607 Phase 1/Phase 2 AXL kinase inhibitor | c-Met inhibitor | FLT3 inhibitor | hepatocyte growth factor receptor inhibitor | macrophage migration inhibiting factor inhibitor | tyrosine kinase inhibitor AXL | FLT3 | MERTK | MET | MST1R | TYRO3 BMS-779788 Phase 1 LXR agonist NR1H2 BMS-806 Phase 1 HIV attachment inhibitor BMS-813160 Phase 2 CC chemokine receptor antagonist CCR2 | CCR5 BMS-817378 Phase 1 c-Met inhibitor | VEGFR inhibitor KDR | MET BMS-833923 Phase 2 smoothened receptor antagonist DHH | IHH | SMO BMS-863233 Phase 1/Phase 2 CDC inhibitor CDC7 | PIM1 BMS-906024 Phase 1 gamma secretase inhibitor APH1A | APH1B BMS-911543 Phase 1/Phase 2 JAK inhibitor JAK1 | JAK3 | TYK2 BMS-935177 Preclinical Bruton's tyrosine kinase (BTK) inhibitor BTK BMS-983970 Phase 1 notch signaling inhibitor BMS-986020 Phase 2 lysophosphatidic acid receptor antagonist LPAR1 BMS-986142 Phase 2 Bruton's tyrosine kinase (BTK) inhibitor BTK BMS-986158 Phase 1/Phase 2 bromodomain inhibitor BRD2 | BRD3 | BRD4 | BRDT BMS-986195 Phase 1 Bruton's tyrosine kinase (BTK) inhibitor BTK BMS-986205 Phase 3 "indoleamine 2,3-dioxygenase inhibitor" IDO1 BMS-CCR2-22 Preclinical CC chemokine receptor antagonist CCR2 BMY-14802 Phase 2 sigma receptor antagonist HTR1A | SIGMAR1 BMY-45778 Preclinical IP1 prostacyclin receptor agonist PTGIR BMY-7378 Preclinical adrenergic receptor antagonist | serotonin receptor antagonist ADRA1A | ADRA1B | ADRA1D | HTR1A BNC105 Phase 2 tubulin polymerization inhibitor BNTX Preclinical opioid receptor antagonist OPRD1 | OPRK1 | OPRM1 boceprevir Launched HCV inhibitor AKR1C3 | CMA1 | CTSA | CTSF | CTSK | CTSL | CTSS | CYP3A5 infectious disease hepatitis C bonaphthone Phase 3 bopindolol Launched adrenergic receptor antagonist ADRB1 | ADRB2 cardiology | cardiology coronary artery disease (CAD) | hypertension (+)-borneol Launched gaba receptor agonist GABRA1 | TRPA1 | TRPM8 | TRPV3 neurology/psychiatry postherpetic neuralgia bornyl acetate Preclinical apoptosis stimulant bornyl-acetate Preclinical boronophenylalanine Phase 2 bortezomib Launched NFkB pathway inhibitor | proteasome inhibitor CASP3 | CYP2C19 | NFKB1 | PSMA1 | PSMA2 | PSMA3 | PSMA4 | PSMA5 | PSMA6 | PSMA7 | PSMA8 | PSMB1 | PSMB10 | PSMB11 | PSMB2 | PSMB3 | PSMB4 | PSMB5 | PSMB6 | PSMB7 | PSMB8 | PSMB9 | PSMD1 | PSMD2 | RELA hematologic malignancy | hematologic malignancy mantle cell lymphoma (MCL) | multiple myeloma BOS-172722 Phase 1 monopolar spindle 1 kinase inhibitor TTK bosentan Launched endothelin receptor antagonist ABCB1 | CYP2C19 | CYP3A4 | EDNRA | EDNRB pulmonary pulmonary arterial hypertension (PAH) bosutinib Launched Abl kinase inhibitor | Bcr-Abl kinase inhibitor | SRC inhibitor ABL1 | BCR | CAMK1D | CAMK2G | CDK2 | FRK | FYN | HCK | LYN | MAP2K1 | MAP2K2 | MAP3K2 | MAP4K5 | SRC | STK10 | STK24 | STK4 | TNK2 | TXK hematologic malignancy chronic myeloid leukemia (CML) BP-554 Preclinical serotonin receptor agonist HTR1A BP-897 Phase 2 dopamine receptor agonist ADRA1A | ADRA1D | ADRA2A | DRD1 | DRD2 | DRD3 | DRD4 | HTR1A | HTR2B bq-123 Phase 2 endothelin receptor antagonist EDNRA BQ-123 Phase 2 endothelin receptor antagonist EDNRA BQ-788 Phase 1 endothelin receptor antagonist EDNRB BQU57 Preclinical Ras GTPase inhibitor RALA | RALB BRD4770 Preclinical histone lysine methyltransferase inhibitor EHMT2 BRD7389 Preclinical ribosomal protein inhibitor RPS6KA1 | RPS6KA2 | RPS6KA3 BRD9876 Preclinical kinesin inhibitor KIF11 brefeldin-A Preclinical protein synthesis inhibitor ARF1 | ARFGEF1 | ARFGEF2 | CYTH2 | GBF1 bremelanotide Launched melanocortin receptor agonist MC1R | MC2R | MC3R | MC4R | MC5R neurology/psychiatry hypoactive sexual desire disorder brequinar Phase 2 dihydroorotate dehydrogenase inhibitor DHODH bretazenil Phase 2 GABA benzodiazepine site receptor partial agonist GABRA1 | GABRA2 | GABRA3 | GABRA4 | GABRA5 | GABRA6 bretylium Launched norepinephrine inhibitor ATP1A1 cardiology | cardiology | cardiology ventricular arrhythmias | ventricular fibrillation (VF) | ventricular tachycardia (VT) brexpiprazole Launched dopamine receptor partial agonist DRD2 | DRD3 | HTR1A | HTR2A neurology/psychiatry | neurology/psychiatry depression | schizophrenia briciclib Phase 1 cyclin D inhibitor CCND1 brigatinib Launched ALK tyrosine kinase receptor inhibitor | EGFR inhibitor ALK | EGFR | IGF1R | ROS1 oncology non-small cell lung cancer (NSCLC) brilliant-green Launched infectious disease antiseptic brimonidine Launched adrenergic receptor agonist ADRA2A | ADRA2B | ADRA2C | AOX1 ophthalmology | ophthalmology | ophthalmology glaucoma | intraocular pressure | ocular hypertension brincidofovir Phase 3 antiviral brinzolamide Launched carbonic anhydrase inhibitor CA1 | CA12 | CA14 | CA2 | CA4 | CA5A | CA7 | CYP2B6 | CYP2C8 ophthalmology | ophthalmology | ophthalmology glaucoma | intraocular pressure | ocular hypertension brivanib Phase 3 FGFR inhibitor | VEGFR inhibitor CYP3A4 | FGFR1 | FGFR2 | FGFR3 | FLT1 | FLT4 | KCNH2 | KDR brivanib-alaninate Phase 3 FGFR inhibitor | VEGFR inhibitor FGFR1 | FGFR3 | FLT1 | KDR brivudine Launched DNA directed DNA polymerase inhibitor infectious disease shingles brl-15572 Preclinical 5-ht1d receptor antagonist HTR1D BRL-15572 Preclinical serotonin receptor antagonist HTR1A | HTR1B | HTR1D | HTR1E | HTR1F | HTR2A | HTR2B | HTR2C | HTR6 BRL-26314 Phase 1 cholesterol inhibitor LPL BRL-37344 Phase 2 adrenergic receptor agonist ADRB1 | ADRB2 | ADRB3 BRL-44408 Preclinical adrenergic receptor antagonist ADRA2A | ADRA2B | ADRA2C BRL-50481 Preclinical phosphodiesterase inhibitor PDE7A | PDE7B BRL-52537 Preclinical opioid receptor agonist OPRK1 BRL-54443 Preclinical serotonin receptor agonist HTR1E | HTR1F brofaromine Phase 1 monoamine oxidase inhibitor MAOA neurology/psychiatry depression brolitene Launched muscle relaxant PTAFR | RYR1 rheumatology lumbago bromantan Launched dopamine reuptake inhibitor | serotonin reuptake inhibitor neurology/psychiatry neurasthenia bromebric-acid Preclinical DNA synthesis inhibitor | purine antagonist bromfenac Withdrawn cyclooxygenase inhibitor PTGS1 | PTGS2 bromhexine Launched mucolytic agent pulmonary chest congestion bromindione Phase 2 anticoagulant bromisoval Preclinical anti-inflammatory agent bromocriptine Launched dopamine receptor agonist ADRA1A | ADRA1B | ADRA1D | ADRA2A | ADRA2B | ADRA2C | DRD1 | DRD2 | DRD3 | DRD4 | DRD5 | HTR1A | HTR1B | HTR1D | HTR2A | HTR2B | HTR2C | HTR6 | HTR7 | PRL endocrinology | endocrinology | neurology/psychiatry acromegaly | hyperprolactinemia | Parkinson's Disease bromodiphenhydramine Launched histamine receptor antagonist HRH1 Allergies allergic rhinitis bromopride Launched dopamine receptor antagonist DRD2 gastroenterology | gastroenterology | gastroenterology gastroesophageal reflux disease (GERD) | nausea | vomiting bromosporine Preclinical bromodomain inhibitor bromperidol Launched dopamine receptor antagonist DRD2 neurology/psychiatry schizophrenia brompheniramine Launched histamine receptor antagonist HRH1 allergy | otolaryngology allergic rhinitis | common cold brompheniramine maleate Launched histamine receptor antagonist HRH1 "allergy, otolaryngology" "allergic rhinitis, common cold" bronopol Launched obstetrics/gynecology mastitis bropirimine Phase 3 interferon inducer broxaldine Preclinical broxaterol Phase 3 adrenergic receptor agonist ADRB2 broxuridine Phase 2 antimetabolite broxyquinoline Phase 1 antiprotozoal agent bruceantin Phase 2 protein synthesis inhibitor brucine Preclinical glycine receptor antagonist CHRM1 | CHRM2 | CHRM3 | CHRM4 | CHRM5 BS-181 Preclinical CDK inhibitor CDK7 BT-11 Phase 2 cAMP stimulant LANCL2 BTB06584 Preclinical ATPase inhibitor ATP5F1 BTB1 Preclinical mitotic kinesin inhibitor KIF18A BTK-IN-1 Preclinical Bruton's tyrosine kinase (BTK) inhibitor BTK BTS Preclinical BTS-54505 Withdrawn dopamine reuptake inhibitor SLC6A2 | SLC6A3 | SLC6A4 BTS-71321 Phase 2 BTS-72664 Phase 1 GABA receptor antagonist GABBR1 BTT-3033 Preclinical integrin inhibitor ITGA2 | ITGB1 BTZ043-racemate Phase 1/Phase 2 DPRE1 inhibitor BU-224 Preclinical imidazoline receptor ligand MAOA | MAOB BU226 Preclinical imidazoline receptor ligand BU-239 Preclinical imidazoline receptor agonist | imidazoline receptor ligand bucetin Withdrawn analgesic agent bucillamine Launched immunosuppressant rheumatology rheumatoid arthritis bucladesine Launched "adenosine receptor agonist | adenosine receptor agonist, camp stimulant | cAMP stimulant" PRKACA dermatology skin ulcer bucladesine (sodium) buclizine Launched histamine receptor antagonist HRH1 neurology/psychiatry migraine headache budesonide Launched glucocorticoid receptor agonist CYP3A5 | CYP3A7 | NR3C1 gastroenterology Crohn's disease budipine Launched glutamate receptor antagonist GRIN1 neurology/psychiatry Parkinson's Disease bufexamac Withdrawn cyclooxygenase inhibitor HDAC10 | HDAC6 buflomedil Launched adrenergic receptor antagonist | calcium channel blocker ADRA1A | CACNA1C cardiology peripheral artery disease (PAD) bumetanide Launched solute carrier family member inhibitor CFTR | GPR35 | SLC12A1 | SLC12A2 | SLC12A4 | SLC12A5 cardiology | cardiology congestive heart failure | edema bunazosin Launched adrenergic receptor antagonist ADRA1A ophthalmology | ophthalmology glaucoma | intraocular pressure buparlisib Phase 3 PI3K inhibitor PIK3CA | PIK3CG buparvaquone Launched antiprotozoal agent infectious disease protozoan infection buphenine Launched adrenergic receptor agonist ADRB2 rheumatology Raynaud's disease bupicomide Phase 1 adrenergic receptor antagonist ADRB1 bupivacaine Launched sodium channel blocker KCNA5 | SCN10A | SCN9A neurology/psychiatry | neurology/psychiatry | neurology/psychiatry caudal epidural block | lumbar epidural block | peripheral nerve block bupivacaine hydrochloride Launched sodium channel blocker KCNA5 | SCN10A neurology/psychiatry "peripheral nerve block, caudal epidural block, lumbar epidural block" bupranolol Launched adrenergic receptor antagonist ADRB1 | ADRB2 | ADRB3 cardiology | ophthalmology glaucoma | hypertension bupropion Launched dopamine reuptake inhibitor CYP2B6 | SLC6A2 | SLC6A3 neurology/psychiatry depression buramate Preclinical antiepileptic burixafor Phase 2 cc chemokine receptor antagonist CXCR4 hematologic malignancy multiple myeloma buserelin Launched gonadotropin releasing factor hormone receptor agonist GNRHR obstetrics/gynecology | oncology endometriosis | prostate cancer buspirone Launched serotonin receptor agonist DRD2 | HTR1A neurology/psychiatry generalized anxiety disorder (GAD) busulfan Launched DNA inhibitor hematologic malignancy chronic myeloid leukemia (CML) butabindide Preclinical tripeptidyl peptidase inhibitor TPP2 butacaine Launched local anesthetic neurology/psychiatry local anesthetic butaclamol Phase 2 dopamine receptor antagonist DRD1 | DRD2 | DRD3 | DRD4 | DRD5 | HTR1A | HTR2A butaclamol (+) Phase 2 dopamine receptor antagonist DRD1 | DRD2 | DRD3 | DRD4 | DRD5 | HTR1A | HTR2A butalbital Launched GABA receptor antagonist CHRNA4 | CHRNA7 | GABRA1 | GABRA2 | GABRA3 | GABRA4 | GABRA5 | GABRA6 | GABRB1 | GABRB2 | GABRB3 | GABRD | GABRE | GABRG1 | GABRG2 | GABRG3 | GABRP | GABRQ | GRIA2 | GRIK2 neurology/psychiatry | neurology/psychiatry headache | muscle relaxant butamben Withdrawn sodium channel blocker butaprost Preclinical prostaglandin receptor agonist PTGER2 butein Preclinical EGFR inhibitor | SRC inhibitor ACE | CXCL8 | IL6 | SIRT1 | SRD5A1 | SRD5A2 | TNF butenafine Launched fungal squalene epoxidase inhibitor SQLE infectious disease | infectious disease | infectious disease tinea corporis | tinea cruris | tinea pedis buthionine-sulfoximine Phase 1 glutathione transferase inhibitor GCLM butibufen Withdrawn cyclooxygenase inhibitor butoconazole Launched bacterial cell wall synthesis inhibitor infectious disease vulvovaginal candidiasis butoconazole nitrate Launched bacterial cell wall synthesis inhibitor infectious disease vulvovaginal candidiasis butofilolol Phase 2 adrenergic receptor antagonist ADRB1 | ADRB2 butylated-hydroxyanisole Preclinical antioxidant butylated-hydroxytoluene Phase 1 carbonic anhydrase inhibitor CA2 butylidenephthalide Phase 1/Phase 2 cyclooxygenase inhibitor PTGS1 | PTGS2 butyl-paraben Preclinical DNA synthesis inhibitor butylphthalide Launched potassium channel antagonist CYP2B6 | CYP2E1 | KCNK2 neurology/psychiatry stroke butylscopolamine bromide Launched cholinergic receptor antagonist gastroenterology abdominal pain butylscopolamine-bromide Launched cholinergic receptor antagonist gastroenterology abdominal pain BVD-523 Phase 2 MAP kinase inhibitor BVT-2733 Preclinical 11-beta hydroxysteroid dehydrogenase inhibitor HSD11B1 | HSD17B1 bvt948 Preclinical tyrosine phosphatase inhibitor PTPN1 | PTPN11 | PTPN2 BVT-948 Preclinical tyrosine phosphatase inhibitor PTPN1 | PTPN11 | PTPN2 BW-180C Phase 2 opioid receptor agonist OPRD1 | OPRM1 | SLC6A2 BW-348U87 Preclinical antiviral BW-373U86 Preclinical opioid receptor agonist OPRD1 BW-616U Preclinical monoamine oxidase inhibitor MAOA BW-723C86 Preclinical serotonin receptor agonist HTR2A | HTR2B | HTR2C BW-A4C Phase 1 lipoxygenase inhibitor ALOX5 BW-B70C Preclinical lipoxygenase inhibitor ALOX5 BX-795 Preclinical IKK inhibitor CDK2 | CHEK1 | GSK3B | IKBKE | KDR | PDK1 | PDPK1 | TBK1 BX-912 Preclinical pyruvate dehydrogenase kinase inhibitor AKT2 | CDK2 | CHEK1 | GSK3B | KDR | PDK1 | PDPK1 BYK-204165 Preclinical PARP inhibitor PARP1 C-021 Preclinical CC chemokine receptor antagonist CCR4 C-1 Preclinical protein kinase inhibitor PRKCA C106 Phase 3 C11-Acetate Phase 3 ABAT | ACE | AKR1C3 | CA2 | CELA1 | ESR2 | FFAR2 | FFAR3 | HPRT1 | LTA4H | MMP12 | NOS1 | NOS3 | PLA2G1B | PTPN1 | SOD1 | TXN C188-9 Preclinical STAT inhibitor STAT3 C34 Preclinical toll-like receptor inhibitor TLR4 C646 Preclinical histone acetyltransferase inhibitor EP300 C-751 Preclinical CA-4948 Phase 1 kinase inhibitor IRAK4 cabagin Launched gastroenterology dyspepsia cabaletta Phase 2 pharmacological chaperone cabazitaxel Launched microtubule inhibitor CYP2C8 | CYP3A5 | SLCO1B3 | TUBA1A | TUBA1B | TUBA1C | TUBA3C | TUBA3D | TUBA3E | TUBA4A | TUBB | TUBB1 | TUBB2A | TUBB2B | TUBB3 | TUBB4A | TUBB4B | TUBB6 | TUBB8 oncology prostate cancer cabergoline Launched dopamine receptor agonist ADRA1A | ADRA1B | ADRA1D | ADRA2A | ADRA2B | ADRA2C | ADRB1 | ADRB2 | DRD1 | DRD2 | DRD3 | DRD4 | DRD5 | HTR1A | HTR1B | HTR1D | HTR2A | HTR2B | HTR2C | HTR7 | PRL endocrinology hyperprolactinemia cabotegravir Phase 3 HIV integrase inhibitor cabozantinib Launched RET tyrosine kinase inhibitor | VEGFR inhibitor CYP2C19 | FLT3 | KDR | KIT | MET | RET | TEK oncology medullary thyroid cancer (MTC) CaCCinh-A01 Preclinical calcium-activated chloride channel inhibitor CLCA1 cadazolid Phase 3 antibacterial cadralazine Launched adrenergic receptor antagonist CACNA1C cardiology hypertension cafestol Launched pregnane X receptor agonist caffeic-acid Preclinical HIV integrase inhibitor | lipoxygenase inhibitor | nitric oxide production inhibitor | tumor necrosis factor production inhibitor ALOX5 | MIF | TNF caffeic-acid-phenethyl-ester Preclinical HIV integrase inhibitor RELA caffeine Launched adenosine receptor antagonist | phosphodiesterase inhibitor ADORA1 | ADORA2A | ADORA2B | ADORA3 | ATM | ATR | ITPR1 | ITPR2 | ITPR3 | PDE10A | PDE11A | PDE1A | PDE1B | PDE1C | PDE2A | PDE3A | PDE3B | PDE4A | PDE4B | PDE4C | PDE4D | PDE5A | PDE6A | PDE6B | PDE6C | PDE7A | PDE7B | PDE8A | PDE8B | PDE9A | PIK3CA | PIK3CB | PIK3CD | PRKDC | RYR1 | RYR2 | RYR3 neurology/psychiatry | neurology/psychiatry drowsiness | fatigue calcifediol Launched vitamin D receptor agonist VDR endocrinology hyperparathyroidism calcipotriol Launched vitamin D receptor agonist VDR dermatology psoriasis calcitonin Launched calcitonin agonist CALCR orthopedics osteoporosis calcitriol Launched vitamin D receptor agonist CYP3A5 | VDR endocrinology | endocrinology | orthopedics hypocalcemia | hypoparathyroidism | osteoporosis calcium-gluceptate Launched calcium-levofolinate Launched Calhex-231 Preclinical calcium sensing receptor negative allosteric modulator CASR calpeptin Preclinical calpain inhibitor camicinal Phase 2 motilin receptor agonist MLNR CaMKII-IN-1 Preclinical calcium/calmodulin dependent protein kinase inhibitor AKT1 | CAMK2A | CAMK4 | MYLK camobucol Preclinical anti-inflammatory agent camostat-mesilate Launched protease inhibitor F10 | F2 | KLK3 | PLG | PRSS1 | PRSS2 | PRSS3 gastroenterology pancreatitis camphor-(+) Phase 2 camphor-(1R) Phase 1 TRPV activator TRPV1 camptothecin Phase 3 topoisomerase inhibitor HIF1A | TOP1 camptothecin-20(s)-o-propionate Phase 1 anticancer agent TOP1 oncology breast cancer camylofine-chlorhydrate Launched gastroenterology abdominal pain canagliflozin Launched sodium/glucose cotransporter inhibitor CYP2B6 | CYP2C8 | SLC5A1 | SLC5A2 endocrinology diabetes mellitus candesartan Launched angiotensin receptor antagonist AGTR1 cardiology | cardiology congestive heart failure | hypertension candesartan-cilexetil Launched angiotensin receptor antagonist cardiology | cardiology congestive heart failure | hypertension candicidin Launched fungal ergosterol inhibitor infectious disease vulvovaginal candidiasis canertinib Phase 3 EGFR inhibitor AKT1 | EGFR | ERBB2 | ERBB4 cangrelor Launched purinergic receptor antagonist P2RY12 cardiology myocardial infarction canrenone Withdrawn mineralocorticoid receptor antagonist NR3C2 cantharidin Launched protein phosphatase inhibitor dermatology blisters capadenoson Phase 2 adenosine receptor agonist ADORA1 capecitabine Launched DNA synthesis inhibitor | thymidylate synthase inhibitor DPYD | TYMS oncology | oncology breast cancer | colorectal cancer capobenic-acid Preclinical capreomycin Launched protein synthesis inhibitor infectious disease tuberculosis capreomycin (sulfate) capreomycin sulfate [4mm] Launched protein synthesis inhibitor infectious disease tuberculosis capromorelin Preclinical growth hormone secretagogue receptor agonist GH1 | GHSR caprylic-acid Launched capsaicin Launched TRPV agonist CFTR | ENOX2 | TRPV1 neurology/psychiatry | rheumatology muscle pain | rheumatoid arthritis capsazepine Preclinical TRPV agonist TRPV1 | TRPV4 captamine Preclinical captan Phase 1 captopril Launched angiotensin converting enzyme inhibitor ACE | LTA4H | MMP2 | MMP9 cardiology | cardiology | cardiology | endocrinology | nephrology congestive heart failure | diabetes mellitus | diabetic nephropathy | hypertension | myocardial infarction caracemide Phase 2 ribonucleotide reductase inhibitor RRM1 caramiphen Launched cholinergic receptor antagonist CHRM1 | CHRM2 neurology/psychiatry Parkinson's Disease carazolol Launched adrenergic receptor antagonist ADRB1 | ADRB2 | ADRB3 cardiology | cardiology | cardiology | cardiology angina pectoris | cardiac arrythmia | hypertension | myocardial infarction carbachol Launched cholinergic receptor agonist CHRM1 | CHRM2 | CHRM3 | CHRM4 | CHRM5 | CHRNA2 ophthalmology intraocular pressure carbadox Launched other antibiotic gastroenterology | infectious disease dysentry | enteritis carbamazepine Launched carboxamide antiepileptic ABCB1 | CYP1A2 | CYP3A4 | SCN10A | SCN11A | SCN1A | SCN2A | SCN3A | SCN4A | SCN5A | SCN7A | SCN8A | SCN9A neurology/psychiatry seizures carbaril Launched acetylcholinesterase inhibitor carbarsone Launched antiprotozoal agent infectious disease amebiasis carbazochrome Launched hematology hemorrhage carbendazim Launched microtubule inhibitor | tubulin polymerization inhibitor TP53 | TUBB infectious disease fungicide carbenicillin Launched bacterial cell wall synthesis inhibitor infectious disease gram-negative bacterial infections carbenoxolone Launched 11-beta hydroxysteroid dehydrogenase inhibitor GJA1 | GJA10 | GJA3 | GJA4 | GJA5 | GJA8 | GJA9 | GJB1 | GJB2 | GJB3 | GJB4 | GJB5 | GJB6 | GJB7 | GJC1 | GJC2 | GJC3 | GJD2 | GJD3 | GJD4 | GJE1 | HSD11B1 | PANX1 | PANX2 | PANX3 dental | gastroenterology mouth inflammation | peptic ulcer disease (PUD) carbenoxolone sodium Launched 11-beta hydroxysteroid dehydrogenase inhibitor GJA1 | GJA10 | GJA3 | GJA4 | GJA5 | GJA8 | GJA9 | GJB1 | GJB2 | GJB3 | GJB4 | GJB5 | GJB6 | GJB7 | GJC1 | GJC2 | GJC3 | GJD2 | GJD3 | GJD4 | GJE1 | HSD11B1 | PANX1 | PANX2 | PANX3 "gastroenterology, dental" "peptic ulcer disease (pud), mouth inflammation" carbetapentane Launched acetylcholine receptor antagonist CHRM2 otolaryngology | otolaryngology | pulmonary bronchitis | common cold | nasal congestion carbetocin Launched oxytocin receptor agonist OXTR hematology hemorrhage carbidopa Launched aromatic L-amino acid decarboxylase inhibitor DDC neurology/psychiatry Parkinson's Disease carbimazole Launched antithyroid agent TPO endocrinology hyperthyroidism carbinoxamine Launched histamine receptor antagonist HRH1 allergy | dermatology | ophthalmology | otolaryngology allergic rhinitis | conjunctivitis | dermatographism | vasomotor rhinitis carbinoxamine maleate Launched histamine receptor antagonist HRH1 "allergy, ophthalmology, otolaryngology, dermatology" "allergic rhinitis, conjunctivitis, vasomotor rhinitis, dermatographism" carboplatin Launched DNA alkylating agent | DNA inhibitor oncology ovarian cancer carboprost Launched prostanoid receptor agonist PTGER1 hematology postpartum hemorrhage (pph) carboxyamidotriazole Phase 3 calcium channel blocker CXCL8 carboxylosartan Phase 1 angiotensin antagonist AGTR1 carboxypyridine-disulfide Phase 2 DHFR carcainium chloride Preclinical antitussive infectious disease pneumonia cardiogenol-C Preclinical cardiomyogenesis inducer cardionogen-1 Preclinical WNT signaling inhibitor CTNNB1 carebastine Phase 1 histamine receptor antagonist HRH1 carfilzomib Launched proteasome inhibitor PSMA1 | PSMA2 | PSMA3 | PSMA4 | PSMA5 | PSMA6 | PSMA7 | PSMA8 | PSMB1 | PSMB10 | PSMB11 | PSMB2 | PSMB3 | PSMB4 | PSMB5 | PSMB6 | PSMB7 | PSMB8 | PSMB9 hematologic malignancy multiple myeloma carglumic-acid Launched carbamoyl phosphate synthase activator CPS1 metabolism hyperammonemia caricotamide Phase 2 NADPH quinone oxidoreductase inhibitor NQO2 cariporide Phase 3 sodium/hydrogen exchanger inhibitor SLC9A1 cariprazine Launched dopamine receptor antagonist DRD2 | DRD3 neurology/psychiatry schizophrenia carmofur Launched thymidylate synthase inhibitor TYMS oncology | oncology breast cancer | colorectal cancer carmoterol Phase 2 adrenergic receptor agonist ADRB2 carmoxirole Phase 2 dopamine receptor agonist DRD2 carmustine Launched DNA alkylating agent | DNA inhibitor GSR | TXNRD1 | TXNRD2 hematologic malignancy | hematologic malignancy | hematologic malignancy | oncology | oncology | oncology | oncology | oncology astrocytoma | brainstem glioma | ependymoma | glioblastoma | Hodgkin's lymphoma | medulloblastoma | multiple myeloma | non-Hodgkin lymphoma (NHL) carnitine-(D/L) Phase 3 carnosine Phase 2 antiglycating agent caroverin Phase 3 cytochrome P450 inhibitor CACNA1C | CYP3A4 caroxazone Withdrawn monoamine oxidase inhibitor MAOA | MAOB carprofen Launched cyclooxygenase inhibitor PTGS1 | PTGS2 rheumatology osteoarthritis carsalam Preclinical analgesic agent carteolol Launched adrenergic receptor antagonist ADRB1 | ADRB2 | ADRB3 ophthalmology | ophthalmology | ophthalmology glaucoma | intraocular pressure | ocular hypertension carteolol hydrochloride Launched adrenergic receptor antagonist ADRB1 | ADRB2 | ADRB3 Cardiology angina pectoris carumonam Launched bacterial cell wall synthesis inhibitor infectious disease | infectious disease gram-negative bacterial infections | urinary tract infections carvedilol Launched adrenergic receptor antagonist ADRB1 | ADRB2 | ADRB3 | CYP2C19 | CYP2E1 | RYR2 cardiology | cardiology | cardiology "hypertension | myocardial infarction | myocardial infarction, hypertension" carvedilol phosphate Launched carzenide Preclinical CA1 | CA12 | CA14 | CA2 | CA6 | CA9 casanthranol-variant Launched gastroenterology constipation casin Preclinical GTPase inhibitor CDC42 caspofungin Launched "bacterial cell wall synthesis inhibitor | fungal 1,3-beta-D-glucan synthase inhibitor" infectious disease | infectious disease | infectious disease | infectious disease | infectious disease aspergillosis | candidemia | esophageal candidiasis | fungal infection | peritonitis caspofungin acetate caspofungin (acetate) castanospermine Phase 2 glucosidase inhibitor GAA | GBA catharanthine Preclinical tubulin polymerization inhibitor cathepsin-inhibitor-1 Preclinical cathepsin inhibitor CTSB | CTSL | CTSV CAY10505 Preclinical PI3K inhibitor PIK3CG CB-03-01 Phase 3 androgen receptor antagonist AR CB-10-277 Phase 1 DNA synthesis inhibitor cb-103 Phase 1/Phase 2 notch signaling inhibitor NOTCH1 oncology breast cancer cb-1158 Phase 1 arginase inhibitor ARG1 | ARG2 | IFNLR1 oncology bladder cancer CB-5083 Phase 1 valosin-containing protein inhibitor VCP CB-839 Phase 2 glutaminase inhibitor GLS CBiPES Preclinical glutamate receptor positive allosteric modulator GRM2 cbl0137 Phase 1 histone chaperone inhibitor SUPT16H cbp/p300-in-4 bromodomain inhibitor CREBBP | EP300 genetics duchenne muscular dystrophy (dmd) CBS-1114 Phase 1 lipoxygenase inhibitor ALOX5 CC-115 Phase 2 DNA protein kinase inhibitor | mTOR inhibitor MTOR CC-223 Phase 2 mTOR inhibitor MTOR CC4 Preclinical nicotinic receptor agonist CHRNA4 | CHRNB2 CC-401 Phase 1 JNK inhibitor MAPK8 CC-90003 Phase 1 MAP kinase inhibitor MAPK1 | MAPK3 cc-92480 Phase 1 ubiquitin ligase inhibitor CRBN hematologic malignancy multiple myeloma CC-930 Phase 2 JNK inhibitor CCG-1423 Preclinical apoptosis stimulant RHOC | SRF CCG-50014 Preclinical G protein signaling inhibitor RGS4 | RGS8 CCG-63802 Preclinical G protein signaling inhibitor RGS4 CCG-63808 Preclinical G protein signaling inhibitor RGS4 CCMI Preclinical acetylcholine receptor allosteric modulator CHRNA7 CCMQ Preclinical homoquinolinic acid binding inhibitor ccr1 antagonist 9 Preclinical ccr antagonist CCR1 rheumatology rheumatoid arthritis ccr2 antagonist 3 Phase 2 potassium channel blocker KCNJ3 cardiology cardiac arrythmia CCT018159 Preclinical HSP inhibitor HSP90AA1 | HSP90AB1 CCT-031374 Preclinical WNT signaling inhibitor CTNNB1 CCT128930 Preclinical AKT inhibitor ROCK1 | ROCK2 CCT129202 Preclinical Aurora kinase inhibitor AURKA | AURKB | AURKC CCT137690 Preclinical Aurora kinase inhibitor AURKA | AURKB | AURKC | FLT3 CCT196969 Preclinical RAF inhibitor BRAF | RAF1 CCT245737 Preclinical kinase inhibitor CHEK1 CD-1530 Preclinical retinoid receptor agonist RARG CD-437 Preclinical retinoid receptor agonist RARG CDBA Phase 3 CDK1-5-inhibitor Preclinical CDK inhibitor | glycogen synthase kinase inhibitor CDK1 | CDK5 | GSK3B CDK9-IN-6 Preclinical CDK inhibitor CCNT1 | CDK9 CDPPB Preclinical glutamate receptor positive allosteric modulator GRM5 ce-245677 Phase 1 tie tyrosine kinase inhibitor NTRK1 | NTRK2 | TEK oncology breast cancer CE3F4 Preclinical rap guanine nucleotide exchange factor inhibitor RAPGEF3 cebranopadol Phase 3 opioid receptor agonist OPRL1 | OPRM1 cediranib Phase 3 KIT inhibitor | VEGFR inhibitor CSF1R | FLT1 | FLT3 | FLT4 | KDR | KIT | PDGFRA | PDGFRB cedrol Phase 2 cedrol-(+) Phase 2 sedative cefaclor Launched bacterial cell wall synthesis inhibitor infectious disease | infectious disease | infectious disease | infectious disease | otolaryngology | otolaryngology pharyngitis | pneumonia | respiratory tract infections | skin infections | tonsillitis | urinary tract infections cefadroxil Launched bacterial cell wall synthesis inhibitor SLC15A1 | SLC15A2 | SLC22A6 | SLC22A8 "infectious disease | infectious disease | infectious disease, otolaryngology | otolaryngology | otolaryngology" "pharyngitis | skin infections | tonsillitis | urinary tract infections | urinary tract infections, skin infections, tonsillitis, pharyngitis" cefalonium Launched bacterial cell wall synthesis inhibitor infectious disease gram-positive bacterial infections cefamandole Launched bacterial cell wall synthesis inhibitor infectious disease | infectious disease | infectious disease respiratory tract infections | skin infections | urinary tract infections cefamandole-nafate Launched bacterial cell wall synthesis inhibitor infectious disease | infectious disease | infectious disease respiratory tract infections | skin infections | urinary tract infections cefathiamidine Launched bacterial cell wall synthesis inhibitor infectious disease gram-positive bacterial infections cefazolin Launched bacterial cell wall synthesis inhibitor PON1 | SLC22A8 infectious disease | infectious disease | infectious disease | infectious disease | infectious disease | infectious disease bacterial septicemia | bone and joint infections | endocarditis | skin infections | surgical prophylaxis | urinary tract infections cefcapene-pivoxil Launched bacterial cell wall synthesis inhibitor infectious disease | infectious disease | infectious disease pneumonia | skin infections | urinary tract infections cefdinir Launched bacterial cell wall synthesis inhibitor MPO infectious disease | infectious disease | otolaryngology | otolaryngology | otolaryngology | otolaryngology | pulmonary bronchitis | otitis | pharyngitis | pneumonia | sinusitis | skin infections | tonsillitis cefditoren-pivoxil Launched bacterial cell wall synthesis inhibitor infectious disease | infectious disease | otolaryngology | otolaryngology | pulmonary bronchitis | pharyngitis | pneumonia | skin infections | tonsillitis cefepime Launched bacterial cell wall synthesis inhibitor | penicillin binding protein inhibitor A1BG infectious disease | infectious disease | infectious disease | infectious disease | Infectious disease gram-negative bacterial infections | intra-abdominal infections | pneumonia | skin infections | urinary tract infections cefetamet Launched bacterial cell wall synthesis inhibitor infectious disease | infectious disease | infectious disease | otolaryngology | otolaryngology | pulmonary bronchitis | ear infections | otitis | pneumonia | sinusitis | urinary tract infections cefetamet-pivoxil Launched bacterial cell wall synthesis inhibitor infectious disease gram-positive bacterial infections cefiderocol Launched antibacterial cefixime Launched bacterial cell wall synthesis inhibitor infectious disease | infectious disease | otolaryngology | otolaryngology | otolaryngology | pulmonary bronchitis | gonorrhea | otitis | pharyngitis | tonsillitis | urinary tract infections cefmenoxime Launched bacterial cell wall synthesis inhibitor infectious disease gram-negative bacterial infections cefmenoxime hydrochloride Launched bacterial cell wall synthesis inhibitor infectious disease gram-negative bacterial infections cefmetazole Launched bacterial cell wall synthesis inhibitor infectious disease | infectious disease skin infections | urinary tract infections cefminox Launched bacterial cell wall synthesis inhibitor infectious disease gram-negative bacterial infections cefodizime Launched bacterial cell wall synthesis inhibitor infectious disease | infectious disease | infectious disease gonorrhea | respiratory tract infections | skin infections cefonicid Launched bacterial cell wall synthesis inhibitor infectious disease gram-positive bacterial infections cefoperazone Launched bacterial cell wall synthesis inhibitor infectious disease gram-negative bacterial infections ceforanide Launched penicillin binding protein inhibitor infectious disease gram-negative bacterial infections cefoselis Launched bacterial cell wall synthesis inhibitor infectious disease | infectious disease gram-negative bacterial infections | gram-positive bacterial infections cefotaxime Launched bacterial cell wall synthesis inhibitor infectious disease | infectious disease | infectious disease | infectious disease | infectious disease | infectious disease | infectious disease | infectious disease | infectious disease bacterial septicemia | bone and joint infections | gynecologic infections | intra-abdominal infections | meningitis | pelvic inflammatory disease | respiratory tract infections | skin infections | urinary tract infections cefotetan Launched bacterial cell wall synthesis inhibitor | penicillin binding protein inhibitor PBP infectious disease | infectious disease | infectious disease | infectious disease | infectious disease | infectious disease | infectious disease | infectious disease | Infectious disease bone and joint infections | chlamydia | gram-positive bacterial infections | gynecologic infections | intra-abdominal infections | respiratory tract infections | skin infections | surgical prophylaxis | urinary tract infections cefotetan disodium Launched cefotiam Launched bacterial cell wall synthesis inhibitor infectious disease | infectious disease | infectious disease | infectious disease | infectious disease bacterial septicemia | bone and joint infections | respiratory tract infections | skin infections | urinary tract infections cefotiam-cilexetil Launched bacterial cell wall synthesis inhibitor infectious disease | infectious disease gram-negative bacterial infections | gram-positive bacterial infections cefoxitin Launched bacterial cell wall synthesis inhibitor infectious disease | infectious disease | infectious disease | infectious disease | infectious disease | infectious disease | infectious disease bacterial septicemia | bone and joint infections | gynecologic infections | intra-abdominal infections | respiratory tract infections | skin infections | urinary tract infections cefozopran Launched bacterial cell wall synthesis inhibitor infectious disease | infectious disease gram-negative bacterial infections | gram-positive bacterial infections cefpiramide Launched bacterial cell wall synthesis inhibitor infectious disease gram-negative bacterial infections cefpirome Launched bacterial cell wall synthesis inhibitor infectious disease gram-negative bacterial infections cefpodoxime Launched bacterial cell wall synthesis inhibitor infectious disease | infectious disease | infectious disease | infectious disease | otolaryngology | otolaryngology | otolaryngology | pulmonary bronchitis | gonorrhea | pharyngitis | pneumonia | sinusitis | skin infections | tonsillitis | urinary tract infections cefprozil Launched bacterial cell wall synthesis inhibitor infectious disease | infectious disease | otolaryngology | otolaryngology | otolaryngology | otolaryngology | pulmonary bronchitis | otitis | pharyngitis | respiratory tract infections | sinusitis | skin infections | tonsillitis cefradine Launched bacterial cell wall synthesis inhibitor CYP3A4 infectious disease | infectious disease | infectious disease | infectious disease | otolaryngology | otolaryngology | otolaryngology otitis | pharyngitis | pneumonia | respiratory tract infections | skin infections | tonsillitis | urinary tract infections cefsulodin Launched bacterial cell wall synthesis inhibitor infectious disease gram-negative bacterial infections ceftaroline-fosamil Launched bacterial cell wall synthesis inhibitor infectious disease | infectious disease pneumonia | skin infections ceftazidime Launched bacterial cell wall synthesis inhibitor infectious disease | infectious disease | infectious disease | infectious disease | infectious disease | infectious disease | infectious disease bacterial septicemia | bone and joint infections | gynecologic infections | intra-abdominal infections | meningitis | respiratory tract infections | skin infections ceftazidime pentahydrate ceftibuten Launched bacterial cell wall synthesis inhibitor otolaryngology | otolaryngology | otolaryngology | pulmonary bronchitis | otitis | pharyngitis | tonsillitis ceftiofur Launched bacterial cell wall synthesis inhibitor infectious disease | infectious disease pneumonia | respiratory tract infections ceftizoxim Launched bacterial cell wall synthesis inhibitor infectious disease | infectious disease | infectious disease | infectious disease | infectious disease | infectious disease | infectious disease | infectious disease | infectious disease bacterial septicemia | bone and joint infections | gonorrhea | intra-abdominal infections | meningitis | pelvic inflammatory disease | respiratory tract infections | skin infections | urinary tract infections ceftobiprole Phase 3 antiinfective drug ceftriaxone Launched bacterial cell wall synthesis inhibitor infectious disease | infectious disease | infectious disease | infectious disease | infectious disease | infectious disease | infectious disease | infectious disease | infectious disease | infectious disease | otolaryngology bacterial septicemia | bone and joint infections | gonorrhea | intra-abdominal infections | meningitis | otitis | pelvic inflammatory disease | pneumonia | skin infections | surgical prophylaxis | urinary tract infections cefuroxime Launched bacterial cell wall synthesis inhibitor infectious disease gram-negative bacterial infections cefuroxime-axetil Launched bacterial cell wall synthesis inhibitor otolaryngology | otolaryngology | otolaryngology | otolaryngology otitis | pharyngitis | sinusitis | tonsillitis celecoxib Launched cyclooxygenase inhibitor CA12 | CASP3 | CYP2C19 | PDPK1 | PTGS2 endocrinology | rheumatology | rheumatology | rheumatology ankylosing spondylitis | osteoarthritis | primary dysmenorrhea (PD) | rheumatoid arthritis celgosivir Phase 2 glucosidase inhibitor MOGS celiprolol Launched adrenergic receptor antagonist ADRA2A | ADRB1 | ADRB2 genetics Ehlers-Danlos syndrome (EDS) cenerimod Phase 2 sphingosine 1-phosphate receptor modulator S1PR1 cenicriviroc Phase 3 CC chemokine receptor antagonist CCR2 | CCR5 cenisertib Phase 1 aurora kinase inhibitor AURKB | KDR oncology pancreatic cancer cenobamate Launched GABA receptor modulator | voltage-gated sodium channel blocker centanafadine Phase 3 dopamine reuptake inhibitor SLC6A2 | SLC6A3 | SLC6A4 centazolone Phase 1 monoamine oxidase inhibitor centhaquin Phase 1 analgesic agent centpropazine Phase 3 inositol monophosphatase inhibitor CEP-32496 Phase 1/Phase 2 RAF inhibitor BRAF | EGFR | RAF1 CEP-33779 Preclinical JAK inhibitor JAK2 CEP-37440 Phase 1 ALK tyrosine kinase receptor inhibitor ALK CEP-40783 Preclinical AXL kinase inhibitor AXL | MET cephalexin Launched bacterial cell wall synthesis inhibitor infectious disease | infectious disease | infectious disease | infectious disease | otolaryngology bone and joint infections | genitourinary tract infections | otitis | respiratory tract infections | skin infections cephalomannine Preclinical DNA polymerase inhibitor cephalosporin-c-zn Preclinical bacterial cell wall synthesis inhibitor cephalothin Launched bacterial cell wall synthesis inhibitor infectious disease | infectious disease skin infections | surgical prophylaxis cephapirin Launched bacterial cell wall synthesis inhibitor obstetrics/gynecology mastitis cepharanthine Phase 2 NFkB pathway inhibitor cephradine Launched bacterial cell wall synthesis inhibitor infectious disease | infectious disease | infectious disease respiratory tract infections | skin infections | urinary tract infections ceralasertib Phase 3 atr kinase inhibitor ATR Oncology breast cancer ceramide Launched phosphoenolpyruvate carboxylase activator | serine/threonine protein phosphatase activator dermatology cosmetic ceritinib Launched ALK tyrosine kinase receptor inhibitor ALK | FLT3 | IGF1R | INSR | TSSK1B oncology non-small cell lung cancer (NSCLC) cerulenin Launched fatty acid synthase inhibitor FASN infectious disease fungal infection ceruletide Preclinical CCK receptor agonist CCK | CCKAR cetaben Phase 2 ACAT inhibitor | cholesterol inhibitor PPARA cetilistat Phase 3 triacylglycerol lipase inhibitor LIPC | LIPE | LIPG | PNLIP cetirizine Launched histamine receptor antagonist HRH1 allergy allergic rhinitis cetrimonium Launched dermatology cosmetic cetrorelix Launched gonadotropin releasing factor hormone receptor antagonist GNRH1 | GNRHR | LHCGR endocrinology premature luteinizing hormone surges cetylpyridinium Launched dental | dental gingivitis | mouth inflammation cevimeline Launched acetylcholine receptor agonist CHRM1 | CHRM3 rheumatology sjogren's syndrome cevimeline hydrochloride Launched acetylcholine receptor agonist CHRM3 rheumatology sjogren's syndrome cevipabulin Phase 1 "microtubule stimulant | microtubule stimulant, tubulin polymerization inhibitor | tubulin polymerization inhibitor" TUBB CF102 Phase 2 adenosine receptor agonist ADORA1 | ADORA2A | ADORA2B | ADORA3 CFI-400945 Phase 2 serine/threonine kinase inhibitor PLK4 CFI-402257 Phase 1/Phase 2 dual specificity protein kinase inhibitor TTK CFM-1571 Preclinical guanylate cyclase activator CFM-2 Preclinical glutamate receptor antagonist CFTRinh-172 Preclinical chloride channel blocker CFTR CG-400549 Phase 2 FABI inhibitor CGH2466 Preclinical adenosine receptor antagonist ADORA1 | ADORA2B | ADORA3 CGK-733 Preclinical ATM kinase inhibitor | ATR kinase inhibitor ATM | ATR CGM097 Phase 1 MDM inhibitor MDM2 | TP53 CGP-12177 Phase 1 adrenergic receptor agonist ADRB1 | ADRB2 | ADRB3 CGP-13501 Preclinical GABA receptor modulator GABBR1 CGP-20712A Preclinical adrenergic receptor antagonist ADRB1 | ADRB3 CGP-25454A Preclinical dopamine receptor antagonist DRD1 | DRD2 | DRD3 | DRD4 | DRD5 CGP-37157 Preclinical mitochondrial Na+/Ca2+ exchanger antagonist | sodium/calcium exchange inhibitor SLC8A1 CGP-37849 Phase 1 glutamate receptor antagonist GRIN1 | GRIN2A | GRIN2B | GRIN2C | GRIN2D CGP-39551 Preclinical NMDA receptor antagonist GRIN1 CGP-52411 Preclinical EGFR inhibitor EGFR CGP-53353 Preclinical EGFR inhibitor | PKC inhibitor EGFR | PRKCB CGP-54626 Preclinical GABA receptor antagonist GABBR1 | GABBR2 | KCTD12 | KCTD16 | KCTD8 cgp 55845 Preclinical gaba receptor antagonist Neurology depression CGP-55845 Preclinical GABA receptor antagonist GABBR1 | GABBR2 | KCTD12 | KCTD16 | KCTD8 CGP-57380 Preclinical MAP kinase inhibitor AURKB | LCK | MKNK1 | MKNK2 | SGK1 CGP-60474 Preclinical CDK inhibitor CDK1 | CDK2 CGP-71683 Preclinical neuropeptide receptor antagonist NPY5R CGP-74514 Preclinical CDK inhibitor CDK1 CGP-78608 Preclinical glutamate receptor antagonist CGP-7930 Preclinical GABA receptor modulator GABBR1 CGS-15943 Preclinical adenosine receptor antagonist ADORA1 | ADORA2A | ADORA2B | ADORA3 CGS-20625 Phase 1 benzodiazepine receptor agonist | GABA benzodiazepine site receptor partial agonist GABRA1 | GABRA2 | GABRA3 | GABRA4 | GABRA5 | GABRA6 CGS-21680 Preclinical adenosine receptor agonist ADORA1 | ADORA2A | ADORA2B | ADORA3 CGS-9896 Preclinical GABA receptor antagonist GABRA1 | GABRB2 | GABRG2 CH-170 Phase 1 CH223191 Preclinical aryl hydrocarbon receptor antagonist AHR CH5132799 Phase 1 PI3K inhibitor MTOR | PIK3CA | PIK3CB | PIK3CD | PIK3CG CH-5183284 Phase 2 fibroblast growth factor inhibitor FGFR1 | FGFR2 | FGFR3 CH55 Preclinical retinoid receptor binder RARA | RARB CHC Preclinical monocarboxylate transporter inhibitor SLC16A1 chenodeoxycholic-acid Launched 11-beta hydroxysteroid dehydrogenase inhibitor | FXR agonist HSD11B1 | NR1H4 cardiology | gastroenterology cerebral cholesterosis | gallstones CHF5074 Phase 2 gamma secretase modulator PSEN1 chicago-sky-blue-6b Preclinical glutamate inhibitor | macrophage migration inhibiting factor inhibitor MIF chidamide Launched HDAC inhibitor HDAC10 | HDAC3 hematologic malignancy peripheral T-cell lymphoma (PTCL) chiniofon Launched antiprotozoal agent infectious disease amebiasis CHIR-124 Preclinical CHK inhibitor CHEK1 CHIR-98014 Preclinical glycogen synthase kinase inhibitor GSK3A | GSK3B CHIR-99021 Preclinical glycogen synthase kinase inhibitor CDK1 | GSK3A | GSK3B | MAPK1 chloralose Preclinical chlorambucil Launched DNA inhibitor hematologic malignancy | hematologic malignancy chronic lymphocytic leukemia (CLL) | Hodgkin's lymphoma chloramine-T Launched infectious disease bacterial gill disease chloramphenicol Launched bacterial 50S ribosomal subunit inhibitor CD55 | CYP2C19 endocrinology | infectious disease | infectious disease cholera | fever | meningitis chloramphenicol palmitate Launched protein synthesis inhibitor "infectious disease, endocrinology" "meningitis, fever, cholera" chloramphenicol-palmitate Launched protein synthesis inhibitor endocrinology | infectious disease | infectious disease cholera | fever | meningitis chloramphenicol-sodium-succinate Launched protein synthesis inhibitor infectious disease gram-negative bacterial infections chlorazanil Preclinical chlorcyclizine Launched histamine receptor antagonist HRH1 allergy allergic rhinitis chlorfenson Phase 2 other antifungal chlorhexidine Launched membrane integrity inhibitor dental | dermatology | infectious disease cosmetic | gingivitis | skin infections chlorindanol Preclinical chlorindione Preclinical chlorisondamine-diiodide Preclinical acetylcholine receptor antagonist CHRNA1 chlormadinone acetate Launched 5 alpha reductase inhibitor PGR endocrinology "hypermenorrhea, amenorrhea, oligomenorrhea, polymenorrhea" chlormadinone-acetate Launched 5 alpha reductase inhibitor PGR endocrinology | endocrinology | endocrinology | endocrinology amenorrhea | hypermenorrhea | oligomenorrhea | polymenorrhea chlormerodrin Withdrawn sodium/potassium/chloride transporter inhibitor ALDH5A1 | SLC12A1 urology urinary frequency chlormethine (hydrochloride) chlormezanone Withdrawn GABA receptor modulator GABRA1 chlormidazole Launched fungal lanosterol demethylase inhibitor infectious disease fungal infection chlorobutanol Launched neurology/psychiatry | neurology/psychiatry anesthetic | sedative chlorocresol Launched ryanodine receptor activator infectious disease first-aid antiseptic chlorogenic-acid Launched antioxidant SLC37A4 allergy | neurology/psychiatry | pulmonary allergic rhinitis | chest congestion | headache chlorophyllin Phase 1 cytochrome p450 inhibitor Infectious disease | urology hepatitis b | urinary incontinence chlorophyllin-copper Phase 1 cytochrome P450 inhibitor chloroprocaine Launched sodium channel blocker ATP1A1 | CHRNA10 | GRIN3A | HTR3A | SCN10A | SLC6A3 neurology/psychiatry local anesthetic chloropyramine Launched histamine receptor antagonist HRH1 allergy | cardiology | ophthalmology | pulmonary allergic rhinitis | asthma | conjunctivitis | edema chloroquine Launched antimalarial agent CYP2C8 | MRGPRX1 infectious disease | infectious disease amebiasis | malaria chlorothiazide Launched diuretic CA1 | CA2 | CA4 | SLC12A3 cardiology hypertension chlorothymol Launched chlorotrianisene Launched estrogenic hormone ESR1 | ESR2 endocrinology | oncology menopause | prostate cancer chloroxine Launched opioid receptor antagonist OPRK1 dermatology | gastroenterology | gastroenterology | infectious disease dandruff | diarrhea | giardiasis | inflammatory bowel disease chloroxoquinoline Launched chloroxylenol Launched ATP synthase inhibitor infectious disease skin infections chlorphenamine Launched histamine receptor antagonist HRH1 allergy | allergy allergic rhinitis | urticaria chlorphenesin Launched muscle relaxant neurology/psychiatry | neurology/psychiatry muscle relaxant | sedative chlorpheniramine maleate Launched histamine receptor antagonist allergy "allergic rhinitis, urticaria" chlorphenoxamine Preclinical histamine receptor antagonist HRH1 chlorphensin-carbamate Launched muscle relaxant neurology/psychiatry spasms chlorproguanil Launched dihydrofolate reductase inhibitor DHFR infectious disease malaria chlorpromazine Launched dopamine receptor antagonist ADRA1A | ADRA1B | ADRA1D | ADRA2A | ADRA2B | ADRA2C | CALM1 | CHRM1 | CHRM3 | DRD1 | DRD2 | DRD3 | DRD4 | DRD5 | HRH1 | HRH4 | HTR1A | HTR2A | HTR2B | HTR2C | HTR6 | HTR7 | KCNH2 | KIF11 | ORM1 | ORM2 | SMPD1 | TRPC5 gastroenterology | gastroenterology | hematology | infectious disease | neurology/psychiatry acute intermittent porphyria (AIP) | nausea | schizophrenia | tetanus | vomiting chlorpropamide Launched ATP channel blocker ABCC8 | KCNJ10 endocrinology diabetes mellitus chlorpropham Phase 1 antiviral chlorprothixene Launched dopamine receptor antagonist CHRM1 | CHRM2 | CHRM3 | CHRM4 | CHRM5 | DRD1 | DRD2 | DRD3 | HRH1 | HTR2A | HTR2B | HTR2C neurology/psychiatry | neurology/psychiatry bipolar disorder | schizophrenia chlorpyrifos Launched acetylcholinesterase inhibitor ACHE chlorquinaldol Launched other antibiotic infectious disease fungal infection chlortetracycline Launched protein synthesis inhibitor ophthalmology conjunctivitis chlortetracycline hcl Launched protein synthesis inhibitor ophthalmology conjunctivitis chlorthalidone Launched carbonic anhydrase inhibitor CA1 | CA12 | CA14 | CA2 | CA4 | CA7 | SLC12A1 cardiology | cardiology | cardiology | gastroenterology | nephrology | nephrology | rheumatology acute glomerulonephritis (AGN) | chronic renal failure | congestive heart failure | edema | hepatic cirrhosis | hypertension | nephrotic syndrome chlorzoxazone Launched bacterial 30S ribosomal subunit inhibitor KCNMA1 | KCNN4 neurology/psychiatry muscle relaxant cholecalciferol Launched CYP2J2 | VDR endocrinology vitamin D deficiency cholesterol Preclinical RORA cholic-acid Launched bile acid ADH1C | CES1 | COX4I1 | COX5A | COX5B | COX6A2 | COX6B1 | COX6C | COX7A1 | COX7B | COX7C | COX8A | ESRRG | FABP6 | FECH | GPBAR1 | MT-CO1 | MT-CO2 | MT-CO3 | PLA2G1B gastroenterology | genetics | neurology/psychiatry bile acid synthesis disorders | peroxisomal disorders | Zellweger syndrome choline Phase 3 acetylcholine precursor ACHE | BCHE | CHRNA2 | PCYT1A | PCYT1B | PHOSPHO1 | PLD1 | PLD2 choline alfoscerate Launched acetylcholine precursor CNS disorders alzheimer's disease choline-alfoscerate Launched acetylcholine precursor CHPG Preclinical glutamate receptor agonist GRM5 CHR-6494 Preclinical serine/threonine kinase inhibitor GSG2 chromanol-(+/-) Preclinical potassium channel blocker "chromanol-293B-(-)-[3R,4S]" Preclinical potassium channel blocker chromium-picolinate Launched insulin sensitizer endocrinology diabetes mellitus chromocarb Launched antispasmodic chrysin Phase 1 breast cancer resistance protein inhibitor ABCG2 | AKR1B1 | CDK6 | CYP19A1 | CYP1B1 chrysophanic-acid Preclinical EGFR inhibitor EGFR | FLT1 | KDR | MTOR chs-828 Phase 1 nampt inhibitor A1BG | NAMPT Oncology lung cancer chuanxiongzine Phase 2 CI-844 Phase 2 CI-923 Phase 1 acetylcholine receptor antagonist CI-953 Phase 1 voltage-gated sodium channel blocker SCN1A | SCN3A CI-966 Phase 1 GAT inhibitor SLC6A1 CI-976 Phase 1 ACAT inhibitor ACAT1 | CES1 | SOAT1 ciaftalan-zinc Phase 1 reactive oxygen species stimulant cianidanol Withdrawn fatty acid synthase inhibitor FASN | PTGS1 | SCN5A cibenzoline Launched sodium channel blocker cardiology cardiac arrythmia ciclesonide Launched glucocorticoid receptor agonist NR3C1 | SERPINA6 allergy allergic rhinitis ciclopirox Launched membrane integrity inhibitor ATP1A1 infectious disease onychomycosis cicloprofen Preclinical cyclooxygenase inhibitor PTGS1 | PTGS2 CID-16020046 Preclinical G protein-coupled receptor antagonist GPR55 CID-2011756 Preclinical protein kinase inhibitor PKD1 CID-2745687 Preclinical G protein-coupled receptor antagonist GPR35 CID-5458317 Preclinical MAP kinase phosphatase inhibitor DUSP6 | MAPK3 cidofovir Launched DNA polymerase inhibitor infectious disease | infectious disease acquired immunodeficiency syndrome (AIDS) | cytomegalovirus retinitis ciglitazone Phase 2 PPAR receptor agonist INS | PPARG cilastatin Launched dehydropeptidase inhibitor DPEP1 cilazapril Launched angiotensin converting enzyme inhibitor ACE cardiology | cardiology congestive heart failure | hypertension cilazapril monohydrate Launched angiotensin converting enzyme inhibitor ACE cardiology "hypertension, congestive heart failure" cilengitide Phase 3 integrin antagonist ITGAV | ITGB3 | ITGB5 cilnidipine Launched calcium channel blocker CACNA1B | CACNA1C cardiology hypertension cilofexor Phase 3 FXR agonist NR1H4 cilomilast Phase 3 phosphodiesterase inhibitor IL12A | IL12B | IL1B | PDE4A | PDE4B | PDE4C | PDE4D | TNF cilostamide Preclinical phosphodiesterase inhibitor PDE3A | PDE3B cilostazol Launched phosphodiesterase inhibitor CYP2C19 | CYP3A5 | PDE3A | PDE3B cardiology claudication ciluprevir Preclinical serine protease inhibitor NS3 CIM-0216 Preclinical transient receptor potential channel agonist TRPM3 cimaterol Preclinical adrenergic receptor agonist ADRB1 | ADRB2 | ADRB3 cimetidine Launched histamine receptor antagonist HRH2 | SLC29A4 | SLC47A1 | SLC47A2 endocrinology | gastroenterology | gastroenterology | gastroenterology | gastroenterology | hematologic malignancy aggressive systemic mastocytosis (ASM) | duodenal ulcer disease | endocrine adenoma | gastroesophageal reflux disease (GERD) | peptic ulcer disease (PUD) | Zollinger-Ellison syndrome cimetropium Launched acetylcholine receptor antagonist CHRM1 gastroenterology irritable bowel syndrome cimlanod Phase 2 nitric oxide donor cardiology congestive heart failure cinacalcet Launched calcium channel activator CASR endocrinology | endocrinology | nephrology | oncology chronic kidney disease (CKD) | hypercalcemia | hyperparathyroidism | parathyroid carcinoma cinaciguat Phase 2 guanylate cyclase activator GUCY1A3 | GUCY1B3 cinalukast Phase 2 leukotriene receptor antagonist CYSLTR1 cinanserin Preclinical serotonin receptor antagonist HTR2A cinchocaine Launched sodium channel blocker CALM1 | SCN10A | SCN5A neurology/psychiatry local anesthetic cinchonidine Phase 1 P glycoprotein inhibitor ABCB1 cinchonine Preclinical P glycoprotein inhibitor CYP2D6 cinchophen Launched analgesic agent rheumatology gout cinepazet Launched vasodilator cinepazide Withdrawn calcium channel activator cinflumide Phase 2 muscle relaxant cinnamaldehyde Preclinical aldose reductase inhibitor | TRPV agonist AKR1B1 | TRPA1 cinnarazine Launched calcium channel blocker gastroenterology | gastroenterology | neurology/psychiatry | ophthalmology Cogan's syndrome | Meniere's disease | nausea | vomiting cinobufotalin Phase 1 anticancer agent cinoctramide Preclinical cinoxacin Launched topoisomerase inhibitor infectious disease urinary tract infections cinoxate Launched dermatology sunscreen lotion CINPA-1 Preclinical CAR antagonist NR1H4 | NR1I3 | PPARG cinromide Phase 3 cintirorgon Phase 1/Phase 2 ROR agonist RORC cintriamide Preclinical cipamfylline Phase 2 phosphodiesterase inhibitor PDE4A | PDE4B | PDE4C | PDE4D cipargamin Phase 2 antimalarial agent cipemastat Phase 3 metalloproteinase inhibitor ADAM17 | MMP1 | MMP13 | MMP2 | MMP3 | MMP8 | MMP9 ciprofibrate Launched PPAR receptor agonist LPL | PPARA endocrinology hyperlipidemia ciprofloxacin Launched bacterial DNA gyrase inhibitor TOP2A otolaryngology otitis ciproxifan Preclinical histamine receptor antagonist ADRA2A | ADRA2C | HRH3 | HRH4 | HTR3A CIQ Preclinical glutamate receptor potentiator GRIN2C | GRIN2D cirazoline Preclinical adrenergic receptor agonist ADRA1A "cis-9,trans-11-conjugated-linoleic-acid" Launched cis-aconitic-acid Preclinical ACO2 cis-ACPD Preclinical glutamate receptor agonist GRM2 | GRM3 | GRM6 | GRM7 | GRM8 cisapride Withdrawn serotonin receptor agonist CYP2B6 | CYP2C8 | CYP3A5 | CYP3A7 | HTR2A | HTR3A | HTR4 | KCNH2 cisatracurium Launched acetylcholine receptor antagonist CHRNA2 critical care | neurology/psychiatry endotracheal intubation | muscle relaxant "cis-exo-camphanediol-2,3" Phase 1 nitric oxide stimulant NOS3 cisplatin Launched DNA alkylating agent | DNA synthesis inhibitor FASLG | SLC22A2 | TXNRD1 | TXNRD2 | XIAP oncology | oncology | oncology bladder cancer | ovarian cancer | testicular carcinoma cis-urocanic acid Phase 2 serotonin receptor agonist HTR2A cis-urocanic-acid Phase 2 serotonin receptor agonist HTR2A citalopram Launched selective serotonin reuptake inhibitor (SSRI) ADRA1A | CHRM1 | HRH1 | SLC6A2 | SLC6A3 | SLC6A4 neurology/psychiatry depression citarinostat Phase 1 HDAC inhibitor HDAC6 CITCO Preclinical constitutive androstane receptor (CAR) agonist NR1I3 citicoline Launched glutathione transferase stimulant | membrane permeability enhancer ACHE | SLC1A2 neurology/psychiatry | neurology/psychiatry | neurology/psychiatry | neurology/psychiatry | neurology/psychiatry | ophthalmology Alzheimer's disease | attention-deficit/hyperactivity disorder (ADHD) | glaucoma | Parkinson's Disease | senile dementia | stroke citiolone Preclinical lipotropic | mucolytic agent citric-acid Preclinical coagulation factor inhibitor AKR1B1 | ANG | APRT | BHMT | C8G | CA4 | CPB1 | CS | CTDSP1 | GNMT | HGS | HS3ST3A1 | IL4I1 | ITPA | LSM6 | MDH2 | MIF | PDE5A | PKD2L1 | PLEKHA1 | RNASE1 | RNASE3 | SRC | TNFSF13B | UCK2 CJ-033466 Preclinical serotonin receptor agonist HTR4 CJ-13610 Phase 2 lipoxygenase inhibitor ALOX5 CK-101 Preclinical EGFR inhibitor EGFR CK-636 Preclinical actin related protein inhibitor ACTR2 | ACTR3 | ARPC1B | ARPC2 | ARPC3 | ARPC4 | ARPC5 CKD-712 Phase 1 NFkB pathway inhibitor IL6 | JAK2 | NFKB1 | STAT1 | TNF CKI-7 Preclinical casein kinase inhibitor CSNK1G2 CL-218872 Phase 1 benzodiazepine receptor agonist GABRA1 | GABRA2 | GABRA3 | GABRA5 | GABRB2 | GABRG2 CL-225385 Phase 2 CL316243 Phase 2 adrenergic receptor agonist ADRB3 | UCP1 | UCP2 | UCP3 cladribine Launched adenosine deaminase inhibitor | ribonucleotide reductase inhibitor ADA | PNP | POLA1 | POLE | POLE2 | POLE3 | POLE4 | RRM1 | RRM2 | RRM2B hematologic malignancy hairy cell leukemia clamikalant Preclinical ATP-sensitive potassium channel antagonist KCNJ8 clanfenur Preclinical anticancer agent clarithromycin Launched bacterial 50S ribosomal subunit inhibitor CYP2C19 | CYP3A4 | CYP3A5 | CYP3A7 infectious disease | infectious disease | otolaryngology | otolaryngology | otolaryngology | otolaryngology | pulmonary bronchitis | otitis | pharyngitis | pneumonia | sinusitis | skin infections | tonsillitis clascoterone Withdrawn androgen receptor antagonist AR dermatology acne vulgaris (av) clavulanate Launched beta lactamase inhibitor otolaryngology otitis clebopride Launched dopamine receptor antagonist ACHE | DRD2 gastroenterology nausea clemastine Launched histamine receptor antagonist HRH1 allergy | allergy allergic rhinitis | urticaria clemizole Launched HCV inhibitor allergy allergic rhinitis clenbuterol Launched adrenergic receptor agonist ABCC8 | ADRB2 | KCNJ11 pulmonary | pulmonary asthma | chronic obstructive pulmonary disease (COPD) clenbuterol hydrochloride Launched adrenergic receptor agonist ABCC8 | ADRB2 | KCNJ11 pulmonary "chronic obstructive pulmonary disease (copd), asthma" cleviprex Launched calcium channel blocker CACNA1C | CACNA1D | CACNA1F | CACNA1S cardiology hypertension clevudine Launched DNA polymerase inhibitor infectious disease hepatitis B clidinium Launched acetylcholine receptor antagonist CHRM1 | CHRM3 gastroenterology | gastroenterology | gastroenterology enterocolitis | irritable bowel syndrome | peptic ulcer disease (PUD) climbazole Launched enzyme inducer dermatology | dermatology dandruff | eczema clinafloxacin Phase 3 bacterial DNA gyrase inhibitor clinafloxacin (pd127391) Phase 3 bacterial dna gyrase inhibitor clindamycin Launched protein synthesis inhibitor infectious disease | infectious disease | infectious disease | infectious disease | infectious disease | infectious disease | infectious disease bacterial septicemia | bone and joint infections | gynecologic infections | intra-abdominal infections | pneumonia | respiratory tract infections | skin infections clindamycin-palmitate Launched bacterial 50S ribosomal subunit inhibitor infectious disease | infectious disease | infectious disease | infectious disease | infectious disease gynecologic infections | intra-abdominal infections | peritonitis | pneumonia | skin infections clindamycin palmitate hcl Launched bacterial 50s ribosomal subunit inhibitor infectious disease "intra-abdominal infections, skin infections, pneumonia, peritonitis, gynecologic infections" clindamycin-phosphate Launched protein synthesis inhibitor obstetrics/gynecology bacterial vaginosis clinofibrate Launched lipase clearing factor inhibitor LPL endocrinology hypertriglyceridemia clioquinol Withdrawn chelating agent OPRK1 clobenpropit Preclinical histamine receptor antagonist HRH1 | HRH2 | HRH3 | HRH4 clobetasol-propionate Launched glucocorticoid receptor agonist NR3C1 | PLA2G1B dermatology corticosteroid-responsive dermatoses clobetasone-butyrate Launched corticosteroid agonist NR3C1 dermatology | dermatology | dermatology dermatitis | eczema | psoriasis clobutinol Withdrawn antitussive clocortolone-pivalate Launched steroid NR3C1 | PLA2G1B dermatology corticosteroid-responsive dermatoses clodronic-acid Launched bone resorption inhibitor SLC25A4 | SLC25A5 | SLC25A6 endocrinology | endocrinology | hematologic malignancy | orthopedics hypercalcemia | hyperparathyroidism | multiple myeloma | osteoporosis clofarabine Launched ribonucleotide reductase inhibitor POLA1 | POLD1 | POLE | RRM1 | RRM2 | RRM2B | SLC22A8 hematologic malignancy acute lymphoblastic leukemia (ALL) clofazimine Launched GK0582 inhibitor infectious disease leprosy clofedanol Launched histamine receptor antagonist HRH1 pulmonary cough suppressant clofibrate Launched PPAR receptor agonist LPL | PPARA cardiology | endocrinology cholesterol | hyperlipidemia clofibric-acid Launched PPAR receptor agonist PPARA endocrinology hyperlipidemia clofilium Phase 2 potassium channel blocker KCNA5 | KCND2 | KCNH1 clofoctol Launched protein synthesis inhibitor infectious disease gram-positive bacterial infections clomesone Phase 1 DNA inhibitor clomethiazole Launched GABA receptor antagonist | GABA receptor modulator GABRA1 neurology/psychiatry | neurology/psychiatry | neurology/psychiatry muscle relaxant | Parkinson's Disease | sedative clomifene Launched estrogen receptor antagonist AR | ESR1 obstetrics/gynecology infertility clomipramine Launched serotonin transporter (SERT) inhibitor CYP2C19 | GSTP1 | HTR2A | HTR2B | HTR2C | SLC6A2 | SLC6A3 | SLC6A4 neurology/psychiatry obsessive compulsive disorder (OCD) clonidine Launched adrenergic receptor agonist ADRA1A | ADRA1B | ADRA1D | ADRA2A | ADRA2B | ADRA2C cardiology | neurology/psychiatry attention-deficit/hyperactivity disorder (ADHD) | hypertension clonixin Preclinical cyclooxygenase inhibitor PTGS1 | PTGS2 infectious disease | rheumatology rheumatoid arthritis | soft tissue infection clonixin-lysinate Launched cyclooxygenase inhibitor neurology/psychiatry pain relief clopamide Launched sodium/chloride cotransporter inhibitor cardiology hypertension cloperastine Launched antitussive pulmonary cough suppressant cloperastine-fendizoate Preclinical potassium channel antagonist KCNH2 clopidogrel Launched purinergic receptor antagonist CYP2B6 | CYP2C19 | CYP3A5 | P2RY12 cardiology | cardiology | cardiology | neurology/psychiatry acute coronary syndrome (ACS) | myocardial infarction | peripheral artery disease (PAD) | stroke clopidol Launched infectious disease coccidiosis cloprostenol-(+/-) Launched prostaglandin receptor agonist PTGDR | PTGER1 | PTGER3 | PTGFR | TBXA2R obstetrics/gynecology endometriosis cloranolol Launched adrenergic receptor antagonist ADRB1 | ADRB2 | ADRB3 cardiology hypertension clorgiline Phase 2 monoamine oxidase inhibitor MAOA clorofene Launched clorotepine Launched adrenergic receptor antagonist | dopamine receptor antagonist ADRA1A | ADRA1B | ADRA1D | DRD2 | HRH1 | HTR2C | HTR6 neurology/psychiatry psychosis clorprenaline Launched adrenergic receptor agonist ADRB1 | ADRB2 pulmonary asthma clorsulon Launched glycolysis inhibitor infectious disease | infectious disease | infectious disease | infectious disease | infectious disease gastrointestinal roundworms | lice | liver flukes | lungworms | mites closantel Launched "chitinase inhibitor | chitinase inhibitor, nfkb pathway inhibitor | NFkB pathway inhibitor" infectious disease liver flukes clotiapine Launched neurology/psychiatry psychosis clotrimazole Launched cytochrome P450 inhibitor | imidazoline receptor ligand CYP3A4 | CYP51A1 | KCNN4 | NR1I2 | NR1I3 | TRPM2 | TRPM4 | TRPM8 infectious disease | infectious disease oropharyngeal candidiasis | vulvovaginal candidiasis cloxacillin Launched bacterial cell wall synthesis inhibitor infectious disease gram-positive bacterial infections cloxyquin Preclinical potassium channel activator KCNK18 clozapine Launched dopamine receptor antagonist | serotonin receptor antagonist ADRA1A | ADRA1B | ADRA1D | ADRA2A | ADRA2B | ADRA2C | CALY | CHRM1 | CHRM2 | CHRM3 | CHRM4 | CHRM5 | CYP2C19 | DRD1 | DRD2 | DRD3 | DRD4 | DRD5 | HRH1 | HRH4 | HTR1A | HTR1B | HTR1D | HTR1E | HTR1F | HTR2A | HTR2B | HTR2C | HTR3A | HTR5A | HTR6 | HTR7 neurology/psychiatry schizophrenia CM-4620 Phase 2 calcium release activated channel modulator ORAI1 | ORAI2 CMPD-1 Preclinical p38 MAPK inhibitor GNRHR | MAPK14 cndac Phase 2 cndac (hydrochloride) Phase 1/Phase 2 antineoplastic agent ATP8A2 | BRCA2 | RAD51D hematologic malignancy acute myeloid leukemia (aml) CNQX Phase 1 glutamate receptor antagonist GRIA1 | GRIA2 | GRIA3 | GRIA4 CNX-2006 Preclinical EGFR inhibitor EGFR CNX-774 Preclinical Bruton's tyrosine kinase (BTK) inhibitor BTK CO-101244 Preclinical glutamate receptor antagonist GRIN2B CO-102862 Phase 1 sodium channel blocker SCN2A | SCN4A | SCN9A cobicistat Launched cytochrome P450 inhibitor CYP3A4 | CYP3A43 | CYP3A5 | CYP3A7 | SLCO1B3 infectious disease human immunodeficiency virus (HIV-1) cobimetinib Launched MEK inhibitor MAP2K1 oncology melanoma coenzyme-A Launched ACAT2 | CRAT | CS | DBI | HMGCR | KAT2A | KAT2B | KAT5 coenzyme-I Phase 2 AASS | ACADS | ADH1A | ADH1B | ADH1C | ADH4 | ADH5 | ADH7 | AKR1B1 | AKR1C1 | AKR1C2 | AKR1C3 | AKR1C4 | ALDH1A1 | ALDH1A2 | ALDH1A3 | ALDH1B1 | ALDH2 | ALDH3A1 | ALDH3A2 | ALDH3B1 | ALDH3B2 | ALDH4A1 | ALDH5A1 | ALDH6A1 | ALDH7A1 | ALDH9A1 | AMT | BDH1 | BLVRA | BLVRB | CDO1 | CYB5R3 | CYP17A1 | CYP4A11 | DHCR7 | DHFR | DLAT | DLD | EHHADH | GAPDH | GAPDHS | GLUD1 | GLUD2 | GPD1 | GSR | H6PD | HADH | HADHA | HIBADH | HMGCR | HMOX1 | HMOX2 | HPGD | HSD11B1 | HSD11B2 | HSD17B1 | HSD17B10 | HSD17B2 | HSD17B3 | HSD17B4 | HSD17B7 | HSD17B8 | HSD3B1 | HSD3B2 | IDH3A | IDH3B | IDH3G | IMPDH1 | IMPDH2 | LDHA | LDHAL6A | LDHAL6B | LDHB | LDHC | MDH1 | MDH2 | ME1 | ME2 | ME3 | MSMO1 | MTHFD1 | MTHFD2 | MT-ND1 | MT-ND2 | MT-ND3 | MT-ND4 | MT-ND4L | MT-ND5 | MT-ND6 | NDUFA1 | NDUFA10 | NDUFA11 | NDUFA12 | NDUFA13 | NDUFA2 | NDUFA3 | NDUFA4 | NDUFA4L2 | NDUFA5 | NDUFA6 | NDUFA7 | NDUFA8 | NDUFA9 | NDUFAB1 | NDUFB1 | NDUFB10 | NDUFB2 | NDUFB3 | NDUFB4 | NDUFB5 | NDUFB6 | NDUFB7 | NDUFB8 | NDUFB9 | NDUFC1 | NDUFC2 | NDUFS1 | NDUFS2 | NDUFS3 | NDUFS4 | NDUFS5 | NDUFS6 | NDUFS7 | NDUFS8 | NDUFV1 | NDUFV2 | NDUFV3 | NNT | NQO2 | NSDHL | OGDH | PDHA1 | PDHA2 | PDHB | PHGDH | PYCR1 | PYCR2 | QDPR | RDH5 | SORD | TSTA3 | TYR | UGDH coenzyme-Q10 Launched COH29 Phase 1 ribonucleotide reductase inhibitor RRM2 colchicine Launched microtubule inhibitor GLRA1 | GLRA2 | TUBA1A | TUBA1B | TUBA1C | TUBA3C | TUBA3D | TUBA3E | TUBA4A | TUBB | TUBB1 | TUBB2A | TUBB2B | TUBB3 | TUBB4A | TUBB4B | TUBB6 | TUBB8 endocrinology | rheumatology fever | gout colforsin Phase 2 adenylyl cyclase activator ADCY2 | ADCY5 colforsin-daproate Launched adenylyl cyclase activator colfosceril-palmitate Launched pulmonary surfactant pulmonary respiratory distress syndrome (RDS) colistimethate Launched bacterial permeability inducer infectious disease gram-negative bacterial infections colistimethate sodium Launched bacterial permeability inducer infectious disease gram-negative bacterial infections colistin Launched bacterial permeability inducer infectious disease gram-negative bacterial infections colistin-b-sulfate colistin sulfate colistin (sulfate) combretastatin-A-4 Phase 2 tubulin polymerization inhibitor compound-401 Preclinical DNA dependent protein kinase inhibitor MTOR | PRKDC compound-58112 Preclinical compound-w Preclinical beta-secretase inhibitor BACE1 conivaptan Launched vasopressin receptor antagonist AVPR1A | AVPR2 | OXT | OXTR endocrinology hyponatremia convallatoxin Preclinical cardiac glycoside ATP1A1 | ATP1A2 | ATP1A3 | ATP1A4 | ATP1B1 | ATP1B2 | ATP1B3 | ATP1B4 copanlisib Launched PI3K inhibitor PIK3CA | PIK3CB | PIK3CD | PIK3CG hematologic malignancy follicular lymphoma copper-histidine Phase 3 SLC15A3 | SLC15A4 | SLC38A5 COR-170 Preclinical cannabinoid receptor inverse agonist CNR2 cordycepin Phase 1/Phase 2 DNA inhibitor corosolic-acid Phase 2 PKC inhibitor | protein tyrosine kinase inhibitor HSD11B1 | PTPN1 CORT-108297 Preclinical glucocorticoid receptor antagonist NR3C1 | NR3C2 corticosterone Preclinical mineralocorticoid receptor agonist HSD11B1 | NCOA1 | NR3C2 cortisone Launched glucocorticoid receptor agonist NR3C1 "dermatology | dermatology | gastroenterology | gastroenterology, rheumatology, dermatology | rheumatology | rheumatology" "eczema | joint inflammation | psoriasis | rheumatoid arthritis | ulcerative colitis | ulcerative colitis, rheumatoid arthritis, psoriasis, joint inflammation, eczema" cortisone-acetate Launched glucocorticoid receptor agonist NR3C1 allergy | allergy | dermatology | gastroenterology | infectious disease | ophthalmology | pulmonary | rheumatology | rheumatology allergic rhinitis | asthma | conjunctivitis | meningitis | osteoarthritis | psoriasis | rheumatoid arthritis | ulcerative colitis | urticaria cortodoxone Phase 3 androgen receptor antagonist AR costunolide Preclinical telomerase inhibitor COTI-2 Phase 1 anticancer agent TP53 cot-inhibitor-1 Preclinical MAPK-interacting kinase inhibitor MAP3K8 | TNF cot-inhibitor-2 Preclinical MAPK-interacting kinase inhibitor MAP3K8 | TNF cotinine Phase 2 nicotine metabolite coumarin Launched vitamin K antagonist CA1 | CA12 | CA14 | CA2 | CA4 | CA6 | CA9 | CYP2A6 gastroenterology | gastroenterology | pulmonary asthma | celiac disease | ulcerative colitis coumophos Preclinical cholinesterase inhibitor "CP-105,696" Preclinical leukotriene receptor antagonist LTB4R CP-316819 Preclinical glycogen phosphorylase inhibitor PYGL CP-339818 Preclinical potassium channel blocker KCNA2 | KCNA3 | KCNA5 | KCNAB2 | KCNC1 | KCNC2 | KCNC3 | KCNE1 | KCNE2 | KCNE3 | KCNE4 | KCNH1 | KCNH2 | KCNQ1 | KCNQ2 | KCNQ3 | KCNQ5 | KCNS3 CP-376395 Phase 1 corticotropin releasing factor receptor antagonist CRHR1 CP-471474 Preclinical matrix metalloprotease inhibitor MMP1 | MMP13 | MMP2 | MMP3 | MMP9 CP-532623 Phase 1 cholesteryl ester transfer protein inhibitor CETP CP-547632 Phase 2 kinase inhibitor DDR2 | EGFR | FGF2 | KDR CP-640186 Preclinical acetyl-CoA carboxylase inhibitor ACACA | ACACB CP-673451 Preclinical PDGFR tyrosine kinase receptor inhibitor KIT | PDGFRA | PDGFRB CP-724714 Phase 2 EGFR inhibitor | protein tyrosine kinase inhibitor ERBB2 CP-775146 Preclinical PPAR receptor agonist PPARA CP-91149 Preclinical glycogen phosphorylase inhibitor PYGL CP-93129 Preclinical serotonin receptor agonist HTR1A | HTR1B CP-94253 Preclinical serotonin receptor agonist HTR1B "CP-945,598" Phase 3 cannabinoid receptor antagonist CNR1 CP-99994 Phase 2 tachykinin antagonist TACR1 CPA-inhibitor Preclinical carboxypeptidase inhibitor CPA1 | CPA2 CPCCOEt Preclinical glutamate receptor antagonist GRM1 CPI-0610 Phase 2 bromodomain inhibitor BRD4 CPI-1189 Phase 2 tumor necrosis factor release inhibitor TNF CPI-1205 Phase 1/Phase 2 EZH2 inhibitor EZH2 CPI-169 Preclinical histone lysine methyltransferase inhibitor EZH2 CPI-203 Preclinical bromodomain inhibitor BRD4 | IL6 CPI-360 Preclinical histone lysine methyltransferase inhibitor EZH2 CPI-444 Phase 1/Phase 2 adenosine receptor antagonist ADORA2A CPI-613 Phase 3 pyruvate dehydrogenase inhibitor OGDH | PDHA1 CPP Phase 2 glutamate receptor antagonist GRIN1 | GRIN2A | GRIN2B | GRIN2C | GRIN2D CPSI-1306-(+/-) Preclinical macrophage migration inhibiting factor inhibitor MIF CQS Preclinical CR8-(R) Preclinical CDK inhibitor CCNA2 | CCNE1 | CCNH | CCNT1 | CDK1 | CDK2 | CDK5 | CDK7 | CDK9 creatine Launched CKB | CKM | CKMT1A | CKMT2 | GAMT | SLC6A8 creatinine Preclinical creatinol-phosphate Launched crenigacestat Preclinical notch signaling inhibitor NOTCH1 | NOTCH2 | NOTCH3 | NOTCH4 crenolanib Phase 3 PDGFR tyrosine kinase receptor inhibitor CSF1R | FLT3 | KIT | PDGFRA | PDGFRB cresol Launched cresopirine Preclinical cridanimod Launched progesterone receptor agonist PGR infectious disease influenza A virus infection crisaborole Launched phosphodiesterase inhibitor CXCL8 | IFNG | IL1B | IL2 | IL6 | PDE4A | PDE4B | PDE4C | PDE4D | TNF dermatology dermatitis crisdesalazine Preclinical free radical scavenger PTGES crizotinib Launched ALK tyrosine kinase receptor inhibitor ALK | CYP2B6 | CYP3A5 | MET | MST1R | ROS1 oncology non-small cell lung cancer (NSCLC) crizotinib-(S) Preclinical MTH1 inhibitor NUDT1 crocin Launched microtubule inhibitor BCL2 | BIRC5 | CCND1 | TPPP endocrinology hyperglycemia croconazole Launched bacterial cell wall synthesis inhibitor infectious disease fungal infection crolibulin Phase 1/Phase 2 tubulin polymerization inhibitor cromakalim Phase 2 ABCC9 | KCNJ8 cromoglicic-acid Launched immunosuppressant KCNMA1 | S100P allergy | gastroenterology | ophthalmology | pulmonary asthma | conjunctivitis | ulcerative colitis | urticaria crotamiton Launched antipruritic infectious disease scabies CRT0044876 Preclinical cryptotanshinone Preclinical acetylcholinesterase inhibitor | STAT inhibitor ACHE | AKR1B1 | PTGS2 | STAT3 crystal violet Launched other antibiotic crystal-violet Launched other antibiotic CS-110266 Preclinical dopamine receptor agonist SLC6A3 CS-917 Phase 2 fructose biphosphate inhibitor FBP1 CT7001 Phase 1/Phase 2 CDK inhibitor CDK7 CT-7758 Phase 2 integrin antagonist ITGA4 CTEP Preclinical glutamate receptor antagonist GRM5 CTS-1027 Phase 2 metalloproteinase inhibitor MMP1 | MMP12 | MMP13 | MMP14 | MMP2 | MMP3 | MMP8 | MMP9 CTS21166 Phase 1 beta-secretase inhibitor BACE1 CU-CPT-4a Preclinical toll-like receptor inhibitor TLR3 CUDC-101 Phase 1 EGFR inhibitor EGFR | ERBB2 CUDC-427 Phase 1 apoptosis inhibitor XIAP CUDC-907 Phase 2 PI3K inhibitor HDAC2 | PIK3R1 CUR-61414 Phase 1 smoothened receptor antagonist DHH | IHH | PTCH1 | SMO curcumin Launched cyclooxygenase inhibitor | histone acetyltransferase inhibitor | lipoxygenase inhibitor | NFkB pathway inhibitor APP | CA1 | CA12 | CA14 | CA2 | CA4 | CA6 | CA9 | CCND1 | CHRM3 | CYP3A4 | DNMT1 | DNMT3B | EP300 | G6PC | MAPT | MMP13 | MMP9 | NOS2 | PTGS1 | PTGS2 | XDH curcumol Phase 1 JAK inhibitor JAK1 | JAK2 | JAK3 CU-T12-9 Preclinical toll-like receptor agonist TLR1 | TLR2 cutamesine Phase 2 sigma receptor agonist SIGMAR1 CV-1808 Preclinical adenosine receptor agonist ADORA2A | ADORA2B CVT-10216 Phase 1 aldehyde dehydrogenase inhibitor ALDH1A2 | ALDH2 | ALDH5A1 | ALDH7A1 CW-008 Preclinical PKA activator PRKACA CX-4945 Phase 1/Phase 2 casein kinase inhibitor CSNK2A1 | CSNK2A2 | CSNK2B | DAPK3 | HIPK3 CX-516 Phase 2/Phase 3 glutamate receptor modulator CX-5461 Phase 1 RNA polymerase inhibitor CXD101 Phase 1/Phase 2 HDAC inhibitor HDAC1 CY208-243 Phase 2 dopamine receptor agonist CALY | DRD1 cyacetacide Preclinical cyamemazine Launched serotonin receptor antagonist HTR1A | HTR2A | HTR2C | HTR7 neurology/psychiatry | neurology/psychiatry anxiety | schizophrenia cyanocobalamin Launched methylmalonyl CoA mutase stimulant | vitamin B MUT gastroenterology | hematology | infectious disease anemia | celiac disease | fish tapeworm infestation cyanopindolol Phase 2 adrenergic receptor antagonist ADRB1 | HTR1A | HTR1D CYC065 Phase 1 CDK inhibitor CDK2 | CDK9 CYC116 Phase 1 Aurora kinase inhibitor AURKA | AURKB | AURKC | KDR cyclamic-acid Preclinical cyclandelate Launched calcium channel blocker cardiology | cardiology | rheumatology arteriosclerosis | claudication | Raynaud's disease cyclic-AMP Preclinical CNGA3 | TRPM7 cyclizine Launched histamine receptor modulator HRH1 | SULT1E1 gastroenterology | gastroenterology | neurology/psychiatry | neurology/psychiatry motion sickness | nausea | vertigo | vomiting cyclobenzaprine Launched adrenergic receptor agonist | serotonin receptor agonist HTR2A neurology/psychiatry spasms cyclocreatine Phase 1 creatine kinase substrate cyclocytidine Preclinical DNA synthesis inhibitor | RNA synthesis inhibitor cycloheximide Preclinical protein synthesis inhibitor GSK3B | RPL3 cyclopamine Preclinical hedgehog pathway inhibitor cyclopenthiazide Launched thiazide diuretic cardiology | cardiology congestive heart failure | hypertension cyclopentolate Launched acetylcholine receptor antagonist ophthalmology | ophthalmology cycloplegia | mydriasis cyclophosphamide Launched DNA alkylating agent BCL2 | CYP2A6 | CYP2B6 | CYP2C18 | CYP2C19 | CYP2C8 | CYP2C9 | CYP2D6 | CYP3A4 | CYP3A5 | CYP3A7 | LGALS1 hematologic malignancy | hematologic malignancy | hematologic malignancy | hematologic malignancy | hematologic malignancy | hematologic malignancy | hematologic malignancy | hematologic malignancy | hematologic malignancy | oncology | oncology | oncology | oncology acute lymphoblastic leukemia (ALL) | acute myeloid leukemia (AML) | breast cancer | Burkitt's lymphoma | chronic lymphocytic leukemia (CLL) | chronic myeloid leukemia (CML) | Hodgkin's lymphoma | multiple myeloma | neuroblastoma | ovarian cancer | retinoblastoma | small lymphocytic lymphoma (SLL) | true histiocytic lymphoma (THL) cyclopiazonic acid Preclinical endoplasmic reticulum calcium atpase inhibitor cyclopiazonic-acid Preclinical ATPase inhibitor ATP2A1 cycloserine-(D) Launched bacterial cell wall synthesis inhibitor GRIN1 infectious disease tuberculosis cyclosporin-A Launched calcineurin inhibitor ABCB11 | CAMLG | CYP3A5 | CYP3A7 | FPR1 | PPIA | PPID | PPIF | PPP3CA | PPP3R2 | SLC10A1 | SLCO1B1 | SLCO1B3 dermatology | rheumatology psoriasis | rheumatoid arthritis cyclothiazide Launched glutamate receptor modulator CA2 | GRIA1 | GRIA2 | GRIA3 | GRIA4 | SLC12A3 cardiology hypertension cyclovalone Launched breast cancer resistance protein inhibitor ABCC1 | ABCG2 gastroenterology bile stimulation cyclovirobuxin-D Preclinical calcium channel modulator CycLuc1 Preclinical CYM-50260 Preclinical sphingosine 1-phosphate receptor agonist S1PR4 CYM-50358 Preclinical sphingosine 1-phosphate receptor antagonist S1PR4 CYM-50769 Preclinical neuropeptide receptor antagonist NPBWR1 CYM-5442 Preclinical sphingosine 1-phosphate receptor agonist S1PR1 CYM-5520 Preclinical sphingosine 1-phosphate receptor agonist S1PR2 CYM-5541 Preclinical sphingosine 1-phosphate receptor agonist S1PR3 cypermethrin Launched infectious disease flea control cyproheptadine Launched histamine receptor antagonist ADRA1A | ADRA1B | ADRA1D | CHRM1 | CHRM2 | CHRM3 | HRH1 | HTR2A | HTR2B | HTR2C | HTR6 | HTR7 allergy | allergy | dermatology | ophthalmology | otolaryngology allergic rhinitis | conjunctivitis | dermatographism | urticaria | vasomotor rhinitis cyproterone cyproterone-acetate Launched androgen receptor antagonist ADORA1 | AR oncology prostate cancer cyromazine Launched cysteamine Launched tissue transglutaminase inhibitor NPY2R | SST | TGM2 metabolism cystinosis cysteamine hcl cyt387 Phase 3 JAK inhibitor JAK1 | JAK2 | JAK3 CYT-997 Phase 2 tubulin polymerization inhibitor TUBB cytarabine Launched ribonucleotide reductase inhibitor POLA1 | POLB | POLD1 | POLE hematologic malignancy | hematologic malignancy | hematologic malignancy | hematologic malignancy acute lymphoblastic leukemia (ALL) | acute myeloid leukemia (AML) | chronic lymphocytic leukemia (CLL) | non-Hodgkin lymphoma (NHL) cytidine Launched UCK2 cytisine Launched acetylcholine receptor agonist CHRNA2 | CHRNA3 | CHRNA4 | CHRNA6 | CHRNA7 | CHRNB2 | CHRNB4 neurology/psychiatry nicotinism cytochalasin-B Phase 2 microtubule inhibitor ACTB cytochlor Phase 1 CZC24832 Preclinical PI3K inhibitor PIK3CG CZC-54252 Preclinical leucine rich repeat kinase inhibitor LRRK2 D-157495 Preclinical decapping scavenger enzyme inhibitor DCPS D-3263 Phase 1 transient receptor potential channel agonist TRPM8 D-4476 Preclinical TGF beta receptor inhibitor CSNK1A1 | CSNK1D | TGFB1 d609 Preclinical phospholipase inhibitor Neurology alzheimer's disease D609 Preclinical phospholipase inhibitor D-64131 Preclinical microtubule inhibitor TUBB D-7193 Phase 2 DAA-1106 Preclinical benzodiazepine receptor agonist TSPO dabigatran Launched thrombin inhibitor F2 hematology | hematology | hematology | neurology/psychiatry deep vein thrombosis (DVT) | pulmonary embolism (PE) | stroke | systemic embolism dabigatran-etexilate Launched thrombin inhibitor F2 hematology | hematology | hematology | neurology/psychiatry deep vein thrombosis (DVT) | pulmonary embolism (PE) | stroke | systemic embolism dabrafenib Launched RAF inhibitor BRAF | CYP2B6 | CYP2C19 | CYP2C8 | CYP3A4 | LIMK1 | NEK11 | RAF1 | SIK1 oncology melanoma dabuzalgron Phase 1 adrenergic receptor agonist ADRB3 urology urinary incontinence dacarbazine Launched DNA alkylating agent PGD | POLA2 hematologic malignancy | oncology Hodgkin's lymphoma | melanoma dacinostat Phase 1 HDAC inhibitor HDAC1 | HDAC2 | HDAC3 | HDAC4 | HDAC5 | HDAC6 | HDAC7 | HDAC8 | HDAC9 daclatasvir Launched HCV inhibitor infectious disease hepatitis C dacomitinib Launched EGFR inhibitor EGFR | ERBB2 | ERBB4 dactinomycin Launched RNA polymerase inhibitor POLR2A oncology | oncology | oncology | oncology | oncology Ewing's sarcoma | gestational trophoblastic disease (GTD) | rhabdomyosarcoma | testicular carcinoma | Wilm's tumor daidzein Phase 2 estrogen receptor agonist ESRRA | ESRRB | ESRRG | TRPC5 daidzin Phase 1 antioxidant ALDH2 "(d-ala2,d-leu5)-enkephalin" Phase 2 opioid receptor agonist OPRD1 | OPRM1 dalargin Phase 2 opioid receptor agonist OPRM1 dalbavancin Launched bacterial cell wall synthesis inhibitor PNLIP infectious disease skin infections dalcetrapib Phase 3 cholesteryl ester transfer protein inhibitor CETP dalfampridine Launched potassium channel blocker KCNA1 | KCNA10 | KCNA2 | KCNA3 | KCNA4 | KCNA5 | KCNA6 | KCNA7 | KCNB1 | KCNB2 | KCNC1 | KCNC2 | KCNC3 | KCNC4 | KCND1 | KCND2 | KCND3 | KCNF1 | KCNG1 | KCNG2 | KCNG3 | KCNG4 | KCNH1 | KCNH2 | KCNH3 | KCNH4 | KCNH5 | KCNH6 | KCNH7 | KCNH8 | KCNJ13 | KCNJ5 | KCNQ1 | KCNQ2 | KCNQ3 | KCNQ4 | KCNQ5 | KCNS1 | KCNS2 | KCNS3 | KCNV1 | KCNV2 neurology/psychiatry multiple sclerosis dalfopristin Preclinical antibacterial D-alpha-tocopheryl-succinate Launched daltroban Phase 3 thromboxane receptor antagonist TBXA2R daminozide Preclinical KDM2A inhibitor KDM2A | KDM7A | PHF8 danazol Launched estrogen receptor antagonist | progesterone receptor agonist AR | CCL2 | CYP2C8 | ESR1 | GNRHR | GNRHR2 | PGR | TNF cardiology | obstetrics/gynecology angioedema | endometriosis danegaptide Phase 2 gap junction modulator danirixin Phase 2 CC chemokine receptor antagonist CXCR2 danofloxacin Launched bacterial DNA gyrase inhibitor pulmonary bovine respiratory disease (BRD) danoprevir Phase 3 HCV inhibitor dantrolene Launched calcium channel blocker RYR1 | RYR3 endocrinology | neurology/psychiatry malignant hyperthermia (MH) | spasms dantron Withdrawn laxative danusertib Phase 2 Aurora kinase inhibitor | growth factor receptor inhibitor AURKA | AURKB | AURKC | BCR | FGFR1 | NTRK1 | RET | SLK dapagliflozin Launched sodium/glucose cotransporter inhibitor SLC5A1 | SLC5A2 endocrinology diabetes mellitus dapansutrile Phase 2 anti-inflammatory agent NLRP3 daphnetin Preclinical protein kinase inhibitor dapiprazole Launched adrenergic receptor antagonist ADRA1A | ADRA1B | ADRA1D ophthalmology mydriasis dapivirine Phase 3 non-nucleoside reverse transcriptase inhibitor CYP2B6 | CYP2C19 | CYP2C8 | CYP3A4 | CYP3A5 dapoxetine Launched selective serotonin reuptake inhibitor (SSRI) HTR1A | HTR1B | HTR2C | SLC6A4 urology premature ejaculation (PE) daprodustat Phase 3 hypoxia inducible factor inhibitor EGLN1 dapsone Launched bacterial antifolate DHFR dermatology | infectious disease dermatitis herpetiformis (DH) | leprosy DAPT Preclinical gamma secretase inhibitor daptomycin Launched bacterial cell wall synthesis inhibitor infectious disease | infectious disease | infectious disease "endocarditis | skin infections | skin infections, endocarditis" darapladib Phase 3 phospholipase inhibitor PLA2G7 darglitazone Phase 2 PPAR receptor antagonist INS | PPARG darifenacin Launched acetylcholine receptor antagonist CHRM1 | CHRM2 | CHRM3 | CHRM4 | CHRM5 urology urinary incontinence darolutamide Launched androgen receptor antagonist AR oncology | oncology breast cancer | prostate cancer darunavir Launched HIV protease inhibitor CYP3A4 | CYP3A5 infectious disease human immunodeficiency virus (HIV-1) darusentan Phase 3 endothelin receptor antagonist EDNRA dasabuvir Launched HCV inhibitor infectious disease hepatitis C dasatinib Launched Bcr-Abl kinase inhibitor | ephrin inhibitor | KIT inhibitor | PDGFR tyrosine kinase receptor inhibitor | SRC inhibitor | tyrosine kinase inhibitor ABL1 | ABL2 | BCR | BLK | BTK | DDR1 | DDR2 | EPHA2 | FGR | FRK | FYN | HCK | KIT | LCK | LYN | PDGFRA | PDGFRB | SRC | SRMS | STAT5B | YES1 hematologic malignancy | hematologic malignancy acute lymphoblastic leukemia (ALL) | chronic myeloid leukemia (CML) dasotraline Phase 3 dopamine-norepinephrine-serotonin reuptake inhibitor DRD2 | HTR1A | SLC6A2 | SLC6A3 | SLC6A4 DAU-5884 Preclinical acetylcholine receptor antagonist CHRM1 | CHRM3 daucosterol Phase 2 apoptosis stimulant daunorubicin Launched RNA synthesis inhibitor | topoisomerase inhibitor TOP2A | TOP2B hematologic malignancy | hematologic malignancy acute lymphoblastic leukemia (ALL) | acute myeloid leukemia (AML) dauricine Preclinical nfkb pathway inhibitor GORASP1 | PTGR1 oncology colorectal cancer dazmegrel Phase 2 thromboxane synthase inhibitor TBXAS1 dazoxiben Phase 2 thromboxane synthase inhibitor TBXAS1 DBeQ Preclinical ATPase inhibitor CASP3 DBPR108 Phase 1 dipeptidyl peptidase inhibitor DPP4 DBPR-211 Preclinical cannabinoid receptor antagonist CNR1 DC-260126 Preclinical free fatty acid receptor antagonist FFAR1 DCC-2618 Phase 1 KIT inhibitor | PDGFR tyrosine kinase receptor inhibitor KIT | PDGFRA DCEBIO Preclinical potassium channel activator KCNN2 | KCNN3 | KCNN4 DCPIB Preclinical chloride channel blocker | gap junction modulator | glutamate inhibitor SLC1A2 DCP-LA Preclinical protein kinase activator PRKCE ddd107498 (succinate) Phase 1 antimalarial agent infectious disease malaria D-delta-tocopherol Launched DDR1-IN-1 Preclinical discoidin domain receptor inhibitor DDR1 | DDR2 deazaguanine Preclinical DNA synthesis inhibitor IDO1 | TDO2 Debio-0932 Phase 1 HSP inhibitor HSP90AA1 | HSP90AB1 | HSP90B1 debrisoquin Launched adrenergic neuron blocker SLC6A2 cardiology hypertension decamethonium Launched acetylcholine receptor agonist ACHE | CHRNA2 neurology/psychiatry muscle relaxant decamethoxine Phase 2 antiseptic decernotinib Phase 2/Phase 3 JAK inhibitor | protein tyrosine kinase inhibitor JAK2 | JAK3 Immunology rheumatoid arthritis decitabine Launched DNA methyltransferase inhibitor DNMT1 | DNMT3A hematologic malignancy | hematologic malignancy | hematology anemia | chronic myeloid leukemia (CML) | myelodysplastic diseases (MDS) declopramide Preclinical cell cycle inhibitor NFKB1 decloxizine Preclinical histamine receptor antagonist HRH1 decoglurant Phase 2 glutamate receptor modulator GRM2 | GRM3 neurology/psychiatry depression decoquinate Launched antiprotozoal agent infectious disease coccidiosis defactinib Phase 2 focal adhesion kinase inhibitor PTK2 deferasirox Launched chelating agent CYP2C19 | CYP2C8 | CYP3A4 hematology | hematology | hematology iron overload | thalassemia | transfusional hemosiderosis deferasirox-iron-chelate Launched deferiprone Launched chelating agent CYP4F2 | UGT1A6 hematology | hematology | hematology iron overload | thalassemia | transfusional hemosiderosis deferoxamine-mesylate Launched chelating agent hematology | hematology acute iron intoxication | iron overload deflazacort Launched glucocorticoid receptor agonist NR3C1 rheumatology joint inflammation deforolimus Phase 3 mTOR inhibitor MTOR degarelix Launched gonadotropin releasing factor hormone receptor antagonist GNRH1 | GNRHR oncology prostate cancer dehydroacetic-acid Preclinical dehydrocholate Preclinical dehydrocholate-acid Preclinical dehydrocorydaline Phase 3 acetylcholinesterase inhibitor ACHE | AKR1B1 dehydroepiandrosterone Launched protein synthesis stimulant AR | CYP3A5 | ESR1 | ESR2 | G6PD | GABRA1 | GABRA2 | GABRA3 | GABRA4 | GABRA5 | GABRA6 | GABRB1 | GABRB2 | GABRB3 | GABRD | GABRE | GABRG1 | GABRG2 | GABRG3 | GABRP | GABRQ | GRIN1 | GRIN2A | GRIN2B | GRIN2C | GRIN2D | GRIN3A | GRIN3B | HSD17B1 | NR1I2 | NR1I3 | PPARA | SIGMAR1 | SULT2A1 | SULT2B1 endocrinology menopause dehydroepiandrosterone-sulfate Launched androgen receptor agonist | estrogen receptor agonist AR | ESR1 | ESR2 endocrinology menopause delafloxacin Phase 3 antiinfective drug delamanid Launched bacterial cell wall synthesis inhibitor infectious disease tuberculosis delanzomib Phase 1/Phase 2 proteasome inhibitor CMA1 | CTSG | CYP3A4 | ELANE delapril Launched angiotensin converting enzyme inhibitor ACE cardiology hypertension delavirdine Launched non-nucleoside reverse transcriptase inhibitor CYP2C19 | CYP3A4 infectious disease human immunodeficiency virus (HIV-1) delcasertib Phase 1 PKC inhibitor PRKCD delgocitinib Phase 2 JAK inhibitor JAK1 | JAK2 | JAK3 | TYK2 delivert Launched angiotensin receptor agonist AGTR1 | AGTR2 critical care sepsis delpazolid Phase 2 antibacterial delphinidin Phase 2 membrane permeability inhibitor EGFR | GLO1 | KDR deltarasin Preclinical phosphodiesterase inhibitor KRAS delta-tocotrienol Phase 1 HMGCR inhibitor HMGCR demecarium Launched acetylcholinesterase inhibitor ACHE | BCHE ophthalmology | ophthalmology glaucoma | intraocular pressure demeclocycline Launched bacterial 30S ribosomal subunit inhibitor endocrinology | infectious disease | infectious disease | infectious disease | infectious disease | infectious disease | infectious disease | infectious disease | infectious disease | infectious disease | infectious disease | infectious disease | ophthalmology | urology actinomycosis | anthrax | brucellosis | chancroid | cholera | conjunctivitis | fever | listeria | psittacosis | respiratory tract infections | syphilis | trachoma | tularemia | urethritis demeclocycline hcl denatonium-benzoate Preclinical denopamine Launched adrenergic receptor agonist ADRB1 cardiology angina pectoris denotivir Launched antiviral infectious disease | infectious disease skin infections | virus herpes simplex (HSV) deoxyarbutin Preclinical tyrosinase inhibitor deoxycholic-acid Launched biliverdin reductase A activator | G protein-coupled receptor agonist FPR1 | GPBAR1 endocrinology submental fat deoxycorticosterone-acetate Preclinical progestogen hormone NR3C2 deoxyepinephrine Preclinical adrenergic receptor agonist | dopamine receptor agonist ADRA1A | DRD1 | DRD2 deprodone propionate Launched anti-inflammatory agent ALOX5AP | CHRNB4 dermatology eczema deptropine Preclinical histamine receptor antagonist HRH1 dequalinium Launched PKC inhibitor KCNN1 | KCNN3 infectious disease first-aid antiseptic deracoxib Launched cyclooxygenase inhibitor PTGS2 rheumatology osteoarthritis derazantinib Phase 2 tyrosine kinase inhibitor FGF2 | FGFR1 | FGFR2 | FGFR3 deserpidine Launched angiotensin converting enzyme inhibitor ACE | SLC18A2 cardiology hypertension desidustat Preclinical hypoxia inducible factor prolyl hydroxylase inhibitor EGLN1 | EGLN2 | EGLN3 desipramine Launched tricyclic antidepressant ADRA1A | ADRA1B | ADRA1D | ADRA2A | ADRA2B | ADRA2C | ADRB1 | ADRB2 | CHRM1 | CHRM2 | CHRM3 | CHRM4 | CHRM5 | DRD2 | HRH1 | HTR1A | HTR2A | HTR2C | SLC6A2 | SLC6A4 | SMPD1 neurology/psychiatry depression desisobutyryl-ciclesonide Launched cytochrome P450 inhibitor CYP3A4 allergy allergic rhinitis deslanoside Launched Na/K-ATPase inhibitor ATP1A1 | ATP1A2 | ATP1A3 | ATP1A4 | ATP1B1 | ATP1B2 | ATP1B3 | FXYD2 cardiology | cardiology cardiac arrythmia | congestive heart failure desloratadine Launched histamine receptor antagonist HRH1 allergy | allergy allergic rhinitis | urticaria deslorelin Phase 2 gonadotropin releasing factor hormone receptor agonist GNRH1 desmethylclozapine Phase 2 acetylcholine receptor agonist CHRM1 | DRD2 | DRD3 | HTR2A | HTR2C desmopressin (acetate) Launched vasopressin receptor agonist AVPR1A | AVPR1B | AVPR2 | OXTR "endocrinology, urology" "central diabetes insipidus, nocturnal enuresis" desmopressin-acetate Launched vasopressin receptor agonist AVPR1A | AVPR1B | AVPR2 | OXTR endocrinology | urology central diabetes insipidus | nocturnal enuresis desogestrel Launched progesterone receptor agonist ESR1 | PGR endocrinology contraceptive desonide Launched glucocorticoid receptor agonist NR3C1 | PLA2G1B gastroenterology Crohn's disease desoximetasone Launched glucocorticoid receptor agonist NR3C1 | PLA2G1B dermatology corticosteroid-responsive dermatoses desoxycorticosterone-pivalate Launched corticosteroid agonist NR3C2 endocrinology Addison's disease desoxycortone Preclinical mineralocorticoid receptor agonist NR3C1 | NR3C2 desoxymetasone Launched glucocorticoid receptor agonist NR3C1 | PLA2G1B dermatology corticosteroid-responsive dermatoses desoxypeganine Phase 1 acetylcholinesterase inhibitor | monoamine oxidase inhibitor ACHE | MAOA desvenlafaxine Launched serotonin‚äìnorepinephrine reuptake inhibitor (snri) | serotonin–norepinephrine reuptake inhibitor (SNRI) SLC6A2 | SLC6A3 | SLC6A4 neurology/psychiatry depression detomidine Launched adrenergic receptor agonist ADRA2A neurology/psychiatry sedative deucravacitinib Launched tyrosine kinase inhibitor TYK2 gastroenterology crohn's disease deutetrabenazine Launched vesicular monoamine transporter inhibitor SLC18A2 neurology/psychiatry huntington's disease devazepide Preclinical CCK receptor antagonist CCKAR | CCKBR dexamethasone Launched glucocorticoid receptor agonist ANXA1 | CYP3A4 | CYP3A5 | NOS2 | NR0B1 | NR3C1 | NR3C2 "allergy | dermatology | dermatology | endocrinology | endocrinology, rheumatology, allergy, gastroenterology, hematology, neurology/psychiatry, dermatology | gastroenterology | gastroenterology | hematology | neurology/psychiatry | rheumatology | rheumatology | rheumatology | rheumatology | rheumatology" "allergic rhinitis | anemia | dermatitis herpetiformis (DH) | enteritis | hypercalcemia | hypercalcemia, rheumatoid arthritis, psoriatic arthritis, osteoarthritis, allergic rhinitis, ulcerative colitis, anemia, multiple sclerosis, enteritis, lupus, dermatitis herpetiformis (dh), nephrotic syndrome, psoriasis | lupus | multiple sclerosis | nephrotic syndrome | osteoarthritis | psoriasis | psoriatic arthritis | rheumatoid arthritis | ulcerative colitis" dexamethasone-acetate Launched glucocorticoid receptor agonist NR3C1 allergy | dermatology | dermatology | endocrinology | gastroenterology | gastroenterology | hematology | neurology/psychiatry | rheumatology | rheumatology | rheumatology | rheumatology | rheumatology allergic rhinitis | anemia | dermatitis herpetiformis (DH) | enteritis | hypercalcemia | lupus | multiple sclerosis | nephrotic syndrome | osteoarthritis | psoriasis | psoriatic arthritis | rheumatoid arthritis | ulcerative colitis dexamethasone palmitate Phase 3 glucocorticoid receptor agonist NR3C1 rheumatology rheumatoid arthritis dexamethasone sodium phosphate glucocorticoid receptor agonist Lung diseases acute respiratory distress syndrome dexbrompheniramine Withdrawn histamine receptor antagonist HRH1 allergy allergic rhinitis dexchlorpheniramine Launched histamine receptor antagonist allergy | allergy | allergy | cardiology allergic conjunctivitis | allergic rhinitis | angioedema | urticaria dexfosfoserine Preclinical membrane integrity inhibitor CFTR | GRM4 | GRM6 | GRM7 | GRM8 | KCNC4 | PDPK1 | PIM1 | PRKACA | PRKCQ | PYGL | PYGM | REG1A | RHO | SERPINB3 | SMAD2 | TAOK2 dexlansoprazole Launched ATPase inhibitor ATP4A | CYP2C19 gastroenterology | gastroenterology erosive esophagitis (EE) | gastroesophageal reflux disease (GERD) dexloxiglumide Phase 3 CCK receptor antagonist CCKAR dexmedetomidine Launched adrenergic receptor agonist ADRA2A | ADRA2B | ADRA2C neurology/psychiatry sedative dexniguldipine Phase 2 calmodulin antagonist ADORA3 | CALM1 | PRKCA dexpanthenol Launched gastroenterology paralytic ileus dexrazoxane Launched chelating agent | topoisomerase inhibitor TOP2A | TOP2B cardiology cardiomyopathy dextran Launched critical care | hematology hypovolemia | thrombosis dextromethorphan Launched glutamate receptor antagonist | sigma receptor agonist CHRNA2 | CHRNA3 | CHRNA4 | CHRNA7 | CHRNB2 | CHRNB4 | CYBA | CYBB | CYP3A5 | GRIN1 | GRIN3A | NCF1 | NCF2 | NCF4 | OPRD1 | OPRK1 | OPRM1 | PGRMC1 | RAC1 | RAC2 | SIGMAR1 | SLC6A2 | SLC6A4 pulmonary cough suppressant dextrorotation-nimorazole-phosphate-ester Preclinical antiinfective drug dextrose Launched endocrinology hypoglycemia dextrothyroxine Launched cholesterol DFB Preclinical glutamate receptor agonist GRM5 d-fructose DG051 Preclinical leukotriene synthesis inhibitor LTA4H DG-172 Preclinical PPAR receptor inverse agonist PPARD DH-97 Preclinical melatonin receptor antagonist MTNR1B DHBP Preclinical ryanodine receptor blocker diacerein Launched interleukin inhibitor IL1B rheumatology osteoarthritis diacetamate Preclinical diadenosine-tetraphosphate Phase 1 adenosine kinase inhibitor P2RY13 | P2RY2 dianhydrogalactitol Phase 3 DNA alkylating agent diarylpropionitrile Preclinical estrogen receptor agonist ESR2 diatrizoate Launched contrast agent radiology mri contrast agent diatrizoic-acid Launched radiology contrast agent diaveridine Launched dihydrofolate reductase inhibitor infectious disease coccidiosis diazoxide Launched potassium channel activator ATP1A1 | CA1 | CA2 | KCNJ11 | KCNJ8 | KCNMA1 | SLC12A3 endocrinology hypoglycemia dibekacin Launched bacterial 30S ribosomal subunit inhibitor infectious disease gram-negative bacterial infections dibenzepine Preclinical norepinephrine reputake inhibitor dibenzothiophene Preclinical dibutyl-phthalate Preclinical TRPA1 dicarbine Preclinical dopamine receptor ligand dichlorisone-acetate Phase 2 dichloroacetate Phase 3 pyruvate dehydrogenase kinase inhibitor dichlorophen Launched anticestodal agent infectious disease | infectious disease hookworm | tapeworm dichlorvos Launched acetylcholinesterase inhibitor diclazuril Launched antiprotozoal agent infectious disease equine protozoal myeloencephalitis (EPM) diclofenac Launched cyclooxygenase inhibitor AKR1C3 | ALOX5 | ASIC1 | ASIC3 | CYP2C8 | KCNQ2 | KCNQ3 | PLA2G2A | PPARG | PTGS1 | PTGS2 | SCN4A neurology/psychiatry | rheumatology | rheumatology migraine headache | osteoarthritis | rheumatoid arthritis diclofenamide Launched carbonic anhydrase inhibitor CA1 | CA12 | CA2 | CA4 | CA7 neurology/psychiatry | ophthalmology epilepsy | glaucoma diclofensine Phase 3 dopamine reuptake inhibitor DRD1 | MAOA | MAOB | SLC6A3 dicloralurea Preclinical dicloxacillin Launched bacterial cell wall synthesis inhibitor infectious disease gram-positive bacterial infections dicoumarol Launched NADPH inhibitor CRYZ | NQO1 | VKORC1 hematology deep vein thrombosis (DVT) dicyclohexylamine Preclinical dicycloverine Launched acetylcholine receptor antagonist CHRM1 | CHRM2 | CHRM3 gastroenterology irritable bowel syndrome didanosine Launched nucleoside reverse transcriptase inhibitor PNP infectious disease human immunodeficiency virus (HIV-1) dideoxyadenosine Phase 1 nucleoside reverse transcriptase inhibitor didox Launched ribonucleotide reductase inhibitor RRM1 oncology breast cancer dienestrol Launched estrogen receptor agonist ESR1 endocrinology menopause dienogest Launched progesterone receptor agonist PGR endocrinology | obstetrics/gynecology contraceptive | endometriosis diethylcarbamazine Launched lipoxygenase inhibitor ALOX5 | PTGS1 infectious disease filariasis diethylstilbestrol Withdrawn estrogen receptor agonist ESR1 | ESR2 | ESRRB | ESRRG diethyltoluamide Launched ionotropic receptor IR40a activator dermatology sunscreen lotion difamilast Phase 3 phosphodiesterase inhibitor PDE4A dermatology dermatitis difelikefalin Launched opioid receptor agonist OPRK1 nephrology uremic pruritus difenpiramide Launched cyclooxygenase inhibitor | prostaglandin inhibitor neurology/psychiatry pain relief diflorasone diacetate Launched glucocorticoid receptor agonist NR3C1 dermatology | Dermatology corticosteroid-responsive dermatoses | psoriasis diflorasone-diacetate Launched glucocorticoid receptor agonist NR3C1 dermatology corticosteroid-responsive dermatoses difloxacin Launched bacterial DNA gyrase inhibitor infectious disease | infectious disease skin infections | urinary tract infections diflunisal Launched prostanoid receptor antagonist PTGS1 | PTGS2 rheumatology | rheumatology osteoarthritis | rheumatoid arthritis difluprednate Launched glucocorticoid receptor agonist NR3C1 ophthalmology endogenous uveitis diftalone Launched cyclooxygenase inhibitor endocrinology thyroiditis digitoxigenin Preclinical ATPase inhibitor ATP1A1 digitoxin Launched ATPase inhibitor ATP1A1 | ATP1A2 | ATP1A3 | ATP1A4 | ATP1B1 | ATP1B2 | ATP1B3 | FXYD2 cardiology | cardiology cardiac arrythmia | congestive heart failure digoxigenin Preclinical steroid digoxin Launched ATPase inhibitor ABCB1 | ATP1A1 | RORC | SLCO1B3 cardiology | cardiology atrial fibrillation (AF) | congestive heart failure dihomo-gamma-linolenic-acid Phase 2 prostanoid receptor agonist PTGS1 | PTGS2 dihydrexidine Phase 2 dopamine receptor agonist DRD1 | DRD2 | DRD3 | DRD4 | DRD5 dihydroartemisinin Launched antimalarial agent infectious disease malaria dihydroergocristine Launched adrenergic receptor antagonist | prolactin inhibitor ADRA1A | ADRB1 | DRD1 | DRD2 | DRD3 | DRD4 | DRD5 | HTR1A | HTR2A | HTR3A | HTR4 | HTR5A | HTR6 | HTR7 neurology/psychiatry | neurology/psychiatry cerebrovascular insufficiency | senile dementia dihydroergotamine Launched serotonin receptor agonist ADRA2A | DRD2 | HTR1B | HTR1D | HTR1E | HTR1F | HTR2B | HTR7 neurology/psychiatry migraine headache dihydromyricetin Preclinical dihydrostreptomycin Withdrawn bacterial 30S ribosomal subunit inhibitor dihydrostreptomycin [5mm] Withdrawn bacterial 30s ribosomal subunit inhibitor Infectious disease tuberculosis dihydrotachysterol Launched vitamin analog VDR endocrinology | endocrinology | orthopedics hypocalcemia | osteomalacia | rickets dihydroxyacetone Launched dermatology skin protectant dihydroxyphenylglycine Preclinical glutamate receptor agonist GRM1 | GRM5 diiodothyropropionic-acid Phase 2 thyroid hormone stimulant dilazep Launched adenosine reuptake inhibitor CACNA1C | SLC29A1 cardiology coronary heart disease dilmapimod Phase 1 p38 MAPK inhibitor MAPK14 diloxanide Launched protein synthesis inhibitor infectious disease amebiasis diltiazem Launched calcium channel blocker CACNA1C | CACNA1S | CACNA2D1 | CACNG1 | CYP3A5 | CYP3A7 | HTR3A | KCNA5 cardiology | cardiology angina pectoris | hypertension dimaprit Preclinical histamine receptor agonist HRH2 | HRH3 | HRH4 DIM-C-pPhCO2Me Preclinical nuclear receptor antagonist NR4A1 dimemorfan Launched sigma receptor agonist SIGMAR1 pulmonary cough suppressant dimenhydrinate Launched histamine receptor antagonist HRH1 gastroenterology | gastroenterology | neurology/psychiatry motion sickness | nausea | vomiting dimercaprol Launched chelating agent neurology/psychiatry metal toxicity dimercaptosuccinic-acid Launched chelating agent DNMT1 neurology/psychiatry metal toxicity dimesna Phase 3 tubulin polymerization inhibitor dimethadione Preclinical oxazolidine antiepileptic dimethicone Launched dermatology cosmetic dimethindene-(S)-(+) Preclinical acetylcholine receptor antagonist HRH1 dimethisoquin Launched local anesthetic neurology/psychiatry local anesthetic dimethyl-fumarate Launched "nuclear factor erythroid derived, like (NRF2) activator" KEAP1 | NFE2L2 neurology/psychiatry multiple sclerosis dimethyl-isosorbide Preclinical cosmetic moisturizer dimetindene Launched cholinergic receptor antagonist | histamine receptor antagonist HRH1 allergy allergic rhinitis dimetridazole Launched bacterial DNA inhibitor infectious disease protozoan infection diminazene-aceturate Phase 3 angiotensin converting enzyme activator ACE2 | AOC1 | PRDX5 | PRSS1 dimpylate Launched acetylcholinesterase inhibitor ACHE infectious disease flea control dinaciclib Phase 3 CDK inhibitor CCNT1 | CDK1 | CDK2 | CDK5 | CDK9 dinitolmide Launched infectious disease coccidiosis dinoprost Launched prostacyclin analog PTGDR | PTGDR2 | PTGER1 | PTGER2 | PTGER3 | PTGER4 | PTGFR | TBXA2R obstetrics/gynecology labor induction dinoprostone Withdrawn prostanoid receptor agonist CATSPER1 | CATSPER2 | CATSPER3 | CATSPER4 | PTGDR | PTGDR2 | PTGER1 | PTGER2 | PTGER3 | PTGER4 | PTGFR | TBXA2R dinotefuran Launched dioscin Preclinical apoptosis stimulant CXCR3 diosgenin Preclinical steroid diosmetin Launched aryl hydrocarbon receptor agonist CYP1B1 dermatology cosmetic diosmin Launched aryl hydrocarbon receptor agonist | capillary stabilizing agent AHR cardiology | cardiology | cardiology | dermatology | hematology chronic venous insufficiency (CVI) | deep vein thrombosis (DVT) | edema | heavy leg syndrome | statis dermatitis dioxybenzone Preclinical topical sunscreen agent dipeptamin Launched diperodon Preclinical local anesthetic diphemanil Launched acetylcholine receptor antagonist CHRM3 neurology/psychiatry spasms diphencyprone Phase 2 immunostimulant diphenhydramine Launched histamine receptor antagonist HRH1 neurology/psychiatry headache diphenidol Launched acetylcholine receptor agonist CHRM1 | CHRM2 | CHRM3 | CHRM4 neurology/psychiatry vertigo diphenyleneiodonium Preclinical nitric oxide synthase inhibitor ALDH1A2 | ALDH2 | ALDH5A1 | ALDH7A1 | NOS2 | NOS3 | NOX3 | XDH diphenylguanidine Preclinical diphenylpyraline Launched dopamine reuptake inhibitor HRH1 | SLC6A3 allergy allergic rhinitis dipivefrine Launched adrenergic receptor agonist ADRA1A ophthalmology | ophthalmology glaucoma | intraocular pressure dipraglurant Phase 2 glutamate receptor negative allosteric modulator GRM5 DIPT Launched dopamine reuptake inhibitor | serotonin reuptake inhibitor HTR1A | HTR2A | HTR2C dipyridamole Launched phosphodiesterase inhibitor ADA | PDE10A | PDE1A | PDE1B | PDE1C | PDE2A | PDE3A | PDE3B | PDE4A | PDE4B | PDE4C | PDE4D | PDE5A | PDE6A | PDE6B | PDE6C | PDE6D | PDE6G | PDE6H | PDE7A | PDE7B | PDE8A | PDE8B | PDE9A | SLC29A1 cardiology | cardiology | cardiology coronary artery disease (CAD) | hypertension | peripheral artery disease (PAD) dipyrocetyl Launched chelating agent endocrinology | neurology/psychiatry fever | pain relief diquafosol Phase 3 purinergic receptor activator P2RY2 dirithromycin bacterial 50S ribosomal subunit inhibitor pulmonary bronchitis diroximel-fumarate Phase 3 anti-inflammatory agent HCAR2 disodium-sebacate Phase 1 HBB disopyramide Launched sodium channel blocker CHRM1 | CHRM2 | CHRM3 | KCND2 | KCND3 | KCNH2 | SCN5A cardiology | cardiology ventricular arrhythmias | ventricular tachycardia (VT) disulfiram Launched aldehyde dehydrogenase inhibitor | DNA methyltransferase inhibitor | TRPV agonist ALDH1A2 | ALDH2 | ALDH5A1 | ALDH7A1 | CYP2E1 | DBH | DNMT1 | TRPA1 neurology/psychiatry abstinence from alcohol dithranol Launched DNA synthesis inhibitor dermatology psoriasis ditiocarb-sodium-trihydrate Phase 3 immunostimulant CA1 | CA2 | CA4 | CYP2E1 ditolylguanidine Preclinical sigma receptor agonist GRIN1 | GRIN2A | GRIN2B | SIGMAR1 dixanthogen Preclinical dixyrazine Preclinical antipsychotic dizocilpine-(-) Phase 1 glutamate receptor antagonist dizocilpine-(+) Preclinical glutamate receptor antagonist GRIN1 | GRIN2A | GRIN2B | GRIN2C | GRIN2D "d,l-3-hydroxybutyric acid" Phase 1 hydroxycarboxylic acid receptor agonist HCAR2 | HDAC2 | HDAC3 dl-cystine D-limonene Phase 1 "D,L-mevalonic-acid-lactone" Preclinical dl-tboa Preclinical excitatory amino acid transporter inhibitor EAAT1 | EAAT2 | EAAT3 dm4 tubulin inhibitor CD19 | MSLN | SDC1 | TUBB hematologic malignancy multiple myeloma DMAB-anabaseine Preclinical adrenergic receptor agonist CHRNA7 D-(+)-maltose Preclinical MGAM DMeOB Preclinical glutamate receptor modulator GRM5 DMH1 Preclinical ALK tyrosine kinase receptor inhibitor ACVR1 DMH4 Preclinical VEGFR inhibitor KDR DMNB Preclinical DNA dependent protein kinase inhibitor DMP-543 Phase 2 acetylcholine release enhancer DMP-777 Phase 2 elastase inhibitor MPO | PI3 DMPS Phase 1 chelating agent DMSO Preclinical control vehicle DNQX Preclinical glutamate receptor antagonist GRIA1 | GRIA2 | GRIK1 | GRIN1 | GRIN2A | GRIN2B dobutamine Launched adrenergic receptor agonist ADRA1A | ADRB1 | ADRB2 cardiology congestive heart failure docebenone Phase 2 lipoxygenase inhibitor ALOX5 docetaxel Launched tubulin polymerization inhibitor BCL2 | MAP2 | MAP4 | MAPT | NR1I2 | TUBA1A | TUBA1B | TUBA1C | TUBA3C | TUBA3D | TUBA3E | TUBA4A | TUBB | TUBB1 | TUBB2A | TUBB2B | TUBB3 | TUBB4A | TUBB4B | TUBB6 | TUBB8 oncology | oncology | oncology | oncology | oncology breast cancer | gastric adenocarcinoma | head and neck squamous cell carcinoma (HNSCC) | non-small cell lung cancer (NSCLC) | prostate cancer doconexent Launched PPAR receptor agonist FFAR1 | PPARA | PTGS1 | PTGS2 doconexent-ethyl-ester Launched omega 3 fatty acid stimulant endocrinology hypertriglyceridemia docosanol Launched lipase clearing factor inhibitor LPL | TLR7 dental cold sore docusate Launched laxative gastroenterology constipation dodecyl-sulfate Preclinical LYZ dofequidar Phase 3 MRP inhibitor | P glycoprotein inhibitor ABCB1 | ABCC1 dofequidar fumarate Phase 3 mrp inhibitor ABCB1 | ABCC1 dofetilide Withdrawn potassium channel blocker KCNH1 | KCNH2 | KCNJ12 | KCNK2 dolasetron Launched serotonin receptor antagonist HTR3A gastroenterology | gastroenterology nausea | vomiting dolastatin-10 Phase 2 tubulin polymerization inhibitor TUBB dolutegravir Launched HIV integrase inhibitor CYP3A4 | CYP3A5 | CYP3A7 | POU2F2 | SLC22A2 | UGT1A1 infectious disease human immunodeficiency virus (HIV-1) dolutegravir (gsk1349572) Launched hiv integrase inhibitor CYP3A4 | CYP3A5 | CYP3A7 | POU2F2 | UGT1A1 infectious disease human immunodeficiency virus (hiv-1) domiphen Preclinical domperidone Launched dopamine receptor antagonist ABCG2 | CYP3A5 | DRD2 | DRD3 infectious disease fescue toxicosis donepezil Launched acetylcholinesterase inhibitor ACHE neurology/psychiatry Alzheimer's disease donitriptan Phase 2 serotonin receptor agonist HTR1A | HTR1B | HTR1D | HTR1E | HTR1F | HTR2A | HTR5A | HTR6 dopamine Launched dopamine receptor agonist DBH | DRD1 | DRD2 | DRD3 | DRD4 | DRD5 | HTR1A | HTR7 | SLC6A2 | SLC6A3 | SLC6A4 cardiology | neurology/psychiatry | neurology/psychiatry | neurology/psychiatry depression | headache | tremors | ventricular arrhythmias doramapimod Phase 2 p38 MAPK inhibitor DDR2 | MAPK11 | MAPK12 | MAPK13 | MAPK14 doramectin Launched infectious disease gastrointestinal roundworms doravirine Launched non-nucleoside reverse transcriptase inhibitor doripenem Launched bacterial cell wall synthesis inhibitor DPEP1 infectious disease | infectious disease | infectious disease intra-abdominal infections | pyelonephritis | urinary tract infections dorsomorphin Preclinical AMPK inhibitor ACVR1 | BMPR1A | BMPR1B | EPHA2 | FKBP1A | FLT1 | FLT3 | KDR | LCK | MKNK1 | PRKAA1 | RPS6KA1 | SRC dorzagliatin Phase 2 glucokinase activator GCK endocrinology diabetes mellitus dorzolamide Launched carbonic anhydrase inhibitor CA1 | CA12 | CA14 | CA2 | CA4 | CA7 ophthalmology | ophthalmology glaucoma | intraocular pressure dorzolamide hcl Launched carbonic anhydrase inhibitor CA1 | CA12 | CA14 | CA2 | CA4 | CA7 ophthalmology "intraocular pressure, glaucoma" dosulepin Launched norepinephrine reuptake inhibitor | serotonin–norepinephrine reuptake inhibitor (SNRI) | tricyclic antidepressant CHRM1 | CHRM2 | CHRM3 | CHRM4 | CHRM5 | CYP2C19 | HRH1 | SLC6A2 | SLC6A4 neurology/psychiatry depression dotinurad Launched urate transporter inhibitor SLC22A12 nephrology hyperuricemia DOTMP Preclinical dovitinib Phase 3 EGFR inhibitor | FGFR inhibitor | FLT3 inhibitor | PDGFR tyrosine kinase receptor inhibitor | VEGFR inhibitor CSF1R | EGFR | FGFR1 | FGFR2 | FGFR3 | FLT1 | FLT3 | FLT4 | INSR | KDR | KIT | PDGFRA | PDGFRB doxapram Launched potassium channel blocker KCNK3 | KCNK9 neurology/psychiatry | pulmonary | pulmonary acute hypercapnia (AHC) | central nervous system depression | respiratory depression doxazosin Launched adrenergic receptor antagonist ADRA1A | ADRA1B | ADRA1D | CYP2C19 cardiology | urology benign prostatic hyperplasia (BPH) | hypertension doxazosin mesylate Launched adrenergic receptor antagonist ADRA1A | ADRA1B | ADRA1D "urology, cardiology" "benign prostatic hyperplasia (bph), hypertension" doxepin Launched histamine receptor antagonist CYP2C19 | HRH1 | HRH2 | SLC6A2 | SLC6A3 | SLC6A4 neurology/psychiatry | neurology/psychiatry anxiety | depression doxercalciferol Launched vitamin D receptor agonist VDR endocrinology | nephrology chronic kidney disease (CKD) | hyperparathyroidism doxifluridine Launched thymidylate synthase inhibitor TYMS oncology colorectal cancer doxofylline Launched adenosine receptor antagonist ADORA1 | PDE4A | PDE4B | PDE4C | PDE4D pulmonary asthma doxorubicin Launched dna polymerase inhibitor | topoisomerase inhibitor TOP2A hematologic malignancy | hematologic malignancy | hematologic malignancy | hematologic malignancy | oncology | oncology | oncology | oncology acute lymphoblastic leukemia (ALL) | acute myeloid leukemia (AML) | bladder cancer | breast cancer | Hodgkin's lymphoma | multiple myeloma | ovarian cancer | Wilm's tumor doxycycline Launched bacterial 30S ribosomal subunit inhibitor | metalloproteinase inhibitor MMP1 | MMP8 dental periodontitis doxycycline hcl Launched "bacterial 30s ribosomal subunit inhibitor, metalloproteinase inhibitor" MMP8 dental periodontitis doxycycline hyclate Launched bacterial 30s ribosomal subunit inhibitor Infectious disease gram-negative bacterial infections doxylamine Launched histamine receptor antagonist HRH1 neurology/psychiatry sedative doxylamine succinate Launched histamine receptor antagonist HRH1 Allergies allergic conjunctivitis DpC Phase 1 DPC-681 Phase 1 HIV protease inhibitor DPCPX Phase 1 adenosine receptor antagonist ADORA1 | ADORA2A | ADORA2B | ADORA3 | CFTR D-phenylalanine Preclinical enkephalinase inhibitor CCBL1 | CRH | HCAR3 DPI-201106 Phase 2 sodium channel activator ADRB2 d-pinitol DPO-1 Preclinical potassium channel blocker KCNA5 DPPE Phase 3 histamine receptor antagonist ABCB1 | HRH1 DQP-1105 Preclinical glutamate receptor antagonist GRIN2C | GRIN2D DR-2313 Preclinical PARP inhibitor PARP1 | PARP3 DR-4485 Preclinical serotonin receptor antagonist HTR7 DRF053-(R) Preclinical CDK inhibitor CSNK1A1 drofenine Launched neurology/psychiatry spasms droloxifene Phase 3 selective estrogen receptor modulator (SERM) ESR1 dromostanolone-propionate Launched androgen receptor modulator AR oncology breast cancer dronedarone Launched adrenergic receptor antagonist ADRA1A | ADRA1B | ADRA1D | ADRA2A | ADRA2B | ADRA2C | ADRB1 | CACNA1C | CACNA1D | CACNA1F | CACNA1S | CACNB1 | CACNB2 | CACNB3 | CACNB4 | KCNA5 | KCNH2 | KCNK2 | SCN1A | SLC22A2 | SLC22A8 | SLCO1B3 cardiology atrial fibrillation (AF) droperidol Launched dopamine receptor antagonist ADRA1A | DRD2 | DRD3 | DRD4 | HTR2A gastroenterology | gastroenterology nausea | vomiting dropropizine Launched antitussive pulmonary cough suppressant drospirenone Launched mineralocorticoid receptor antagonist AR | NR3C2 | PGR endocrinology contraceptive drotaverine Launched phosphodiesterase inhibitor obstetrics/gynecology labor induction droxicam Launched cyclooxygenase inhibitor PTGS1 | PTGS2 rheumatology | rheumatology osteoarthritis | rheumatoid arthritis droxidopa Launched norepinephrine precursor ADRA1A | ADRA1B | ADRA1D | ADRA2A | ADRA2B | ADRA2C | ADRB1 | ADRB2 | ADRB3 | PAH cardiology | neurology/psychiatry hypertension | Parkinson's Disease droxinostat Preclinical HDAC inhibitor HDAC6 | HDAC8 ds-1971a Phase 2 voltage-gated sodium channel blocker SCN9A neurology/psychiatry peripheral neuropathy DS2-(806622) Preclinical D-serine Launched glutamate receptor agonist GLRA1 | GRIN1 | GRIN2A | GRIN2B | GRIN2C | GRIN2D | SERPINB3 DSM265 Phase 2 dihydroorotate dehydrogenase inhibitor DHODH DSPC Preclinical DSR-6434 Preclinical toll-like receptor agonist TLR7 dtp3 dual specificity protein kinase inhibitor MAP2K7 hematologic malignancy multiple myeloma DU-728 Phase 1 structural glycoprotein antagonist ITGA2B | ITGB3 duloxetine Launched norepinephrine reuptake inhibitor | serotonin–norepinephrine reuptake inhibitor (SNRI) HTR2A | HTR2C | HTR6 | SLC6A2 | SLC6A3 | SLC6A4 neurology/psychiatry | neurology/psychiatry | neurology/psychiatry | neurology/psychiatry depression | generalized anxiety disorder (GAD) | muscle pain | peripheral neuropathy DUP-697 Phase 1 cyclooxygenase inhibitor PTGS2 dusquetide Phase 3 dusquetide (tfa) Phase 2 immunostimulant SQSTM1 dental mucositis dutasteride Launched 5 alpha reductase inhibitor CYP3A5 | SRD5A1 | SRD5A2 | SRD5A3 urology benign prostatic hyperplasia (BPH) duvelisib Launched PI3K inhibitor PIK3CA | PIK3CB | PIK3CD | PIK3CG DVD-111 Phase 2 DWK-1339 Preclinical beta amyloid aggregation inhibitor APP dxd topoisomerase inhibitor TOP1 oncology breast cancer DY131 Preclinical estrogen-related receptor agonist ESRRB | ESRRG dyclonine Launched sodium channel blocker SCN10A | SCN5A neurology/psychiatry local anesthetic dydrogesterone Launched progesterone receptor agonist PGR obstetrics/gynecology infertility dynasore Preclinical dynamin inhibitor DNM1 | DNM1L | DNM2 dynole-34-2 Preclinical dynamin inhibitor DNM1 dyphylline Launched adenosine receptor antagonist | phosphodiesterase inhibitor PDE4A pulmonary | pulmonary | pulmonary asthma | bronchitis | emphysema e1210 other antifungal infectious disease cutaneous candidiasis E-2001 Preclinical antioxidant E-2012 Phase 1 gamma secretase modulator APH1A | APH1B | APP | PSENEN "(e)-2-(2-(2,5-dimethyl-1-phenyl-1h-pyrrol-3-yl)vinyl)-6-(dimethylamino)-1-methylquinolin-1-ium 4,4'-methylenebis(3-hydroxy-2-naphthoate)" E3330 Preclinical NFkB pathway inhibitor APEX1 | NFKB1 | NFKB2 E-4031 Phase 1 potassium channel blocker KCNH1 | KCNH2 e-64 E-64 Preclinical calpain inhibitor | cysteine protease inhibitor CTSS E7046 Phase 1 prostanoid receptor antagonist PTGER4 e-7386 Phase 1 CREBBP | CTNNB1 oncology colorectal cancer E7449 Phase 2 PARP inhibitor PARP1 | PARP2 | TNKS | TNKS2 E7820 Phase 2 angiogenesis inhibitor ITGA2 eact Preclinical calcium-activated chloride channel inhibitor ANO1 EB-47 Preclinical PARP inhibitor PARP1 ebastine Launched histamine receptor antagonist CYP2J2 | CYP3A4 | HRH1 allergy | allergy allergic rhinitis | urticaria EBPC Preclinical aldose reductase inhibitor AKR1B1 ebrotidine Withdrawn histamine receptor antagonist HRH2 ebselen Phase 2/Phase 3 cyclooxygenase inhibitor | glutathione peroxidase agonist | H+/K+-ATPase inhibitor | nitric oxide synthase inhibitor ALB | LTB4R | NOX3 EC-144 Preclinical HSP inhibitor HSP90AA1 | HSP90AB1 EC-23 Preclinical retinoid receptor agonist RARA | RARB | RARG ec5026 Phase 1 epoxide hydolase inhibitor EPHX2 neurology/psychiatry pain relief ecabapide Phase 3 ecabet Launched gastrin inhibitor | urease inhibitor CCKBR | GAST | NOXO1 ophthalmology dry eye syndrome ecamsule triethanolamine Launched dermatology "skin protectant, sunscreen lotion" ecamsule-triethanolamine Launched dermatology | dermatology skin protectant | sunscreen lotion echinomycin Phase 2 DNA intercalating agent econazole Launched lanosterol demethylase inhibitor | sterol demethylase inhibitor NPY1R | NPY2R | TRPM2 | TRPV5 infectious disease | infectious disease | infectious disease | infectious disease | infectious disease cutaneous candidiasis | tinea corporis | tinea cruris | tinea pedis | tinea versicolor ecothiopate Launched acetylcholinesterase inhibitor BCHE ophthalmology glaucoma ectoine Launched anti-inflammatory agent edaglitazone Phase 2 PPAR receptor agonist INS | PPARG edaravone Launched nootropic agent BCL2 neurology/psychiatry stroke edasalonexent Phase 3 NFkB pathway inhibitor NFKB1 | NFKB2 edelfosine Phase 2 phospholipase inhibitor editol Preclinical edonerpic-maleate Preclinical beta amyloid inhibitor APP EDO-S101 Phase 1/Phase 2 HDAC inhibitor HDAC1 | HDAC2 | HDAC3 | HDAC6 edoxaban Launched coagulation factor inhibitor CYP3A5 | F10 cardiology | hematology | hematology | hematology | neurology/psychiatry atrial fibrillation (AF) | deep vein thrombosis (DVT) | pulmonary embolism (PE) | stroke | systemic embolism edoxudine Launched DNA directed DNA polymerase inhibitor infectious disease virus herpes simplex (HSV) edrophonium Launched acetylcholinesterase inhibitor ACHE | BCHE neurology/psychiatry myasthenia gravis EDTMP Preclinical chelating agent EED226 Preclinical polycomb protein inhibitor EED EF5 Phase 2 cytochrome P450 activator POR efaproxiral Phase 3 hemoglobin oxygen release stimulant HBA1 | HBB efaroxan Phase 2 adrenergic receptor antagonist ADORA2A efatutazone Phase 2 PPAR receptor agonist PPARG efavirenz Launched HIV protease inhibitor CYP1A2 | CYP2B6 | CYP2C19 | CYP2C8 | CYP2C9 | CYP2D6 | CYP3A4 | CYP3A5 infectious disease human immunodeficiency virus (HIV-1) efinaconazole Launched fungal lanosterol demethylase inhibitor | lanosterol demethylase inhibitor CYP51A1 infectious disease | Infectious disease fungal infection | onychomycosis efletirizine Phase 3 antihistamine HRH1 eflornithine Launched ornithine decarboxylase inhibitor ARG2 | ODC1 dermatology facial hair reduction efloxate Preclinical vasodilator efonidipine Launched calcium channel blocker CACNA1C | CACNA1F | CACNA1G cardiology hypertension efonidipine hydrochloride monoethanolate EG00229 Preclinical neuropilin receptor antagonist NRP1 EGF816 Phase 2 EGFR inhibitor EGFR eglumetad Phase 2 glutamate receptor agonist GRM2 | GRM3 | GRM6 | GRM8 EHop-016 Preclinical Ras GTPase inhibitor RAC1 | RAC3 EI1 Preclinical histone lysine methyltransferase inhibitor EZH2 EIPA Preclinical sodium/hydrogen exchanger inhibitor | transient receptor potential polycystic inhibitor ADRA2A | ASIC1 | PKD2L1 EIT-hydrobromide Preclinical nitric oxide synthase inhibitor NOS2 | NOS3 elacestrant Phase 3 estrogen receptor degrader ESR1 elacridar Phase 1 P glycoprotein inhibitor ABCB1 elactocin Phase 1 exportin antagonist XPO1 elacytarabine Phase 3 antineoplastic agent DCK elafibranor Phase 3 PPAR receptor agonist PPARA | PPARD | PPARG elagolix Launched gonadotropin releasing factor hormone receptor antagonist GNRH1 | GNRHR elamipretide Phase 3 CRLS1 ophthalmology macular degeneration elbasvir Launched HCV inhibitor infectious disease hepatitis C eldecalcitol Phase 3 bone formation stimulant VDR eleclazine Phase 3 late sodium current inhibitor elemene Phase 3 VEGFR inhibitor elenbecestat Phase 3 beta secretase inhibitor BACE1 neurology/psychiatry alzheimer's disease elesclomol Phase 3 oxidative stress inducer HSPA1A | TOP2A eletriptan Launched serotonin receptor agonist HTR1A | HTR1B | HTR1D | HTR1E | HTR1F | HTR2B | HTR7 neurology/psychiatry migraine headache elexacaftor Launched cystic fibrosis transmembrane conductance regulator inhibitor CFTR pulmonary cystic fibrosis eliglustat Launched glycosyl transferase inhibitor UGCG hematology Gaucher disease elinogrel Phase 2 purinergic receptor antagonist P2RY12 eliprodil Phase 3 glutamate receptor antagonist GRIN1 | GRIN2B ellagic-acid Phase 2 glutathione transferase inhibitor | non-nucleoside reverse transcriptase inhibitor AKR1B1 | BACE1 | CA1 | CA12 | CA14 | CA2 | CA3 | CA4 | CA5A | CA5B | CA6 | CA7 | CA9 | CSNK2A1 | GSK3B | PRKACA | PRKCA | PRKCB | SQLE | SYK ELN-441958 Preclinical bradykinin receptor antagonist BDKRB1 eltanexor Preclinical exportin inhibitor XPO1 eltanolone Phase 3 GABA receptor positive allosteric modulator GABRA1 | GABRA2 | GABRA3 | GABRA4 | GABRA5 | GABRA6 | GABRB2 | GABRG2 eltoprazine Phase 2 serotonin receptor agonist HTR1A | HTR1B eltrombopag Launched thrombopoietin receptor agonist CYP2C8 | MPL "hematology | hematology | hematology, infectious disease | infectious disease" "anemia | anemia, hepatitis c, thrombocytopenia | hepatitis C | thrombocytopenia" elubrixin Phase 2 cc chemokine receptor antagonist CXCR2 pulmonary cystic fibrosis eluxadoline Launched opioid receptor agonist | opioid receptor antagonist OPRD1 | OPRK1 | OPRM1 gastroenterology irritable bowel syndrome elvitegravir Launched HIV integrase inhibitor infectious disease human immunodeficiency virus (HIV-1) elx-02 Phase 1 emamectin Preclinical GABA receptor agonist embelin Preclinical HCV inhibitor | XIAP inhibitor XIAP EMD-1214063 Phase 2 hepatocyte growth factor receptor inhibitor MET EMD-386088 Preclinical serotonin receptor agonist HTR6 EMD534085 Preclinical kinesin inhibitor KIF11 EMD-53998 Phase 1 phosphodiesterase inhibitor PDE3A | TNNC1 EMD-66684 Preclinical angiotensin receptor antagonist AGTR1 emedastine Launched histamine receptor antagonist HRH1 ophthalmology conjunctivitis emeramide Phase 2 antioxidant GSR emetine Phase 2 protein synthesis inhibitor RPS2 emiglitate Preclinical alpha glucoside inhibitor GAA emixustat Phase 3 retinoid isomerohydrolase inhibitor RPE65 emodepside Phase 1 nematocide emodin Preclinical 11-beta hydroxysteroid dehydrogenase inhibitor CSNK2A1 | CSNK2A2 | CSNK2B | IL6 | PTP4A3 emorfazone Launched anti-inflammatory agent | cyclooxygenase inhibitor dental mouth inflammation emoxipin Phase 3 empagliflozin Launched sodium/glucose cotransporter inhibitor SLC5A1 | SLC5A2 endocrinology diabetes mellitus emricasan Phase 2 caspase inhibitor CASP1 | CASP3 | CASP7 | CASP8 | CASP9 emtricitabine Launched nucleoside reverse transcriptase inhibitor infectious disease human immunodeficiency virus (HIV-1) EN460 Preclinical endoplasmic reticulum oxidation inhibitor ERO1A enalapril Launched angiotensin converting enzyme inhibitor ACE cardiology | cardiology | cardiology congestive heart failure | hypertension | left ventricular systolic dysfunction (LVSD) enalaprilat Launched angiotensin converting enzyme inhibitor ACE cardiology hypertension enarodustat Phase 3 hypoxia inducible factor prolyl hydroxylase inhibitor EGLN1 hematology anemia enasidenib Launched isocitrate dehydrogenase inhibitor IDH1 hematologic malignancy acute myeloid leukemia (AML) enbucrilate Launched dermatology | dermatology skin lacerations | tissue adhesive enciprazine Phase 3 GABA receptor modulator GABRA1 encorafenib Launched RAF inhibitor | serine/threonine kinase inhibitor BRAF | CCND1 oncology melanoma endo-IWR-1 Preclinical PARP inhibitor TNKS | TNKS2 endoxifen Phase 2 estrogen receptor antagonist ESR1 enflurane Launched membrane permeability inhibitor CYP2E1 | GABRA1 | GABRA2 | GABRA3 | GABRA4 | GABRA5 | GABRA6 | GABRB1 | GABRB2 | GABRB3 | GABRD | GABRE | GABRG1 | GABRG2 | GABRG3 | GABRP | GABRQ | GLRA1 | GLRB | KCNK10 | KCNK18 | KCNK2 | KCNK3 | KCNK9 neurology/psychiatry anesthetic enilconazole Launched sterol demethylase inhibitor CYP19A1 | CYP1A2 | CYP2B6 | CYP2C9 | CYP2J2 | CYP3A4 | CYP3A5 | NR1I2 | PPARA | PTGER2 infectious disease skin infections eniluracil Phase 3 dihydropyrimidine dehydrogenase inhibitor AOX1 | DPYD | XDH eniporide Preclinical sodium/hydrogen antiport inhibitor SLC9A1 | SLC9A3 enisamium-iodide Launched ENMD-2076 Phase 2 Aurora kinase inhibitor | FLT3 inhibitor | VEGFR inhibitor AURKA | CSF1R | EPHA1 | FGFR1 | FGFR2 | FGFR3 | FLT3 | FLT4 | KDR | KIT | PDGFRA | PTK2 | SRC enocitabine Launched DNA synthesis inhibitor CMPK1 | POLA1 | POLB | RRM1 | TYMS hematologic malignancy acute myeloid leukemia (AML) enoxacin Launched topoisomerase inhibitor TOP2A infectious disease | infectious disease gonorrhea | urinary tract infections enoximone Launched phosphodiesterase inhibitor PDE3A cardiology congestive heart failure enoxolone Launched gap junction modulator HSD11B1 | HSD11B2 | HSD17B3 gastroenterology | otolaryngology common cold | peptic ulcer disease (PUD) enprofylline Phase 3 phosphodiesterase inhibitor ADORA1 | ADORA2A | ADORA2B | ADORA3 | PDE4A | PDE4B enrofloxacin Launched bacterial DNA gyrase inhibitor infectious disease gram-negative bacterial infections ensartinib Phase 2 alk inihibitor ALK oncology non-small cell lung cancer (nsclc) entacapone Launched catechol O methyltransferase inhibitor COMT neurology/psychiatry Parkinson's Disease entasobulin Preclinical tubulin polymerization inhibitor TUBB entecavir Launched DNA replication inhibitor | nucleoside reverse transcriptase inhibitor infectious disease hepatitis B entinostat Phase 3 HDAC inhibitor HDAC1 | HDAC2 | HDAC3 | HDAC9 entrectinib Launched ALK tyrosine kinase receptor inhibitor | proto-oncogene tyrosine protein kinase inhibitor ALK | AURKB | IGF1R | NTRK1 | NTRK2 | NTRK3 | ROS1 oncology non-small cell lung cancer (NSCLC) enzacamene Launched enzalutamide Launched androgen receptor antagonist AR | CYP2C19 | CYP2C8 | CYP3A4 oncology prostate cancer enzastaurin Phase 3 PKC inhibitor AKT1 | GSK3B | PRKCA | PRKCB | PRKCD | PRKCG EO-1428 Preclinical p38 MAPK inhibitor MAPK11 | MAPK14 epacadostat Phase 3 "indoleamine 2,3-dioxygenase inhibitor" IDO1 epalrestat Launched aldose reductase inhibitor AKR1B1 nephrology diabetic nephropathy eperezolid Phase 1 bacterial 30S ribosomal subunit inhibitor eperisone Launched acetylcholine receptor antagonist CYP2J2 neurology/psychiatry | neurology/psychiatry | neurology/psychiatry | neurology/psychiatry amyotrophic lateral sclerosis (ALS) | head injury | spasms | spinal injury epetraborole Preclinical leucyl-tRNA synthetase inhibitor LARS2 ephedrine Launched adrenergic receptor agonist ACHE | ADRA1A | ADRB2 | SLC18A2 | SLC6A2 cardiology | endocrinology | neurology/psychiatry | pulmonary asthma | hypotension | narcolepsy | obesity ephedrine-(racemic) Launched adrenergic receptor agonist ADRA1A | ADRA2A | ADRB1 | ADRB2 | ATF1 | ATF2 | ATF3 | ATF4 | ATF5 | ATF6 | ATF7 | FOS | IL2 | JDP2 | JUN | NFATC1 | SLC6A2 | SLC6A3 | SLC6A4 | TNF cardiology | endocrinology | neurology/psychiatry | pulmonary asthma | hypotension | narcolepsy | obesity epi-001 Preclinical ppar receptor modulator AR oncology prostate cancer epiandrosterone Preclinical steroid G6PD epicatechin-gallate-(-) Phase 2 bacterial DNA gyrase inhibitor APP | BACE1 | FASN | SLC5A1 epiestriol Launched estrogen receptor agonist ESR1 | ESR2 "endocrinology, obstetrics/gynecology, infectious disease" "menopause, vaginal atrophy, urinary tract infections" epigallocatechin-(-) Phase 2 epigallocatechin-gallate-(-) Phase 2/Phase 3 bacterial DNA gyrase inhibitor APP | CYP19A1 | DYRK1A | ELANE | ENOX2 | EP300 | FASN | IDO1 | KAT2B | KDR | MMP14 | MMP2 | PREP | SLC5A1 epinastine Launched histamine receptor antagonist HRH1 ophthalmology conjunctivitis epinephrine Launched adrenergic receptor agonist | carbonic anhydrase activator | neurotransmitter ADRA1A | ADRA1B | ADRA1D | ADRA2A | ADRA2B | ADRA2C | ADRB1 | ADRB2 | ADRB3 | PAH | TNF allergy | cardiology | pulmonary anaphylactic shock | asthma | cardiac arrest epirizole Launched cyclooxygenase inhibitor PTGS1 | PTGS2 neurology/psychiatry pain relief epirubicin Launched topoisomerase inhibitor CHD1 | TOP2A oncology breast cancer epitalon Withdrawn epitalon (tfa) Withdrawn TERT ophthalmology retinitis pigmentosa (rp) epitiostanol Launched androgen receptor agonist AR oncology breast cancer eplerenone Launched cytochrome P450 inhibitor CYP3A5 | NR3C2 cardiology | cardiology congestive heart failure | hypertension epomediol Launched cholesterol inhibitor CYP7A1 neurology/psychiatry itching epoprostenol Launched prostacyclin analog P2RY12 | PTGER1 | PTGER4 | PTGIR | PTGIS cardiology hypertension epoprostenol sodium Launched prostacyclin analog Lung diseases acute respiratory distress syndrome epothilone-A Preclinical microtubule stabilizing agent epothilone-B Phase 3 microtubule stabilizing agent | tubulin polymerization inhibitor TUBB "epothilone b (epo906, patupilone)" Phase 3 "microtubule stabilizing agent, tubulin polymerization inhibitor" TUBB epothilone-D Phase 2 microtubule stabilizing agent | tubulin polymerization inhibitor TUBB EPPTB Preclinical trace amine associated receptor antagonist TAAR1 eprazinone Launched mucolytic agent pulmonary bronchospasm eprinomectin Launched benzodiazepine receptor agonist infectious disease | infectious disease | infectious disease "gastrointestinal roundworms | gastrointestinal roundworms, lungworms | lungworms" epristeride Preclinical 5 alpha reductase inhibitor SRD5A1 | SRD5A2 eprobemide Launched monoamine oxidase inhibitor MAOA neurology/psychiatry depression eprodisate Phase 3 amyloid protein inhibitor | antiamyloidogenic agent SAA1 eprosartan Launched angiotensin receptor antagonist AGTR1 cardiology hypertension eptifibatide Launched platelet aggregation inhibitor ITGA2B | ITGB3 cardiology | cardiology | cardiology "acute coronary syndrome (ACS) | acute coronary syndrome (acs), percutaneous coronary intervention (pci) | percutaneous coronary intervention (PCI)" EPZ004777 Preclinical histone lysine methyltransferase inhibitor DOT1L EPZ005687 Preclinical histone lysine methyltransferase inhibitor EZH2 EPZ011989 Preclinical histone lysine methyltransferase inhibitor EZH2 EPZ015666 Preclinical protein arginine N-methyltransferase inhibitor PRMT5 EPZ020411 Preclinical protein arginine N-methyltransferase inhibitor PRMT6 EPZ-5676 Phase 1 histone lysine methyltransferase inhibitor DOT1L equilin Preclinical estrogen receptor agonist HSD17B1 equol Launched estrogen receptor agonist ESR1 | ESR2 ER-27319 Preclinical mediator release inhibitor | SYK inhibitor SYK ER-50891 Preclinical retinoid receptor antagonist RARA erastin Preclinical ion channel antagonist VDAC2 eravacycline Launched antibacterial | bacterial 30s ribosomal subunit inhibitor infectious disease gram-positive bacterial infections erbstatin-analog Preclinical EGFR inhibitor | tyrosine kinase inhibitor EGFR ercalcitriol Phase 1 vitamin D receptor agonist VDR erdafitinib Launched FGFR inhibitor FGFR1 | FGFR2 | FGFR3 | FGFR4 erdosteine Launched mucolytic agent infectious disease | pulmonary | pulmonary | pulmonary bronchitis | chronic obstructive pulmonary disease (COPD) | cough suppressant | respiratory tract infections ergocalciferol Launched vitamin analog VDR endocrinology | endocrinology | orthopedics hypoparathyroidism | hypophosphatemia | rickets ergoloid mesylate Launched serotonin receptor antagonist ADRA1A | ADRB1 | DRD1 | HTR1A neurology/psychiatry senile dementia ergonovine Launched adrenergic receptor agonist | serotonin receptor agonist ADRA1A | HTR1E hematology postpartum hemorrhage (PPH) ergonovine maleate Launched "adrenergic receptor agonist, serotonin receptor agonist" ADRA1A | HTR1E hematology postpartum hemorrhage (pph) ergosterol Preclinical vitamin D precursor ergotamine Launched adrenergic receptor antagonist ADRA1A | ADRA1B | ADRA1D | ADRA2A | ADRA2B | DRD1 | DRD2 | DRD5 | HTR1A | HTR1B | HTR1D | HTR1E | HTR1F | HTR2A | HTR2B | HTR2C | HTR5A | HTR6 | SLC6A2 neurology/psychiatry migraine headache ergotamine tartrate Launched adrenergic receptor antagonist ADRA1A | ADRA1B | ADRA1D | ADRA2A | ADRA2B | DRD1 | DRD2 | DRD5 | HTR1A | HTR1B | HTR1D | HTR1E | HTR1F | HTR2A | HTR2B | HTR2C | HTR5A | HTR6 | SLC6A2 neurology/psychiatry migraine headache eribulin Launched microtubule inhibitor oncology breast cancer ERK5-IN-1 Preclinical MAP kinase inhibitor LRRK2 | MAPK7 erlotinib Launched EGFR inhibitor EGFR | NR1I2 oncology | oncology non-small cell lung cancer (NSCLC) | pancreatic cancer ertapenem Launched bacterial cell wall synthesis inhibitor infectious disease | infectious disease | infectious disease | infectious disease | infectious disease | infectious disease gynecologic infections | intra-abdominal infections | pneumonia | postpartum endomyometritis | skin infections | urinary tract infections erteberel Phase 2 estrogen receptor agonist ESR1 | ESR2 ertugliflozin Launched sodium/glucose cotransporter inhibitor SLC5A2 endocrinology diabetes mellitus erythritol Launched erythromycin Launched NFkB pathway inhibitor MLNR infectious disease | infectious disease | infectious disease | infectious disease | infectious disease | infectious disease | infectious disease | infectious disease | infectious disease amebiasis | chlamydia | diphtheria | erythrasma | listeria | pelvic inflammatory disease | respiratory tract infections | skin infections | syphilis erythromycin-estolate Launched bacterial 50S ribosomal subunit inhibitor ABCB1 | ALB | CYP3A4 | CYP51A1 | KCNH2 | MLNR | SLC47A1 infectious disease | infectious disease | infectious disease | infectious disease | infectious disease | infectious disease | infectious disease | infectious disease | infectious disease amebiasis | chlamydia | diphtheria | erythrasma | listeria | pelvic inflammatory disease | respiratory tract infections | skin infections | syphilis erythromycin-ethylsuccinate Launched cytochrome P450 inhibitor | protein synthesis inhibitor ABCB1 | ALB | CYP3A4 | CYP51A1 | KCNH2 | MLNR | SLC47A1 infectious disease | infectious disease | infectious disease | infectious disease | infectious disease | infectious disease | infectious disease | infectious disease | infectious disease amebiasis | chlamydia | diphtheria | erythrasma | listeria | pelvic inflammatory disease | respiratory tract infections | skin infections | syphilis erythrosine Preclinical coloring agent esaprazole Phase 2 esaxerenone Preclinical mineralocorticoid receptor antagonist NR3C2 escin Launched nitric oxide synthase stimulant dermatology varicose veins escitalopram Launched selective serotonin reuptake inhibitor (SSRI) CYP2C19 | SLC6A4 neurology/psychiatry | neurology/psychiatry depression | generalized anxiety disorder (GAD) escitalopram oxalate Launched selective serotonin reuptake inhibitor (ssri) ADRA1A | CHRM1 | HRH1 | SLC6A2 | SLC6A3 | SLC6A4 neurology/psychiatry depression esculin Phase 1 antioxidant eseroline-(-) Preclinical acetylcholinesterase inhibitor ACHE | OPRD1 | OPRM1 ESI-09 Preclinical EPAC inhibitor RAPGEF3 | RAPGEF4 eslicarbazepine-acetate Launched sodium channel blocker CYP2C19 | CYP3A4 | SCN10A | SCN11A | SCN1A | SCN2A | SCN3A | SCN4A | SCN5A | SCN7A | SCN8A | SCN9A neurology/psychiatry seizures esmolol Launched adrenergic receptor antagonist ADRB1 cardiology | cardiology hypertension | ventricular tachycardia (VT) esmolol hcl Launched adrenergic receptor antagonist ADRB1 cardiology "ventricular tachycardia (vt), hypertension" esomeprazole Launched ATPase inhibitor ATP4A | CYP2C19 | CYP3A4 gastroenterology | gastroenterology | gastroenterology gastroesophageal reflux disease (GERD) | peptic ulcer disease (PUD) | Zollinger-Ellison syndrome esonarimod Preclinical antirheumatic drug IL6R | MMP1 estetrol Phase 3 selective estrogen receptor modulator (SERM) ESR1 estradiol Launched estrogen receptor agonist CYP2B6 | CYP2C19 | CYP2C8 | CYP2E1 | CYP3A5 | CYP3A7 | ESR1 | ESR2 | GPER1 | KCNMA1 | NR1I2 endocrinology contraceptive estradiol-3-O-sulfamate Phase 2 steryl sulfatase inhibitor STS estradiol-acetate Launched estrogen receptor agonist ESR1 endocrinology | obstetrics/gynecology menopause | vaginal atrophy estradiol-benzoate Preclinical contraceptive agent ESR1 estradiol cypionate Launched estrogen receptor agonist ESR1 endocrinology "hypoestrogenism, menopause" estradiol-cypionate Launched estrogen receptor agonist ESR1 endocrinology | endocrinology hypoestrogenism | menopause estradiol-valerate Launched estrogen receptor agonist ESR1 endocrinology | endocrinology | obstetrics/gynecology | oncology hypoestrogenism | menopause | prostate cancer | vaginal atrophy estramustine Launched DNA alkylating agent ESR1 | ESR2 | MAP1A | MAP2 oncology | Oncology breast cancer | prostate cancer estramustine-phosphate Launched DNA synthesis inhibitor | microtubule inhibitor ESR1 | ESR2 | MAP1A | MAP2 oncology prostate cancer estriol Launched estrogen receptor agonist ESR1 | ESR2 endocrinology | infectious disease | obstetrics/gynecology menopause | urinary tract infections | vaginal atrophy estrone Launched estrogenic hormone | estrogen receptor agonist ESR1 | ESR2 endocrinology menopause estropipate Launched estrogen receptor agonist ESR1 | ESR2 "endocrinology | endocrinology | obstetrics/gynecology | orthopedics | orthopedics, endocrinology, obstetrics/gynecology" "hypoestrogenism | menopause | osteoporosis | osteoporosis, menopause, vaginal atrophy, hypoestrogenism | vaginal atrophy" etacrynic-acid Launched sodium/potassium/chloride transporter inhibitor ATP1A1 | SLC12A1 | SLC12A2 cardiology | cardiology | cardiology | gastroenterology | nephrology | rheumatology chronic renal failure | congestive heart failure | edema | hepatic cirrhosis | hypertension | nephrotic syndrome etafenone Launched calcium channel blocker etamsylate Launched hemostatic agent hematology hemorrhage etanidazole Phase 3 bacterial cell wall synthesis inhibitor etazolate Phase 2 phosphodiesterase inhibitor GABRB3 | PDE4A ETC-159 Phase 1 beta catenin inhibitor | porcupine inhibitor PORCN ETC-206 Phase 1 MAPK-interacting kinase inhibitor MKNK1 | MKNK2 etebenecid Preclinical uricosuric blocker etelcalcetide Launched calcium-sensing receptor agonist CASR endocrinology hyperparathyroidism eterobarb Phase 2 anticonvulsant ethacizin Launched anticonvulsant cardiology | cardiology ventricular tachycardia (VT) | Wolff-Parkinson-White Syndrome (WPW) ethacridine-lactate-monohydrate Preclinical DNA intercalating agent ethambutol Launched bacterial cell wall synthesis inhibitor infectious disease tuberculosis ethamivan Preclinical respiratory stimulant ethanolamine-oleate Launched immunostimulant F12 | FABP4 | FFAR1 | FFAR4 | PLD2 gastroenterology esophageal varices ethaverine Launched calcium channel blocker neurology/psychiatry | neurology/psychiatry muscle relaxant | spasms ethenzamide Launched analgesic agent endocrinology | neurology/psychiatry | otolaryngology common cold | fever | headache ethimizol Phase 1 ethinyl-estradiol Launched estrogenic hormone | estrogen receptor agonist CYP2C8 | ESR1 | ESR2 | NR1I2 endocrinology contraceptive ethionamide Launched mycolic synthesis inhibitor infectious disease tuberculosis ethisterone Launched progestogen hormone TYR endocrinology amenorrhea ethopabate Launched antiprotozoal agent infectious disease coccidiosis ethosuximide Launched succinimide antiepileptic CACNA1G | CACNA1H | CACNA1I neurology/psychiatry epilepsy ethotoin Launched hydantoin antiepileptic SCN5A neurology/psychiatry seizures ethoxyquin Preclinical antioxidant ethoxzolamide Launched carbonic anhydrase inhibitor CA1 | CA12 | CA13 | CA14 | CA2 | CA3 | CA4 | CA5A | CA5B | CA6 | CA7 | CA9 gastroenterology | ophthalmology duodenal ulcer disease | glaucoma ethyl-2-(carbamoyloxy)benzoate Phase 1 ethylenediaminetetraacetic-acid Launched PKC inhibitor neurology/psychiatry metal toxicity ethylnorepinephrine Preclinical bronchodilator ethyl-paraben Preclinical ethyl pyruvate Phase 2 tnf production inhibitor HMGB1 | TNF gastroenterology pancreatitis ethyl-pyruvate Phase 2 tumor necrosis factor production inhibitor ethyl-vanillin Preclinical ethynodiol-diacetate Launched ESR1 | PGR endocrinology contraceptive ethynylcytidine Preclinical antimetabolite eticlopride Preclinical dopamine receptor antagonist DRD2 | DRD3 | DRD4 etidocaine Withdrawn sodium channel blocker A1BG neurology/psychiatry anesthetic etidronic-acid Launched bone resorption inhibitor ATP6V1A | FDPS | PTPRS endocrinology | orthopedics heterotopic ossification | Paget's disease etifenin Preclinical renal function diagnostic agent etifoxine Launched GABA receptor modulator GABRA1 | GABRA2 | GABRA3 | GABRA5 neurology/psychiatry anxiety etifoxine (hydrochloride) etilefrine Launched adrenergic receptor agonist ADRA1A | ADRB1 endocrinology | neurology/psychiatry | otolaryngology | otolaryngology | pulmonary common cold | cough suppressant | fever | headache | nasal congestion etilevodopa Phase 3 dopamine receptor agonist DDC | DRD3 etizolam Launched benzodiazepine receptor agonist GABRA1 | GABRA2 | GABRA3 | GABRA5 | PTAFR neurology/psychiatry | neurology/psychiatry anxiety | insomnia etodolac Launched cyclooxygenase inhibitor PTGS2 | TRPV1 rheumatology | rheumatology osteoarthritis | rheumatoid arthritis etofenamate Launched cyclooxygenase inhibitor PTGS1 | PTGS2 neurology/psychiatry | rheumatology joint pain | muscle pain etofibrate Launched PPAR receptor agonist LPL | PPARA endocrinology hypertriglyceridemia etofylline Launched adenosine receptor antagonist ADORA1 pulmonary | pulmonary asthma | bronchitis etofylline-clofibrate Launched platelet aggregation inhibitor LPL | PPARA endocrinology hyperlipidemia etomidate Launched GABA receptor modulator ADRA2B | GABRA1 | GABRA2 | GABRA3 | GABRA4 | GABRA5 | GABRA6 | GABRB1 | GABRB2 | GABRB3 | GABRD | GABRE | GABRG1 | GABRG2 | GABRG3 | GABRP | GABRQ neurology/psychiatry general anaesthetic etomoxir Phase 2 carnitine palmitoyltransferase inhibitor CPT1A | CPT1B etonogestrel Launched progesterone receptor agonist CYP2C19 | ESR1 | PGR endocrinology contraceptive etoposide Launched topoisomerase inhibitor CYP2E1 | CYP3A5 | TOP2A | TOP2B oncology non-small cell lung cancer (NSCLC) etoposide-phosphate Launched topoisomerase inhibitor TOP2A oncology | oncology small cell lung cancer | testicular carcinoma etoricoxib Launched cyclooxygenase inhibitor PTGS2 rheumatology | rheumatology | rheumatology | rheumatology | rheumatology ankylosing spondylitis | gout | osteoarthritis | psoriatic arthritis | rheumatoid arthritis etosalamide Preclinical anti-inflammatory agent etoxybamide Phase 2 ETP-45658 Preclinical PI3K inhibitor PIK3CA | PIK3CB | PIK3CD | PIK3CG ETP-46464 Preclinical ATR kinase inhibitor etrabamine Phase 2 dopamine receptor agonist DRD2 etrasimod Phase 3 sphingosine 1-phosphate receptor antagonist S1PR1 etravirine Launched non-nucleoside reverse transcriptase inhibitor CYP2C19 | CYP2C9 | CYP3A4 infectious disease human immunodeficiency virus (HIV-1) etretinate Withdrawn protein synthesis inhibitor RARA | RXRG etripamil Phase 2 calcium channel blocker CACNA1C cardiology ventricular tachycardia (vt) eucalyptol Launched acetylcholinesterase inhibitor ACHE dental gingivitis eucatropine Preclinical acetylcholine receptor antagonist eugenol Launched androgen receptor antagonist AR | MAOA dental toothache EUK-134 Preclinical catalase stimulant APP | CAT | SOD2 eupatilin Launched mucus protecting agent evacetrapib Phase 3 cholesteryl ester transfer protein inhibitor CETP evans-blue Launched glutamate receptor negative allosteric modulator ENPP2 | GRIA1 | PTPN1 evatanepag Phase 2 prostaglandin inhibitor PTGER2 | PTGER4 evenamide Phase 2 voltage-gated sodium channel blocker SCN10A | SCN3A | SCN9A everolimus Launched mTOR inhibitor CYP3A5 | FKBP1A | MTOR genetics | neurology/psychiatry | oncology | oncology | oncology | urology breast cancer | neuroendocrine tumors of pancreatic origin (PNET) | renal angiomyolipoma | renal cell carcinoma (RCC) | subependymal giant cell astrocytoma (SEGA) | tuberous sclerosis complex (TSC) evobrutinib Phase 2 Bruton's tyrosine kinase (BTK) inhibitor BTK evocalcet Phase 3 calcium sensitizer CASR evodiamine Preclinical ATPase inhibitor | TRPV agonist TRPV1 evogliptin Phase 1 dipeptidyl peptidase inhibitor DPP4 endocrinology diabetes mellitus EVP4593 Preclinical NFkB pathway inhibitor EVP-6124 Phase 3 acetylcholine receptor agonist CHRNA7 EW-7197 Phase 2 TGF beta receptor inhibitor ACVR1B | TGFBR1 EX-527 Phase 2 SIRT inhibitor SIRT1 exalamide Launched membrane permeability inhibitor examorelin Phase 2 growth hormone releasing factor agonist GH1 | GHRHR | GHSR exatecan-mesylate Phase 3 topoisomerase inhibitor TOP1 exemestane Launched aromatase inhibitor CYP19A1 oncology breast cancer exenatide Launched GLP receptor agonist GCG | GLP1R | INS endocrinology diabetes mellitus exendin-4 Launched glp receptor agonist GLP1R endocrinology diabetes mellitus exherin Phase 2 cadherin antagonist CDH2 exifone Withdrawn nootropic agent TYR exisulind Phase 3 phosphodiesterase inhibitor PDE2A | PDE5A EXO-1 Preclinical ARF inhibitor exo-IWR-1 Preclinical WNT signaling inhibitor negative control TNKS ezatiostat Phase 2 glutathione transferase inhibitor GSTP1 ezetimibe Launched "cholesterol inhibitor | cholesterol inhibitor, niemann-pick c1-like 1 protein antagonist | Niemann-Pick C1-like 1 protein antagonist" ANPEP | NPC1L1 | SOAT1 "endocrinology | endocrinology | endocrinology, metabolism | metabolism" "hypercholesterolemia | hyperlipidemia | hyperlipidemia, hypercholesterolemia, sitosterolemia | sitosterolemia" ezutromid Phase 2 utrophin enhancer UTRN F-11440 Phase 2 serotonin receptor agonist HTR1A F-16915 Preclinical KCNA5 F351 Phase 2 TGF beta receptor inhibitor TGFB1 fadrozole Launched aromatase inhibitor CYP11B1 | CYP19A1 oncology breast cancer fagomine Phase 2 glucosidase inhibitor GLB1 falecalcitriol Launched vitamin D receptor agonist VDR endocrinology hyperparathyroidism famciclovir Launched DNA polymerase inhibitor dental | infectious disease | infectious disease cold sore | genitial herpes | shingles famotidine Launched histamine receptor antagonist HRH2 gastroenterology heartburn famprofazone Preclinical cyclooxygenase inhibitor fananserin Phase 2 dopamine receptor antagonist | serotonin receptor antagonist DRD4 | HTR2A fanetizole Phase 3 neutrophil superoxide production fantofarone Preclinical calcium channel blocker CACNA1C | CACNA1D | CACNA1F | CACNA1S fapi-4 fibroblast activation protein inhibitor FAP oncology breast cancer farampator Preclinical ionotropic glutamate receptor agonist GRIA1 | GRIA2 | GRIA3 | GRIA4 farnesyl-thiosalicylic-acid-amide Phase 1 Ras GTPase inhibitor HRAS faropenem Launched lactamase inhibitor infectious disease | infectious disease | infectious disease | otolaryngology | pulmonary bronchitis | pneumonia | sinusitis | skin infections | urinary tract infections faropenem-medoxomil Launched lactamase inhibitor infectious disease | infectious disease | infectious disease | otolaryngology | pulmonary bronchitis | pneumonia | sinusitis | skin infections | urinary tract infections fasoracetam Preclinical GABA receptor antagonist GABBR1 | GABBR2 fasudil Launched rho associated kinase inhibitor PKIA | PRKACA | ROCK1 | ROCK2 neurology/psychiatry cerebral vasospasm favipiravir Phase 3 RNA polymerase inhibitor fce-22250 Phase 1 dna directed dna polymerase inhibitor FCE-22250 Phase 1 DNA directed DNA polymerase inhibitor fdcyd Phase 2 DNA methyltransferase inhibitor febantel Launched anthelmintic agent infectious disease gastrointestinal parasites febuprol Launched choleretic agent febuxostat Launched xanthine oxidase inhibitor XDH nephrology hyperuricemia fedovapagon Phase 2 vasopressin receptor agonist AVPR2 urology benign prostatic hyperplasia (bph) fedratinib Launched FLT3 inhibitor | JAK inhibitor BRD4 | FLT3 | JAK1 | JAK2 | JAK3 | RET | TYK2 hematologic malignancy myelofibrosis felbamate Launched glutamate receptor antagonist GRIN1 | GRIN2A | GRIN2B | GRIN2C | GRIN2D | GRIN3A | GRIN3B neurology/psychiatry epilepsy felbinac Launched cyclooxygenase inhibitor CTSL neurology/psychiatry | rheumatology muscle pain | rheumatoid arthritis felbinac-ethyl Launched cyclooxygenase inhibitor PTGS1 | PTGS2 felodipine Launched calcium channel blocker CACNA1C | CFTR cardiology angina pectoris | hypertension felypressin Preclinical vasopressin receptor agonist AVPR1A fenaclon Preclinical fenbendazole Launched tubulin polymerization inhibitor CYP2C19 | CYP2D6 | CYP2J2 | CYP3A4 | TUBB infectious disease | infectious disease gastrointestinal parasites | gastrointestinal roundworms fenbufen Launched cyclooxygenase inhibitor PTGS1 | PTGS2 neurology/psychiatry pain relief fenclonine-(+/-) Preclinical tryptophan hydroxylase inhibitor PAH | TPH1 | TPH2 fendiline Preclinical calcium channel blocker HTR2B fenebrutinib Phase 2 Bruton's tyrosine kinase (BTK) inhibitor BTK fenigam Launched benzodiazepine receptor agonist GABBR1 | GABBR2 neurology/psychiatry | neurology/psychiatry | neurology/psychiatry anxiety | depression | posttraumatic stress disorder fenipentol Launched choleretic agent gastroenterology bile stimulation fenobam Phase 2 glutamate receptor antagonist GRM5 fenofibrate Launched PPAR receptor agonist APOA1 | CYP2C19 | CYP2C8 | MMP25 | PPARA endocrinology | endocrinology hypercholesterolemia | hypertriglyceridemia fenofibric-acid Launched cytochrome P450 inhibitor CLCN1 | CYP2C19 | CYP2C8 | PPARA cardiology dyslipidemia fenoldopam Launched dopamine receptor agonist DRD1 | DRD4 cardiology hypertension fenoldopam hydrochloride Launched dopamine receptor agonist DRD1 | DRD4 Cardiovascular hypertension fenoprofen Launched prostaglandin inhibitor PTGS1 | SLC5A8 rheumatology | rheumatology | rheumatology "osteoarthritis | rheumatoid arthritis | rheumatoid arthritis, osteoarthritis" fenoterol Withdrawn adrenergic receptor agonist ADRB2 fenoterol hydrobromide Withdrawn adrenergic receptor agonist ADRB2 fenoverine Launched acetylcholine receptor antagonist CHRM1 | CHRM2 | CHRM3 | CHRM4 neurology/psychiatry spasms fenoxaprop-p-ethyl Preclinical NOS3 fenretinide Phase 3 apoptosis stimulant | retinoid receptor agonist CYP2C8 | CYP3A5 | RARA | RARG fenspiride Launched bronchodilator otolaryngology | otolaryngology | otolaryngology | otolaryngology | pulmonary asthma | laryngitis | otitis | rhinopharyngitis | sinusitis fenthion Launched cholinesterase inhibitor fentiazac Launched cyclooxygenase inhibitor PTGS1 | PTGS2 neurology/psychiatry | rheumatology joint pain | muscle pain fenticonazole Launched bacterial cell wall synthesis inhibitor infectious disease vulvovaginal candidiasis FERb-033 Preclinical EGFR inhibitor ERBB2 ferroquine Phase 2 antimalarial agent ferrostatin-1 Preclinical ferroptosis inhibitor ferulic-acid Phase 2 antioxidant CA1 | CA12 | CA14 | CA2 | CA4 | CA6 | CA9 fesoterodine Launched acetylcholine receptor antagonist CHRM1 | CHRM2 | CHRM3 | CHRM4 | CHRM5 urology urinary incontinence fevipiprant Phase 2 prostaglandin inhibitor PTGDR2 fexaramine Preclinical FXR agonist NR1H4 fexinidazole Phase 3 fexofenadine Launched histamine receptor antagonist HRH1 allergy | allergy allergic rhinitis | urticaria fezolinetant Phase 2 neurokinin receptor antagonist TACR3 FG-2216 Phase 2 hypoxia inducible factor prolyl hydroxylase inhibitor EGLN1 | EGLN2 | HIF1A FG-4592 Phase 3 hypoxia inducible factor prolyl hydroxylase inhibitor EGLN1 | EGLN2 | EGLN3 FG-7142 Preclinical GABA benzodiazepine site receptor inverse agonist FGIN-1-27 Preclinical inositol monophosphatase inhibitor TSPO FGIN-1-43 Preclinical benzodiazepine receptor agonist TSPO FH1 Preclinical hepatocyte function enhancer FH-535 Preclinical PPAR receptor antagonist | WNT signaling inhibitor PPARD | PPARG fiacitabine Phase 2 DNA synthesis inhibitor fidarestat Phase 3 aldose reductase inhibitor AKR1B1 fidaxomicin Launched RNA polymerase inhibitor gastroenterology diarrhea filanesib Phase 3 kinesin inhibitor | kinesin-like spindle protein inhibitor KIF11 filgotinib Phase 3 JAK inhibitor JAK1 | JAK2 | JAK3 | TYK2 filibuvir Phase 2 non-nucleoside reverse transcriptase inhibitor infectious disease hepatitis c fimasartan Launched angiotensin receptor antagonist AGTR1 cardiology | cardiology congestive heart failure | hypertension finafloxacin Launched bacterial DNA gyrase inhibitor infectious disease | pulmonary | pulmonary chronic obstructive pulmonary disease (COPD) | cystic fibrosis | intra-abdominal infections finasteride Launched 5 alpha reductase inhibitor AKR1D1 | AR | SRD5A1 | SRD5A2 endocrinology androgenetic alopecia finerenone Launched mineralocorticoid receptor antagonist NR3C2 nephrology chronic kidney disease (ckd) fingolimod Launched immunosuppressant | sphingosine 1-phosphate receptor agonist CYP2E1 | CYP4F2 | S1PR1 | S1PR3 | S1PR4 | S1PR5 | SPHK1 neurology/psychiatry multiple sclerosis fipexide Withdrawn psychoactive drug FIPI Preclinical phospholipase inhibitor PLD1 | PLD2 fipronil Launched chloride channel blocker | GABA gated chloride channel blocker infectious disease flea control firategrast Phase 2 integrin antagonist ITGA4 | ITGB1 | ITGB7 firocoxib Launched cyclooxygenase inhibitor PTGS2 rheumatology osteoarthritis firsocostat Phase 2 acetyl-CoA carboxylase inhibitor ACACA | ACACB fisetin Preclinical Aurora kinase inhibitor AKR1B1 | AURKB | CDK6 | FASN | SIRT1 fisogatinib Phase 1 fibroblast growth factor inhibitor FGFR4 FIT Preclinical opioid receptor agonist OPRD1 FK-3311 Phase 2 cyclooxygenase inhibitor PTGS2 FK-33-824 Phase 2 opioid receptor agonist OGFR | OPRM1 FK-409 Phase 2 guanylyl cyclase activator GUCY2D FK-866 Phase 2 niacinamide phosphoribosyltransferase inhibitor NAMPT | PARP1 FK-888 Phase 2 tachykinin antagonist TACR1 | TACR2 FK-962 Phase 2 somatostatin receptor agonist flavin-adenine-dinucleotide Preclinical ACAD8 | ACADM | ACADS | ACOX1 | AIFM1 | CYB5R1 | CYB5R3 | DAO | DLD | DPYD | ERO1LB | FDXR | GCDH | GFER | GSR | IL4I1 | IVD | MAOA | MAOB | NOS1 | NQO1 | NQO2 | POR | TXNRD1 | XDH flavoxate Launched acetylcholine receptor antagonist CHRM1 | CHRM2 urology | urology | urology | urology interstitial cystitis (IC) | prostatitis | urethritis | urinary incontinence flecainide Launched sodium channel blocker KCNA5 | KCNA7 | SCN5A cardiology | cardiology | cardiology atrial fibrillation (AF) | ventricular arrhythmias | ventricular tachycardia (VT) fleroxacin Launched topoisomerase inhibitor TOP2A gastroenterology | gastroenterology | infectious disease | infectious disease diarrhea | enteritis | gonorrhea | respiratory tract infections flesinoxan Preclinical serotonin receptor agonist HTR1A cardiology hypertension FLI-06 Preclinical notch signaling inhibitor flibanserin Launched serotonin receptor agonist DRD4 | HTR1A | HTR2A neurology/psychiatry hypoactive sexual desire disorder flindokalner Phase 3 potassium channel agonist KCNMA1 | KCNMB1 | KCNN4 | KCNQ2 | KCNQ4 | KCNQ5 floctafenine Launched cyclooxygenase inhibitor PTGS1 | PTGS2 neurology/psychiatry pain relief flopropione Launched serotonin receptor antagonist HTR1A neurology/psychiatry spasms florbetaben Launched beta amyloid plaque binder APP neurology/psychiatry alzheimer's disease florbetapir Launched beta amyloid plaque binder APP neurology/psychiatry alzheimer's disease florfenicol Launched protein synthesis inhibitor pulmonary bovine respiratory disease (BRD) florifenine Preclinical anti-inflammatory agent PTGS1 | PTGS2 flortaucipir f18 Launched pet imaging agent MAOA | MAOB | MAPT neurology/psychiatry alzheimer's disease flosequinan Withdrawn phosphodiesterase inhibitor PDE3A floxuridine Launched DNA synthesis inhibitor TYMS oncology colorectal cancer FLT3-IN-1 Preclinical FLT3 inhibitor FLT3 flubendazole Launched tubulin polymerization inhibitor TUBB infectious disease gastrointestinal parasites fluciclovine (18f) Launched pet imaging agent radiology pet imaging flucloxacillin Launched bacterial cell wall synthesis inhibitor dermatology | gastroenterology | infectious disease | infectious disease | infectious disease | infectious disease | infectious disease | otolaryngology | otolaryngology bacterial septicemia | eczema | endocarditis | enteritis | gram-positive bacterial infections | meningitis | pneumonia | sinusitis | tonsillitis fluconazole Launched sterol demethylase inhibitor CYP3A5 | CYP3A7 | CYP51A1 infectious disease | infectious disease esophageal candidiasis | meningitis flucytosine Launched other antifungal DNMT1 infectious disease | infectious disease | infectious disease | infectious disease bacterial septicemia | endocarditis | meningitis | urinary tract infections fludarabine Launched ribonucleotide reductase inhibitor ADA | DCK | POLA1 | RRM1 | RRM2 hematologic malignancy chronic lymphocytic leukemia (CLL) fludarabine-phosphate Launched ribonucleotide reductase inhibitor POLA1 | POLD1 | POLE | RRM1 | RRM2 | RRM2B hematologic malignancy chronic lymphocytic leukemia (CLL) fludrocortisone-acetate Launched NR3C2 endocrinology | endocrinology Addison's disease | adrenogenital syndrome fludroxycortide Launched glucocorticoid receptor agonist NR3C1 | SERPINA6 dermatology | infectious disease psoriasis | skin infections flufenamic-acid Preclinical chloride channel blocker AKR1C3 | ANO1 | AR | GJA1 | GJA10 | GJA3 | GJA4 | GJA5 | GJA8 | GJA9 | GJB1 | GJB2 | GJB3 | GJB4 | GJB5 | GJB6 | GJB7 | GJC1 | GJC2 | GJC3 | GJD2 | GJD3 | GJD4 | GJE1 | PANX1 | PANX2 | PANX3 | PKD2L1 | PTGS1 | PTGS2 | TRPC5 | TRPM2 | TRPM5 flumatinib Phase 3 Bcr-Abl kinase inhibitor ABL1 | BCR | PDGFRB flumazenil Launched benzodiazepine receptor antagonist GABRA1 | GABRA2 | GABRA3 | GABRA4 | GABRA5 | GABRA6 | GABRB1 | GABRB2 | GABRB3 | GABRD | GABRE | GABRG1 | GABRG2 | GABRG3 | GABRP | GABRQ neurology/psychiatry sedative flumecinol Launched flumequine Launched topoisomerase inhibitor infectious disease urinary tract infections flumethasone Launched glucocorticoid receptor agonist NR3C1 | PLA2G1B dermatology | infectious disease | otolaryngology corticosteroid-responsive dermatoses | ear infections | otitis flumethasone pivalate Launched glucocorticoid receptor agonist NR3C1 Dermatology dermatitis flumethasone-pivalate Launched glucocorticoid receptor agonist NR3C1 | SERPINA6 allergy allergic rhinitis flumexadol Preclinical flunarizine Launched calcium channel blocker CACNA1G | CACNA1H | CACNA1I | CALM1 | CYP2J2 | HRH1 cardiology | neurology/psychiatry | neurology/psychiatry migraine headache | peripheral artery disease (PAD) | vertigo flunisolide Launched cytochrome P450 inhibitor NR3C1 allergy allergic rhinitis flunixin-meglumin Launched prostanoid receptor antagonist pulmonary bovine respiratory disease (BRD) fluocinolone-acetonide Launched glucocorticoid receptor agonist NR3C1 | SERPINA6 dermatology seborrheic dermatitis fluocinonide Launched glucocorticoid receptor agonist NR3C1 | SERPINA6 | SMO dermatology | dermatology eczema | seborrheic dermatitis fluorescein Launched SLC22A6 ophthalmology ophthalmology diagnostic fluorofenidone Preclinical nadph oxidase inhibitor NOX1 pulmonary idiopathic pulmonary fibrosis (ipf) fluorometholone Launched glucocorticoid receptor agonist NR3C1 ophthalmology eye inflammation fluorometholone-acetate Launched NR3C1 ophthalmology eye inflammation fluorometholone(brd-a13133631) Launched glucocorticoid receptor agonist NR3C1 ophthalmology eye inflammation fluoromethylcholine Launched fluoxetine Launched selective serotonin reuptake inhibitor (SSRI) ANO1 | CYP2C19 | HTR2B | SLC6A4 neurology/psychiatry | neurology/psychiatry | neurology/psychiatry | neurology/psychiatry | neurology/psychiatry bipolar disorder | bulimia nervosa | depression | obsessive compulsive disorder (OCD) | panic disorders fluoxetine hydrochloride Launched serotonin transporter (sert) inhibitor SCN10A | SCN11A | SCN1A | SCN2A | SCN3A | SCN5A | SCN7A | SCN8A | SCN9A | SLC6A4 Neurology depression flupentixol Launched dopamine receptor antagonist ADRA1A | CHRM1 | DRD1 | DRD2 | DRD3 | DRD5 | HTR2A neurology/psychiatry | neurology/psychiatry depression | schizophrenia fluphenazine Launched dopamine receptor antagonist CALM1 | CHRNA7 | DRD1 | DRD2 | DRD5 | HRH1 | HTR2A | HTR6 | HTR7 neurology/psychiatry schizophrenia fluphenazine-decanoate Launched dopamine receptor antagonist DRD2 | HTR1B | HTR4 neurology/psychiatry schizophrenia flupirtine Launched glutamate receptor antagonist ADRA2A | KCNQ1 | KCNQ2 | KCNQ3 neurology/psychiatry pain relief fluprazine Phase 1 serotonin receptor agonist HTR1A | HTR1B fluprednisolone Withdrawn glucocorticoid receptor agonist NR3C1 ophthalmology contact dermatitis fluralaner Launched gaba gated chloride channel blocker | GABA receptor antagonist CLCN1 | GABRA1 | GABRB1 | GABRD infectious disease mites flurandrenolide Launched glucocorticoid receptor agonist NR3C1 | SERPINA6 "nephrology | nephrology, infectious disease, dermatology" "chronic kidney disease (ckd) | chronic kidney disease (ckd), skin infections, psoriasis" flurbiprofen-(+/-) Launched cyclooxygenase inhibitor PTGS1 | PTGS2 rheumatology | rheumatology osteoarthritis | rheumatoid arthritis flurbiprofen-axetil Launched analgesic agent PTGS1 | PTGS2 flurbiprofen-(S)-(+) Launched cyclooxygenase inhibitor PTGS1 | PTGS2 rheumatology | rheumatology osteoarthritis | rheumatoid arthritis flurizan Phase 3 gamma secretase inhibitor APH1B | BACE1 | IKBKG | PSEN1 | PSEN2 | PTGS1 | PTGS2 flurofamide Preclinical urease inhibitor flurothyl Preclinical fluroxene Preclinical local anesthetic fluspirilene Launched dopamine receptor antagonist CACNG1 | DRD2 | HRH1 | HTR1A | HTR1D | HTR1E | HTR2A neurology/psychiatry schizophrenia flutamide Launched androgen receptor antagonist AHR | AR | CYP2C19 oncology prostate cancer flutemetamol Launched pet imaging agent APP neurology/psychiatry alzheimer's disease fluticasone furoate Launched glucocorticoid receptor agonist NR3C1 | NR3C2 | PGR pulmonary asthma fluticasone propionate Launched glucocorticoid receptor agonist NR3C1 | NR3C2 | PGR | PLA2G4A dermatology corticosteroid-responsive dermatoses fluticasone-propionate Launched glucocorticoid receptor agonist CYP3A5 | CYP3A7 | NR3C1 | NR3C2 | PGR | PLA2G4A dermatology corticosteroid-responsive dermatoses flutrimazole Launched sterol demethylase inhibitor infectious disease mycosis fluvastatin Launched HMGCR inhibitor CYP2C8 | HMGCR cardiology | endocrinology congenital heart defects | hypercholesterolemia fluvoxamine Launched selective serotonin reuptake inhibitor (SSRI) CYP2C19 | SLC6A4 neurology/psychiatry obsessive compulsive disorder (OCD) fmoc-L-leucine Phase 2 PPAR receptor agonist FN-1501 Phase 1 tyrosine kinase inhibitor CDk2 | CDK4 | CDK6 | FLT3 folic-acid Launched folate receptor ligand FOLR2 | FOLR3 | SLC19A1 | SLC46A1 hematology megaloblastic anemia foliglurax (monohydrochloride) glutamate receptor modulator GRM4 neurology/psychiatry parkinson's disease fomepizole Launched alcohol dehydrogenase inhibitor ADH1A | ADH1B | ADH1C | AKR1A1 | CAT critical care poison antidote fomocaine Launched voltage-gated sodium channel modulator neurology/psychiatry local anesthetic fondaparinux Launched coagulation factor inhibitor F10 | SERPINC1 hematology deep vein thrombosis (DVT) foretinib Phase 2 VEGFR inhibitor AXL | FLT1 | FLT3 | FLT4 | KDR | KIT | MET | MST1R | TEK formestane Launched aromatase inhibitor CYP19A1 oncology breast cancer formononetin Preclinical alcohol dehydrogenase inhibitor ADH1C | SLC5A2 formoterol Launched adrenergic receptor agonist ADRB2 | CYP2C19 pulmonary | pulmonary | pulmonary asthma | bronchospasm | chronic obstructive pulmonary disease (COPD) forodesine Launched purinergic receptor antagonist PNP hematologic malignancy peripheral T-cell lymphoma (PTCL) foropafant Phase 3 platelet activating factor receptor antagonist PTAFR forskolin Launched adenylyl cyclase activator ADCY2 | ADCY5 | GNAS fosamprenavir Launched HIV protease inhibitor infectious disease human immunodeficiency virus (HIV-1) fosaprepitant-dimeglumine Launched tachykinin antagonist TACR1 gastroenterology | gastroenterology nausea | vomiting fosbretabulin Phase 3 "tubulin polymerization inhibitor | tubulin polymerization inhibitor, ve-cadherin antagonist | VE-cadherin antagonist" CDH5 foscarnet Launched DNA polymerase inhibitor infectious disease | infectious disease | infectious disease acquired immunodeficiency syndrome (AIDS) | cytomegalovirus retinitis | virus herpes simplex (HSV) foscenvivint Phase 1/Phase 2 wnt signaling inhibitor CCND1 | CTNNB1 oncology hepatocellular carcinoma (hcc) fosdagrocorat Phase 2 glucocorticoid receptor agonist NR3C1 rheumatology rheumatoid arthritis fosfestrol Launched synthetic estrogen ESR1 | ESR2 oncology prostate cancer fosfluconazole Preclinical other antifungal fosfomycin Launched bacterial cell wall synthesis inhibitor infectious disease urinary tract infections fosfomycin calcium Launched bacterial cell wall synthesis inhibitor infectious disease urinary tract infections fosfosal Launched phosphodiesterase inhibitor PDE4A | PDE4B | PDE4C | PDE4D | PTGS1 | PTGS2 neurology/psychiatry pain relief fosfructose Phase 3 fructose diphosphate stimulant fosifloxuridine nafalbenamide Phase 1 thymidylate synthase inhibitor TYMS oncology colorectal cancer fosinopril Launched angiotensin converting enzyme inhibitor ABCG2 | ACE cardiology | cardiology congestive heart failure | hypertension fosinoprilat Launched angiotensin converting enzyme inhibitor ACE cardiology hypertension foslinanib Phase 2 anticancer agent oncology neuroendocrine tumors of pancreatic origin (pnet) fosphenytoin Launched sodium channel blocker CYP2C19 | SCN1A | SCN3A | SCN5A neurology/psychiatry | neurology/psychiatry epilepsy | seizures fostamatinib Launched SYK inhibitor FLT3 | SYK hematology chronic immune thrombocytopenia (ITP) fostemsavir Phase 3 antiviral fotemustine Launched thioredoxin inhibitor oncology melanoma foxy-5 Phase 2 WNT5a peptide mimetic WNT5A fpa-124 Preclinical apoptosis stimulant FPA-124 Preclinical AKT inhibitor FPH1-(BRD-6125) Preclinical hepatocyte function enhancer FPL-12495 Phase 1 glutamate receptor antagonist FPL-55712 Phase 1 leukotriene receptor antagonist FPL-62064 Phase 2 cyclooxygenase inhibitor | lipoxygenase inhibitor FPL-64176 Preclinical calcium channel activator CACNA1C | CACNA1S FPS-ZM1 Preclinical RAGE receptor antagonist AGER FR-122047 Preclinical cyclooxygenase inhibitor FR-139317 Phase 1 endothelin receptor antagonist EDNRA FR-180204 Preclinical MAP kinase inhibitor MAPK1 | MAPK3 frakefamide Phase 2 opioid receptor agonist OPRD1 neurology/psychiatry depression FRAX486 Preclinical serine/threonine kinase inhibitor PAK1 | PAK2 | PAK3 | PAK4 frentizole Phase 1 immunosuppressant freselestat Preclinical elastase inhibitor CELA1 | ELANE frovatriptan Launched serotonin receptor agonist HTR1A | HTR1B | HTR1D neurology/psychiatry migraine headache fructose fruquintinib Launched VEGFR inhibitor KDR oncology colorectal cancer FT011 Preclinical TGF beta receptor inhibitor TGFB1 ftaxilide Preclinical ftorafur Launched thymidylate synthase inhibitor TYMS oncology colorectal cancer fucoxanthin Phase 2 anticancer agent fudosteine Launched mucolytic agent pulmonary chest congestion fulacimstat Phase 2 chymotrypsin inhibitor CTRL endocrinology diabetes mellitus fulvestrant Launched estrogen receptor antagonist EPHX2 | ESR1 | ESR2 | GPER1 oncology breast cancer fumagillin Launched methionine aminopeptidase inhibitor METAP2 infectious disease | Infectious disease fungal infection | microsporidiosis fumonisin-B1 Preclinical CERS1 | CERS2 | CERS3 | CERS4 | CERS5 | CERS6 funapide Preclinical sodium channel blocker SCN9A furagin Preclinical antibacterial furaltadone Launched bacterial DNA inhibitor infectious disease gram-negative bacterial infections furaltadone hcl Launched bacterial dna inhibitor infectious disease gram-negative bacterial infections furamidine Preclinical protein arginine N-methyltransferase inhibitor PRMT1 furazolidone Launched bacterial DNA inhibitor gastroenterology | gastroenterology | infectious disease cholera | diarrhea | enteritis furegrelate Phase 1 thromboxane synthase inhibitor TBXAS1 furosemide Launched diuretic CA2 | GPR35 | SLC12A1 | SLC12A2 cardiology | cardiology | cardiology | rheumatology congestive heart failure | edema | hypertension | nephrotic syndrome furprofen prostagladin inhibitor PTGS2 neurology/psychiatry pain relief fursultiamine Launched vitamin B metabolism thiamine deficiency furvina Preclinical quorum sensing signaling inhibitor fusidic acid Launched bacterial 30s ribosomal subunit inhibitor dermatology acne vulgaris (av) fusidic-acid Launched bacterial 30S ribosomal subunit inhibitor dermatology acne vulgaris (AV) futibatinib Phase 3 FGFR inhibitor FGF2 | FGFR1 G007-LK Preclinical tankyrase inhibitor TNKS | TNKS2 G-1 Preclinical G protein-coupled receptor agonist GPER1 G-15 Preclinical estrogen receptor antagonist GPER1 G-749 Preclinical tyrosine kinase inhibitor FLT3 GABA-linoleamide Phase 2 benzodiazepine receptor agonist gabapentin Launched calcium channel blocker ADORA1 | CACNA1A | CACNA1B | CACNA1C | CACNA1D | CACNA1E | CACNA1F | CACNA1G | CACNA1H | CACNA1I | CACNA1S | CACNA2D1 | CACNA2D2 | CACNA2D3 | CACNA2D4 | CACNB1 | CACNB2 | CACNB3 | CACNB4 | CACNG1 | CACNG2 | CACNG3 | CACNG4 | CACNG5 | CACNG6 | CACNG7 | CACNG8 | GRIN1 | GRIN2A | GRIN2B | GRIN2C | GRIN2D | GRIN3A | GRIN3B infectious disease | infectious disease | neurology/psychiatry | neurology/psychiatry restless leg syndrome | seizures | shingles | virus herpes simplex (HSV) gabapentin-enacarbil Launched adrenergic receptor agonist CACNA1G | CACNA2D1 | CACNA2D2 | SLC22A2 neurology/psychiatry | neurology/psychiatry postherpetic neuralgia | restless leg syndrome gabazine Preclinical GABA receptor antagonist GABRA1 | GABRA2 | GABRA3 | GABRA4 | GABRA5 | GABRA6 | GABRG2 gabexate Launched serine protease inhibitor PRSS1 | TPSAB1 gastroenterology pancreatitis gaboxadol Phase 3 benzodiazepine receptor agonist GABRA1 | GABRA2 | GABRA3 | GABRA4 | GABRA5 | GABRA6 | GABRD | GABRR1 | GABRR2 | GABRR3 gadobutrol Launched radiopaque medium radiology MRI contrast agent gadodiamide Launched radiopaque medium radiology MRI contrast agent gadopentetic-acid Launched contrast agent PGD radiology contrast agent gadoterate-meglumine Launched radiopaque medium radiology MRI contrast agent gadoteridol Launched radiopaque medium radiology MRI contrast agent gadoxetate disodium Launched contrast agent radiology mri contrast agent GAL-021 Preclinical calcium channel blocker KCNMA1 galantamine Launched acetylcholinesterase inhibitor ACHE | BCHE | CHRNA1 | CHRNA10 | CHRNA2 | CHRNA3 | CHRNA4 | CHRNA5 | CHRNA6 | CHRNA7 | CHRNA9 | CHRNB1 | CHRNB2 | CHRNB3 | CHRNB4 | CHRND | CHRNE | CHRNG neurology/psychiatry senile dementia galeterone Phase 3 androgen receptor modulator AR | CYP17A1 galidesivir Phase 1 antiviral gallamine-triethiodide Launched acetylcholine receptor antagonist CHRM2 | CHRNA1 neurology/psychiatry muscle relaxant gallic-acid Preclinical beta amyloid protein neurotoxicity inhibitor | PPAR receptor agonist APP | CA1 | CA12 | CA14 | CA2 | CA4 | CA6 | CA9 | PPARG | SELP gallium-triquinolin-8-olate Phase 1 gallopamil Launched L-type calcium channel blocker ATP2A2 | CACNA1C cardiology | cardiology cardiac arrythmia | hypertension gambogic-acid Phase 2 caspase activator BCL2 | TOP2A gamithromycin Preclinical antibacterial gamma-aminobutyric-acid Preclinical benzodiazepine receptor agonist GABBR1 | GABBR2 | GABRA1 | GABRA2 | GABRA3 | GABRA5 | GABRB2 | GABRG2 | GATM | KCTD12 | KCTD16 | KCTD8 | SLC6A1 gamma-linolenic-acid Phase 2 cyclooxygenase inhibitor | prostanoid receptor agonist PTGS1 | PTGS2 | TBXAS1 ganaxolone Phase 3 GABA receptor modulator GABRA1 | GABRA2 | GABRA3 | GABRA4 | GABRA5 | GABRA6 ganciclovir Launched DNA polymerase inhibitor infectious disease cytomegalovirus (CMV) ganetespib Phase 3 HSP inhibitor HSP90AA1 | WT1 ganoderic-acid-a Preclinical JAK inhibitor GANT-58 Preclinical GLI antagonist DHH | GLI1 | IHH GANT-61 Preclinical GLI antagonist DHH | GLI1 | GLI2 | IHH garenoxacin Launched topoisomerase inhibitor TOP2A infectious disease respiratory tract infections gastrodin Phase 2 gatifloxacin Withdrawn bacterial DNA gyrase inhibitor gavestinel Phase 3 glutamate receptor antagonist GLRB | GRIN1 | GRIN2A | GRIN2B | GRIN2C | GRIN2D | GRIN3A | GRIN3B gavorestat aldose reductase inhibitor AKR1B1 GBR-12783 Preclinical dopamine reuptake inhibitor GBR-12935 Preclinical dopamine reuptake inhibitor AGTR1 | SLC6A3 GBR-13069 Preclinical dopamine reuptake inhibitor SLC6A3 g-caryophyllene Preclinical acetylcholinesterase inhibitor ACHE GDC-0068 Phase 3 AKT inhibitor AKT1 | AKT2 | AKT3 | CYP3A5 | PRKG1 GDC-0077 Phase 1 PI3K inhibitor PIK3CA GDC-0084 Phase 2 mTOR inhibitor | PI3K inhibitor MTOR | PIK3CA | PIK3CB | PIK3CD | PIK3CG GDC-0152 Phase 1 XIAP inhibitor BIRC2 | BIRC3 | BIRC7 | XIAP GDC-0349 Phase 1 Pim kinase inhibitor PIK3CA | PIM3 GDC-0575 Phase 1 CHK inhibitor CHEK1 GDC-0623 Phase 1 MEK inhibitor GDC-0810 Phase 2 selective estrogen receptor destabilizer ESR1 GDC-0834 Phase 1 Bruton's tyrosine kinase (BTK) inhibitor BTK GDC-0879 Preclinical RAF inhibitor BRAF GDC-0927 Phase 1 estrogen receptor antagonist ESR1 | ESR2 GDC-0941 Phase 2 PI3K inhibitor PIK3CA | PIK3CB | PIK3CD | PIK3CG GDC-0980 Phase 2 mTOR inhibitor | PI3K inhibitor FGR | MAP3K9 | MTOR | PIK3CA | PIK3CB | PIK3CD | PIK3CG | SYK GDC-0994 Phase 1 MAP kinase inhibitor MAPK1 | MAPK3 gedunin Preclinical HSP inhibitor HSP90AA1 gefapixant Phase 3 purinergic receptor antagonist P2RX3 gefitinib Launched EGFR inhibitor CYP2C19 | EGFR oncology non-small cell lung cancer (NSCLC) geldanamycin Preclinical HSP inhibitor HSP90AA1 gemcabene Phase 2 ppar receptor agonist APOB | LPA | PCSK9 | PPARA | PPARG endocrinology hypercholesterolemia gemcadiol Phase 2 antilipemic gemcitabine Launched ribonucleotide reductase inhibitor CMPK1 | RRM1 | RRM2 | TYMS oncology | oncology | oncology | oncology breast cancer | non-small cell lung cancer (NSCLC) | ovarian cancer | pancreatic cancer gemcitabine-elaidate Phase 1 apoptosis inhibitor | DNA synthesis inhibitor CMPK1 | RRM1 | TYMS gemfibrozil Launched lipoprotein lipase activator CYP2C8 | LPL | PPARA | SLCO1B1 | SLCO1B3 | SLCO2B1 cardiology | endocrinology coronary heart disease | hyperlipidemia gemifloxacin Launched bacterial DNA gyrase inhibitor infectious disease | pulmonary bronchitis | pneumonia gemigliptin Launched dipeptidyl peptidase inhibitor DPP4 gemilukast Phase 2 leukotriene receptor antagonist CYSLTR1 | CYSLTR2 pulmonary asthma genipin Preclinical choleretic agent geniposide Preclinical GLP receptor agonist GLP1R geniposidic-acid Preclinical cyclooxygenase inhibitor genistein Phase 2/Phase 3 tyrosine kinase inhibitor CFTR | EGFR | ESR1 | ESR2 | ESRRA | ESRRB | ESRRG | NCOA1 | NCOA2 | PPARG | PTK2B | TOP2A | TRPC5 gentamicin Launched bacterial 30s ribosomal subunit inhibitor Infectious disease gram-negative bacterial infections gentamycin Launched bacterial 50S ribosomal subunit inhibitor HSPA8 critical care | infectious disease | infectious disease | infectious disease | infectious disease | infectious disease | infectious disease bone and joint infections | endocarditis | meningitis | pelvic inflammatory disease | pneumonia | sepsis | urinary tract infections gentiopicrin Phase 3 glutamate receptor downregulator GRIN2B | SRD5A2 genz-123346 Preclinical glucosylceramidase inhibitor UGCG genz-644282 Phase 1 topoisomerase inhibitor TOP1 gepefrine Launched adrenergic receptor agonist cardiology hypotension gepon Phase 1 gepotidacin Phase 2 topoisomerase inhibitor TOP2A geranyl-farnesylacetate Phase 2 mucin production enhancer gestodene Launched contraceptive agent endocrinology contraceptive gestrinone Launched progesterone receptor antagonist AR | ESR1 | PGR obstetrics/gynecology endometriosis GF109203X Preclinical PKC inhibitor CCND1 | CDK4 | LRRK2 | PDPK1 | PIM1 | PRKCI | PRKCZ GGsTop Preclinical gamma glutamyltransferase Inhibitor GGT1 GGTI-298 Preclinical GGTase inhibitor CDKN1A gilteritinib Launched FLT3 inhibitor FLT3 gimeracil Launched dihydropyrimidine dehydrogenase inhibitor DPYD oncology gastric adenocarcinoma ginkgolide-A Preclinical GABA receptor antagonist APP | GLRA1 | GLRB ginkgolide-B Phase 3 platelet activating factor receptor antagonist GLRA1 | GLRA2 | GLRA3 | GLRB | HTR3A | HTR3B | PTAFR ginsenoside-C-K Phase 1 NFkB pathway inhibitor | nitric oxide synthase inhibitor CASP3 | NR3C1 | PTGS2 ginsenoside rd Phase 3 apoptosis stimulant Immunology immunostimulant ginsenoside-RD Phase 3 calcium channel blocker ginsenoside-RE Phase 1 anti-inflammatory agent MAPK8 | NFKB1 | NFKB2 | REL | RELA | RELB ginsenoside-re3 antiamyloidogenic agent CHRNA9 | KCNH2 | PI4K2A | PI4K2B | PI4KA | PI4KB | SIRT1 Neurology alzheimer's disease ginsenoside-RE3 Launched angiogenesis inhibitor | apoptosis stimulant KCNH2 | SCN2A ginsenoside rg1 Preclinical solute carrier family member inhibitor SLCO1B3 neurology/psychiatry alzheimer's disease ginsenoside rg3 Phase 2 givinostat Phase 3 HDAC inhibitor HDAC1 | HDAC2 | HDAC3 | HDAC4 | HDAC5 | HDAC6 | HDAC7 | HDAC8 | HDAC9 | IL1B | IL1R2 | IL6R | TNF GK921 Preclinical transglutaminase inhibitor TGM2 GKA-50 Preclinical glucokinase activator GCK GKT137831 Phase 2 NADPH oxidase inhibitor NOX1 | NOX4 glafenine Withdrawn "cystic fibrosis transmembrane conductance regulator inhibitor | DeltaF508-CFTR Correctors | deltaf508-cftr correctors, cystic fibrosis transmembrane conductance regulator inhibitor" CFTR Pulmonology pain relief glasdegib Launched hedgehog pathway inhibitor DHH | IHH | SMO hematologic malignancy acute myeloid leukemia (AML) glecaprevir Launched serine protease inhibitor NS3/4A infectious disease hepatitis C glesatinib Phase 2 tyrosine kinase inhibitor AXL | FLT1 | FLT4 | KDR | MET | MST1R | TEK gliclazide Launched ATP channel blocker | insulin secretagogue ABCC8 | KCNJ11 endocrinology diabetes mellitus glimepiride Launched insulin secretagogue ABCC8 | KCNJ1 | KCNJ11 endocrinology diabetes mellitus glipizide Launched sulfonylurea ABCC8 | KCNJ10 | KCNJ11 | PPARG endocrinology | endocrinology diabetes mellitus | hyperglycemia gliquidone Launched sulfonylurea ABCC8 | KCNJ10 | KCNJ11 | KCNJ8 endocrinology diabetes mellitus Gln-1062 Preclinical cholinesterase inhibitor ACHE | BCHE GLPG0187 Phase 1 integrin antagonist ITGA1 | ITGB1 GLPG0492 Phase 1 androgen receptor modulator AR GLPG0492-R-enantiomer Phase 1 androgen receptor modulator AR glpg0974 Phase 2 free fatty acid receptor antagonist FFAR2 gastroenterology ulcerative colitis GLPG1837 Phase 2 CFTR channel potentiator CFTR glucaric-acid Phase 1 gluconolactone Launched LCT glucosamine Launched glycosylated protein precursor IL1B neurology/psychiatry | neurology/psychiatry | rheumatology | rheumatology backache | joint pain | muscle pain | rheumatoid arthritis glutathione Phase 3 antioxidant ESD | GGT1 | GLO1 | GLRX | GLRX2 | GPX1 | GPX2 | GPX3 | GPX4 | GPX5 | GPX6 | GPX7 | GPX8 | GSR | GSS | GSTA1 | GSTA2 | GSTA3 | GSTA4 | GSTA5 | GSTK1 | GSTM1 | GSTM2 | GSTM3 | GSTM4 | GSTM5 | GSTO1 | GSTO2 | GSTP1 | GSTT1 | GSTZ1 | HAGH | HPGDS | LTC4S | MGST1 | MGST2 | MGST3 | TXNDC12 glutathione disulfide Launched glutathione reductase (nadph) activators GSR | GSTM2 | MGST1 ophthalmology ocular hypertension glutathione-monoisopropyl-ester Phase 2 lipid peroxidase inhibitor glyburide Launched ATP channel blocker | insulin secretagogue | sulfonylurea ABCA1 | ABCB11 | ABCC8 | ABCC9 | CFTR | CPT1A | KCNJ1 | KCNJ11 | KCNJ5 | KCNJ8 | SLCO2B1 | TRPA1 endocrinology | endocrinology diabetes mellitus | hyperglycemia glycerol-monolaurate Launched beta lactamase inhibitor glycerol-phenylbutyrate Phase 1 sigma receptor ligand CYP3A5 | TMEM97 glycitein Phase 3 tumor necrosis factor release inhibitor APP | IL1B | TNF glycol salicylate Launched prostaglandin inhibitor PTGS1 | PTGS2 neurology/psychiatry muscle pain glycopyrrolate Launched acetylcholine receptor antagonist CHRM1 | CHRM2 | CHRM3 | CHRM4 | CHRM5 gastroenterology peptic ulcer disease (PUD) gly-gln Phase 2 GM-1485 Preclinical immunophilin ligand FKBP1A GMX1778 Phase 1/Phase 2 NAMPT inhibitor NAMPT gne-477 Preclinical mtor inhibitor MTOR | PIK3CA oncology renal cell carcinoma (rcc) GNE-7915 Preclinical leucine rich repeat kinase inhibitor LRRK2 GNF-2 Preclinical Bcr-Abl kinase inhibitor ABL1 | BCR GNF-5 Preclinical Bcr-Abl kinase inhibitor ABL1 | BCR GNF-5837 Preclinical growth factor receptor inhibitor NTRK1 | NTRK2 | NTRK3 GNF-7 Preclinical glucokinase inhibitor | protein kinase inhibitor ABL1 | BCR | GCK | TNK2 GNTI Preclinical opioid receptor antagonist OPRK1 | OPRM1 go-6983 Preclinical protein kinase inhibitor PRKCA | PRKCB | PRKCD | PRKCG | PRKCZ golgicide-A Preclinical ARF inhibitor GBF1 golvatinib Phase 2 VEGFR inhibitor KDR | MET gonadorelin Launched gonadotropin releasing factor hormone receptor agonist GNRH1 | GNRHR obstetrics/gynecology | obstetrics/gynecology cystic ovaries | reproductive synchrony goserelin-acetate Launched gonadotropin releasing factor hormone receptor agonist GNRH1 | GNRHR | LHCGR obstetrics/gynecology | oncology | oncology breast cancer | endometriosis | prostate cancer gossypol Phase 2 BCL inhibitor | MCL1 inhibitor BCL2 | BCL2L1 | BCL2L2 | CTGF | EGF | MCL1 GP1a Preclinical cannabinoid receptor agonist CNR2 GP2a Preclinical cannabinoid receptor agonist CNR2 GPBAR-A Preclinical G protein-coupled receptor agonist GPBAR1 GPI-1046 Preclinical FKBP inhibitor FKBP1A GPi-688 Preclinical glycogen phosphorylase inhibitor GPP-78 Preclinical NAMPT inhibitor NAMPT GPR120-modulator-1 Preclinical G protein-coupled receptor modulator FFAR4 gprp (acetate) FGB | ITGA2B hematology thrombosis GR-103691 Preclinical dopamine receptor antagonist DRD3 GR-113808 Preclinical serotonin receptor antagonist HTR4 GR125487 Preclinical serotonin receptor antagonist HTR4 GR-127935 Preclinical serotonin receptor antagonist HTR1A | HTR1B | HTR1D | HTR1E | HTR1F | HTR2A | HTR2B | HTR2C | HTR6 GR-135531 Preclinical melatonin receptor agonist GR-144053 Preclinical integrin antagonist ITGA2B | ITGB3 GR-159897 Preclinical tachykinin antagonist TAC1 | TACR2 GR-235 Launched estrogen receptor agonist | FXR antagonist | progesterone receptor agonist ESR1 | IKBKB | NR1H4 | NR1I2 | PGR GR46611 Preclinical serotonin receptor agonist HTR1D GR-79236 Phase 1 adenosine receptor agonist ADORA1 | ADORA2A gramicidin Launched bacterial permeability inducer infectious disease first-aid antibiotic gramicidin (gramicidin a shown) Launched bacterial permeability inducer infectious disease first-aid antibiotic gramine Preclinical norepinephrine reputake inhibitor granisetron Launched serotonin receptor antagonist CYP3A5 | HTR3A gastroenterology | gastroenterology nausea | vomiting grapiprant Launched prostaglandin inhibitor PTGER4 rheumatology osteoarthritis grazoprevir Launched HCV inhibitor infectious disease hepatitis C grepafloxacin Withdrawn bacterial dna gyrase inhibitor infectious disease gonorrhea griseofulvin Launched tubulin polymerization inhibitor KRT12 infectious disease | infectious disease ringworm | tinea pedis GS-143 Preclinical ubiquitin ligase inhibitor BTRC | NFKBIA GS-39783 Preclinical GABA receptor modulator GABBR1 GS-6201 Phase 1 adenosine receptor antagonist ADORA1 | ADORA2A | ADORA2B | ADORA3 GS-9620 Phase 2 toll-like receptor agonist TLR7 GS-967 Preclinical voltage-gated sodium channel blocker SCN5A GS-9973 Phase 2 SYK inhibitor SYK GSK0660 Preclinical PPAR receptor antagonist PPARD GSK1059615 Phase 1 PI3K inhibitor PIK3CA | PIK3CG GSK1070916 Phase 1 Aurora kinase inhibitor AURKA | AURKB | AURKC | CYP2D6 | CYP3A4 GSK1292263 Phase 2 glucose dependent insulinotropic receptor agonist GPR119 | GRPR GSK1562590 Preclinical urotensin receptor antagonist UTS2R GSK163090 Phase 2 serotonin receptor antagonist HTR1A | HTR1B | HTR1D GSK1838705A Preclinical insulin growth factor receptor inhibitor ALK | IGF1R | INSR | RPS6KA1 GSK189254 Phase 2 histamine receptor antagonist HRH3 GSK1904529A Preclinical IGF-1 inhibitor | insulin growth factor receptor inhibitor | insulin receptor ligand IGF1R | INSR GSK2110183 Phase 2 AKT inhibitor AKT1 | AKT2 | AKT3 GSK2126458 Phase 1 mTOR inhibitor | PI3K inhibitor MTOR | PIK3CA | PIK3CB | PIK3CD | PIK3CG GSK2190915 Phase 2 lipoxygenase inhibitor ALOX5AP GSK2193874 Preclinical transient receptor potential channel antagonist TRPV4 GSK2194069 Preclinical fatty acid synthase inhibitor FASN GSK2239633A Preclinical CC chemokine receptor antagonist CCR4 gsk2245035 Phase 2 toll-like receptor agonist TLR7 pulmonary asthma GSK2256098 Phase 2 kinase inhibitor PTK2 GSK2256294A Phase 1 epoxide hydolase inhibitor EPHX2 GSK2330672 Phase 2 bile acid transporter inhibitor SLC10A2 GSK2334470 Preclinical phosphoinositide dependent kinase inhibitor AURKA | AURKB | PDPK1 GSK239512 Preclinical histamine receptor antagonist HRH3 GSK256066 Phase 2 phosphodiesterase inhibitor PDE4A | PDE4B | PDE4C | PDE4D GSK2578215A Preclinical leucine rich repeat kinase inhibitor LRRK2 GSK2606414 Preclinical protein kinase inhibitor EIF2AK3 | MYLK2 GSK2636771 Phase 2 PI3K inhibitor PIK3CB GSK2656157 Preclinical PERK inhibitor GSK269962 Preclinical rho associated kinase inhibitor ROCK1 | ROCK2 GSK2801 Preclinical bromodomain inhibitor BAZ2A | BAZ2B | ZNF215 GSK2816126 Phase 1 histone lysine methyltransferase inhibitor EZH2 GSK2830371 Preclinical protein phosphatase inhibitor PPM1D GSK2837808A Preclinical lactate dehydrogenase inhibitor LDHA GSK2838232 Phase 2 HIV gag inhibitor GSK2879552 Phase 1/Phase 2 histone lysine demethylase inhibitor KDM1A GSK2881078 Phase 2 androgen receptor modulator AR GSK2981278 Phase 1/Phase 2 ROR modulator RORC GSK2982772 Phase 2 RIPK inhibitor RIPK1 gsk2983559 (free acid) Phase 1 ripk inhibitor RIPK2 gastroenterology inflammatory bowel disease GSK3117391 Phase 1/Phase 2 HDAC inhibitor GSK3179106 Phase 1 RET tyrosine kinase inhibitor RET GSK3326595 Phase 1/Phase 2 protein arginine N-methyltransferase inhibitor PRMT5 GSK356278 Preclinical phosphodiesterase inhibitor PDE4A | PDE4B | PDE4C | PDE4D GSK369796 Phase 1 potassium channel antagonist KCNH2 GSK37647 Preclinical free fatty acid receptor agonist FFAR4 GSK3787 Preclinical PPAR receptor antagonist PPARD GSK-3-inhibitor-IX Preclinical glycogen synthase kinase inhibitor | lipoxygenase inhibitor ALOX5 | GSK3A | GSK3B GSK429286A Preclinical rho associated kinase inhibitor ROCK1 GSK461364 Phase 1 PLK inhibitor PLK1 GSK503 Preclinical histone lysine methyltransferase inhibitor EZH2 gsk-626616 Phase 1 dual specificity protein kinase inhibitor DYRK3 hematology anemia GSK650394 Preclinical serum/glucocorticoid regulated kinase inhibitor SGK1 | SGK2 GSK656 Preclinical leucyl-tRNA synthetase inhibitor LARS2 GSK690693 Phase 1 AKT inhibitor AKT1 | AKT2 | AKT3 | PAK4 | PAK6 | PAK7 | PRKCQ | PRKG1 | PRKX GSK9027 Preclinical glucocorticoid receptor agonist NR3C1 GSK923295 Phase 1 centromere associated protein inhibitor CENPE GSK-J1 Preclinical histone demethylase inhibitor KDM6A | KDM6B | TNF GSK-J2 Preclinical histone demethylase inhibitor GSK-J4 Preclinical histone lysine demethylase inhibitor KDM6A | KDM6B | TNF GSK-J5 Preclinical histone demethylase control GSK-LSD-1 Preclinical histone lysine demethylase inhibitor KDM1A GTP-14564 Preclinical FLT3 inhibitor | tyrosine kinase inhibitor CSF1R | FLT3 | KIT | PDGFRB GTS21 Phase 1/Phase 2 cholinergic receptor agonist CHRNA7 guacetisal Launched immunosuppressant pulmonary cough suppressant guadecitabine Phase 3 DNA methyltransferase inhibitor DNMT1 | DNMT3A | DNMT3B | DNMT3L guaiacol Launched local anesthetic CA2 pulmonary cough suppressant guaifenesin Launched expectorant pulmonary cough suppressant guanaben-acetate Launched adrenergic receptor agonist ADRA2A | ADRA2B | ADRA2C cardiology hypertension guanadrel Launched adrenergic inhibitor SLC6A2 cardiology hypertension guancydine Preclinical antihypertensive agent guanethidine Launched adrenergic inhibitor SLC6A2 cardiology hypertension guanfacine Launched adrenergic receptor agonist ADRA2A | ADRA2B | ADRA2C | CYP3A5 | HCN1 | HCN2 | HCN3 | HCN4 cardiology hypertension guanidine Launched HSP inhibitor ALDH2 | DLG4 | GAMT | RNASE1 neurology/psychiatry Lambert-Eaton myasthenic syndrome (LEMS) guanidinoethyldisulfide-bicarbonate Phase 2 nitric oxide synthase inhibitor NOS2 guanidinopropionic-acid Phase 2 creatine kinase inhibitor CKM guanosine Preclinical PNP Gue-1654 Preclinical oxoeicosanoid receptor modulator OXER1 guggulsterone Launched "estrogen receptor agonist, fxr antagonist, progesterone receptor agonist" NR1H4 gusacitinib Phase 2 jak inhibitor CLDN23 | IL13 | IL36G | JAK1 | SYK dermatology dermatitis guvacine Preclinical GABA uptake inhibitor SLC6A1 | SLC6A11 | SLC6A12 | SLC6A13 GW-0742 Preclinical PPAR receptor agonist INS | PPARD GW-1100 Preclinical G protein-coupled receptor agonist FFAR1 GW-1929 Preclinical PPAR receptor agonist INS | PPARG GW-2580 Preclinical cFMS kinase inhibitor CSF1R GW274150 Phase 2 nitric oxide synthase inhibitor NOS2 GW-311616 Phase 1 elastase inhibitor | leukocyte elastase inhibitor ELANE GW-3965 Preclinical LXR agonist ABCA1 | NR1H2 | NR1H3 GW-405833 Preclinical cannabinoid receptor agonist CNR2 GW-4064 Preclinical FXR agonist NR1H4 GW-438014A Preclinical neuropeptide receptor antagonist NPY5R GW-441756 Preclinical growth factor receptor inhibitor LRRK2 | NTRK1 GW-501516 Phase 2 PPAR receptor agonist INS | PPARA | PPARD GW-5074 Phase 1/Phase 2 leucine rich repeat kinase inhibitor | RAF inhibitor LRRK1 | LRRK2 | NTRK1 | RAF1 GW-542573X Preclinical calcium channel activator KCNN1 GW-583340 Preclinical EGFR inhibitor EGFR | ERBB2 GW-627368 Preclinical prostanoid receptor antagonist PTGER4 GW-6471 Preclinical PPAR receptor antagonist PPARA gw7604 Preclinical selective estrogen receptor destabilizer ESR1 oncology breast cancer GW-7647 Preclinical PPAR receptor agonist PPARA GW-788388 Preclinical ALK tyrosine kinase receptor inhibitor LCK | MAPK14 | TGFBR1 GW-803430 Phase 1 melanin inhibitor KCNH2 | MCHR1 GW-842166 Phase 2 cannabinoid receptor agonist CNR2 GW-843682X Preclinical PLK inhibitor PLK1 | PLK3 GW-9508 Preclinical free fatty acid receptor agonist | G protein-coupled receptor agonist FFAR1 | FFAR4 GW-9662 Preclinical PPAR receptor antagonist NCOA2 | PPARG | RXRA GYKI-52466 Preclinical glutamate receptor antagonist GRIA1 | GRIA2 | GRIA3 | GRIA4 gynostemma-extract Phase 2 calcium channel modulator GZD824 Preclinical Bcr-Abl kinase inhibitor ABL1 | BCR H-151 Preclinical STING antagonist TMEM173 H2L-5765834 Preclinical lysophosphatidic acid receptor antagonist LPAR1 | LPAR3 h3b-6527 Phase 1 fgfr inhibitor FGFR4 oncology hepatocellular carcinoma (hcc) H-89 Preclinical PKA inhibitor GSG2 | KCNA2 | KCNA3 | KCNA5 | KCNAB2 | KCNC1 | KCNC2 | KCNC3 | KCNE1 | KCNE2 | KCNE3 | KCNE4 | KCNH1 | KCNH2 | KCNQ1 | KCNQ2 | KCNQ3 | KCNQ5 | KCNS3 | PKIA | PRKACA HA-1004 Phase 2 calcium channel blocker HA-130 Preclinical autotaxin inhibitor ENPP2 ha14-1 Preclinical bcl inhibitor BCL2 Oncology acute myeloid leukemia (aml) HA14-1 Preclinical BCL inhibitor BCL2 HA-966-(R)-(+) Preclinical glutamate receptor agonist GRIA1 HA-966-(S)-(-) Preclinical glutamate receptor antagonist GRIA1 halazone Launched infectious disease disinfectant halcinonide Launched glucocorticoid receptor agonist NR3C1 dermatology corticosteroid-responsive dermatoses halobetasol propionate Launched glucocorticoid receptor agonist NR3C1 | PLA2G1B dermatology corticosteroid-responsive dermatoses halobetasol-propionate Launched glucocorticoid receptor agonist NR3C1 | PLA2G1B dermatology corticosteroid-responsive dermatoses halofantrine Launched antimalarial agent CYP3A5 | KCNN4 infectious disease malaria halofuginone Launched collagenase inhibitor COL1A1 | MMP2 rheumatology scleroderma halopemide Phase 2 phospholipase inhibitor PLD1 | PLD2 haloperidol Launched dopamine receptor antagonist CYP3A7 | DRD1 | DRD2 | DRD3 | DRD4 | DRD5 | GRIN2B | HRH1 | HTR1A | HTR1D | HTR2A | HTR2B | HTR7 | KCNH1 neurology/psychiatry | neurology/psychiatry schizophrenia | Tourette's disorder haloperidol-decanoate Launched psychoactive drug CYP1A1 | CYP1A2 | CYP2D6 | CYP3A4 | CYP3A7 | DRD2 | DRD3 | DRD4 | HTR2A neurology/psychiatry schizophrenia haloprogin Launched other antifungal infectious disease tinea pedis halothane Launched glutamate receptor antagonist CYP2E1 | GABRA1 | GABRA2 | GABRA3 | GABRA4 | GABRA5 | GABRA6 | GABRB1 | GABRB2 | GABRB3 | GABRD | GABRE | GABRG1 | GABRG2 | GABRG3 | GABRP | GABRQ | GLRA1 | GLRB | KCNK10 | KCNK12 | KCNK13 | KCNK15 | KCNK18 | KCNK2 | KCNK3 | KCNK9 neurology/psychiatry general anaesthetic harmane Preclinical monoamine oxidase inhibitor MAOA | MAOB harringtonine Phase 3 protein synthesis inhibitor HBED Phase 3 chelating agent HC-030031 Phase 1 TRPA1 channel blocker TRPA1 HC-067047 Preclinical transient receptor potential channel antagonist TRPV4 HC-070 Preclinical transient receptor potential channel antagonist TRPC4 | TRPC5 heclin Preclinical ubiquitin ligase inhibitor NEDD4 | SMURF2 | WWP1 HEMADO Preclinical adenosine receptor agonist ADORA1 | ADORA2A | ADORA2B | ADORA3 hematoporphyrin Launched neurology/psychiatry | neurology/psychiatry depression | psychosis hematoporphyrin (dihydrochloride) hematoxylin Preclinical hemin Phase 2 "enzyme inducer | heme oxygenase activators | heme oxygenase activators, enzyme inducer" HMOX1 | HMOX2 "cardiology | cardiology | hematology | Neurology | Neurology, hematology, cardiology" "acute intermittent porphyria (AIP) | hypertension | multiple sclerosis | multiple sclerosis, acute intermittent porphyria (aip), hypertension, ventricular tachycardia (vt) | ventricular tachycardia (VT)" hemomex-s Launched PPARG heparin (sodium salt) Withdrawn thrombin inhibitor SERPIND1 hepsulfam Preclinical DNA cross-linking heptaminol Launched vasoconstrictor cardiology hypotension HER2-Inhibitor-1 Preclinical EGFR inhibitor ERBB2 hesperadin Preclinical Aurora kinase inhibitor AURKB hesperetin Launched ACAT inhibitor CYP1B1 | DGAT1 | MTTP | SOAT1 | SOAT2 hesperidin Launched flavanone glycoside AURKB | CACNA1B hetacillin Withdrawn bacterial cell wall synthesis inhibitor | penicillin binding protein inhibitor Infectious disease | obstetrics/gynecology gram-positive bacterial infections | mastitis hetacillin potassium Withdrawn "bacterial cell wall synthesis inhibitor, penicillin binding protein inhibitor" "Infectious disease, obstetrics/gynecology" "gram-positive bacterial infections, mastitis" hexachlorophene Launched potassium channel activator ENPP2 | GLUD1 | SDHD infectious disease gram-positive bacterial infections hexafluronium bromide Withdrawn acetylcholinesterase inhibitor BCHE neurology/psychiatry muscle relaxant hexamethonium Preclinical cholinergic receptor antagonist CHRNA2 | CHRNA3 | CHRNA4 | CHRNA6 hexamethylenebisacetamide Phase 2 AKT inhibitor | differentiation inducer | NFKB pathway inhibitor AKT1 hexaminolevulinate Launched radiology diagnostic agent hexasodium-phytate Phase 2 hexestrol Launched synthetic estrogen AKR1C1 | ESR1 | ESR2 endocrinology hypoestrogenism hexetidine Launched local anesthetic dental | gastroenterology | infectious disease | otolaryngology | otolaryngology gingivitis | laryngitis | meningitis | pharyngitis | ulcerative colitis hexonic-acid Preclinical hexoprenaline Launched adrenergic receptor agonist ADRB2 pulmonary asthma hexylcaine Launched sodium channel blocker SCN5A neurology/psychiatry local anesthetic hexylene-glycol Preclinical AKR1C3 | CTPS1 | DLG4 | HSP90AA1 | NOS3 | PGF | PLA2G1B | PTPN1 | SELP hexylresorcinol Launched local anesthetic TYR infectious disease | infectious disease first-aid antiseptic | skin infections higenamine Phase 1 adrenergic receptor agonist ADRB2 h-ile-pro-pro-oh (hydrochloride) angiotensin converting enzyme inhibitor ACE cardiology hypertension hippuric-acid Preclinical histamine Launched histamine receptor agonist HRH1 | HRH2 | HRH3 | HRH4 | NOX3 allergy allergic rhinitis HJC-0350 Preclinical GTPase inhibitor RAPGEF4 HKI-357 Phase 1 EGFR inhibitor EGFR HLCL-61 Preclinical protein arginine N-methyltransferase inhibitor PRMT5 HM-30181 Phase 1 P glycoprotein inhibitor ABCB1 hmn-176 Phase 1 plk inhibitor NFYA | PLK1 oncology breast cancer HMN-214 Phase 1 PLK inhibitor PLK1 HOKU-81 Preclinical bronchodilator homatropine Launched acetylcholine receptor antagonist CHRM1 ophthalmology | ophthalmology pupil dilation | uveal tract inflammation homatropine methylbromide Launched acetylcholine receptor antagonist CHRM5 ophthalmology uveal tract inflammation homatropine-methylbromide Launched acetylcholine receptor antagonist CHRM5 ophthalmology uveal tract inflammation homidium Preclinical homochlorcyclizine Launched antihistamine HRH1 allergy allergic rhinitis homochlorcyclizine 2hcl Launched antihistamine HRH1 allergy allergic rhinitis homochlorcyclizine(brd-a22769835) Launched antihistamine HRH1 allergy allergic rhinitis homoharringtonine Launched protein synthesis inhibitor RPL3 hematologic malignancy chronic myeloid leukemia (CML) homoquinolinic-acid Preclinical glutamate receptor agonist GRIN1 | GRIN2A | GRIN2B | GRIN2C | GRIN2D homosalate Preclinical HSP inducer homoveratrylamine Preclinical monoamine oxidase inhibitor honokiol Phase 3 AKT inhibitor ALOX5 | PTGS1 | PTGS2 hordenine Preclinical HP-228 Preclinical nitric oxide synthase inhibitor NOS2 hPGDS-IN-1 Preclinical prostaglandin inhibitor HPGDS HPPH Phase 2 photosensitizing agent HQK-1001 Phase 2 HSR6071 Preclinical antiallergic agent HT-2157 Phase 1/Phase 2 galanin receptor 3 antagonist GALR3 HTH-01-015 Preclinical protein kinase inhibitor NUAK1 HTHQ Preclinical antioxidant HTMT Preclinical histamine receptor agonist HRH4 (-)-huperzine a Phase 2 acetylcholinesterase inhibitor ACHE huperzine-A Phase 2 acetylcholinesterase inhibitor ACHE h-val-pro-pro-oh (tfa) angiotensin converting enzyme inhibitor ACE cardiology hypertension hyaluronic-acid Launched C1QBP | CD44 | HABP2 | HAPLN1 | HAPLN3 | HAPLN4 | HMMR | ICAM1 | NCAN | VCAN rheumatology | urology interstitial cystitis (IC) | osteoarthritis hycanthone Launched RNA synthesis inhibitor infectious disease schistosomiasis hydralazine Launched myeloperoxidase inhibitor | vasodilator MPO cardiology hypertension "hydrastine-(1R,9S)" Preclinical tyrosine hydroxylase inhibitor hydrastinine Preclinical hemostatic agent hydrochlorothiazide Launched thiazide diuretic CA1 | CA12 | CA2 | CA4 | CA9 | KCNMA1 | SLC12A3 cardiology | cardiology congestive heart failure | hypertension hydrocortisone Launched glucocorticoid receptor agonist ANXA1 | NOS2 | NR3C1 | NR3C2 dermatology | dermatology | dermatology | neurology/psychiatry eczema | itching | psoriasis | seborrheic dermatitis hydrocortisone acetate Launched glucocorticoid receptor agonist NR3C1 dermatology corticosteroid-responsive dermatoses hydrocortisone-acetate Launched glucocorticoid receptor agonist NR3C1 dermatology corticosteroid-responsive dermatoses hydrocortisone buteprate Launched glucocorticoid receptor modulator ANXA1 | NR3C1 dermatology dermatosis hydrocortisone-butyrate Launched glucocorticoid receptor agonist NR3C1 dermatology | dermatology corticosteroid-responsive dermatoses | eczema hydrocortisone hemisuccinate Phase 2/Phase 3 hydrocortisone-hemisuccinate Phase 2/Phase 3 hydrocortisone-phosphate Launched gastroenterology | gastroenterology | gastroenterology | gastroenterology | hematologic malignancy | ophthalmology | pulmonary asthma | colitis | contact dermatitis | enteritis | multiple myeloma | nausea | vomiting hydrocortisone valerate Launched glucocorticoid receptor agonist NR3C1 dermatology corticosteroid-responsive dermatoses hydrocortisone-valerate Launched glucocorticoid receptor agonist NR3C1 dermatology corticosteroid-responsive dermatoses hydroflumethiazide Launched sodium/potassium/chloride transporter inhibitor ATP1A1 | CA1 | CA12 | CA2 | CA4 | CA9 | KCNMA1 | SLC12A1 | SLC12A3 cardiology | cardiology | cardiology | gastroenterology | nephrology | nephrology | rheumatology acute glomerulonephritis (AGN) | chronic renal failure | congestive heart failure | edema | hepatic cirrhosis | hypertension | nephrotic syndrome hydroquinidine Launched antiarrhythmic cardiology cardiac arrythmia hydroquinone Launched melanin inhibitor TYR dermatology dyschromia hydroxocobalamin Launched vitamin B hydroxyamphetamine Launched trace amine associated receptor agonist TAAR1 ophthalmology mydriasis hydroxychloroquine Launched antimalarial agent TLR7 | TLR9 infectious disease malaria hydroxychloroquine sulfate Launched angiotensin converting enzyme inhibitor ACE2 Infectious disease human immunodeficiency virus (hiv-1) hydroxyfasudil Preclinical rho associated kinase inhibitor PKIA | PRKACA | ROCK1 | ROCK2 hydroxyprogesterone Launched progesterone receptor agonist PGR obstetrics/gynecology spontaneous preterm birth hydroxyprogesterone-acetate Launched progesterone receptor agonist PGR | SRD5A1 | SRD5A2 hydroxyprogesterone caproate Launched progesterone receptor agonist AR | ESR1 | ESR2 | NR1H4 | NR1I2 | NR3C1 | PGR obstetrics/gynecology spontaneous preterm birth hydroxypropyl-beta-cyclodextrin Phase 2/Phase 3 hydroxysafflor-yellow-A Preclinical antitumor agent hydroxystilbamidine Launched "hydroxytacrine-maleate-(R,S)" Preclinical cholinesterase inhibitor ACHE hydroxytoluic-acid Preclinical hydroxytyrosol Phase 2/Phase 3 lipoxygenase inhibitor ALOX5 oncology breast cancer hydroxyurea Launched ribonucleotide reductase inhibitor RRM1 | RRM2 | RRM2B hematologic malignancy | oncology chronic myeloid leukemia (CML) | head and neck squamous cell carcinoma (HNSCC) hydroxyzine Launched antihistamine HRH1 allergy | dermatology | neurology/psychiatry | neurology/psychiatry anxiety | dermatosis | itching | urticaria hydroxyzine pamoate Launched antihistamine HRH1 "neurology/psychiatry, allergy, dermatology" "anxiety, urticaria, itching, dermatosis" hygromycin-B Preclinical polypeptide synthesis inhibitor hymecromone Phase 2 monoamine oxidase inhibitor MAOA | MAOB hyodeoxycholic-acid Phase 1 atherosclerosis formation inhibitor hyoscyamine Launched acetylcholine receptor antagonist CHRM1 | CHRM2 | CHRM3 | CHRM4 allergy | gastroenterology | gastroenterology | gastroenterology | gastroenterology | gastroenterology | neurology/psychiatry | urology acute abdominal visceral spasm | allergic rhinitis | enterocolitis | interstitial cystitis (IC) | irritable bowel syndrome | peptic ulcer disease (PUD) | tremors | ulcerative colitis hypericin Phase 3 tyrosine kinase inhibitor hyperin Preclinical aldose reductase inhibitor ACE | AKR1B1 hypoestoxide Phase 1 IKK inhibitor IKBKB | IL1B | IL6 | TNF hypoxanthine Preclinical PARP inhibitor PNP IACS-10759 Preclinical mitochondrial complex I inhibitor NDUFAF1 ibandronate Launched bone resorption inhibitor FDPS orthopedics osteoporosis IBC-293 Preclinical hydroxycarboxylic acid receptor agonist HCAR3 iberdomide Preclinical cereblon modulator CRBN I-BET151 Preclinical bromodomain inhibitor BRD2 | BRD3 | BRD4 I-BET-762 Phase 2 bromodomain inhibitor APOA1 | BRD2 | BRD3 | BRD4 ibiglustat Preclinical glucosylceramidase inhibitor UGCG IB-MECA Phase 3 adenosine receptor agonist ADORA1 | ADORA2A | ADORA2B | ADORA3 IBMX Preclinical phosphodiesterase inhibitor ADORA1 | PDE2A | PDE3B | PDE4D | PDE5A | PDE6G | PDE7A | PDE8A | PDE9A ibotenic-acid Preclinical glutamate receptor agonist GRIN1 I-BRD9 Preclinical bromodomain inhibitor BRD9 ibrolipim Phase 2 lipoprotein lipase activator LPL ibrutinib Launched Bruton's tyrosine kinase (BTK) inhibitor BLK | BMX | BTK hematologic malignancy | hematologic malignancy | hematologic malignancy chronic lymphocytic leukemia (CLL) | mantle cell lymphoma (MCL) | Waldenstrom's macroglobulinemia (WM) ibudilast Launched leukotriene receptor antagonist | phosphodiesterase inhibitor CYSLTR1 | IL1B | IL6 | MIF | PDE10A | PDE11A | PDE3A | PDE4A | PDE4B | PDE4C | PDE4D | PDE5A | TLR4 neurology/psychiatry | pulmonary asthma | stroke ibuprofen Launched cyclooxygenase inhibitor dental | endocrinology | neurology/psychiatry | neurology/psychiatry | neurology/psychiatry | obstetrics/gynecology | otolaryngology | rheumatology backache | common cold | fever | headache | menstrual pain | muscle pain | rheumatoid arthritis | toothache ibuprofen-lysine Launched cyclooxygenase inhibitor CYP2C8 | PTGS1 | PTGS2 cardiology patent ductus arteriosus (PDA) ibuprofen-piconol Launched cyclooxygenase inhibitor PTGS1 | PTGS2 neurology/psychiatry pain relief ibuprofen-(S) Launched cyclooxygenase inhibitor ASIC1 | PTGS1 | PTGS2 | SLC5A8 neurology/psychiatry pain relief ibuproxam Launched cyclooxygenase inhibitor | prostaglandin inhibitor ALOX5 | PTGS1 | PTGS2 endocrinology | neurology/psychiatry | rheumatology fever | joint inflammation | pain relief ibutamoren Phase 2 growth hormone secretagogue receptor agonist GH1 | GHR | GHSR ibutilide Launched potassium channel blocker CACNA1C | KCNH2 | SCN5A cardiology atrial fibrillation (AF) I-BZA Phase 2 I-BZA2 Phase 3 IC261 Preclinical casein kinase inhibitor CSNK1A1 | CSNK1D | CSNK1E | CSNK1G2 ic-87114 Preclinical pi3k inhibitor PIK3C2B | PIK3CD | PIK3CG hematologic malignancy acute myeloid leukemia (aml) ICA-069673 Preclinical voltage-gated potassium channel activator KCNQ2 | KCNQ3 ICA-110381 Preclinical voltage-gated potassium channel activator KCNQ2 ICA-121431 Preclinical sodium channel blocker SCN1A | SCN3A icariin Phase 3 phosphodiesterase inhibitor NMUR2 | PDE5A | SORD icaritin Phase 3 PPAR receptor antagonist PDE5A icatibant-acetate Launched bradykinin receptor antagonist BDKRB2 cardiology angioedema I-CBP-112 Preclinical bromodomain inhibitor CREBBP | EP300 ICG-001 Preclinical beta-catenin inhibitor CTNNB1 "ICI-118,551" Phase 2 adrenergic receptor antagonist ADRB2 | ADRB3 ICI-162846 Phase 1 histamine receptor antagonist HRH2 ICI-169369 Phase 2 serotonin receptor antagonist HTR2A "ICI-185,282" Phase 1 thromboxane receptor antagonist ICI-192605 Phase 2 thromboxane receptor antagonist TBXA2R ICI-199441 Preclinical opioid receptor agonist CYP2D6 | OPRD1 | OPRK1 | OPRM1 | UTS2R "ICI-215,001" Preclinical adrenergic receptor agonist ADRB3 ICI-63197 Preclinical phosphodiesterase inhibitor ICI-89406 Phase 1 adrenergic receptor antagonist ADRB1 | ADRB2 icilin Phase 1 TRPV agonist TRPA1 | TRPM8 iclaprim Phase 3 dihydrofolate reductase inhibitor DHFR icomucret Phase 3 mucin production enhancer LTB4R2 icosapent Launched platelet aggregation inhibitor ACSL3 | ACSL4 | FADS1 | FFAR1 | PPARD | PPARG | PTGS1 | PTGS2 | SLC8A1 | TRPV1 endocrinology hypertriglyceridemia icotinib Launched EGFR inhibitor EGFR oncology non-small cell lung cancer (NSCLC) iCRT-14 Preclinical beta catenin inhibitor | WNT signaling inhibitor CTNNB1 | TCF4 ID-1101 Phase 1 insulin sensitizer INS | INSR ID-8 Preclinical idalopirdine Phase 3 serotonin receptor antagonist HTR6 idarubicin Launched topoisomerase inhibitor TOP2A hematologic malignancy acute myeloid leukemia (AML) idasanutlin Phase 3 MDM inhibitor MDM2 | TP53 idazoxan Phase 3 adrenergic receptor antagonist ADRA2A | NISCH | PTGS2 idebenone Launched calcium channel modulator neurology/psychiatry | neurology/psychiatry | ophthalmology Alzheimer's disease | Friedreich's ataxia | Leber hereditary optic neuropathy (LHON) idelalisib Launched PI3K inhibitor CCL3 | CCL4 | PIK3CA | PIK3CB | PIK3CD | PIK3CG hematologic malignancy chronic lymphocytic leukemia (CLL) IDF-11774 Preclinical hypoxia inducible factor inhibitor HIF1A IDH-305 Phase 2 isocitrate dehydrogenase inhibitor IDH1 ido1-in-5 Phase 1 "indoleamine 2,3-dioxygenase inhibitor" IDO1 oncology renal cell carcinoma (rcc) IDO5L Preclinical "indoleamine 2,3-dioxygenase inhibitor" IDO1 idoxuridine Launched DNA directed DNA polymerase inhibitor | DNA synthesis inhibitor infectious disease virus herpes simplex (HSV) IDRA-21 Preclinical glutamate receptor positive allosteric modulator GRIA1 | GRIA2 | GRIA3 | GRIA4 idramantone Preclinical idronoxil Phase 3 XIAP inhibitor CFLAR | ENOX2 | SPHK1 | SRD5A1 | TOP2A | XIAP IEM1460 Preclinical glutamate receptor antagonist GRIA2 IEM1754 Preclinical glutamate receptor antagonist GRIA1 ifenprodil Launched adrenergic receptor antagonist | glutamate receptor antagonist GRIN1 | GRIN2B ifenprodil hemitartrate Launched "adrenergic receptor antagonist, glutamate receptor antagonist" GRIN2B ifenprodil tartrate Launched glutamate receptor antagonist GIRK | GRIN2B | NR1A | NR2B Pulmonology acute resperatory distress syndrome ifosfamide Launched DNA alkylating agent CYP2A6 | CYP2B6 | CYP2C18 | CYP2C19 | CYP2C8 | CYP2C9 | CYP3A4 | CYP3A5 | CYP3A7 | PTGS1 oncology | urology hemorrhagic cystitis | testicular carcinoma igmesine Phase 2 sigma receptor agonist SIGMAR1 iguratimod Launched cyclooxygenase inhibitor | NFkB pathway inhibitor PTGS2 rheumatology rheumatoid arthritis IKK-16 Preclinical IKK inhibitor IKBKB IKK-2-inhibitor Preclinical IKK inhibitor | SYK inhibitor IKBKB IKK-2-inhibitor-V Phase 1 IKK inhibitor | NFkB pathway inhibitor IKBKB ilaprazole Launched proton pump inhibitor ATP4A gastroenterology gastroesophageal reflux disease (GERD) ilepcimide Phase 3 anticonvulsant ilomastat Phase 3 matrix metalloprotease inhibitor ACAN | ADAM28 | MMP1 | MMP12 | MMP13 | MMP14 | MMP2 | MMP3 | MMP8 | MMP9 iloperidone Launched dopamine receptor antagonist | serotonin receptor antagonist ADRA1A | ADRA2C | DRD1 | DRD2 | DRD3 | DRD4 | HRH1 | HTR1A | HTR2A | HTR6 | HTR7 neurology/psychiatry schizophrenia iloprost Launched platelet aggregation inhibitor | prostanoid receptor agonist PTGDR | PTGER1 | PTGER2 | PTGER3 | PTGER4 | PTGFR | PTGIR | TBXA2R pulmonary pulmonary arterial hypertension (PAH) ilorasertib Phase 3 aurora kinase inhibitor AURKC | KDR | VEGFA hematologic malignancy chronic myelomonocytic leukemia (cmmol) im156 Phase 1 ampk activator NDUFS1 | PRKAA2 oncology breast cancer imatinib Launched Bcr-Abl kinase inhibitor | KIT inhibitor | PDGFR tyrosine kinase receptor inhibitor ABCG2 | ABL1 | BCR | CSF1R | CYP2C19 | CYP2C8 | CYP3A5 | DDR1 | KIT | NTRK1 | PDGFRA | PDGFRB | RET hematologic malignancy | hematologic malignancy | hematologic malignancy | hematologic malignancy | hematologic malignancy | hematologic malignancy | oncology | oncology acute lymphoblastic leukemia (ALL) | aggressive systemic mastocytosis (ASM) | chronic eosinophilic leukemia (CEL) | chronic myeloid leukemia (CML) | dermatofibrosarcoma protuberans (DFSP) | gastrointestinal stromal tumors (GIST) | hypereosinophilic syndrome (HES) | myelodysplastic diseases (MDS) Imazodan Phase 1 phosphodiesterase inhibitor PDE3A | PDE3B imeglimin Phase 2 gluconeogenesis inhibitor imepitoin Launched gaba receptor agonist GABRA2 neurology/psychiatry epilepsy imetit Preclinical histamine receptor agonist HRH3 | HRH4 imexon Phase 2 apoptosis stimulant | ribonucleotide reductase inhibitor imidacloprid Launched acetylcholine receptor antagonist imidafenacin Launched acetylcholine receptor antagonist CHRM1 | CHRM3 neurology/psychiatry spasms imidapril Launched angiotensin converting enzyme inhibitor ACE cardiology | cardiology congestive heart failure | hypertension imidapril hcl Launched angiotensin converting enzyme inhibitor ACE cardiology "hypertension, congestive heart failure" imidazoacridinone Preclinical anticancer agent FLT3 | HIF1A | TOP2A imidurea Preclinical other antibiotic imiloxan Phase 1 adrenergic receptor antagonist ADRA2A | ADRA2B imipenem Launched bacterial cell wall synthesis inhibitor infectious disease | infectious disease | infectious disease | infectious disease | infectious disease | infectious disease | infectious disease | infectious disease bacterial septicemia | bone and joint infections | endocarditis | gynecologic infections | intra-abdominal infections | pneumonia | skin infections | urinary tract infections imipramine Launched norepinephrine reputake inhibitor | serotonin reuptake inhibitor ADRA1A | ADRA1B | ADRA1D | CHRM1 | CHRM2 | CHRM3 | CHRM4 | CHRM5 | CYP2C19 | DRD1 | DRD2 | DRD5 | HRH1 | HTR1A | HTR2A | HTR2C | HTR6 | HTR7 | KCND2 | KCND3 | KCNH1 | KCNH2 | SLC6A2 | SLC6A3 | SLC6A4 neurology/psychiatry | urology depression | nocturnal enuresis imiquimod Launched interferon inducer | toll-like receptor agonist TLR7 | TLR8 dermatology | infectious disease | oncology actinic keratosis (AK) | basal cell carcinoma (BCC) | genital warts imirestat Preclinical aldose reductase inhibitor AKR1B1 imisopasem-manganese Preclinical superoxide dismutase mimetic SOD2 immepip Preclinical histamine receptor agonist HRH3 | HRH4 immethridine Phase 1 histamine receptor agonist HRH3 impentamine Preclinical histamine receptor antagonist HRH3 imrecoxib Phase 1 cyclooxygenase inhibitor PTGS2 rheumatology osteoarthritis IMREG-1 Phase 3 inarigivir Phase 2 antiviral inarigivir-soproxil Phase 2 antiviral INC-280 Phase 3 c-Met inhibitor MET INCA-6 Preclinical calcineurin inhibitor NFATC1 INCB-003284 Phase 2 CC chemokine receptor antagonist INCB-057643 Phase 1/Phase 2 bromodomain inhibitor BRD2 | BRD3 | BRD4 INCB-3284 Phase 2 CC chemokine receptor antagonist CCR2 incyclinide Phase 2 matrix metalloprotease inhibitor MMP2 | MMP9 indacaterol Launched adrenergic receptor agonist ADRB1 | ADRB2 pulmonary chronic obstructive pulmonary disease (COPD) indalpine Withdrawn selective serotonin reuptake inhibitor (SSRI) SLC6A4 indapamide Launched thiazide diuretic CA2 | CA7 | HTR3A | KCNQ1 | SLC12A3 cardiology | cardiology congestive heart failure | hypertension indatraline Preclinical norepinephrine transporter inhibitor MAOA | MAOB | SLC6A2 | SLC6A3 | SLC6A4 indeglitazar Phase 2 PPAR receptor agonist NCOA1 | PPARA | PPARD | PPARG indeloxazine Withdrawn norepinephrine reuptake inhibitor | serotonin reuptake inhibitor SLC6A4 indibulin Phase 1/Phase 2 tubulin polymerization inhibitor indinavir Launched HIV protease inhibitor CYP3A4 | CYP3A5 | CYP3A7 infectious disease human immunodeficiency virus (HIV-1) indiplon Phase 3 benzodiazepine receptor agonist GABRA1 | GABRA2 | GABRA3 | GABRA5 indirubin Phase 2/Phase 3 CDK inhibitor | glycogen synthase kinase inhibitor CDK1 | CDK2 | CDK4 | CDK5 | GSK3A | GSK3B indirubin-3-monoxime Preclinical CDK inhibitor | glycogen synthase kinase inhibitor CCNE1 | CDK1 | CDK2 | CDK4 | CDK5 | CDK5R1 | CDK9 | GSK3B | LCK | LRRK1 | LRRK2 indisulam Phase 2 CDK inhibitor CA1 | CA12 | CA14 | CA2 | CA4 | CA5B | CA6 | CA7 | CA9 | CDKN1A | TOP2A | TP53 indium(III)-isopropoxide Preclinical indium-tri(2-propanolate) Preclinical indobufen Launched cyclooxygenase inhibitor | platelet aggregation inhibitor PTGS1 | PTGS2 hematology thrombosis indocyanine-green Launched contrast agent SLCO1B1 cardiology vascular imaging agent indole-3-carbinol Phase 2/Phase 3 "aryl hydrocarbon receptor agonist | indoleamine 2,3-dioxygenase inhibitor" AHR | IDO1 indole-3-pyrubate Phase 2 melatonin receptor agonist indomethacin Launched cyclooxygenase inhibitor GLO1 | PLA2G2A | PPARA | PPARG | PTGDR2 | PTGR2 | PTGS1 | PTGS2 | SLC46A1 orthopedics | rheumatology | rheumatology | rheumatology | rheumatology ankylosing spondylitis | bursitis | osteoarthritis | rheumatoid arthritis | tendinitis indoprofen Withdrawn cyclooxygenase inhibitor | prostanoid receptor antagonist CXCR1 | CXCR2 | PTGS1 | PTGS2 indoramin Launched adrenergic receptor antagonist ADRA1A | ADRA1B | ADRA1D | ADRA2B | ADRA2C cardiology | urology benign prostatic hyperplasia (BPH) | hypertension indotecan Phase 1 topoisomerase inhibitor CHEK1 | PDLIM7 | TOP1 oncology soft tissue sarcoma (sts) indoxacarb Launched indoximod Phase 2 "indoleamine 2,3-dioxygenase inhibitor" IDO1 ingenol Launched PKC activator PRKCD | PRKCE | PRRT2 dermatology keratosis ingenol-mebutate Launched PKC activator PRKCA | PRKCB | PRKCD | PRKCE | PRKCG dermatology actinic keratosis (AK) INH1 Preclinical Hec1 inhibitor CFTR | NDC80 inimur Launched other antifungal iniparib Phase 3 PARP inhibitor PARP1 inosine Launched neurotrophic agent PARP1 | PNP inositol Launched insulin sensitizer CDIPT obstetrics/gynecology polycystic ovary syndrom (PCOS) inositol-hexanicotinate Launched cardiology | cardiology | cardiology | dermatology | dermatology | dermatology | neurology/psychiatry | neurology/psychiatry | neurology/psychiatry | rheumatology acne vulgaris (AV) | atherosclerosis | claudication | hypertension | insomnia | psoriasis | Raynaud's disease | restless leg syndrome | schizophrenia | statis dermatitis INS316 Phase 2 purinergic receptor antagonist INT-747 Phase 3 FXR agonist NR1H4 INT-767 Phase 1 FXR agonist GPBAR1 | NR1H4 integrin-antagonist-1 Phase 1 integrin antagonist ITGAV | ITGB6 INX-08189 Phase 2 antiviral iobenguane Launched antineoplastic agent cardiology | endocrinology | oncology congestive heart failure | neuroblastoma | pheochromocytoma iocetamic-acid Launched radiopaque medium radiology contrast agent iodipamide Launched radiopaque medium ALB radiology contrast agent iodixanol Launched radiopaque medium radiology contrast agent iodoantipyrine Preclinical iododexetimide Phase 2 acetylcholine receptor antagonist iodophenpropit Preclinical histamine receptor antagonist GRIN2B | HRH3 | HRH4 iodoquinol Launched antiseptic infectious disease amebiasis iodoxamic acid Withdrawn radiopaque medium radiology contrast agent iofendylate Withdrawn radiopaque medium radiology mri contrast agent iohexol Launched radiopaque medium radiology contrast agent iomazenil Launched radiopaque medium TSPO neurology/psychiatry epilepsy iopamidol Launched radiopaque medium radiology contrast agent iopanic-acid Withdrawn thyroid hormone inhibitor iopodic-acid Launched radiology contrast agent iopromide Launched radiopaque medium radiology contrast agent iothalamic-acid-d3 Preclinical radiopaque medium ioversol Launched radiopaque medium radiology contrast agent IOWH032 Phase 2 CFTR channel antagonist CFTR IOX1 Preclinical histone demethylase inhibitor EGLN1 | KDM3A | KDM4A | KDM4C | KDM6B IOX2 Preclinical hypoxia inducible factor inhibitor EGLN1 | KDM2A | KDM5C ioxaglic-acid Launched radiopaque medium radiology contrast agent ioxilan Launched radiopaque medium radiology angiography IPA-3 Preclinical p21 activated kinase inhibitor PAK1 IPAG Preclinical IPI549 Phase 2 PI3K inhibitor PIK3CG ipidacrine Phase 3 acetylcholinesterase inhibitor ACHE ipragliflozin-L-proline Launched sodium/glucose cotransporter inhibitor SLC5A2 endocrinology diabetes mellitus ipratropium Launched acetylcholine receptor antagonist CHRM1 | CHRM2 | CHRM3 | CHRM4 | CHRM5 pulmonary | pulmonary | pulmonary | pulmonary bronchitis | bronchospasm | chronic obstructive pulmonary disease (COPD) | emphysema ipratropium bromide Launched acetylcholine receptor antagonist CHRM1 | CHRM2 | CHRM3 | CHRM4 | CHRM5 pulmonary "bronchospasm, chronic obstructive pulmonary disease (copd), bronchitis, emphysema" ipriflavone Launched bone resorption inhibitor orthopedics osteoporosis iproniazid Withdrawn monoamine oxidase inhibitor MAOA | MAOB ipsapirone Phase 3 serotonin receptor agonist HTR1A irbesartan Launched angiotensin receptor antagonist AGTR1 | JUN | SLC10A1 cardiology | nephrology diabetic nephropathy | hypertension irganox-1010 Preclinical antioxidant iRGD-peptide Preclinical integrin signaling activator ITGAV irinotecan Launched topoisomerase inhibitor CYP3A5 | TOP1 | TOP1MT oncology colorectal cancer IRL-2500 Preclinical endothelin receptor antagonist EDNRB irosustat Phase 2 steroid sulfatase inhibitor CA2 | STS irsogladine Launched phosphodiesterase inhibitor PDE4A gastroenterology peptic ulcer disease (PUD) isamoltane Phase 1 adrenergic receptor antagonist ADRB1 | ADRB2 | HTR1A | HTR1B isavuconazole Launched cytochrome P450 inhibitor | fungal lanosterol demethylase inhibitor CYP3A4 | CYP51A1 Infectious disease fungal infection isavuconazonium sulfate Launched lanosterol demethylase inhibitor infectious disease aspergillosis isaxonine Withdrawn nerve growth factor agonist isbufylline Phase 2 phosphodiesterase inhibitor isepamicin Launched protein synthesis inhibitor infectious disease | infectious disease peritonitis | pneumonia islatravir Phase 3 nucleoside reverse transcriptase inhibitor infectious disease human immunodeficiency virus (hiv-1) ISO-1 Preclinical macrophage migration inhibiting factor inhibitor MIF isobutamben Preclinical local anesthetic isobutyramide Phase 2 gene expression stimulant HBB | HBE1 | HBG1 isocarboxazid Launched monoamine oxidase inhibitor MAOA | MAOB neurology/psychiatry depression isoconazole Launched fungal lanosterol demethylase inhibitor CYP17A1 infectious disease gram-positive bacterial infections isodibut Phase 2 aldehyde reductase inhibitor isoetharine Launched adrenergic receptor agonist pulmonary | pulmonary asthma | bronchospasm isofloxythepin Phase 2 dopamine receptor antagonist isoflupredone-acetate Preclinical NR3C1 isoflurane Launched inhaled anaesthetic GABRA1 | GABRA2 | GABRA3 | GABRA4 | GABRA5 | GABRA6 | GABRB1 | GABRB2 | GABRB3 | GABRD | GABRE | GABRG1 | GABRG2 | GABRG3 | GABRP | GABRQ | GLRA1 | GLRB | KCNK10 | KCNK18 | KCNK2 | KCNK3 | KCNK9 neurology/psychiatry general anaesthetic isoflurophate Launched cholinesterase inhibitor ACHE | BCHE ophthalmology glaucoma isoguvacine Preclinical benzodiazepine receptor agonist GABRA1 | GABRA2 | GABRA3 | GABRA4 | GABRA5 | GABRA6 | GABRR1 | GABRR2 | GABRR3 isoleucine Launched isoliquiritigenin Preclinical guanylate cyclase activator AKR1B1 | GABBR1 | HRH2 | SIRT1 isometheptene-mucate Launched neurology/psychiatry headache isoniazid Launched FABI inhibitor CYP1A2 | CYP2C19 | CYP2C8 | CYP2E1 | CYP3A4 infectious disease tuberculosis isopentyl-4-methoxycinnamate Launched dermatology sunscreen lotion isoprenaline Launched adrenergic receptor agonist ADRB1 | ADRB2 | ADRB3 cardiology | cardiology | pulmonary asthma | bradycardia | heart block isopropamide-iodide Launched acetylcholine receptor antagonist CHRM3 | CHRM4 gastroenterology | gastroenterology gastrointestinal acidosis | peptic ulcer disease (PUD) isopropyl-myristate Launched dermatology cosmetic isopropyl-palmitate Launched cosmetic moisturizer dermatology cosmetic isoquercitrin Phase 2/Phase 3 antioxidant "Isoquinoline,-6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydro," Preclinical isosorbide Launched nitric oxide stimulant cardiology | cardiology angina pectoris | coronary artery disease (CAD) isosorbide-dinitrate Launched nitric oxide stimulant GUCY1A2 | GUCY1A3 | GUCY1B2 | GUCY1B3 | NPR1 cardiology | cardiology angina pectoris | coronary artery disease (CAD) isosorbide-mononitrate Launched nitric oxide stimulant GUCY1A2 | GUCY1A3 | GUCY1B2 | GUCY1B3 cardiology | cardiology angina pectoris | coronary artery disease (CAD) isosteviol Phase 2 isotiquimide Phase 1 isotretinoin Launched retinoid receptor agonist CYP2B6 | CYP2C19 | CYP2C8 | CYP3A5 | CYP3A7 | RARA | RARB | RARG dermatology acne vulgaris (AV) isovaleramide Phase 2 alcohol dehydrogenase inhibitor isoxepac Phase 2 anti-inflammatory agent isoxicam Withdrawn cyclooxygenase inhibitor PTGS1 | PTGS2 isoxsuprine Launched adrenergic receptor agonist ADRB2 cardiology | rheumatology | rheumatology arteriosclerosis | Buerger's disease | Raynaud's disease isoxsuprine hydrochloride Launched adrenergic receptor agonist ADRB2 "rheumatology, cardiology" "raynaud's disease, arteriosclerosis, buerger's disease" ispinesib Phase 2 kinesin inhibitor KIF11 isradipine Launched calcium channel blocker CACNA1C | CACNA1D | CACNA1F | CACNA2D1 cardiology hypertension ISRIB Preclinical eukaryotic translation initiation factor inhibitor | PERK inhibitor EIF2A | EIF2AK3 istaroxime Phase 2 ATPase inhibitor ATP1A1 | ATP1A2 | ATP1A3 | ATP1A4 | ATP1B1 | ATP1B2 | ATP1B3 | ATP1B4 | FXYD2 istradefylline Launched adenosine receptor antagonist ADORA1 | ADORA2A | ADORA2B | ADORA3 neurology/psychiatry | neurology/psychiatry dyskinesia | Parkinson's Disease isuzinaxib Preclinical nadph oxidase inhibitor NOX1 | NOX4 nephrology diabetic nephropathy ISX-9 Preclinical neural stem cell inducer NEUROD1 IT1t Preclinical CC chemokine receptor antagonist CXCR4 itacitinib Phase 3 JAK inhibitor JAK1 ITD-1 Preclinical TGF beta receptor inhibitor TGFBR2 ITE Preclinical aryl hydrocarbon receptor agonist AHR ITI214 Phase 1/Phase 2 phosphodiesterase inhibitor PDE1A itopride Launched dopamine receptor antagonist ACHE | CHRM3 | DRD2 gastroenterology | gastroenterology | gastroenterology | gastroenterology | gastroenterology | neurology/psychiatry anorexia | dyspepsia | gastroparesis | heartburn | nausea | vomiting itraconazole Launched cytochrome P450 inhibitor CYP3A5 | CYP3A7 | KDR infectious disease | infectious disease | infectious disease | infectious disease | infectious disease "aspergillosis | blastomycosis | histoplasmosis | onychomycosis | onychomycosis, histoplasmosis, blastomycosis, aspergillosis" ITX3 Preclinical GEF inhibitor TRIO ITX5061 Phase 1 SR-BI inhibitor MAPK14 IU1 Preclinical ubiquitin C-terminal hydrolase inhibitor USP14 ivabradine Launched HCN channel blocker | potassium channel blocker | sodium channel blocker HCN1 | HCN2 | HCN3 | HCN4 cardiology angina pectoris ivabradine hcl Launched "hcn channel blocker, potassium channel blocker, sodium channel blocker" HCN1 | HCN3 | HCN4 cardiology angina pectoris ivacaftor Launched CFTR channel potentiator CFTR | CYP3A5 | CYP3A7 pulmonary cystic fibrosis ivermectin Launched benzodiazepine receptor agonist CHRNA7 | P2RX7 infectious disease | infectious disease | infectious disease | infectious disease | infectious disease | infectious disease cattle grubs | gastrointestinal roundworms | horn flies | lice | lungworms | mites ivosidenib Launched isocitrate dehydrogenase inhibitor IDH1 hematologic malignancy acute myeloid leukemia (AML) IWP-L6 Preclinical porcupine inhibitor PORCN ixabepilone Launched microtubule stabilizing agent TUBB oncology breast cancer ixazomib Launched proteasome inhibitor hematologic malignancy multiple myeloma ixazomib-citrate Launched proteasome inhibitor hematologic malignancy multiple myeloma J147 Phase 1 BDNF inducer JAK3-inhibitor-V Preclinical JAK inhibitor JAK3 JD-5037 Preclinical cannabinoid receptor antagonist CNR1 JDTic Phase 1 opioid receptor antagonist OPRK1 JHW-007 Preclinical dopamine reuptake inhibitor SLC6A3 JI-101 Phase 1/Phase 2 kinase inhibitor EPHB4 | KDR | PDGFRB JIB04 Preclinical histone lysine demethylase inhibitor KDM4E JK-184 Preclinical hedgehog pathway inhibitor JLK-6 Preclinical gamma secretase inhibitor PSEN1 JNJ-10191584 Preclinical histamine receptor antagonist HRH4 JNJ-10397049 Preclinical orexin receptor antagonist HCRTR1 | HCRTR2 JNJ-16259685 Preclinical glutamate receptor antagonist GRM1 JNJ-1661010 Preclinical FAAH inhibitor FAAH JNJ-17203212 Preclinical TRPV antagonist TRPV1 JNJ-26481585 Phase 2 HDAC inhibitor HDAC1 | HDAC10 | HDAC11 | HDAC2 | HDAC3 | HDAC4 | HDAC5 | HDAC6 | HDAC7 | HDAC8 | HDAC9 | MDM2 JNJ-26990990 Phase 2 anticonvulsant JNJ-27141491 Preclinical CC chemokine receptor antagonist CCR2 JNJ-37822681 Phase 2 dopamine receptor antagonist DRD2 JNJ-38877605 Phase 1 tyrosine kinase inhibitor MET JNJ-38877618 Phase 1 c-Met inhibitor MET JNJ-39758979 Phase 2 histamine receptor antagonist HRH4 JNJ-40411813 Phase 2 glutamate receptor positive allosteric modulator GRM2 JNJ-42041935 Preclinical hypoxia inducible factor prolyl hydroxylase inhibitor PDK2 JNJ-42165279 Phase 2 FAAH inhibitor FAAH JNJ-47965567 Preclinical purinergic receptor antagonist IL1B | P2RX7 jnj-5207852 Phase 2 histamine receptor antagonist HRH3 neurology/psychiatry epilepsy JNJ-54175446 Phase 1 purinergic receptor antagonist P2RX7 JNJ-63533054 Preclinical G protein-coupled receptor agonist GPR139 JNJ-64619178 Phase 1 protein arginine N-methyltransferase inhibitor PRMT5 JNJ-678 Phase 1 RSV fusion inhibitor JNJ-7706621 Preclinical CDK inhibitor AURKA | AURKB | CDK1 | CDK2 JNJ-7777120 Preclinical histamine receptor antagonist HRH4 josamycin Launched bacterial 50S ribosomal subunit inhibitor pulmonary bronchitis JPH203 Preclinical solute carrier family member inhibitor SLC7A5 JQ1-(+) Preclinical bromodomain inhibitor BRD2 | BRD3 | BRD4 | BRDT JTC-801 Phase 2 opioid receptor antagonist OPRL1 JTE-013 Preclinical lysophospholipid receptor antagonist P2RY10 | S1PR2 JTE-607 Phase 2 cytokine production inhibitor IL10 | IL1B | IL6 | TNF JTE-907 Phase 1 cannabinoid receptor inverse agonist CNR2 JW-55 Preclinical tankyrase inhibitor TNKS | TNKS2 JW-642 Preclinical monoacylglycerol lipase inhibitor MGLL JW-67 Preclinical WNT pathway inhibitor APC | AXIN1 | GSK3B JW-74 Preclinical tankyrase inhibitor | WNT signaling inhibitor TNKS | TNKS2 JX-401 Preclinical p38 MAPK inhibitor MAPK14 JZL-184 Preclinical monoacylglucerol lipase inhibitor MGLL JZL-195 Preclinical FAAH inhibitor | monoacylglycerol lipase inhibitor FAAH | MGLL K02288 Preclinical bone morphogenic protein inhibitor ABL1 | ABL2 | ACVR1 | ACVRL1 | BMP1 | BMPR1A | HCK | LCK | MAP4K4 | PTK6 K145 Preclinical sphingosine kinase inhibitor SPHK2 K-247 Phase 1 k-80003 Preclinical retinoid receptor antagonist RXRA cardiology atherosclerosis K-858 Preclinical kinesin-like spindle protein inhibitor KIF11 kaempferol Preclinical bone resorption inhibitor | estrogen-related receptor inverse agonist AKR1B1 | ALOX15B | ALOX5 | AR | CYP1B1 | ESRRA | ESRRG | GLO1 | HSD17B1 | JAK3 | PTGS1 | STAT6 | UGT3A1 | XDH KAF-156 Preclinical antimalarial agent kainic-acid Preclinical kainate receptor agonist GRIA1 | GRIK1 | GRIK2 | GRIK3 | GRIK4 | GRIK5 kakonein Phase 2 GABA receptor antagonist | serotonin receptor antagonist kanamycin Launched bacterial 30S ribosomal subunit inhibitor infectious disease gram-negative bacterial infections karenitecin Phase 3 topoisomerase inhibitor TOP1 kartogenin Preclinical chondrocyte differentiation stimulator FLNA kasugamycin Preclinical bacterial 30S ribosomal subunit inhibitor kb-0742 Phase 1 kb-0742 (dihydrochloride) Phase 1/Phase 2 cdk9 inhibitor CDK9 oncology prostate cancer KBG Phase 2 neprilysin inhibitor MME KB-R7943 Preclinical sodium/calcium exchange inhibitor SLC8A1 | TRPC3 | TRPC5 | TRPC6 KB-SRC-4 Preclinical SRC inhibitor SRC KD-023 Phase 2 ACAT inhibitor ACACA | ACACB | CHAT KD025 Phase 2 rho associated kinase inhibitor ROCK2 kenpaullone Preclinical CDK inhibitor | glycogen synthase kinase inhibitor CCNB1 | CDK1 | CDK2 | CDK5 | GSK3B | LCK ketanserin Launched serotonin receptor antagonist ADRA1A | ADRA1B | ADRA1D | DRD1 | DRD5 | HTR1A | HTR1B | HTR1D | HTR2A | HTR2B | HTR2C | HTR5A | HTR7 | SLC18A1 | SLC18A2 cardiology hypertension ketoconazole Launched sterol demethylase inhibitor AR | CYP19A1 | CYP2C19 | CYP3A5 | CYP3A7 | KCNA10 dermatology seborrheic dermatitis ketohexokinase-inhibitor-1 Preclinical kinase inhibitor ketoprofen Launched cyclooxygenase inhibitor PTGS1 | PTGS2 | SLC5A8 rheumatology | rheumatology osteoarthritis | rheumatoid arthritis ketorolac Launched cyclooxygenase inhibitor PTGS1 | PTGS2 neurology/psychiatry pain relief ketorolac tromethamine Launched cyclooxygenase inhibitor PTGS1 | PTGS2 neurology/psychiatry pain relief ketotifen Launched histamine receptor agonist | histamine receptor antagonist | leukotriene receptor antagonist | phosphodiesterase inhibitor HRH1 neurology/psychiatry | pulmonary asthma | itching kevetrin Phase 1 p53 activator KF-38789 Preclinical P selectin inhibitor SELP KG-5 Preclinical RAF inhibitor BRAF | FLT3 | KIT | PDGFRA | PDGFRB KH-CB19 Preclinical CDC inhibitor CLK1 | CLK3 | DYRK1A khellin Phase 2 vasodilator KHK-IN-1 Preclinical hexokinase inhibitor CYP2C19 | KHK KHS-101 Preclinical neural stem cell inducer TACC3 ki16198 Preclinical lipoprotein antagonist LPA KI-16425 Preclinical lysophosphatidic acid receptor antagonist LPAR1 | LPAR3 KI-20227 Preclinical c-Fms inhibitor CSF1R | KDR | KIT | PDGFRB KI-8751 Preclinical KIT inhibitor | PDGFR tyrosine kinase receptor inhibitor | VEGFR inhibitor KDR kifunensine Phase 1 mannosidase inhibitor MAN1B1 | MAN2A1 kinetin Launched cell division inducer dermatology sunburn KL-001 Preclinical proteasome inhibitor CRY1 | CRY2 KM-0118 Phase 1 anticancer agent LGALS1 K-MAP Phase 2 KME-4 Preclinical prostaglandin inhibitor KML29 Preclinical monoacylglucerol lipase inhibitor MGLL KN-62 Preclinical calcium/calmodulin dependent protein kinase inhibitor | purinergic receptor antagonist AKT1 | CAMK2A | CHEK1 | LCK | MAPK1 | MAPK11 | MAPK12 | MAPK14 | MAPK8 | P2RX7 | PRKCA | ROCK1 | RPS6KB1 | SGK1 KN-93 Preclinical calcium/calmodulin dependent protein kinase inhibitor CAMK2A Ko143 Preclinical BCRP inhibitor ABCB1 | ABCC1 | ABCG2 kojic acid Preclinical nfkb pathway inhibitor NFKB1 KP-1212 Phase 2 KPT-185 Preclinical exportin antagonist XPO1 KPT-276 Preclinical exportin antagonist XPO1 KPT-9274 Phase 1 NAMPT inhibitor NAMPT KR-33494 Preclinical cell death inhibitor FAF1 K-Ras(G12C)-inhibitor-12 Preclinical K-Ras inhibitor KRAS K-Ras(G12C)-inhibitor-6 Preclinical K-Ras inhibitor KRCA-0008 Preclinical ALK inihibitor ALK KRN-633 Preclinical VEGFR inhibitor FLT1 | FLT4 | KDR KS-176 Preclinical BCRP inhibitor ABCG2 K-strophanthidin Phase 2 ATPase inhibitor ATP1A1 | ATP1A2 | ATP1A3 | ATP1A4 | ATP1B1 | ATP1B2 | ATP1B3 | ATP1B4 | FXYD2 KT-433 Phase 2 uricosuric agent SLC22A12 KU-0063794 Preclinical mTOR inhibitor MTOR KU14R Preclinical imidazoline receptor antagonist KU-55933 Preclinical ATM kinase inhibitor ATM | PRKDC KU-60019 Preclinical ATM kinase inhibitor ATM kuromanin Preclinical ribosyl cyclase inhibitor CD38 | INS KW-2449 Phase 1 Abl kinase inhibitor | Aurora kinase inhibitor | FLT3 inhibitor ABL1 | AURKA | AURKB | FGFR1 | FLT3 KW-2478 Phase 1/Phase 2 HSP inhibitor KW-3902 Phase 3 adenosine receptor antagonist ADORA1 | ADORA2A | ADORA2B | ADORA3 KX2-391 Phase 3 SRC inhibitor | tubulin polymerization inhibitor SRC KY02111 Preclinical WNT pathway inhibitor DKK1 kynurenic-acid Phase 1 glutamate receptor antagonist GPR35 | GRIN1 | GRIN2A | GRIN2B L-152804 Preclinical neuropeptide receptor antagonist NPY5R L-161982 Preclinical prostanoid receptor antagonist PTGER4 L-165041 Preclinical PPAR receptor agonist PPARD L-168049 Preclinical glucagon receptor antagonist GCGR L-365260 Phase 2 CCK receptor antagonist CCKAR | CCKBR | KCNQ1 L-368899 Phase 1 oxytocin receptor antagonist AVPR1A | AVPR2 | OXT | OXTR "l-368,899 hydrochloride" Phase 1 oxytocin receptor antagonist AVPR1A | AVPR2 | OXTR L-655240 Phase 1 thromboxane receptor antagonist PTGES "L-655,708" Preclinical GABA receptor inverse agonist GABRA1 | GABRA2 | GABRA3 | GABRA5 | GABRG2 L-670596 Preclinical prostanoid receptor antagonist L-689560 Preclinical glutamate receptor antagonist GRIN1 | GRIN2A | GRIN2B | GRIN2C | GRIN2D L-690330 Preclinical inositol monophosphatase inhibitor IMPA1 L-693403 Preclinical sigma receptor agonist | sigma receptor antagonist DRD2 | SIGMAR1 L-694247 Preclinical serotonin receptor agonist HTR1A | HTR1B | HTR1D L-701252 Preclinical glutamate receptor antagonist GRIN1 L-701324 Preclinical glutamate receptor antagonist GRIN1 | GRIN2A | GRIN2B | GRIN2C | GRIN2D "L-732,138" Preclinical tachykinin antagonist TACR1 | TACR2 L-733060 Preclinical tachykinin antagonist TACR1 L-741742 Preclinical dopamine receptor antagonist DRD3 | DRD4 | SCN1A | SCN3A L-745870 Preclinical dopamine receptor antagonist DRD1 | DRD2 | DRD3 | DRD4 | HTR1A | HTR2A | HTR6 | HTR7 L-755507 Preclinical adrenergic receptor agonist ADRB1 | ADRB2 | ADRB3 L-760735 Preclinical tachykinin antagonist TACR1 L-778123 Phase 1 farnesyltransferase inhibitor FNTA | FNTB | PGGT1B L-798106 Preclinical prostanoid receptor antagonist PTGER3 L-838417 Preclinical GABA receptor partial agonist GABRA1 | GABRA2 | GABRA3 | GABRA5 labetalol Launched adrenergic receptor antagonist ADRA1A | ADRA1D | ADRB1 | ADRB2 cardiology hypertension labetalol hydrochloride Launched adrenergic receptor antagonist ADRA1D | ADRB1 | ADRB2 cardiology hypertension lacidipine Launched calcium channel blocker CACNA1C cardiology hypertension lacitol Launched laxative gastroenterology constipation lactulose Launched laxative gastroenterology portal-systemic encephalopathy (PSE) laflunimus Phase 2 prostagladin inhibitor PTGS1 | PTGS2 lafutidine Launched histamine receptor antagonist HRH2 gastroenterology | gastroenterology | gastroenterology "duodenal ulcer disease | duodenal ulcer disease, peptic ulcer disease (pud) | peptic ulcer disease (PUD)" L-alanine Launched AARS | AARS2 | ABAT | AGXT | AGXT2 | GPRC6A | GPT | GPT2 | KYNU | NFS1 | PHYKPL | SLC1A4 | SLC36A1 | SLC7A8 lamivudine Launched nucleoside reverse transcriptase inhibitor infectious disease | infectious disease | infectious disease | infectious disease "acquired immunodeficiency syndrome (AIDS) | hepatitis B | human immunodeficiency virus (HIV-1) | human immunodeficiency virus (hiv-1), acquired immunodeficiency syndrome (aids), hepatitis b" lamotrigine Launched serotonin receptor antagonist | sodium channel blocker SCN10A | SCN11A | SCN1A | SCN2A | SCN3A | SCN4A | SCN5A | SCN7A | SCN8A | SCN9A neurology/psychiatry | neurology/psychiatry bipolar disorder | epilepsy lanabecestat Phase 3 beta secretase inhibitor BACE1 lanatoside-C Preclinical cardiac glycoside landiolol Launched adrenergic receptor antagonist ADRB1 cardiology cardiac arrythmia lanifibranor Phase 2 PPAR receptor agonist PPARA | PPARD | PPARG lanoconazole Launched sterol demethylase inhibitor infectious disease fungal infection lanraplenib Phase 2 protein tyrosine kinase inhibitor A1BG | LAT | TNK1 rheumatology lupus lanreotide Launched somatostatin receptor agonist SSTR2 | SSTR3 | SSTR5 endocrinology acromegaly lansoprazole Launched ATPase inhibitor ATP4A | ATP4B | CYP2C19 | CYP3A4 | CYP3A5 gastroenterology heartburn lapatinib Launched EGFR inhibitor CYP3A5 | EGFR | ERBB2 oncology breast cancer lapirium chloride Withdrawn cationic surfactant infectious disease antiseptic lappaconite Phase 2 sodium channel blocker lappaconite hbr Phase 2 sodium channel blocker laquinimod Phase 3 immunosuppressant CXCL2 larazotide-acetate Phase 2 tight junction regulator HP | TJP1 L-arginine Launched nitric oxide precursor ARG2 | ASL | ASS1 | AZIN2 | GPRC6A | NOS2 | NOS3 | SLC7A1 | SLC7A3 | SLC7A4 cardiology | cardiology | cardiology | cardiology | neurology/psychiatry | obstetrics/gynecology | otolaryngology | urology claudication | common cold | congestive heart failure | coronary artery disease (CAD) | erectile dysfunction | hypertension | infertility | senile dementia l-arginine hcl Launched nitric oxide precursor ARG2 | ASL | ASS1 | AZIN2 | GPRC6A | NOS2 | NOS3 | SLC7A1 | SLC7A3 | SLC7A4 "cardiology, neurology/psychiatry, urology, obstetrics/gynecology, otolaryngology" "congestive heart failure, hypertension, coronary artery disease (cad), claudication, senile dementia, erectile dysfunction, infertility, common cold" laropiprant Launched prostanoid receptor antagonist PTGDR | PTGDR2 | PTGER1 | PTGER2 | PTGER3 | PTGFR | PTGIR | TBXA2R cardiology cholesterol larotrectinib Launched alk tyrosine kinase receptor inhibitor | tropomyosin receptor kinase inhibitor NTRK1 | NTRK2 | NTRK3 hematologic malignancy myeloproliferative neoplasms las101057 Phase 1 adenosine receptor antagonist ADORA2B pulmonary asthma lasalocid Launched bacterial permeability inducer infectious disease coccidiosis lasalocid sodium Launched bacterial permeability inducer infectious disease coccidiosis L-ascorbyl-6-palmitate Preclinical lasmiditan Launched serotonin receptor agonist HTR1F lasofoxifene Phase 2 selective estrogen receptor modulator (SERM) ESR1 | ESR2 oncology | orthopedics breast cancer | osteoporosis L-asparagine Phase 3 ASNS | ASRGL1 | NARS | NARS2 | SLC1A5 | SLC38A3 L-asparagine-N-hydroxy Preclinical L-aspartic-acid Launched metallic radical formation stimulant ACY1 | ACY3 | ADSS | ADSSL1 | ASNS | ASPA | ASPH | ASRGL1 | ASS1 | CAD | DARS | DARS2 | GOT1 | GOT2 | GRIN1 | GRIN2A | GRIN2B | GRIN2C | GRIN2D | LYZ | PAICS | RNASE1 | SLC1A1 | SLC25A12 | SLC25A13 latanoprost Launched prostanoid receptor agonist PTGFR ophthalmology | ophthalmology glaucoma | ocular hypertension latanoprostene bunod Launched prostanoid receptor agonist GUCY1A1 | PTGFR ophthalmology intraocular pressure latrepirdine Phase 3 glutamate receptor antagonist GRIN2B | HRH1 | HTR6 latrunculin-B Phase 1 actin polymerization inhibitor ACTA1 | MKL1 | SPIRE2 lauric-acid Phase 3 bacterial permeability inducer GPR84 | HNF4A | LTF | LY96 | PLA2G2A | TLR4 lauric-diethanolamide Preclinical laurocapram Phase 3 lazabemide Phase 3 monoamine oxidase inhibitor MAOB lazertinib Phase 1/Phase 2 tyrosine kinase inhibitor EGFR lb-100 Phase 2 protein phosphatase inhibitor PPP5C Neurology depression LB-100 Phase 2 protein phosphatase inhibitor LB42708 Preclinical farnesyltransferase inhibitor L-citrulline Launched nitric oxide stimulant ASS1 | DDAH1 | DDAH2 | GPRC6A | NOS1 | NOS2 | NOS3 | OTC | PADI1 | PADI2 | PADI3 | PADI4 | PADI6 cardiology | urology erectile dysfunction | hypertension LCL-161 Phase 2 XIAP inhibitor BIRC2 | XIAP LCQ908 Phase 3 diacylglycerol O acyltransferase inhibitor DGAT1 L-cysteine Launched CARS | CARS2 | CBS | CDO1 | CDO-1 | CSAD | CTH | GCLC | GCLM | GOT1 | GSS | MGMT | NFS1 | SLC19A3 rheumatology | rheumatology osteoarthritis | rheumatoid arthritis L-cysteinesulfinic-acid Preclinical glutamate receptor agonist GRM1 | GRM5 | GSR | HMGCS2 | PAPOLA | PRDX2 L-cystine Launched CTNS | SLC3A1 | SLC7A11 | SLC7A9 LCZ696 Launched angiotensin receptor antagonist cardiology | cardiology angioedema | hypotension LDC1267 Preclinical protein tyrosine kinase inhibitor AURKB | AXL | MERTK | MET | TYRO3 LDN193189 Preclinical bone morphogenic protein inhibitor ACVR1 | BMPR1A LDN-209929 Preclinical haspin kinase inhibitor GSG2 LDN-212854 Preclinical bone morphogenic protein inhibitor ABL1 | ACVR1 | ACVRL1 | RIPK2 LDN-27219 Preclinical tissue transglutaminase inhibitor TGM2 LDN-57444 Preclinical ubiquitin C-terminal hydrolase inhibitor LE-135 Preclinical retinoid receptor agonist RARB ledipasvir Launched HCV inhibitor infectious disease hepatitis C lefamulin Launched bacterial 50s ribosomal subunit inhibitor infectious disease pneumonia leflunomide Launched dihydroorotate dehydrogenase inhibitor | PDGFR tyrosine kinase receptor inhibitor AHR | CYP2C19 | DHODH | JAK3 | PTK2B | STAT6 rheumatology rheumatoid arthritis lemborexant Launched orexin receptor antagonist HCRTR1 | HCRTR2 lenacapavir Launched hiv capsid assembly inhibitor infectious disease human immunodeficiency virus (hiv-1) lenalidomide Launched anticancer agent CRBN | TNF hematologic malignancy | hematologic malignancy | hematologic malignancy mantle cell lymphoma (MCL) | multiple myeloma | myelodysplastic diseases (MDS) leniolisib Phase 2/Phase 3 PI3K inhibitor PIK3CD lenvatinib Launched FGFR inhibitor | KIT inhibitor | PDGFR tyrosine kinase receptor inhibitor | VEGFR inhibitor FGFR1 | FGFR2 | FGFR3 | FGFR4 | FLT1 | FLT4 | KDR | KIT | PDGFB | PDGFRB | RET oncology thyroid cancer leonurine Preclinical anti-inflammatory agent leptomycin b Phase 1 exportin antagonist XPO1 Oncology anticancer antibiotic LEQ506 Phase 1 G protein signaling inhibitor DHH | IHH | PTCH1 | SMO lercanidipine Launched calcium channel blocker CACNA1C | CACNA2D1 cardiology hypertension L-ergothioneine Phase 3 free radical scavenger lerisetron Phase 3 serotonin receptor antagonist HTR3A lersivirine Phase 2 non-nucleoside reverse transcriptase inhibitor lesinurad Launched uric acid diuretic SLC22A12 rheumatology gout lestaurtinib Phase 2/Phase 3 FLT3 inhibitor | growth factor receptor inhibitor | JAK inhibitor FLT3 | JAK2 | NTRK1 | NTRK2 | NTRK3 Oncology acute myeloid leukemia (aml) leteprinim Phase 2 nerve growth factor agonist letermovir Launched CMV terminase inhibitor infectious disease cytomegalovirus (CMV) letosteine Launched mucolytic agent infectious disease | pulmonary bronchitis | pneumonia letrazuril Phase 1 antiinfective drug letrozole Launched aromatase inhibitor CYP19A1 oncology breast cancer leucomethylene-blue Phase 3 nitric oxide production inhibitor | tau aggregation inhibitor MAPT leucovorin Launched folate receptor ligand oncology osteosarcoma leucovorin calcium Launched folate receptor ligand oncology osteosarcoma leucylleucine-methyl-ester Phase 2 leuprolide Launched gonadotropin releasing factor hormone receptor agonist GNRH1 | GNRHR oncology prostate cancer levalbuterol Launched adrenergic receptor agonist ADRB2 pulmonary bronchospasm levallorphan Launched opioid receptor antagonist CHRNA2 | OPRM1 pulmonary respiratory depression levamisole Withdrawn acetylcholine receptor agonist ALPL levamlodipine Launched calcium channel blocker CACNA1C | CACNA1D | CACNA1F | CACNA1S cardiology hypertension levcromakalim Phase 3 potassium channel activator ABCC9 | KCNJ5 | KCNJ8 levetiracetam Launched calcium channel blocker CACNA1B | SCN1A | SV2A neurology/psychiatry seizures levobetaxolol Launched adrenergic receptor antagonist ADRB1 | ADRB2 ophthalmology | ophthalmology glaucoma | intraocular pressure levobunolol Launched adrenergic receptor antagonist ADRB1 | ADRB2 | ADRB3 ophthalmology | ophthalmology glaucoma | ocular hypertension levobunolol-(+/-) Preclinical adrenergic receptor antagonist levobunolol-(+) Preclinical adrenergic receptor antagonist levobupivacaine Launched voltage-gated potassium channel blocker KCNA5 Anesthesia local anesthetic levocabastine Launched histamine receptor antagonist HRH1 | NTSR2 ophthalmology conjunctivitis levocarnitine Launched CRAT | CROT endocrinology carnitine deficiency levocarnitine-propionate Launched carnitine palmitoyltransferase inhibitor CRAT endocrinology | neurology/psychiatry carnitine deficiency | peripheral neuropathy levocetirizine Launched histamine receptor antagonist CXCL8 | HRH1 allergy | allergy allergic rhinitis | urticaria levodopa Launched dopamine analog | dopamine precursor DDC | DRD1 | DRD2 | DRD3 | DRD4 | DRD5 | GPR143 neurology/psychiatry Parkinson's Disease levodropropizine Launched antitussive pulmonary cough suppressant levofloxacin Launched bacterial DNA gyrase inhibitor TOP2A infectious disease | infectious disease | infectious disease | infectious disease | infectious disease | infectious disease | otolaryngology | pulmonary | urology anthrax | bronchitis | plague | pneumonia | prostatitis | pyelonephritis | sinusitis | skin infections | urinary tract infections levomenol Launched infectious disease | neurology/psychiatry skin infections | spasms levomenthol Launched OPRK1 | TRPA1 | TRPM8 | TRPV3 neurology/psychiatry pain relief levomepromazine Launched dopamine receptor antagonist ADRA1A | ADRA1B | ADRA1D | ADRA2A | ADRA2B | ADRA2C | CHRM1 | CHRM2 | CHRM3 | CHRM4 | CHRM5 | DRD1 | DRD2 | DRD3 | DRD4 | DRD5 | HRH1 | HTR2A | HTR2C gastroenterology | neurology/psychiatry | neurology/psychiatry | neurology/psychiatry | neurology/psychiatry bipolar disorder | insomnia | nausea | psychosis | schizophrenia levomequitazine Phase 2 histamine receptor antagonist HRH1 | HRH4 | PDE4A levonordefrin Launched vasodilator ADRA1A | ADRA1B | ADRA1D | ADRA2A | ADRA2B | ADRA2C | SLC6A2 hematology hemorrhage levonorgestrel Launched estrogen receptor agonist | glucocorticoid receptor antagonist | progesterone receptor agonist | progesterone receptor antagonist PGR endocrinology contraceptive levo-phencynonate Launched acetylcholine receptor antagonist CHRM1 levopropoxyphene Launched antitussive pulmonary cough suppressant levosimendan Launched calcium sensitizer KCNJ11 | KCNJ8 | PDE3A | TNNC1 cardiology congestive heart failure levosulpiride Launched dopamine receptor antagonist CA1 | CA12 | CA7 | DRD2 | DRD3 gastroenterology | gastroenterology | neurology/psychiatry | neurology/psychiatry | neurology/psychiatry | neurology/psychiatry | urology anxiety | dyspepsia | irritable bowel syndrome | premature ejaculation (PE) | psychosis | schizophrenia | vertigo levothyroxine Launched thyroid hormone stimulant THRA | THRB endocrinology myxedema coma LFM-A13 Preclinical Bruton's tyrosine kinase (BTK) inhibitor BTK LGD-6972 Phase 2 glucagon receptor antagonist GCGR LGK-974 Phase 2 porcupine inhibitor PORCN L-glutamic-acid Launched glutamate receptor agonist AADAT | AASS | ABAT | ALDH18A1 | ASNS | BCAT1 | BCAT2 | CCBL2 | DNPEP | EARS2 | ENPEP | EPRS | FOLH1 | FPGS | FTCD | GAD1 | GAD2 | GATB | GCLC | GCLM | GGCX | GLS | GLS2 | GLUD1 | GLUD2 | GLUL | GMPS | GOT1 | GOT2 | GPT | GPT2 | GRIA1 | GRIA2 | GRIA3 | GRIA4 | GRID1 | GRID2 | GRIK1 | GRIK2 | GRIK3 | GRIK4 | GRIK5 | GRIN1 | GRIN2A | GRIN2B | GRIN2C | GRIN2D | GRIN3A | GRIN3B | GRM1 | GRM2 | GRM3 | GRM4 | GRM6 | GRM7 | GRM8 | LGSN | NADSYN1 | NAGS | OPLAH | PFAS | PGCP | PSAT1 | SLC1A1 | SLC1A2 | SLC1A3 | SLC1A6 | SLC1A7 | SLC25A18 | SLC25A22 | SLC7A11 | TAT L-glutamine Launched CTPS1 | GLUL | GPRC6A | PPAT dental | gastroenterology | gastroenterology | gastroenterology | gastroenterology | neurology/psychiatry | neurology/psychiatry | neurology/psychiatry | rheumatology anxiety | Crohn's disease | diarrhea | insomnia | joint pain | mucositis | muscle pain | peptic ulcer disease (PUD) | ulcerative colitis LH846 Preclinical casein kinase inhibitor CSNK1D lhf-535 Phase 1 antiviral endocrinology fever L-hydroxyproline Launched liarozole Phase 2/Phase 3 cytochrome P450 inhibitor CYP17A1 | CYP19A1 | CYP26A1 licarbazepine Phase 3 voltage-gated sodium channel blocker SCN1A | SCN3A | SCN5A licochalcone a Phase 3 topoisomerase inhibitor PTPN1 licochalcone-A Phase 3 topoisomerase inhibitor PTPN1 | TOP1 licofelone Phase 3 cyclooxygenase inhibitor | lipoxygenase inhibitor ALOX5 | PLA2G2E | PTGES | PTGS1 | PTGS2 licogliflozin Preclinical sodium/glucose cotransporter inhibitor SLC5A1 | SLC5A2 licostinel Phase 1 NMDA receptor antagonist GRIN1 | GRIN2A | GRIN3A lidamidine Launched adrenergic receptor agonist gastroenterology diarrhea lidocaine Launched histamine receptor agonist EGFR | SCN10A | SCN5A | SCN9A dermatology | hematology | neurology/psychiatry eczema | hemorrhage | itching lidoflazine Launched calcium channel blocker SCN1A | SCN3A | SLC29A1 cardiology coronary artery disease (CAD) lifirafenib Phase 1/Phase 2 RAF inhibitor BRAF | EGFR lifitegrast Launched lymphocyte function-associated antigen negative modulator ICAM1 | ITGAL ophthalmology dry eye syndrome ligandrol Phase 2 androgen receptor modulator AR | SARM1 endocrinology cachexia ligustilide Preclinical tumor necrosis factor production inhibitor TNF limaprost-alfadex Launched prostanoid receptor agonist PTGER1 cardiology claudication LIMKi-3 Preclinical LIM kinase inhibitor LIMK1 limonin Preclinical HIV protease inhibitor linaclotide Launched guanylate cyclase activator GUCY2C gastroenterology | gastroenterology | gastroenterology "constipation | irritable bowel syndrome | irritable bowel syndrome, constipation" linagliptin Launched dipeptidyl peptidase inhibitor DPP4 endocrinology diabetes mellitus linalool Phase 1 anticonvulsant linaprazan Preclinical ATP-sensitive potassium channel inhibitor ATP12A lincomycin Launched bacterial 30S ribosomal subunit inhibitor gastroenterology enteritis lincomycin hcl Launched bacterial 30s ribosomal subunit inhibitor gastroenterology enteritis lincomycin hydrochloride Launched bacterial 30s ribosomal subunit inhibitor gastroenterology enteritis lincomycin hydrochloride (lincocin) lindane Launched GABRB1 | GLRA1 | GLRA2 | GLRA3 | GLRB infectious disease scabies linezolid Launched bacterial 50S ribosomal subunit inhibitor MAOA | MAOB infectious disease | infectious disease pneumonia | skin infections linifanib Phase 3 PDGFR tyrosine kinase receptor inhibitor | VEGFR inhibitor CSF1 | CSF1R | FLT1 | FLT3 | FLT4 | KDR | KIT | PDGFRA | PDGFRB | RET | TEK linoleic-acid Phase 3 oxidative stress inducer FABP4 | FFAR1 | FFAR4 | HNF4A | KCNB1 | PPARG | TRPM8 linopirdine Phase 3 potassium channel blocker KCNQ2 | KCNQ3 | KCNQ4 | KCNQ5 linsidomine Launched nitric oxide donor urology erectile dysfunction linsitinib Phase 3 IGF-1 inhibitor IGF1R | INSR | INSRR lintopride Preclinical serotonin receptor antagonist HTR3A | HTR3B | HTR3C | HTR3D | HTR3E | HTR4 liothyronine Launched thyroid hormone stimulant THRA | THRB endocrinology | endocrinology hypothyroidism | myxedema coma liothyronine-(isomer) Preclinical lipoamide Preclinical liquiritin Preclinical antioxidant liraglutide Launched GLP receptor agonist GCG | GLP1R | INS endocrinology | endocrinology | endocrinology "diabetes mellitus | weight-loss aid | weight-loss aid, diabetes mellitus" liranaftate Launched fungal squalene epoxidase inhibitor infectious disease fungal infection lirimilast Phase 2 phosphodiesterase inhibitor lisadimate Launched topical sunscreen agent dermatology sunscreen lotion lisinopril Launched angiotensin converting enzyme inhibitor ACE | ACE2 cardiology | cardiology | endocrinology congestive heart failure | diabetes mellitus | hypertension lisofylline Phase 2 interleukin receptor antagonist | STAT inhibitor lisuride Launched dopamine receptor agonist ADRA1A | ADRA2A | ADRA2B | ADRA2C | DRD1 | DRD2 | DRD3 | DRD4 | DRD5 | HTR1A | HTR1B | HTR1D | HTR2A | HTR2B | HTR2C | HTR6 neurology/psychiatry Parkinson's Disease lithium-acetoacetate Preclinical FAH lithium-citrate Launched neurology/psychiatry | neurology/psychiatry bipolar disorder | depression lithocholic-acid Preclinical FXR antagonist | vitamin D receptor agonist GPBAR1 | MDM2 | MDM4 | NR1H4 | NR1I2 | PTPN1 | VDR litronesib Phase 2 kinesin-like spindle protein inhibitor KIF11 lixivaptan Phase 3 vasopressin receptor antagonist AVPR2 L-kynurenine Phase 1 aryl hydrocarbon receptor agonist AHR L-leucine Phase 3 BCAT1 | BCAT2 | LARS | LARS2 | LCMT1 | LCMT2 L-lysine Phase 2 serotonin receptor agonist GPRC6A | KARS | SLC7A1 | SLC7A2 | SLC7A3 | SLC7A4 LM11A-31 Phase 1 neurotrophic agent NGFR LM-22A4 Preclinical tropomyosin receptor kinase inhibitor NTRK2 L-methionine Launched voltage-gated calcium channel ligand BHMT | BHMT2 | METAP2 | MTR | MTRR allergy | neurology/psychiatry | neurology/psychiatry | neurology/psychiatry | pulmonary allergic rhinitis | asthma | depression | Parkinson's Disease | schizophrenia LMI070 Phase 1/Phase 2 survival motor neuron protein modulator SMN1 L-mimosine Preclinical dopamine beta hydroxylase inhibitor | eukaryotic translation initiation factor inhibitor DBH | EIF5A LMK-235 Preclinical HDAC inhibitor HDAC4 | HDAC5 L-monomethylarginine Phase 3 nitric oxide synthase inhibitor NOS1 | NOS2 lmp744 hydrochloride Phase 1 topoisomerase inhibitor TOP1 oncology ovarian cancer lmp7-in-1 Preclinical PSMB8 L-NAME Phase 2/Phase 3 nitric oxide synthase inhibitor NOS3 L-NIL Preclinical nitric oxide synthase inhibitor NOS1 | NOS2 | NOS3 lobeline Launched acetylcholine receptor antagonist CHRNA10 | CHRNA4 | CHRNA9 | CHRNB2 | OPRM1 | SLC18A2 neurology/psychiatry smoking cessation lobeline hydrochloride Launched acetylcholine receptor antagonist CHRNA10 | CHRNA9 | SLC18A2 neurology/psychiatry smoking cessation lobendazole Preclinical anthelmintic agent lobenzarit Launched immunosuppressant rheumatology rheumatoid arthritis lodenosine Phase 2 antiretroviral lodoxamide Launched histamine receptor antagonist ophthalmology vernal keratoconjunctivitis (VKC) lofemizole Phase 3 cyclooxygenase inhibitor lofepramine Launched norepinephrine reuptake inhibitor | serotonin–norepinephrine reuptake inhibitor (SNRI) HTR1A | SLC6A2 | SLC6A4 neurology/psychiatry depression lofexidine Launched adrenergic receptor agonist ADRA2A neurology/psychiatry opioid withdrawal lomefloxacin Launched bacterial DNA gyrase inhibitor infectious disease | infectious disease respiratory tract infections | urinary tract infections lomefloxacin hcl Launched bacterial dna gyrase inhibitor infectious disease "respiratory tract infections, urinary tract infections" lomeguatrib Phase 2 O6-alkylguanine-DNA alkyltransferase inhibitor MGMT lomerizine Launched calcium channel blocker ABCB1 | CACNA1B | SCN5A neurology/psychiatry migraine headache lometrexol Phase 2 glycinamide ribonucleotide formyltransferase inhibitor GART lomitapide Launched microsomal trigylceride transfer protein inhibitor CYP2B6 | CYP2C19 | CYP2C8 | MTTP endocrinology hypercholesterolemia lomustine Launched DNA synthesis inhibitor hematologic malignancy | oncology brain tumors | Hodgkin's lymphoma lonafarnib Phase 3 farnesyltransferase inhibitor FNTA | HRAS | KRAS | NRAS lonapalene Preclinical lipoxygenase inhibitor ALOX5 dermatology psoriasis lonidamine Launched glucokinase inhibitor GCK loperamide Launched opioid receptor agonist CACNA1A | CALM1 | CYP2B6 | CYP2C8 | NPR2 | OPRD1 | OPRK1 | OPRM1 | POMC gastroenterology diarrhea lopinavir Launched HIV protease inhibitor infectious disease human immunodeficiency virus (HIV-1) loracarbef Launched bacterial cell wall synthesis inhibitor infectious disease | infectious disease | infectious disease | infectious disease | otolaryngology | pulmonary bronchitis | ear infections | laryngitis | pneumonia | skin infections | urinary tract infections loratadine Launched histamine receptor antagonist CYP2C19 | CYP3A5 | HRH1 allergy | neurology/psychiatry allergic rhinitis | itching loreclezole Phase 2 benzodiazepine receptor agonist GABRB2 | GABRB3 lorediplon Phase 2 GABA receptor modulator GABRA1 lorglumide Phase 1 CCK receptor antagonist CCKAR | CCKBR lorglumide sodium Phase 1 cck receptor antagonist CCKAR | CCKBR lorlatinib Launched ALK tyrosine kinase receptor inhibitor ALK | ROS1 oncology non-small cell lung cancer (NSCLC) lornoxicam Launched cyclooxygenase inhibitor PTGS1 | PTGS2 neurology/psychiatry | rheumatology osteoarthritis | sciata losartan Launched angiotensin receptor antagonist AGTR1 cardiology | nephrology diabetic nephropathy | hypertension losmapimod Phase 3 p38 MAPK inhibitor MAPK14 lotamilast Preclinical phosphodiesterase inhibitor PDE4A | PDE4B | PDE4C | PDE4D loteprednol Launched glucocorticoid receptor agonist | phospholipase inhibitor NR3C1 ophthalmology conjunctivitis lotilaner Launched gaba receptor antagonist GABRA1 infectious disease flea control lovastatin Launched HMGCR inhibitor CYP3A5 | HDAC2 | HMGCR | ITGAL | NR1I2 cardiology | cardiology | endocrinology coronary heart disease | hypercholesterolemia | myocardial infarction loxapine Launched dopamine receptor antagonist | serotonin receptor antagonist ADRA1A | ADRA1B | ADRA2A | ADRA2B | ADRA2C | ADRB1 | CHRM1 | CHRM2 | CHRM3 | CHRM4 | CHRM5 | DRD1 | DRD2 | DRD3 | DRD4 | DRD5 | HRH1 | HRH2 | HRH4 | HTR1A | HTR1B | HTR1D | HTR1E | HTR2A | HTR2C | HTR3A | HTR5A | HTR6 | HTR7 | SLC6A2 | SLC6A3 | SLC6A4 neurology/psychiatry schizophrenia loxistatin-acid Preclinical cysteine peptidase inhibitor CTSB loxoprofen Launched cyclooxygenase inhibitor | prostanoid receptor antagonist PTGS2 neurology/psychiatry pain relief LP-533401 Preclinical tryptophan hydroxylase inhibitor TPH1 | TPH2 LPA2-antagonist-1 Preclinical lysophosphatidic acid receptor antagonist LPAR2 L-phenylisopropyladenosine Preclinical L-proline Launched glutamate receptor agonist EPRS | L3HYPDH | P3H1 | P3H2 | P3H3 | P4HA1 | P4HA2 | PARS2 | PPIA | PPIB | PPIC | PPIF | PPIG | PPIH | PRODH | PROSC | PYCR1 | PYCR2 | PYCRL | SLC6A14 | SLC6A7 L-quisqualic-acid Preclinical glutamate receptor agonist FOLH1 | GRIA2 | GRIK1 | GRIK2 | GRM1 | GRM2 | GRM3 | GRM5 | GRM7 | GRM8 L-(+)-rhamnose-monohydrate Preclinical LRRK2-IN-1 Preclinical leucine rich repeat kinase inhibitor LRRK2 LSN-2463359 Preclinical glutamate receptor positive allosteric modulator GRM5 l(-)sorbose Launched phosphorylase inhibitor PYGL LSZ-102 Phase 1 selective estrogen receptor modulator (SERM) ESR1 | ESR2 LTA Phase 2 lta4h-in-1 Phase 2 leukotriene inhibitor LTA4H gastroenterology inflammatory bowel disease LTB4 Phase 2 leukocyte activator LTB4R | LTB4R2 l-theanine Launched glutamate receptor antagonist L-theanine Launched glutamate receptor antagonist L-threonine Phase 2 TARS | TARS2 | THNSL1 LTX-315 Phase 2 anticancer agent Lu-AA-47070 Phase 2 adenosine receptor antagonist ADORA2A lubiprostone Launched chloride channel activator CLCN2 gastroenterology | gastroenterology constipation | irritable bowel syndrome lucanthone Phase 2 endonuclease inhibitor APEX1 | TOP1 | TOP2A lucitanib Phase 2 FGFR inhibitor | VEGFR inhibitor CSF1R | FGFR1 | FGFR2 | FLT1 | FLT4 | KDR | KIT | PDGFRA | PDGFRB | RET LUF-5834 Preclinical adenosine receptor agonist ADORA2A | ADORA2B lufenuron Launched chitin inhibitor infectious disease flea control luliconazole Launched sterol demethylase inhibitor infectious disease | infectious disease | infectious disease tinea corporis | tinea cruris | tinea pedis lumacaftor Launched CFTR channel agonist CFTR pulmonary cystic fibrosis lumateperone Launched dopamine receptor modulator | serotonin receptor antagonist DRD2 | HTR2A lumefantrine Launched antimalarial agent ATP1A1 infectious disease malaria lumiracoxib Withdrawn cyclooxygenase inhibitor PTGS1 | PTGS2 lupanine Preclinical "insulin secretagogue | sodium channel blocker | sodium channel blocker, insulin secretagogue" INS Endocrinology diabetes mellitus lurasidone Launched dopamine receptor antagonist | serotonin receptor antagonist ADRA2A | ADRA2C | DRD2 | HTR1A | HTR2A | HTR7 neurology/psychiatry schizophrenia lurbinectedin Phase 3 DNA binding agent lusaperidone Preclinical adrenergic receptor antagonist ADRA2A lusutrombopag Launched thrombopoietin receptor agonist MPL | THPO lutein Launched antioxidant ophthalmology | ophthalmology | ophthalmology cataracts | macular degeneration | retinitis pigmentosa (RP) luteolin Phase 2 glucosidase inhibitor AKR1B1 | GAA | MAOA | TOP1 | XDH luzindole Preclinical melatonin receptor antagonist MTNR1A | MTNR1B L-valine Phase 2 LX1031 Phase 2 tryptophan hydroxylase inhibitor TPH1 LX7101 Phase 1/Phase 2 LIM kinase inhibitor | rho associated kinase inhibitor LIMK2 | ROCK1 | ROCK2 LXH254 Phase 1 RAF inhibitor RAF1 LXR-623 Phase 1 LXR agonist ABCA1 | AR | NR1H2 | NR1H3 | NR1I2 | NR3C1 LXS196 Phase 1 PKC inhibitor GSK3B | PRKCA | PRKCQ LY2090314 Phase 2 glycogen synthase kinase inhibitor GSK3B LY2109761 Preclinical TGF beta receptor inhibitor TGFBR1 | TGFBR2 LY2140023 Phase 3 glutamate receptor agonist GRM2 | GRM3 LY215490 Phase 1 glutamate receptor antagonist GRIA1 | GRIA2 | GRIA3 | GRIA4 | GRIK1 LY2157299 Phase 2/Phase 3 TGF beta receptor inhibitor TGFBR1 LY2183240 Preclinical FAAH inhibitor | FAAH reuptake inhibitor FAAH LY2228820 Phase 2 p38 MAPK inhibitor MAPK14 LY223982 Phase 2 leukotriene receptor antagonist LTB4R LY225910 Preclinical CCK receptor antagonist CCKBR LY231617 Preclinical lipid peroxidase inhibitor LY2334737 Phase 1 antitumor agent | ribonucleotide reductase inhibitor LY2365109 Preclinical glycine transporter inhibitor SLC6A9 LY2452473 Phase 2 androgen receptor modulator AR LY2510924 Phase 2 CC chemokine receptor antagonist CXCR4 LY255283 Preclinical leukotriene receptor antagonist LTB4R | LTB4R2 ly2562175 Phase 2 fxr agonist NR1H4 gastroenterology non-alcoholic steatohepatitis (nash) LY2584702 Phase 1 ribosomal protein inhibitor RPS6KB1 LY2603618 Phase 2 CHK inhibitor CHEK1 LY2606368 Phase 2 CHK inhibitor CHEK1 LY2608204 Phase 2 glucokinase activator GCK LY266097 Preclinical serotonin receptor antagonist HTR2B LY2784544 Phase 2 JAK inhibitor JAK2 | JAK3 LY2795050 Preclinical opioid receptor antagonist OPRK1 LY2801653 Phase 2 MET inhibitor MET | MST1R LY2811376 Phase 1 beta-secretase inhibitor BACE1 LY2828360 Phase 2 cannabinoid receptor agonist CNRIP1 LY2857785 Preclinical CDK inhibitor CDK8 | CDK9 LY2874455 Phase 1 FGFR antagonist FGFR1 | FGFR2 | FGFR3 | FGFR4 | KDR LY288513 Preclinical CCK receptor antagonist CCKBR ly2886721 Phase 1/Phase 2 beta-secretase inhibitor BACE1 LY2886721 Phase 1/Phase 2 beta-secretase inhibitor BACE1 | BACE2 ly2922470 Phase 1 g protein-coupled receptor agonist FFAR1 endocrinology diabetes mellitus LY294002 Preclinical DNA dependent protein kinase inhibitor | mTOR inhibitor | phosphodiesterase inhibitor | PI3K inhibitor | PLK inhibitor AKT1 | CHEK1 | GSK3B | LCK | MAPK1 | MAPK11 | MAPK12 | MAPK14 | MAPK8 | MTOR | PDE2A | PIK3CA | PIK3CB | PIK3CD | PIK3CG | PIM1 | PLK1 | PRKCA | PRKDC | ROCK1 | RPS6KB1 | SGK1 ly2940094 Phase 2 nociceptin/orphanin fq (nop) receptor antagonist OPRL1 neurology/psychiatry depression LY2979165 Phase 1 glutamate receptor agonist GRM2 LY3000328 Phase 1 cathepsin inhibitor CTSS LY3009120 Phase 1 RAF inhibitor ARAF | BRAF | RAF1 LY3023414 Phase 2 mTOR inhibitor | PI3K inhibitor AKT1 | MTOR LY303511 Preclinical casein kinase inhibitor | mTOR inhibitor | PI3K inhibitor BRD2 | BRD3 | BRD4 | CSNK2A1 | CSNK2A2 | CSNK2B | MTOR LY310762 Preclinical serotonin receptor antagonist HTR1D LY311727 Preclinical phospholipase inhibitor PLA2G2A LY3200882 Phase 1 TGF beta receptor inhibitor TGFBR1 LY320135 Preclinical cannabinoid receptor antagonist CNR1 LY3214996 Phase 1 ERK inhibitor MAPK1 | MAPK3 LY3295668 Phase 1/Phase 2 Aurora kinase inhibitor AURKA LY334370 Preclinical serotonin receptor agonist HTR1F LY344864 Preclinical serotonin receptor agonist HTR1A | HTR1B | HTR1D | HTR1E | HTR1F | HTR2A | HTR2B | HTR2C | HTR7 LY364947 Preclinical p38 MAPK inhibitor | TGF beta receptor inhibitor TGFBR1 LY393558 Preclinical serotonin receptor antagonist HTR1B | HTR1D | HTR2A | HTR2B | SLC6A4 LY404187 Preclinical glutamate receptor positive allosteric modulator GRIA1 | GRIA2 | GRIA3 | GRIA4 LY411575 Preclinical gamma secretase inhibitor LY450108 Phase 1 glutamate receptor modulator LY456236 Preclinical glutamate receptor antagonist GRM1 lycopene Launched free radical scavenger lylamine Preclinical cannabinoid receptor agonist CNR1 lymecycline Launched bacterial 50S ribosomal subunit inhibitor dermatology acne vulgaris (AV) lynestrenol Launched progestogen hormone endocrinology contraceptive lypressin Launched vasopressin receptor agonist AVPR1A | AVPR1B | AVPR2 endocrinology central diabetes insipidus M-14157 Phase 2 ATP-sensitive potassium channel antagonist KCNQ1 M-25 Preclinical smoothened receptor antagonist DHH | IHH | PTCH1 | SMO M-344 Preclinical HDAC inhibitor HDAC8 m-3M3FBS Preclinical phospholipase activator PLCB2 | PLCB3 | PLCD1 | PLCG1 | PLCG2 M8-B Preclinical transient receptor potential channel antagonist TRPM8 mabuprofen Launched cyclooxygenase inhibitor neurology/psychiatry pain relief mabuterol Launched adrenergic receptor agonist ADRB2 pulmonary asthma macelignan Preclinical anti-inflammatory agent | antioxidant PPARA | PPARG macimorelin Launched ghrelin receptor agonist GHSR endocrinology cachexia macitentan Launched endothelin receptor antagonist EDNRA | EDNRB endocrinology contraceptive macitentan-n-butyl-analogue Preclinical endothelin receptor antagonist EDNRA | EDNRB macozinone Preclinical DPRE1 inhibitor DprE1 madecassoside Preclinical anti-inflammatory agent madrasin Preclinical cell splicing inhibitor maduramicin acid Launched other antibiotic PPP2CA | PTEN infectious disease coccidiosis mafenide Launched carbonic anhydrase inhibitor CA12 | CA14 | CA2 | CA4 | CA6 | CA9 infectious disease | infectious disease first-aid antibiotic | skin infections magnolol Preclinical PPAR receptor agonist GABRA1 | KCNA2 | KCNA3 | KCNA5 | KCNAB2 | KCNC1 | KCNC2 | KCNC3 | KCNE1 | KCNE2 | KCNE3 | KCNE4 | KCNH1 | KCNH2 | KCNQ1 | KCNQ2 | KCNQ3 | KCNQ5 | KCNS3 | PPARG malathion Launched cholinesterase inhibitor ACHE infectious disease lice malic-acid Launched PKD2L1 malotilate Launched protein synthesis stimulant gastroenterology hepatic cirrhosis maltobionic-acid Launched matrix metalloprotease inhibitor dermatology cosmetic mandelic-acid Launched mangafodipir Launched contrast agent radiology contrast agent manidipine Launched calcium channel blocker CACNA1C | CACNA1D cardiology hypertension manidipine hydrochloride Launched calcium channel blocker CACNA1C | CACNA1D cardiology hypertension manitimus Preclinical dehydrogenase inhibitor DHODH mannitol-D Launched diuretic gastroenterology | neurology/psychiatry | ophthalmology constipation | intracranial pressure | intraocular pressure map4343 Phase 2 microtubule stimulant MAP2 neurology/psychiatry depression mapracorat Phase 3 glucocorticoid receptor agonist CXCL8 | MYOC | NR3C1 ophthalmology cataracts maprotiline Launched norepinephrine reputake inhibitor | tricyclic antidepressant SLC6A2 neurology/psychiatry | neurology/psychiatry depression | dysthymic disorder maprotiline hcl Launched "norepinephrine reputake inhibitor, tricyclic antidepressant" SLC6A2 neurology/psychiatry "depression, dysthymic disorder" maraviroc Launched CC chemokine receptor antagonist CCR5 | CYP3A5 infectious disease human immunodeficiency virus (HIV-1) marbofloxacin Launched bacterial DNA gyrase inhibitor infectious disease gram-negative bacterial infections maribavir Phase 3 cytomegalovirus inhibitor | protein kinase inhibitor PYGM marimastat Phase 3 matrix metalloprotease inhibitor MMP1 | MMP10 | MMP11 | MMP12 | MMP13 | MMP14 | MMP15 | MMP16 | MMP17 | MMP19 | MMP2 | MMP20 | MMP21 | MMP23A | MMP24 | MMP25 | MMP26 | MMP27 | MMP28 | MMP3 | MMP7 | MMP8 | MMP9 maropitant Launched neurokinin receptor antagonist TACR1 gastroenterology vomiting masitinib Launched KIT inhibitor | PDGFR tyrosine kinase receptor inhibitor | SRC inhibitor FGFR3 | KIT | LYN | PDGFRA | PDGFRB dermatology mastocytoma masoprocol Launched lipoxygenase inhibitor ALOX5 | IGF1R dermatology actinic keratosis (AK) matrine Phase 2 opioid receptor agonist OPRK1 (+)-matrine Phase 2 opioid receptor agonist OPRK1 mavacamten Phase 3 myosin inhibitor MYH7 mavacoxib Launched cyclooxygenase inhibitor PTGS2 rheumatology joint inflammation mavatrep Preclinical transient receptor potential channel antagonist TRPV1 mavoglurant Phase 2 glutamate receptor antagonist CYP2C19 | CYP2C8 | GRM5 maxacalcitol Launched vitamin D receptor agonist VDR endocrinology hyperparathyroidism maytansinol-isobutyrate Preclinical mb-07344 Preclinical thyroid hormone receptor agonist THRB endocrinology hypercholesterolemia MBX-2982 Phase 2 glucose dependent insulinotropic receptor agonist GPR119 MC-1 Phase 3 AADAT | ABAT | AGXT | AGXT2 | ALAS1 | AZIN2 | BCAT1 | BCAT2 | CBS | CCBL1 | CCBL2 | CSAD | CTH | DDC | FTCD | GAD1 | GAD2 | GADL1 | GCAT | GLDC | GOT1 | GOT2 | GPT | GPT2 | HDC | IGSF10 | KYNU | MOCOS | NFS1 | OAT | ODC1 | PDXDC1 | PDXP | PHYKPL | PNPO | PROSC | PSAT1 | PYGB | PYGL | PYGM | SCLY | SDS | SDSL | SEPSECS | SGPL1 | SHMT1 | SHMT2 | SPTLC1 | SPTLC2 | SPTLC3 | SRR | TAT | THNSL1 MC1568 Preclinical HDAC inhibitor HDAC2 mcb-3681 Phase 2 other antibiotic infectious disease gram-positive bacterial infections MCC950 Preclinical NOD like receptor inhibitor IL1B | NLRP3 m-chlorophenylbiguanide Preclinical serotonin receptor agonist HTR3A | HTR3B McN-5652-(+/-) Preclinical selective serotonin reuptake inhibitor (SSRI) MCOPPB Preclinical nociceptin/orphanin FQ receptor agonist OPRL1 mCPP Phase 2 serotonin receptor agonist HTR1A | HTR1D | HTR1E | HTR2A | HTR2B | HTR2C | HTR6 MD-920 Phase 1 NFkB pathway inhibitor AADACL2 mdivi-1 Preclinical dynamin inhibitor DNM1 MDL-11939 Phase 2 serotonin receptor antagonist HTR2A | HTR2B | HTR2C MDL-27531 Preclinical glycine receptor agonist MDL-29951 Preclinical glutamate receptor antagonist FBP1 | GPR17 mdl 72222 Phase 3 serotonin receptor antagonist HTR3A | HTR3B MDL-72832 Preclinical serotonin receptor agonist HTR1A MDL-73005EF Phase 1 serotonin receptor antagonist HTR1A MDMS Phase 2 DNA inhibitor mdr-652 Preclinical trpv agonist TRPV1 neurology/psychiatry chronic pain ME0328 Preclinical PARP inhibitor PARP1 | PARP3 ME-0328 Preclinical PPAR receptor antagonist PARP3 mebendazole Launched tubulin polymerization inhibitor TUBA1A | TUBB | TUBB4B infectious disease | infectious disease | infectious disease | infectious disease ascariasis | hookworm | pinworm | whipworm mebeverine Launched acetylcholine receptor antagonist CHRM1 | CHRM2 | CHRM3 | CHRM4 gastroenterology irritable bowel syndrome mebhydrolin Launched antihistamine allergy | allergy allergic rhinitis | urticaria mebicar Launched anxiolytic neurology/psychiatry anxiety mebrofenin Launched radiology diagnostic agent mecamylamine Launched acetylcholine receptor antagonist CHRNA1 | CHRNA2 | CHRNA3 | CHRNA4 | CHRNA6 | CHRNA7 | CHRNB4 cardiology hypertension mecamylamine hydrochloride Launched nicotinic receptor antagonist CHRNA7 Neurology depression mecarbinate Preclinical meclinertant Phase 2/Phase 3 neurotensin receptor antagonist NTSR1 | NTSR2 meclizine Launched constitutive androstane receptor (CAR) agonist NR1I3 gastroenterology | gastroenterology | neurology/psychiatry motion sickness | nausea | vomiting meclizine hydrochloride Launched constitutive androstane receptor (car) agonist NR1I3 "gastroenterology, neurology/psychiatry" "nausea, vomiting, motion sickness" meclocycline Launched ribosomal protein inhibitor dental mucositis meclocycline-sulfosalicylate Launched bacterial 50S ribosomal subunit inhibitor dermatology | infectious disease acne vulgaris (AV) | skin infections meclofenamic-acid Launched cyclooxygenase inhibitor | prostanoid receptor antagonist ALOX5 | CNR1 | KCNQ2 | KCNQ3 | PTGS1 | PTGS2 endocrinology | neurology/psychiatry | rheumatology | rheumatology joint pain | muscle pain | primary dysmenorrhea (PD) | rheumatoid arthritis meclofenoxate Launched nootropic agent neurology/psychiatry | neurology/psychiatry Alzheimer's disease | senile dementia mecysteine Launched analgesic agent pulmonary chest congestion mecysteine hydrochloride Launched analgesic agent pulmonary chest congestion medetomidine Launched adrenergic receptor agonist ADRA1A | ADRA1B | ADRA1D | ADRA2A | ADRA2B | ADRA2C neurology/psychiatry sedative medica-16 Phase 2 ATP citrase lyase inhibitor ACLY | FFAR1 medorinone Phase 1 medronic-acid Launched bone resorption inhibitor radiology skeletal imaging agent medroxyprogesterone Launched progesterone receptor agonist PGR endocrinology contraceptive medroxyprogesterone acetate Launched progesterone receptor agonist ESR1 | PGR endocrinology contraceptive medroxyprogesterone-acetate Launched progesterone receptor agonist ESR1 | PGR endocrinology contraceptive medrysone Launched glucocorticoid receptor agonist NR3C1 ophthalmology | ophthalmology | ophthalmology "conjunctivitis | conjunctivitis, episcleritis | episcleritis" mefenamic-acid Launched cyclooxygenase inhibitor KCNQ1 | PTGS1 | PTGS2 | TRPM3 endocrinology primary dysmenorrhea (PD) mefexamide Preclinical psychoactive drug mefloquine Launched adenosine receptor antagonist | hemoglobin antagonist | protein synthesis inhibitor PANX1 infectious disease malaria megestrol Launched progesterone receptor agonist PGR oncology breast cancer megestrol-acetate Launched progesterone receptor agonist NR3C1 | PGR endocrinology | neurology/psychiatry anorexia | cachexia meglitinide Phase 2 potassium channel blocker ABCC8 | CCR2 | KCNJ11 meglumine Launched excipient meglutol Launched HMGCR inhibitor HMGCR meisoindigo Phase 3 STAT inhibitor STAT3 MEK1-2-inhibitor Preclinical MEK inhibitor MAP2K1 | MAP2K2 melanotan i melanotan-ii Launched melanocortin receptor agonist MC1R | MC3R | MC4R | MC5R melatonin Launched melatonin receptor agonist | nitric oxide synthase inhibitor ASMT | CALM1 | CALR | EPX | ESR1 | HTR2B | MPO | MTNR1A | MTNR1B | NQO2 | RORB | TH neurology/psychiatry sleep cycle support meldonium Launched gamma butyrobetaine hydroxylase inhibitor BBOX1 cardiology coronary artery disease (CAD) melengestrol-acetate Preclinical progesterone receptor agonist melevodopa Launched "dopamine precursor | dopamine precursor, dopamine receptor agonist | dopamine receptor agonist" DDC neurology/psychiatry Parkinson's Disease melflufen (hydrochloride) Launched dna alkylating agent hematologic malignancy multiple myeloma meloxicam Launched cyclooxygenase inhibitor PTGS1 | PTGS2 rheumatology | rheumatology | rheumatology "osteoarthritis | osteoarthritis, rheumatoid arthritis | rheumatoid arthritis" melperone Launched dopamine receptor antagonist | serotonin receptor antagonist DRD2 | HTR1A | HTR2A neurology/psychiatry psychosis melphalan Launched DNA alkylating agent | DNA inhibitor hematologic malignancy multiple myeloma melphalan flufenamide Launched dna alkylating agent hematologic malignancy multiple myeloma melphalan-n-oxide Phase 1 hypoxia inducible factor inhibitor HIF1A meluadrine Preclinical memantine Launched glutamate receptor antagonist CYP2E1 | GRIN1 neurology/psychiatry | neurology/psychiatry Alzheimer's disease | senile dementia memantine hcl Launched glutamate receptor antagonist neurology/psychiatry "alzheimer's disease, senile dementia" menadiol sodium sulfate Withdrawn vitamin k F10 | F2 | F7 | F9 | GGCX | PROC | PROS1 hematology hemorrhage menadione Launched mitochondrial DNA polymerase inhibitor | phosphatase inhibitor AOX1 | BGLAP | F10 | F2 | F7 | F9 | GGCX | NQO1 | NQO2 | PKM | PROC | PROS1 | PROZ | VKORC1 | VKORC1L1 dermatology | gastroenterology | gastroenterology | neurology/psychiatry | rheumatology diarrhea | headache | rheumatoid arthritis | ulcerative colitis | varicose veins menadione-bisulfite Phase 2 vitamin K GGCX | VKORC1 | VKORC1L1 menaquinone-7 Phase 2 osteoclast inhibitor TNFRSF11B cardiology arteriosclerosis menatetrenone Launched bone resorption inhibitor orthopedics osteoporosis menbutone Launched gastroenterology bile stimulation mepacrine Launched cytokine production inhibitor | NFkB pathway inhibitor | TP53 activator AKT1 | MTOR | NFKB1 | PLA2G1B | PLA2G2A | PLA2G2D | TP53 infectious disease giardiasis meparfylon Preclinical mepazine Phase 2 MALT1 inhibitor (JH) MALT1 mepenzolate Launched acetylcholine receptor antagonist gastroenterology peptic ulcer disease (PUD) mephenesin Launched muscle relaxant neurology/psychiatry muscle relaxant mephentermine Launched adrenergic receptor agonist ADRA1A | ADRA1B | ADRA1D | ADRA2A | ADRA2B | ADRA2C | ADRB1 | ADRB2 | ADRB3 cardiology hypotension mephenytoin Launched hydantoin antiepileptic CYP2C19 | SCN5A neurology/psychiatry seizures mepiroxol Preclinical mepivacaine Launched potassium channel blocker | sodium channel blocker SCN9A neurology/psychiatry local anesthetic meprednisone Launched NR3C1 meprylcaine Preclinical local anesthetic meptazinol Launched opioid receptor agonist BCHE neurology/psychiatry pain relief mepyramine Launched histamine receptor antagonist HRH1 obstetrics/gynecology | otolaryngology common cold | menstrual pain mequinol Launched TYR dermatology skin depigmentation merbarone Phase 2 topoisomerase inhibitor TOP2A | TOP2B merbromin Launched antiseptic infectious disease first-aid antiseptic mercaptopurine Launched immunosuppressant | protein synthesis inhibitor | purine antagonist HPRT1 | IMPDH1 | IMPDH2 | PPAT hematologic malignancy acute lymphoblastic leukemia (ALL) mercaptosuccinic-acid Launched Merck60 Preclinical HDAC inhibitor HDAC1 | HDAC2 mericitabine Phase 2 HCV inhibitor merimepodib Phase 2 inosine monophosphate dehydrogenase inhibitor IMPDH1 meropenem Launched bacterial cell wall synthesis inhibitor infectious disease | infectious disease | infectious disease intra-abdominal infections | meningitis | skin infections mertansine Phase 2 microtubule inhibitor TUBA1A | TUBB | TUBD1 | TUBE1 | TUBG1 mesalazine Launched cyclooxygenase inhibitor | lipoxygenase inhibitor | prostanoid receptor antagonist ALOX5 | CHUK | CTNNB1 | IKBKB | MPO | NAT1 | PPARG | PTGS1 | PTGS2 gastroenterology | gastroenterology inflammatory bowel disease | ulcerative colitis mesna Launched antioxidant urology hemorrhagic cystitis mesoridazine Launched dopamine receptor antagonist DRD2 | HTR2A neurology/psychiatry schizophrenia mestinon Launched cholinesterase inhibitor ACHE | BCHE neurology/psychiatry myasthenia gravis mestranol Launched estrogen receptor agonist ESR1 endocrinology contraceptive mesulergine Phase 2 dopamine receptor agonist HTR2A | HTR2B | HTR2C | HTR3A | HTR3B | HTR6 | HTR7 metacetamol Preclinical analgesic agent metacresol Launched INS meta-cresyl-acetate Preclinical metaflumizone Withdrawn sodium channel blocker SCN8A infectious disease flea control metafolin Launched metamizole Withdrawn cyclooxygenase inhibitor | opioid receptor agonist PTGS1 metaphit Preclinical phencyclidine receptor acylator metaproterenol Launched adrenergic receptor agonist ADRB2 pulmonary | pulmonary | pulmonary | pulmonary | pulmonary "asthma | bronchitis | bronchospasm | bronchospasm, asthma, bronchitis, emphysema | emphysema" metaraminol Launched adrenergic receptor agonist ADRA1A cardiology hypotension metarrestin Phase 1 rna polymerase inhibitor EEF1A2 oncology pancreatic cancer metatinib Phase 1 Bcr-Abl kinase inhibitor ABL1 | BCR | KDR | MET metaxalone Launched muscle relaxant neurology/psychiatry muscle pain metazosin Phase 2 adrenergic receptor antagonist ADRA1A metenkephalin Phase 2 immunostimulant OGFR | OPRD1 metergoline Launched "dopamine receptor agonist | dopamine receptor agonist, serotonin receptor antagonist | serotonin receptor antagonist" DRD2 | HTR1A | HTR1B | HTR1D | HTR1E | HTR1F | HTR2A | HTR2B | HTR2C | HTR5A | HTR6 | HTR7 "endocrinology | neurology/psychiatry | neurology/psychiatry | neurology/psychiatry, endocrinology" "anxiety | hyperprolactinemia | seasonal affective disorder | seasonal affective disorder, anxiety, hyperprolactinemia" metformin Launched insulin sensitizer ACACB | INS | PRKAB1 endocrinology diabetes mellitus methacholine Launched acetylcholine receptor agonist CHRM2 | CHRM4 pulmonary bronchial hyperresponsiveness diagnostic methacycline Preclinical protein synthesis inhibitor pulmonary bronchitis methacycline hcl Preclinical protein synthesis inhibitor pulmonary bronchitis methanesulfonyl-fluoride Phase 2 acetylcholinesterase inhibitor ACHE methantheline Launched acetylcholine receptor antagonist CHRM1 | HRH2 gastroenterology | gastroenterology | gastroenterology | neurology/psychiatry | urology dyskinesia | irritable bowel syndrome | neurogenic bladder | pancreatitis | peptic ulcer disease (PUD) methapyrilene Withdrawn histamine receptor antagonist HRH1 metharbital Launched GABA receptor modulator CHRNA4 | CHRNA7 | GABRA1 | GABRA2 | GABRA3 | GABRA4 | GABRA5 | GABRA6 | GABRB1 | GABRB2 | GABRB3 | GABRD | GABRE | GABRG1 | GABRG2 | GABRG3 | GABRP | GABRQ | GRIA2 | GRIK2 neurology/psychiatry epilepsy methazolamide Launched carbonic anhydrase inhibitor CA1 | CA12 | CA14 | CA2 | CA4 | CA7 | INS ophthalmology | ophthalmology | ophthalmology "glaucoma | glaucoma, intraocular pressure | intraocular pressure" methenamine Launched bacterial DNA inhibitor infectious disease urinary tract infections methiazole Preclinical anthelmintic agent methicillin Launched bacterial cell wall synthesis inhibitor infectious disease | infectious disease gram-negative bacterial infections | gram-positive bacterial infections methimazole Launched antithyroid agent TPO endocrinology hyperthyroidism methionine Launched METAP2 methiopril Phase 2 angiotensin converting enzyme inhibitor ACE methocarbamol Launched muscle relaxant CA1 neurology/psychiatry muscle relaxant methoprene-(s) Preclinical methotrexate Launched dihydrofolate reductase inhibitor AOX1 | DHFR | FOLR1 | TYMS dermatology | hematologic malignancy | oncology | oncology | rheumatology acute lymphoblastic leukemia (ALL) | gestational choriocarcinoma | hydatidiform mole | psoriasis | rheumatoid arthritis methotrexate(+/-) methoxamine Launched adrenergic receptor agonist ADRA1A | ADRA1B | ADRA1D cardiology hypotension methoxsalen Launched DNA synthesis inhibitor ACHE | CYP1A1 | CYP1A2 | CYP2A13 | CYP2A6 | CYP3A4 dermatology psoriasis methoxyamine Phase 2 DNA repair enzyme inhibitor APEX1 methoxyflurane Launched membrane permeability inhibitor ATP2C1 | ATP5D | GABRA1 | GABRA2 | GABRA3 | GABRA4 | GABRA5 | GABRA6 | GABRB1 | GABRB2 | GABRB3 | GABRD | GABRE | GABRG1 | GABRG2 | GABRG3 | GABRP | GABRQ | GLRA1 | GLRB | GRIA1 | KCNA1 | MT-ND1 neurology/psychiatry general anaesthetic methoxyphenamine Launched adrenergic receptor agonist pulmonary asthma methscopolamine Launched acetylcholine receptor antagonist CHRM1 | CHRM2 | CHRM3 | HRH1 gastroenterology peptic ulcer disease (PUD) methscopolamine bromide Launched acetylcholine receptor antagonist CHRM1 | CHRM2 | CHRM3 gastroenterology peptic ulcer disease (pud) methsuximide Launched T-type calcium channel blocker CACNA1G | CACNA1H | CACNA1I neurology/psychiatry seizures methyclothiazide Launched chloride reabsorption inhibitor SLC12A1 | SLC12A3 cardiology | cardiology edema | hypertension methyl-5-hydroxytryptamine Preclinical methyl-aminolevulinate Launched oxidizing agent FCGR1A | FECH dermatology actinic keratosis (AK) methylatropine-nitrate Preclinical acetylcholine receptor antagonist CHRM1 methylbenactyzium-bromide Preclinical cholinergic receptor antagonist CHRM1 | CHRM2 | CHRM3 | CHRM4 | CHRM5 methylbenzethonium-chloride Preclinical other antibiotic methylcobalamin Phase 3 vitamin B methyldopa Launched adrenergic receptor agonist ADRA2A | ADRA2B | ADRA2C | DDC cardiology hypertension methyldopate Launched cardiology hypertension methylene-blue Launched guanylyl cyclase inhibitor | nitric oxide production inhibitor ACHE | MAPT hematology methemoglobinemia methylergometrine Launched dopamine receptor antagonist | serotonin receptor antagonist DRD1 | HTR1E | HTR1F | HTR2A | HTR2B | HTR2C hematology | neurology/psychiatry migraine headache | postpartum hemorrhage (PPH) methyllycaconitine Preclinical acetylcholine receptor antagonist CHRNA7 methylnaltrexone Launched opioid receptor antagonist OPRD1 | OPRK1 | OPRM1 gastroenterology constipation methylnaltrexone (bromide) Launched opioid receptor antagonist OPRD1 | OPRK1 | OPRM1 gastroenterology constipation methyl-nicotinate Phase 2 methylparaben Launched other antifungal dermatology cosmetic methylphenidate hydrochloride methylprednisolone Launched glucocorticoid receptor agonist NR3C1 allergy | dermatology | dermatology | endocrinology | endocrinology | gastroenterology | gastroenterology | hematology | infectious disease | neurology/psychiatry | rheumatology | rheumatology | rheumatology | rheumatology allergic rhinitis | anemia | ankylosing spondylitis | bursitis | enteritis | hypercalcemia | multiple sclerosis | mycosis | osteoarthritis | psoriasis | psoriatic arthritis | seborrheic dermatitis | thyroiditis | ulcerative colitis methylprednisolone-aceponate Launched anti-inflammatory agent | glucocorticoid receptor agonist NR3C1 allergy | dermatology | endocrinology | endocrinology | endocrinology | gastroenterology | gastroenterology | hematology | infectious disease | neurology/psychiatry | pulmonary | rheumatology | rheumatology | rheumatology allergic rhinitis | anemia | asthma | bursitis | congenital adrenal hyperplasia | enteritis | epicondylitis | hypercalcemia | multiple sclerosis | osteoarthritis | psoriasis | rheumatoid arthritis | thyroiditis | ulcerative colitis methylprednisolone sodium succinate Launched glucocorticoid receptor agonist "endocrinology, rheumatology, dermatology, pulmonary, allergy, infectious disease, ophthalmology, gastroenterology, hematology, neurology/psychiatry" "hypercalcemia, thyroiditis, osteoarthritis, rheumatoid arthritis, seborrheic dermatitis, asthma, allergic rhinitis, shingles, conjunctivitis, ulcerative colitis, enteritis, anemia, multiple sclerosis, mycosis" methylprednisolone-sodium-succinate Launched glucocorticoid receptor agonist allergy | dermatology | endocrinology | endocrinology | gastroenterology | gastroenterology | hematology | infectious disease | infectious disease | neurology/psychiatry | ophthalmology | pulmonary | rheumatology | rheumatology allergic rhinitis | anemia | asthma | conjunctivitis | enteritis | hypercalcemia | multiple sclerosis | mycosis | osteoarthritis | rheumatoid arthritis | seborrheic dermatitis | shingles | thyroiditis | ulcerative colitis methyl-salicylate Launched endocrinology | neurology/psychiatry fever | pain relief methylthiouracil Launched endocrinology hyperthyroidism methysergide Launched serotonin receptor antagonist HTR1B | HTR1D | HTR1E | HTR1F | HTR2A | HTR2B | HTR2C | HTR5A | HTR6 | HTR7 neurology/psychiatry headache meticrane Launched diuretic cardiology edema metipranolol Withdrawn adrenergic receptor antagonist ADRB1 | ADRB2 metirosine Launched tyrosine hydroxylase inhibitor TH cardiology hypertension metitepine Preclinical anti-HCVE2 | serotonin receptor antagonist HTR1A | HTR1B | HTR1D | HTR1E | HTR1F | HTR2A | HTR2B | HTR2C | HTR5A | HTR6 | HTR7 Infectious disease antiviral metixene Launched acetylcholine receptor antagonist CHRM5 neurology/psychiatry Parkinson's Disease metixene hydrochloride Launched acetylcholine receptor antagonist CHRM5 neurology/psychiatry parkinson's disease metoclopramide Launched dopamine receptor antagonist | serotonin receptor antagonist CHRM1 | DRD2 | HTR3A | HTR3B | HTR4 gastroenterology | gastroenterology | gastroenterology gastroparesis | nausea | vomiting metocurine Launched acetylcholine receptor antagonist CHRM2 | CHRNA2 neurology/psychiatry muscle relaxant metolazone Launched carbonic anhydrase inhibitor CA2 | CA7 | SLC12A3 cardiology | cardiology edema | hypertension metomidate Launched cytochrome p450 inhibitor CYP1B1 | CYP3A4 radiology pet imaging metoprine Phase 2 histamine n-methyltransferase inhibitor DHFR | HNMT oncology renal cell carcinoma (rcc) metoprolol Launched adrenergic receptor antagonist ADRB1 | ADRB2 cardiology | cardiology | cardiology angina pectoris | hypertension | myocardial infarction metoprolol tartrate Launched adrenergic receptor antagonist ADRB1 | ADRB2 cardiology "hypertension, angina pectoris, myocardial infarction" metoxibutropate Launched cyclooxygenase inhibitor PTGS1 | PTGS2 metrifonate Phase 3 acetylcholinesterase inhibitor ACHE | BCHE metrizamide Launched radiopaque medium radiology contrast agent metrizoic-acid Launched radiopaque medium radiology contrast agent metronidazole Launched DNA inhibitor CYP2C8 | CYP2C9 | CYP2E1 | CYP3A4 | CYP3A5 | CYP3A7 dermatology rosacea metyrapone Launched cytochrome P450 inhibitor CYP11B1 | HSD11B1 | NR3C2 nephrology adrenal diagnostic agent mevastatin Preclinical HMGCR inhibitor HMGCR mexeneone Preclinical mexiletine Launched sodium channel blocker CYP2B6 | CYP2E1 | KCNK2 | KCNK3 | PLAU | SCN4A | SCN5A cardiology | cardiology ventricular arrhythmias | ventricular tachycardia (VT) mezlocillin Launched bacterial cell wall synthesis inhibitor infectious disease | infectious disease gram-negative bacterial infections | gram-positive bacterial infections MF-101 Phase 3 estrogen receptor agonist CYP19A1 | ESR2 | XDH MG-132 Preclinical proteasome inhibitor PSMB1 MG-624 Preclinical acetylcholine receptor antagonist CHRNA7 MGCD-265 Preclinical VEGFR inhibitor AXL | KDR | MET mhp sphingosine kinase inhibitor SPHK1 dermatology sunburn MI-14 Preclinical PI4K inhibitor PI4KB mi-773 mianserin Launched serotonin receptor antagonist ADRA1A | ADRA1B | ADRA1D | HRH1 | HRH2 | HTR2A | HTR2B | HTR2C | HTR6 | HTR7 neurology/psychiatry depression mianserin hydrochloride Launched 5-ht2a receptor antagonist HTR2A Neurology depression mibampator Phase 2 glutamate receptor modulator GRIA1 mibefradil Withdrawn T-type calcium channel blocker ANO1 | CACNA1C | CACNA1D | CACNA1F | CACNA1G | CACNA1H | CACNA1I | CACNA1S | CACNB1 | CACNB2 | CACNB3 | CACNB4 | CATSPER1 | CATSPER2 | CATSPER3 | CATSPER4 | SCN2A | SCN4A | SCN5A | SCN9A micafungin Launched "fungal 1,3-beta-D-glucan synthase inhibitor" infectious disease | infectious disease | infectious disease | infectious disease "candidemia | candidemia, peritonitis, esophageal candidiasis | esophageal candidiasis | peritonitis" micafungin (sodium) miconazole Launched bacterial cell wall synthesis inhibitor CYP19A1 | TRPM2 | TRPV5 infectious disease | neurology/psychiatry itching | yeast infection miconazole nitrate Launched bacterial cell wall synthesis inhibitor TRPM2 | TRPV5 "infectious disease, neurology/psychiatry" "yeast infection, itching" micronomicin Launched protein synthesis inhibitor infectious disease gram-negative bacterial infections midafotel Phase 3 glutamate receptor antagonist GRIN1 | GRIN2A | GRIN2B | GRIN2C | GRIN2D midecamycin Launched protein synthesis inhibitor infectious disease | infectious disease | infectious disease ear infections | respiratory tract infections | skin infections midodrine Launched adrenergic receptor agonist ADRA1A | ADRA1B | ADRA1D cardiology hypotension midostaurin Launched FLT3 inhibitor | KIT inhibitor | PKC inhibitor CCNB1 | FLT1 | FLT3 | KDR | KIT | PDGFRB | PRKCA | PRKCG | VEGFA hematologic malignancy acute myeloid leukemia (AML) mifepristone Launched glucocorticoid receptor antagonist | progesterone receptor antagonist AR | CYP2B6 | CYP2C8 | CYP3A5 | CYP3A7 | NR1I2 | NR3C1 | PGR endocrinology | endocrinology diabetes mellitus | hyperglycemia mifobate Phase 2 PPAR receptor antagonist PPARG | REN migalastat Launched alpha-galactosidase a inhibitor GLA endocrinology fabry disease miglitol Launched glucosidase inhibitor GAA | GANAB | GANC | MGAM | SLC5A4 endocrinology diabetes mellitus miglustat Launched glycosyl transferase inhibitor GAA | SLC5A4 | UGCG hematology Gaucher disease mik665 Phase 1 mcl1 inhibitor MCL1 hematologic malignancy multiple myeloma milacemide Phase 3 monoamine oxidase inhibitor MAOB milademetan Phase 1 MDM inhibitor MDM2 milnacipran Launched serotonin–norepinephrine reuptake inhibitor (SNRI) SLC6A2 | SLC6A4 rheumatology fibromyalgia milnacipran hydrochloride Launched serotonin–norepinephrine reuptake inhibitor (snri) SLC6A2 | SLC6A4 rheumatology fibromyalgia milnacipran (hydrochloride) milrinone Launched phosphodiesterase inhibitor PDE2A | PDE3A | PDE3B | PDE5A cardiology congestive heart failure miltefosine Launched membrane integrity inhibitor PLA2G1B infectious disease leishmaniasis mimosine Preclinical DNA replication inhibitor CCL2 | SHMT1 | SHMT2 | TYR minaprine Withdrawn serotonin reuptake inhibitor ACHE | CHRM1 | DRD1 | DRD2 | HTR2A | HTR2B | HTR2C | MAOA | SLC6A4 minerval Phase 1/Phase 2 FAAH inhibitor FAAH minocycline Launched bacterial 30S ribosomal subunit inhibitor | ribosomal protein inhibitor PARP1 endocrinology | infectious disease | infectious disease | infectious disease | infectious disease | infectious disease | infectious disease | infectious disease | neurology/psychiatry | ophthalmology | urology brucellosis | chancroid | cholera | conjunctivitis | fever | psittacosis | respiratory tract infections | stroke | trachoma | tularemia | urethritis minocycline hydrochloride Launched "ribosomal protein inhibitor, bacterial 30s ribosomal subunit inhibitor" "neurology/psychiatry, endocrinology, infectious disease, ophthalmology, urology" "stroke, fever, respiratory tract infections, psittacosis, trachoma, conjunctivitis, urethritis, chancroid, tularemia, cholera, brucellosis" minodronic-acid Launched bone resorption inhibitor FDPS | GGPS1 orthopedics osteoporosis minoxidil Launched KATP activator | Kir6 channel (KATP) activator | vasodilator ABCC9 | KCNJ1 | KCNJ10 | KCNJ11 | KCNJ8 | PTGS1 | REN endocrinology androgenetic alopecia miocamycin Launched other antibiotic infectious disease | infectious disease chlamydia | urinary tract infections MIRA-1 Preclinical apoptosis stimulant mirabegron Launched adrenergic receptor agonist ADRB1 | ADRB2 | ADRB3 urology urinary incontinence miridesap Preclinical amyloid protein inhibitor APCS mirin Preclinical MRE11A exonuclease inhibitor MRE11A miriplatin Launched dna alkylating drug | DNA synthesis inhibitor oncology | Oncology hepatic cancer | hepatocellular carcinoma (HCC) mirodenafil Launched phosphodiesterase inhibitor PDE5A urology erectile dysfunction mirogabalin-besylate Preclinical calcium channel antagonist CACNA2D2 mirtazapine Launched adrenergic receptor antagonist | serotonin receptor antagonist ADRA2A | ADRA2B | ADRA2C | HTR2A | HTR2C | HTR3A neurology/psychiatry depression misonidazole Phase 3 misoprostol Launched prostanoid receptor agonist PTGER1 | PTGER2 | PTGER3 | PTGER4 | PTGIR gastroenterology duodenal ulcer disease mitapivat Preclinical pyruvate kinase isozyme activator PKM mitiglinide Launched insulin secretagogue ABCC8 | INS | KCNJ10 | KCNJ11 | PPARG endocrinology diabetes mellitus mitoflaxone Phase 2 antitumor agent VWF mitoguazone Phase 2 polyamine biosynthesis inhibitor AMD1 oncology follicular lymphoma mitomycin-C Launched DNA alkylating agent | DNA synthesis inhibitor oncology | oncology gastric adenocarcinoma | pancreatic cancer mitoquinone Launched antioxidant mitotane Launched antineoplastic agent CYP11A1 | CYP11B1 | CYP3A4 | ESR1 oncology adrenal cortical carcinoma mitoxantrone Launched topoisomerase inhibitor PIM1 | TOP2A hematologic malignancy | neurology/psychiatry | oncology acute myeloid leukemia (AML) | multiple sclerosis | prostate cancer mivacurium Launched acetylcholine receptor antagonist CHRNA2 critical care | neurology/psychiatry endotracheal intubation | muscle relaxant mivacurium chloride Launched mivebresib Phase 1 bromodomain inhibitor BRD4 | MYC | TMPRSS2-ERG mivobulin Phase 2 microtubule inhibitor MIW-815 Preclinical interferon inducer TMEM173 mizolastine Launched histamine receptor antagonist HRH1 allergy | allergy allergic rhinitis | urticaria mizoribine Launched immunosuppressant | inosine monophosphate dehydrogenase inhibitor IMPDH1 rheumatology | transplant nephrotic syndrome | organ rejection MJ-15 Preclinical cannabinoid receptor antagonist CNR1 MK-0354 Phase 2 niacin receptor agonist HCAR2 | HCAR3 mk-0429 Phase 1 integrin antagonist ITGAV nephrology diabetic nephropathy MK-0557 Phase 3 neuropeptide receptor antagonist NPY5R MK-0608 Phase 1 antiviral MK-0752 Phase 1/Phase 2 gamma secretase inhibitor MK-0773 Phase 2 androgen receptor modulator AR MK-0812 Phase 2 CC chemokine receptor antagonist CCR2 MK-0893 Phase 2 glucagon receptor antagonist GCGR mk-0941 Phase 2 glucokinase activator GCK endocrinology diabetes mellitus MK-1064 Phase 1 orexin receptor antagonist HCRTR2 MK-1775 Phase 2 WEE1 kinase inhibitor WEE1 MK-1903 Phase 2 niacin receptor agonist HCAR2 MK-2048 Preclinical HIV integrase inhibitor MK-2206 Phase 2 AKT inhibitor AKT1 | AKT2 | AKT3 MK-2295 Phase 2 TRPV antagonist TRPV1 MK-2461 Phase 1/Phase 2 FGFR inhibitor | VEGFR inhibitor FGFR1 | FGFR2 | FGFR3 | FLT1 | FLT3 | FLT4 | KDR | MERTK | MET | MST1R | NTRK1 | NTRK2 | PDGFRB MK-2894 Preclinical prostaglandin inhibitor PTGER4 MK2-IN-1 Preclinical MAP kinase inhibitor MAPKAPK2 MK-3207 Phase 2 calcitonin antagonist CALCA | CALCRL | RAMP1 MK-3697 Phase 2 orexin receptor antagonist HCRTR2 MK-4074 Phase 1 acetyl-CoA carboxylase inhibitor ACACA | ACACB MK-5046 Preclinical bombesin receptor agonist BRS3 | GRPR | NMBR MK-5108 Phase 1 Aurora kinase inhibitor AURKA | AURKB | AURKC MK-571 Phase 2 leukotriene receptor antagonist ABCC2 | CYSLTR1 MK-6096 Phase 2 orexin receptor antagonist HCRTR1 | HCRTR2 MK-7246 Preclinical CRTH receptor antagonist PTGDR2 MK-7622 Phase 2 cholinergic receptor agonist CHRM1 MK-8033 Phase 1 c-Met inhibitor MET | MST1R MK-8245 Phase 2 stearoyl-CoA desaturase inhibitor SCD MK-8617 Preclinical hypoxia inducible factor prolyl hydroxylase inhibitor EGLN1 | EGLN2 | EGLN3 MK-8745 Preclinical Aurora kinase inhibitor AURKA MK-886 Preclinical lipoxygenase inhibitor ALOX5AP MK-8998 Phase 2 T-type calcium channel blocker CACNA1G mkc8866 ire1 inhibitor ERN1 oncology prostate cancer MKT-077 Phase 1 HSP inhibitor ML10302 Preclinical serotonin receptor partial agonist HTR3A | HTR3B | HTR4 ML130 Preclinical NOD1 inhibitor ML133 Preclinical potassium channel blocker ML141 Preclinical GTPase inhibitor CDC42 ML161 Preclinical protease-activated receptor inhibitor ML167 Preclinical CLK inhibitor | DYRK inhibitor CLK1 | CLK4 | DYRK1B ML179 Preclinical liver receptor homolog inverse agonist NR5A2 ML193 Preclinical G protein-coupled receptor antagonist GPR55 ML204 Preclinical transient receptor potential channel antagonist TRPC4 | TRPC5 ML213 Preclinical potassium channel activator KCNQ2 | KCNQ4 ML218 Preclinical T-type calcium channel blocker CACNA1G | CACNA1H | CACNA1I ML228 Preclinical hypoxia inducible factor activator HIF1A ML277 Preclinical potassium channel activator KCNQ1 ML281 Preclinical serine/threonine kinase inhibitor STK33 ML297 Preclinical inward rectifier potassium channel activator KCNJ3 ML298 Preclinical phospholipase inhibitor PLD2 ML314 Preclinical neurotensin agonist NTSR1 ML323 Preclinical ubiquitin specific protease inhibitor USP1 ML324 Preclinical histone lysine demethylase inhibitor KDM4A | KDM4E ML3403 Preclinical MAP kinase inhibitor CYP3A4 | IL1B | MAPK11 | MAPK12 | MAPK14 | TNF ML347 Preclinical ALK tyrosine kinase receptor inhibitor ACVR1 | ACVRL1 | BMPR1A ML348 Preclinical lysophospholipase inhibitor LYPLA1 ml355 Phase 1 lipoxygenase inhibitor ALOX12 hematology thrombosis ML365 Preclinical potassium channel blocker KCNK3 | KCNK9 ML786 Preclinical RAF inhibitor BRAF | RAF1 ML9 Preclinical myosin light chain kinase inhibitor TRPC6 MLN0128 Phase 2 mTOR inhibitor MTOR | PIK3CA | PIK3CD | PIK3CG MLN1117 Phase 2 PI3K inhibitor PIK3CA MLN2480 Phase 1/Phase 2 RAF inhibitor MLN8054 Phase 1 Aurora kinase inhibitor AURKA MLN9708 Phase 3 proteasome inhibitor MM-102 Preclinical WDR5/MLL interaction inhibitor MM-11253 Preclinical retinoid receptor antagonist RARG MM-206 Preclinical STAT inhibitor MM77 Preclinical serotonin receptor antagonist ADRA1A | HTR1A mmaf (hydrochloride) tubulin polymerisation inhibitor TPPP oncology breast cancer MMPX Preclinical phosphodiesterase inhibitor MMV-390048 Preclinical PI4K inhibitor PI4KB MN-64 Preclinical tankyrase inhibitor TNKS MNITMT Preclinical lymphocyte inhibitor mobocertinib Phase 2 egfr inhibitor EGFR oncology non-small cell lung cancer (nsclc) mocetinostat Phase 2 HDAC inhibitor HDAC1 | HDAC11 | HDAC2 | HDAC3 moclobemide Launched monoamine oxidase inhibitor CYP2C19 | MAOA | MAOB neurology/psychiatry | neurology/psychiatry anxiety | depression modaline Preclinical moexipril Launched angiotensin converting enzyme inhibitor ACE | ACE2 cardiology hypertension mofegiline Phase 1 monoamine oxidase inhibitor MAOA | MAOB mofezolac Launched cyclooxygenase inhibitor PTGS1 orthopedics | rheumatology osteoporosis | rheumatoid arthritis moguisteine Phase 2 ATP-sensitive potassium channel inhibitor molidustat Phase 3 hypoxia inducible factor inhibitor EGLN2 molindone Launched dopamine receptor antagonist DRD2 | DRD5 | HRH1 | HTR2A neurology/psychiatry schizophrenia molnupiravir Phase 2/Phase 3 antiviral molsidomine Launched guanylate cyclase stimulant GUCY1A3 cardiology coronary artery disease (CAD) mometasone Launched glucocorticoid receptor agonist NR3C1 dermatology corticosteroid-responsive dermatoses mometasone-furoate Launched glucocorticoid receptor agonist NR3C1 dermatology corticosteroid-responsive dermatoses monastrol Preclinical kinesin inhibitor KIF11 monensin Launched bacterial permeability inducer infectious disease gastrointestinal parasites monepantel Preclinical mTOR inhibitor MTOR monobenzone Launched melanin inhibitor TYR dermatology skin depigmentation monocrotaline Preclinical antitumor agent monoctanoin Launched gastroenterology gallstones monomethyl-fumarate Launched HCAR2 neurology/psychiatry multiple sclerosis monosodium-alpha-luminol Launched monostearin Preclinical montelukast Launched leukotriene receptor antagonist ALOX5 | CYP2C8 | CYSLTR1 allergy | pulmonary | pulmonary allergic rhinitis | asthma | exercise-induced bronchoconstriction (EIB) moprolol Launched adrenergic receptor antagonist cardiology | neurology/psychiatry | ophthalmology anxiety | glaucoma | hypertension moracizine Withdrawn sodium channel blocker SCN5A cardiology ventricular arrhythmias morantel Launched acetylcholine receptor agonist infectious disease tapeworm morin Preclinical cytochrome P450 inhibitor ADORA2A | CYP1A2 | ESR2 | FASN | MCL1 | SLC22A12 morinidazole Launched other antibiotic CYP51A1 morniflumate Launched anti-inflammatory agent neurology/psychiatry pain relief moroxydine Launched antiviral infectious disease influenza A virus infection moroxydine hcl Launched antiviral infectious disease influenza a virus infection morphothiadin Preclinical antiinfective drug mosapride Launched serotonin receptor agonist HTR3A | HTR4 gastroenterology | gastroenterology | gastroenterology | gastroenterology dyspepsia | gastroesophageal reflux disease (GERD) | hypertrophic gastritis (GHG) | irritable bowel syndrome mosapride citrate Launched 5-ht4 receptor agonist 5-HT4 Gastroenterology gastroesophageal reflux disease (gerd) motapizone Preclinical phosphodiesterase inhibitor motesanib Phase 3 KIT inhibitor | PDGFR tyrosine kinase receptor inhibitor | VEGFR inhibitor FLT1 | FLT4 | KDR | KIT | PDGFRA | RET motolimod Phase 2 toll-like receptor agonist TLR8 moxalactam Launched bacterial cell wall synthesis inhibitor infectious disease | infectious disease | infectious disease | infectious disease | infectious disease | infectious disease | infectious disease bone and joint infections | gram-negative bacterial infections | gram-positive bacterial infections | meningitis | pneumonia | skin infections | urinary tract infections moxalactam (sodium salt) moxaverine Launched phosphodiesterase inhibitor neurology/psychiatry spasms moxidectin Launched chloride channel antagonist infectious disease gastrointestinal parasites moxifloxacin Launched bacterial DNA gyrase inhibitor TOP2A infectious disease | infectious disease | infectious disease | otolaryngology | pulmonary bronchitis | intra-abdominal infections | pneumonia | sinusitis | skin infections moxisylyte Withdrawn adrenergic receptor antagonist moxonidine Launched imidazoline receptor agonist ADRA2A | ADRA2B | ADRA2C | NISCH cardiology hypertension mozavaptan Launched vasopressin receptor antagonist AVPR1A | AVPR1B | AVPR2 endocrinology hyponatremia MPEP Preclinical glutamate receptor antagonist GRM1 | GRM4 | GRM5 MPI-0479605 Preclinical mitotic kinase inhibitor TTK Mps1-IN-1 Preclinical monopolar spindle 1 kinase inhibitor ALK | TTK Mps1-IN-5 Phase 1 protein kinase inhibitor TTK Mps-BAY-2a Preclinical monopolar spindle 1 kinase inhibitor TTK MR-16728 Preclinical acetylcholine release enhancer MR-948 Phase 1 thromboxane synthase inhibitor TBXAS1 MRK-016 Phase 1 GABA receptor inverse agonist GABRA1 | GABRA2 | GABRA3 | GABRA5 MRK-409 Phase 1 benzodiazepine receptor agonist MRK-560 Preclinical gamma secretase inhibitor APP MRS-1220 Preclinical adenosine receptor antagonist ADORA2B | ADORA3 MRS-1334 Preclinical adenosine receptor antagonist ADORA3 MRS-1845 Preclinical calcium channel blocker MRS-2578 Preclinical purinergic receptor antagonist P2RY6 MRS-3777 Preclinical adenosine receptor antagonist ADORA1 | ADORA2A | ADORA2B | ADORA3 mrtx849 Phase 3 ras gtpase inhibitor KRAS oncology gastric adenocarcinoma MRX-2843 Phase 1 MER tyrosine kinase inhibitor FLT3 | MERTK MS-424 Phase 2 glutamate transporter modulator SLC1A2 msc2360844 Phase 1 pi3k inhibitor PIK3CD rheumatology lupus MSDC-0160 Phase 2 insulin sensitizer INS MSDC-0602K Phase 2 mitochondrial pyruvate carrier modulator MPC1 | MPC2 MSX-122 Phase 2 CC chemokine receptor antagonist CXCR4 mtep Preclinical glutamate metabotropic receptor antagonist GRM5 Neurology parkinson's disease m-THP Phase 1 MTPG Preclinical glutamate receptor antagonist GRM2 | GRM3 mubritinib Phase 1 protein tyrosine kinase inhibitor EGFR | ERBB2 mupirocin Launched isoleucyl-tRNA synthetase inhibitor infectious disease impetigo muscimol Phase 1 benzodiazepine receptor agonist GABRA1 | GABRA2 | GABRA3 | GABRA4 | GABRA5 | GABRA6 | GABRR1 | GABRR2 | GABRR3 MUT056399 Phase 1 FABI inhibitor mw-150 Preclinical p38 mapk inhibitor MAPK14 neurology/psychiatry alzheimer's disease MY-5445 Preclinical phosphodiesterase inhibitor | platelet aggregation inhibitor PDE5A mycophenolate-mofetil Launched dehydrogenase inhibitor | inositol monophosphatase inhibitor HCAR2 | IMPDH1 | IMPDH2 transplant organ rejection mycophenolic-acid Launched dehydrogenase inhibitor | inositol monophosphatase inhibitor IMPDH1 | IMPDH2 transplant organ rejection myricetin Preclinical androgen receptor agonist | cytochrome P450 inhibitor AR | CYP3A4 | PIK3CG myricitrin Preclinical PKC inhibitor AKR1B1 | NOS1 | PRKCA myristyl-nicotinate Phase 1 topical sunscreen agent N20C Preclinical glutamate receptor antagonist N-(2-chlorophenyl)-2-({(2E)-2-[1-(2-pyridinyl)ethylidene]hydrazino}carbothioyl)hydrazinecarbothioamide Preclinical N-[2-(piperidinylamino)ethyl]-4-iodobenzamide Preclinical sigma receptor ligand n-(4-carboxyphenyl)pentopyranosylamine N6022 Phase 1/Phase 2 alcohol dehydrogenase inhibitor ADH5 N6-cyclopentyladenosine Preclinical adenosine receptor agonist ADORA1 | ADORA2A | ADORA2B | ADORA3 | SLC29A1 N6-methyladenosine Preclinical NAB-2 Preclinical ubiquitin ligase transport promoter NEDD4 nabumetone Launched cyclooxygenase inhibitor AKR1C3 | CYP2B6 | CYP2C19 | CYP2E1 | PTGS1 | PTGS2 rheumatology | rheumatology osteoarthritis | rheumatoid arthritis N-acetylcarnosine Launched n-acetylcysteine amide Preclinical antioxidant PSEN2 neurology/psychiatry parkinson's disease N-acetyl-D-glucosamine Phase 2/Phase 3 B4GALT1 | B4GALT2 | B4GALT3 | B4GALT4 | NAGK | NAGLU | NAGPA | RENBP N-acetylglycyl-D-glutamic-acid Preclinical glutamate receptor agonist N-acetylmannosamine Phase 2 N-acetyltryptamine Preclinical melatonin receptor agonist N-acetyl-tyrosine Launched nadide Launched free radical scavenger AHCY | AKR1A1 | ALDH2 | BLVRA | DHPS | DLD | GALE | HMGCR | HSD17B1 | HSD17B4 | IMPDH2 | MGAM | P2RY11 | SORD | TRPM2 nadifloxacin Launched bacterial DNA gyrase inhibitor dermatology | infectious disease acne vulgaris (AV) | skin infections nadolol Launched adrenergic receptor antagonist ADRB1 | ADRB2 | ADRB3 cardiology | cardiology angina pectoris | hypertension NADPH Preclinical DRD2 | DRD3 | DRD4 | GHSR | HTR2A | HTR2C nafadotride Preclinical dopamine receptor antagonist DRD2 | DRD3 | HTR1A nafamostat Launched serine protease inhibitor ASIC1 | ASIC2 | ASIC3 | C1R | PRSS1 | TPSAB1 | TRPM7 cardiology anticoagulent nafcillin Launched bacterial cell wall synthesis inhibitor CYP1A2 | CYP3A4 | SLC22A6 infectious disease gram-positive bacterial infections naftidrofuryl Launched adrenergic receptor antagonist cardiology claudication naftifine Launched fungal squalene epoxidase inhibitor infectious disease | infectious disease | infectious disease tinea corporis | tinea cruris | tinea pedis naftopidil Launched adrenergic receptor antagonist ADRA1A | ADRA1D urology benign prostatic hyperplasia (BPH) naftopidil dihcl Launched adrenergic receptor antagonist ADRA1A urology benign prostatic hyperplasia (bph) nalbuphine Launched opioid receptor agonist | opioid receptor antagonist OPRD1 | OPRK1 | OPRM1 neurology/psychiatry pain relief naldemedine Launched opioid receptor antagonist OPRD1 | OPRK1 | OPRM1 gastroenterology constipation nalfurafine Launched opioid receptor agonist OPRK1 | OPRM1 nephrology uremic pruritus nalidixic-acid Launched bacterial DNA gyrase inhibitor infectious disease urinary tract infections nalmefene Launched opioid receptor antagonist OPRD1 | OPRK1 | OPRM1 pulmonary respiratory depression nalmefene hcl Launched opioid receptor antagonist OPRD1 | OPRK1 | OPRM1 pulmonary respiratory depression naloxegol Launched opioid receptor antagonist OPRM1 gastroenterology constipation naloxone Launched opioid receptor antagonist CREB1 | ESR1 | OPRD1 | OPRK1 | OPRM1 | TLR4 pulmonary respiratory depression naloxone-benzoylhydrazone Preclinical opioid receptor antagonist OPRK1 | OPRM1 N-alpha-methylhistamine-dihydrochloride Phase 3 histamine receptor agonist HRH4 naltrexone Launched opioid receptor antagonist OPRD1 | OPRK1 | OPRM1 | SIGMAR1 neurology/psychiatry abstinence from alcohol naltriben Preclinical opioid receptor antagonist OPRD1 | OPRK1 | OPRM1 naltrindole Preclinical opioid receptor antagonist OPRD1 | OPRK1 | OPRM1 namitecan Phase 1 topoisomerase inhibitor TOP1 oncology soft tissue sarcoma (sts) Nampt-IN-1 Preclinical NAN-190 Preclinical serotonin receptor agonist ADRA1A | ADRA1B | ADRA1D | HTR1A | HTR1F nanchangmycin Preclinical other antibiotic napabucasin Phase 3 STAT inhibitor STAT3 napamezole Preclinical adrenergic receptor antagonist | monoamine reuptake inhibitor naphazoline Launched adrenergic receptor agonist ADRA1A | ADRA2A ophthalmology eye irritation naphthoquine-phosphate Launched antimalarial agent infectious disease malaria napirimus Phase 1 immunosuppressant naproxen Launched cyclooxygenase inhibitor PTGS1 | PTGS2 dental | endocrinology | neurology/psychiatry | neurology/psychiatry | neurology/psychiatry | neurology/psychiatry | otolaryngology | rheumatology backache | common cold | fever | headache | muscle pain | pain relief | rheumatoid arthritis | toothache naquotinib Phase 3 EGFR inhibitor EGFR narasin Launched antiprotozoal agent infectious disease coccidiosis naratriptan Launched serotonin receptor agonist HTR1A | HTR1B | HTR1D | HTR1E | HTR1F neurology/psychiatry migraine headache naringenin Phase 1 aromatase inhibitor | TRPV antagonist CYP19A1 | CYP1B1 | ESR2 | GLO1 | HSD17B1 naringeninic-acid Phase 1 HCAR2 | PTGR1 naringin Preclinical cytochrome P450 inhibitor SLCO1A2 naringin-dihydrochalcone Preclinical cytochrome P450 inhibitor narlaprevir Phase 3 HCV inhibitor NAS-181 Preclinical serotonin receptor antagonist HTR1B nastorazepide Phase 2 CCK receptor antagonist CCKBR natamycin Launched fungal ergosterol inhibitor infectious disease | ophthalmology | ophthalmology blepharitis | conjunctivitis | fungal keratosis nateglinide Launched insulin secretagogue ABCC8 | CYP3A4 | INS | KCNJ10 | KCNJ11 | PPARG endocrinology diabetes mellitus NAV-26 Preclinical voltage-gated sodium channel blocker SCN9A navarixin Phase 2 CC chemokine receptor antagonist CXCR1 | CXCR2 navitoclax Phase 2 BCL inhibitor BCL2 | BCL2L1 | BCL2L2 navoximod Phase 1 "indoleamine 2,3-dioxygenase inhibitor" IDO1 oncology melanoma naxagolide Phase 3 dopamine receptor agonist DRD2 NB-001 Preclinical antiviral N-benzylnaltrindole Preclinical opioid receptor antagonist NBI-27914 Preclinical corticotropin releasing factor receptor antagonist CRHR1 NBI-74330-(+/-) Preclinical CC chemokine receptor antagonist CXCR3 NBI-98782 Preclinical vesicular monoamine transporter inhibitor SLC18A2 NBQX Preclinical glutamate receptor antagonist GRIA1 | GRIA2 | GRIA3 | GRIA4 | GRIK1 | GRIN1 | GRIN2A | GRIN2B ncs-382 Preclinical gaba receptor antagonist Neurology epilepsy NCS-382 Preclinical GABA receptor antagonist GABBR1 | GABBR2 | SLC52A2 NCX-1015 Preclinical interleukin sythesis stimulator N-cyclohexyl-2-benzothiazolesulfenamide Preclinical NDD-094 Preclinical NDT-9513727 Preclinical complement antagonist C5AR1 NE-100 Phase 2 sigma receptor antagonist SIGMAR1 nebivolol Launched adrenergic receptor antagonist ADRB1 cardiology hypertension nebivolol hydrochloride adrenergic receptor antagonist ADRB1 cardiology hypertension nebracetam Phase 3 acetylcholine receptor agonist CHRM1 NECA Launched adenosine receptor agonist ADORA1 | ADORA2A | ADORA2B | ADORA3 necrostatin-1 Preclinical RIPK inhibitor IDO1 | KRR1 | RIPK1 necrostatin-2 Preclinical necroptosis inhibitor | RIPK inhibitor KRR1 | RIPK2 nedaplatin Launched DNA inhibitor oncology | oncology | oncology | oncology "esophageal cancer | non-small cell lung cancer (NSCLC) | non-small cell lung cancer (nsclc), small cell lung cancer, esophageal cancer | small cell lung cancer" nedocromil Launched histamine receptor antagonist CYSLTR1 | CYSLTR2 | FPR1 | HSP90AA1 | PTGDR neurology/psychiatry | ophthalmology conjunctivitis | itching nefazodone Withdrawn adrenergic inhibitor | norepinephrine reuptake inhibitor | serotonin receptor antagonist | serotonin reuptake inhibitor ADRA1A | ADRA1B | ADRA2A | CYP3A4 | CYP3A5 | CYP3A7 | HTR1A | HTR2A | HTR2C | SLC6A2 | SLC6A3 | SLC6A4 nefiracetam Phase 3 acetylcholine receptor agonist | benzodiazepine receptor agonist CHAT | CHRM1 nefopam Launched cyclooxygenase inhibitor neurology/psychiatry pain relief nelarabine Launched DNA synthesis inhibitor | T cell inhibitor ADA | POLA1 hematologic malignancy acute lymphoblastic leukemia (ALL) nelfinavir Launched HIV protease inhibitor CYP1A2 | CYP2B6 | CYP2C19 | CYP2C9 | CYP2D6 | CYP3A4 | CYP3A5 | CYP3A7 infectious disease human immunodeficiency virus (HIV-1) nelociguat Preclinical guanylate cyclase stimulant GUCY1A1 nelotanserin Phase 2 serotonin receptor inverse agonist HTR2A nemazoline Phase 2 adrenergic receptor agonist | adrenergic receptor antagonist nemiralisib Phase 2 PIK3CD nemonapride Launched dopamine receptor antagonist DRD2 | DRD3 | DRD4 neurology/psychiatry schizophrenia nemorexant Preclinical orexin receptor antagonist HCRTR1 | HCRTR2 nemorubicin Phase 2 topoisomerase inhibitor TOP1 | TOP2A neo-gilurytmal Launched cardiology cardiac arrythmia neohesperidin Preclinical neohesperidin-dihydrochalcone Preclinical neomycin Launched bacterial 30S ribosomal subunit inhibitor CXCR4 gastroenterology | infectious disease | infectious disease first-aid antibiotic | hepatic encephalopathy (HE) | intra-abdominal infections neostigmine Launched acetylcholinesterase inhibitor ACHE neurology/psychiatry myasthenia gravis nepafenac Launched cyclooxygenase inhibitor PTGS1 | PTGS2 ophthalmology eye inflammation nepicastat Phase 2 dopamine beta hydroxylase inhibitor DBH nepinalone Preclinical antitussive SIGMAR1 pulmonary cough suppressant neratinib Launched EGFR inhibitor EGFR | ERBB2 | ERBB4 | KDR oncology breast cancer nerbacadol Phase 3 cyclooxygenase inhibitor neridronic-acid Launched bone resorption inhibitor FDPS endocrinology | endocrinology brittle bone disease | Paget's disease nesbuvir Phase 2 RNA polymerase inhibitor netarsudil Launched rho associated kinase inhibitor ROCK2 ophthalmology ocular hypertension neticonazole Preclinical other antifungal infectious disease fungal infection netilmicin Launched protein synthesis inhibitor infectious disease gram-negative bacterial infections netilmicin sulfate Launched protein synthesis inhibitor infectious disease gram-negative bacterial infections netilmicin (sulfate) netupitant Launched neurokinin receptor antagonist | tachykinin antagonist TACR1 gastroenterology | gastroenterology nausea | vomiting Neu2000 Phase 2 ionotropic glutamate receptor antagonist GRIN1 | GRIN2A | GRIN2B | GRIN2C | GRIN2D | GRIN3A | GRIN3B neurodazine Preclinical neurogenesis of non-pluripotent C2C12 myoblast inducer neuropathiazol Preclinical neural stem cell inducer BMP2 | LIF nevanimibe Phase 2 nevanimibe hydrochloride Phase 2 acat inhibitor ACAT1 endocrinology congenital adrenal hyperplasia nevirapine Launched non-nucleoside reverse transcriptase inhibitor CYP1A2 | CYP2A6 | CYP2B6 | CYP2C19 | CYP2C9 | CYP2D6 | CYP3A4 | CYP3A5 infectious disease human immunodeficiency virus (HIV-1) nexturastat-A Preclinical HDAC inhibitor HDAC1 | HDAC6 NFKB-activation-inhibitor-II Preclinical NFkB pathway inhibitor RELA NGB-2904 Preclinical dopamine receptor antagonist DRD3 NGD-94-1 Phase 1 dopamine receptor antagonist DRD4 NGD-98-2 Preclinical corticotropin releasing factor receptor antagonist CRHR1 NG-nitro-arginine Phase 1 nitric oxide synthase inhibitor NOS1 | NOS2 | NOS3 NGP555 Phase 1 gamma secretase modulator APH1A | APH1B NH125 Preclinical eukaryotic translation elongation factor 2 inhibitor NHI-2 Preclinical lactate dehydrogenase inhibitor LDHA N-hydroxynicotinamide Preclinical NI-57 Preclinical bromodomain inhibitor BRD1 | BRPF1 | BRPF3 niacin Launched NAD precursor | vitamin B DGAT2 | HCAR1 | HCAR2 | HCAR3 | NNMT | QPRT endocrinology hypertriglyceridemia nialamide Withdrawn monoamine oxidase inhibitor COMT | MAOA | MAOB nibentan Phase 2 potassium channel blocker nicainoprol Preclinical angiotensin converting enzyme inhibitor ACE | ACE2 | SCN5A nicaraven Phase 3 free radical scavenger nicardipine Launched calcium channel blocker ADORA3 | CACNA1C cardiology | cardiology chronic stable angina | hypertension nicardipine hydrochloride Launched potassium channel blocker KCND2 | KCND3 Cardiology angina pectoris nicergoline Launched adrenergic receptor antagonist ADRA1A cardiology | hematology | neurology/psychiatry | rheumatology atherosclerosis | migraine headache | Raynaud's disease | thrombosis niceritrol Launched NAD precursor HCAR2 endocrinology hyperlipidemia niclosamide Launched DNA replication inhibitor | STAT inhibitor STAT3 infectious disease tapeworm nicodicosapent Preclinical sterol regulatory element binding protein (SREBP) inhibitor SREBF1 | SREBF2 nicorandil Launched nitric oxide donor | potassium channel activator ABCC9 | KCNJ11 | KCNJ8 cardiology angina pectoris nicotinamide Launched protein synthesis stimulant AOX1 | BST1 | CYP2E1 | LDHA | PARP1 | SIRT5 dermatology acne vulgaris (AV) nicotinamide riboside Phase 3 sirt activator SIRT1 cardiology cardiomyopathy nicotine Launched acetylcholine receptor agonist AOX1 | CHAT | CHRNA10 | CHRNA2 | CHRNA3 | CHRNA4 | CHRNA5 | CHRNA6 | CHRNA7 | CHRNA9 | CHRNB2 | CHRNB3 | CHRNB4 | CYP19A1 | CYP2B6 | TBXAS1 | TRPA1 neurology/psychiatry smoking cessation nicotine bitartrate Launched nicotinic receptor agonist NACHR Smoking smoking cessation nicotinyl-alcohol-tartrate Launched cardiology | neurology/psychiatry vascular spasm | vertigo NIDA-41020 Preclinical cannabinoid receptor antagonist CNR1 nidufexor Phase 2 fxr agonist NR1H4 gastroenterology non-alcoholic steatohepatitis (nash) nifedipine Launched calcium channel blocker CACNA1C | CACNA1D | CACNA1F | CACNA1H | CACNA1S | CACNA2D1 | CACNB2 | CALM1 | CYP3A5 | GLRA1 | GLRA3 | GLRB | KCNA1 | KCNA5 | NR1I2 | TRPM3 cardiology | cardiology chronic stable angina | vasospastic angina nifekalant Launched potassium channel blocker cardiology | cardiology ventricular arrhythmias | ventricular tachycardia (VT) nifenalol Launched adrenergic receptor antagonist ADRB1 | ADRB2 nifenazone Launched analgesic agent neurology/psychiatry pain relief niflumic-acid Launched cyclooxygenase inhibitor ANO1 | CLCN1 | CLCNKA | CLCNKB | KCNQ1 | PLA2G1B | PLA2G4A | PTGS1 | PTGS2 | UGT1A9 neurology/psychiatry | rheumatology joint pain | muscle pain nifuroxazide Launched bacterial DNA inhibitor gastroenterology | gastroenterology colitis | diarrhea nifursol Launched bacterial DNA inhibitor nifurtimox Launched DNA inhibitor infectious disease | infectious disease | infectious disease "African trypanosomiasis | Chagas disease | chagas disease, african trypanosomiasis" niguldipine-(R)-(-) Preclinical niguldipine-(S)-(+) Preclinical adrenergic receptor antagonist ADRA1A nikethamide Withdrawn immunostimulant nilotinib Launched Abl kinase inhibitor | Bcr-Abl kinase inhibitor ABL1 | BCR | CYP2B6 | CYP2C8 | DDR1 | DDR2 | KIT | PDGFRA hematologic malignancy chronic myeloid leukemia (CML) nilutamide Launched androgen receptor antagonist AR | CYP2C19 oncology prostate cancer nilvadipine Launched calcium channel blocker CACNA1C | CACNA1D | CACNA1G cardiology | cardiology cerebral artery occlusion | hypertension NIM811 Phase 2 mitochondrial permeability transition inhibitor nimesulide Launched cyclooxygenase inhibitor LTF | PLA2G2E | PTGS1 | PTGS2 obstetrics/gynecology | rheumatology menstrual pain | osteoarthritis nimodipine Launched calcium channel blocker CACNA1C | CFTR | NR3C2 hematology hemorrhage nimorazole Launched bacterial DNA inhibitor oncology head and neck squamous cell carcinoma (HNSCC) nimustine Phase 2 DNA alkylating agent | dna damage inducer oncology brain tumors ningetinib-tosylate Preclinical protein tyrosine kinase inhibitor AXL | KDR | MET nintedanib Launched FGFR inhibitor | PDGFR tyrosine kinase receptor inhibitor | VEGFR inhibitor FGFR1 | FGFR2 | FGFR3 | FGFR4 | FLT1 | FLT4 | KDR | LYN | PDGFRA | PDGFRB pulmonary idiopathic pulmonary fibrosis (IPF) niraparib Launched PARP inhibitor PARP1 | PARP2 oncology primary peritoneal cancer (PPC) niridazole Launched phosphofructokinase inhibitor infectious disease schistosomiasis nisin Phase 1 bacterial cell wall synthesis inhibitor nisoldipine Launched calcium channel blocker A1BG | CACNA1C | CACNA1D | CACNA1F | CACNA1S | CYP3A5 cardiology hypertension nisoxetine Phase 1 norepinephrine reuptake inhibitor SLC6A2 | SLC6A3 | SLC6A4 nisoxetine hydrochloride Phase 1 norepinephrine reuptake inhibitor SLC6A2 | SLC6A3 | SLC6A4 nitarsone Launched dermatology blackhead disease nitazoxanide Launched pyruvate ferredoxin oxidoreductase inhibitor gastroenterology diarrhea nitecapone Phase 2 catechol O methyltransferase inhibitor COMT nitenpyram Launched infectious disease flea control nithiamide Preclinical bacterial DNA inhibitor nitisinone Launched hydroxyphenylpyruvate dioxygenase inhibitor HPD metabolism tyrosinemia nitrendipine Launched calcium channel blocker CACNA1C | CACNA1D | CACNA2D1 | KCNN4 cardiology hypertension nitrocaramiphen Preclinical cholinergic receptor antagonist CHRM1 nitroflurbiprofen Preclinical cyclooxygenase inhibitor NOS2 | PTGS1 | PTGS2 nitrofurantoin Launched DNA inhibitor infectious disease | infectious disease pyelonephritis | urinary tract infections nitrofurazone Launched bacterial DNA inhibitor infectious disease first-aid antibiotic nitromide Launched infectious disease coccidiosis nitroscanate Launched anthelmintic agent infectious disease hookworm nitrosodimethylurea Preclinical DNA synthesis inhibitor nitroxoline Launched cathepsin inhibitor CTSB | METAP1 | METAP2 | SIRT1 infectious disease urinary tract infections nizatidine Launched histamine receptor antagonist HRH2 gastroenterology | gastroenterology | gastroenterology | gastroenterology duodenal ulcer disease | erosive esophagitis (EE) | gastroesophageal reflux disease (GERD) | ulcerative esophagitis (UE) nizofenone Launched ion channel antagonist neurology/psychiatry stroke NK-252 Preclinical "nuclear factor erythroid derived, like (NRF2) activator" NFE2L2 nkp-1339 Phase 1 hsp inhibitor NKP-1339 Phase 1 HSP inhibitor NKY-80 Preclinical adenylyl cyclase inhibitor ADCY5 NLG919 Phase 1 "indoleamine 2,3-dioxygenase inhibitor" IDO1 nm107 Phase 2 rna polymerase inhibitor NM107 Phase 2 RNA polymerase inhibitor NMDA Preclinical glutamate receptor agonist GRIN1 | GRIN2A | GRIN2B | GRIN2C | GRIN2D "N-methyl-(-)ephedrine-[1R,2S]" Preclinical N-methylformamide Phase 2 N-methyllidocaine-iodide Preclinical antiarrhythmic medication N-methylpyrrolidone Phase 1 N-methylquipazine Preclinical serotonin receptor agonist N-MPPP Preclinical opioid receptor agonist NMS-1286937 Phase 2 PLK inhibitor FLT3 | PLK1 | PLK2 | PLK3 NMS-873 Preclinical ATPase inhibitor VCP NMS-E973 Preclinical HSP inhibitor NMS-P715 Preclinical protein kinase inhibitor TTK NNC-05-2090 Preclinical GABA uptake inhibitor | GAT inhibitor SLC6A11 | SLC6A12 | SLC6A13 NNC-55-0396 Preclinical T-type calcium channel blocker CATSPER1 | CATSPER2 | CATSPER3 | CATSPER4 NNC-63-0532 Preclinical opioid receptor agonist OPRL1 NNC-711 Preclinical GABA uptake inhibitor SIGMAR1 | SLC6A1 NN-DNJ Preclinical glucosidase inhibitor AGL | GBA | MGAM NO-ASA Phase 2 cyclooxygenase inhibitor IKBKB | INS | PTGS1 | PTGS2 nobiletin Preclinical MEK inhibitor ABCB1 | MAP2K1 | TYR nocodazole Preclinical tubulin polymerization inhibitor HPGDS nolatrexed Phase 3 thymidylate synthase inhibitor TYMS nomegestrol-acetate Launched progesterone receptor agonist PGR endocrinology contraceptive nomifensine Launched dopamine reuptake inhibitor | noradrenaline uptake inhibitor DRD2 | SLC6A2 | SLC6A3 Antidepressant depression nonivamide Launched TRPV agonist TRPV1 neurology/psychiatry | rheumatology muscle pain | rheumatoid arthritis nonoxinol 9 Launched contraceptive nonoxynol-9 Launched membrane integrity inhibitor endocrinology contraceptive nor-binaltorphimine Preclinical opioid receptor antagonist OPRD1 | OPRK1 | OPRM1 norcyclobenzaprine Preclinical adrenergic receptor agonist | serotonin receptor antagonist norelgestromin Launched PGR endocrinology contraceptive norepinephrine Launched adrenergic receptor agonist ADRA1A | ADRA1B | ADRA1D | ADRA2A | ADRA2B | ADRA2C | ADRB1 | ADRB2 | ADRB3 | PAH | SLC18A1 | SLC18A2 allergy | cardiology | neurology/psychiatry | neurology/psychiatry headache | hypertension | seasonal affective disorder | urticaria norethindrone Launched progesterone receptor agonist PGR obstetrics/gynecology endometriosis norethindrone acetate Launched progesterone receptor agonist PGR "endocrinology, orthopedics, obstetrics/gynecology" "menopause, osteoporosis, vaginal atrophy" norethindrone-acetate Launched progesterone receptor agonist PGR endocrinology | obstetrics/gynecology | orthopedics menopause | osteoporosis | vaginal atrophy norethisterone-enanthate Launched contraceptive agent endocrinology contraceptive noretynodrel Launched progestogen hormone PGR endocrinology contraceptive norfloxacin Launched bacterial DNA gyrase inhibitor TOP2A infectious disease | infectious disease | urology gonorrhea | prostatitis | urinary tract infections norfluoxetine Phase 1 selective serotonin reuptake inhibitor (SSRI) HTR2B norgestimate Launched progesterone receptor agonist ESR1 | PGR endocrinology contraceptive norgestrel Launched progesterone receptor agonist AR | CYP2E1 | ESR1 | PGR | SRD5A1 endocrinology contraceptive nornicotine Preclinical acetylcholine receptor agonist nortriptyline Launched tricyclic antidepressant ADRA1A | ADRA1B | ADRA1D | ADRA2A | ADRA2B | ADRA2C | ADRB1 | ADRB2 | ADRB3 | CHRM1 | CHRM2 | CHRM3 | CHRM4 | CHRM5 | CYP2C19 | DRD2 | HRH1 | HTR1A | HTR2A | HTR2C | HTR6 | KCNJ10 | PGRMC1 | PIK3CD | SIGMAR1 | SLC6A2 | SLC6A4 neurology/psychiatry depression norvancomycin Preclinical noscapine Launched bradykinin receptor antagonist | tubulin polymerization inhibitor BDKRB2 | SIGMAR1 pulmonary cough suppressant noscapine hydrochloride Launched "bradykinin receptor antagonist, tubulin polymerization inhibitor" SIGMAR1 pulmonary cough suppressant NOV-002 Phase 3 GSR novobiocin Launched bacterial DNA gyrase inhibitor obstetrics/gynecology mastitis N-oxydiethylenebenzothiazole-2-sulfenamide Preclinical N-(p-amylcinnamoyl)-anthranilic-acid Preclinical phospholipase inhibitor TRPC6 | TRPM2 | TRPM8 NPC-01 Phase 3 steroid NPC-15199 Phase 2 ICAM1 antagonist ICAM1 | PPARG np-g2-044 Phase 1 PDCD1 oncology breast cancer NPPB Preclinical chloride channel blocker ANO1 | CLCN2 | CLCN7 | TRPA1 NPS-2143 Preclinical calcium receptor antagonist CASR | PTH NPS-2407 Preclinical glutamate receptor antagonist NPY-5RA972 Preclinical neuropeptide receptor antagonist NPY5R NQDI-1 Preclinical caspase inhibitor CASP3 | MAP3K5 nrc-2694 Phase 1 anticancer agent EGFR oncology non-small cell lung cancer (nsclc) NS-018 Phase 1/Phase 2 JAK inhibitor JAK1 | JAK2 | JAK3 | TYK2 NS-11021 Preclinical calcium-activated potassium channel activator KCNMA1 NS-11394 Preclinical GABA receptor agonist GABRA3 NS-1643 Preclinical voltage-gated potassium channel activator KCNH2 | KCNH6 | KCNMA1 NS-19504 Preclinical calcium-activated potassium channel activator KCNMA1 NS-309 Preclinical calcium-activated potassium channel activator KCNN1 | KCNN2 | KCNN3 | KCNN4 NS-3623 Preclinical voltage-gated potassium channel activator KCNH2 NS-3861 Preclinical acetylcholine receptor agonist CHRNA3 | CHRNB4 NS-5806 Preclinical voltage-gated potassium channel activator KCND3 NS-8 Phase 2 potassium channel agonist KCNMA1 | KCNMB1 NS-8593 Preclinical calcium-activated potassium channel modulator KCNN1 | KCNN2 | KCNN3 NS-9283 Preclinical acetylcholine receptor allosteric modulator CHRNA4 N-salicoylaminophenol Phase 1/Phase 2 ribonucleotide reductase inhibitor NSC-23766 Preclinical Ras GTPase inhibitor NSC-319726 Preclinical p53 activator NSC-3852 Preclinical HDAC inhibitor HDAC1 NSC-405020 Preclinical matrix metalloprotease inhibitor MMP1 NSC-4644 Phase 2 ACAT inhibitor | sterol regulatory element binding protein (SREBP) inhibitor PYGM | SOAT1 NSC-5844 Preclinical CC chemokine receptor agonist CCR1 NSC-625987 Preclinical CDK inhibitor CDK2 | CDK4 NSC-632839 Preclinical ubiquitin specific protease inhibitor SENP2 | USP1 | USP2 | USP7 NSC-636819 Preclinical histone demethylase inhibitor KDM4A | KDM4B NSC-663284 Preclinical CDC inhibitor CDC25A | CDC25B | CDC25C NSC-697923 Preclinical ubiquitin-conjugating enzyme inhibitor UBE2N NSC-95397 Preclinical CDC inhibitor CASP3 | CDC25A | CDC25B NSC-9965 Preclinical acetylcholine receptor antagonist CHRNA4 | CHRNB2 NSI-189 Phase 2 neurotrophic agent NSP-805 Preclinical phosphodiesterase inhibitor PDE3A NT157 Preclinical IGF-1 inhibitor IGF1R NTNCB Preclinical neuropeptide receptor antagonist NPY5R NTRC-824 Preclinical neurotensin receptor antagonist NTSR2 nTZDpa Preclinical PPAR receptor agonist PPARG NU-1025 Preclinical PARP inhibitor PARP1 NU-2058 Preclinical cyclin D inhibitor CCNA2 | CDK2 NU-6027 Preclinical CDK inhibitor ATR | CCNA2 | CDK1 | CDK2 NU-7026 Preclinical DNA dependent protein kinase inhibitor | mTOR inhibitor | PI3K inhibitor PRKDC NU-7441 Preclinical DNA dependent protein kinase inhibitor ABCB1 | PRKDC nuclomedone Phase 3 immunosuppressant nutlin-3 Preclinical MDM inhibitor MDM2 | TP53 nuvenzepine Preclinical acetylcholine receptor antagonist CHRM1 | CHRM2 | CHRM3 | CHRM4 | CHRM5 NVP-231 Preclinical ceramidase inhibitor CERK NVP-ADW742 Preclinical insulin growth factor receptor inhibitor IGF1R NVP-AEW541 Preclinical IGF-1 inhibitor IGF1R | INSR NVP-AUY922 Phase 2 HSP inhibitor HSP90AA1 | HSP90AB1 NVP-BEZ235 Phase 3 mTOR inhibitor | PI3K inhibitor ATR | MTOR | PIK3CA | PIK3CB | PIK3CD | PIK3CG NVP-BGJ398 Phase 3 FGFR inhibitor FGFR1 | FGFR2 | FGFR3 | FGFR4 | KDR NVP-BHG712 Preclinical ephrin inhibitor EPHB4 NVP-BSK805 Preclinical JAK inhibitor JAK2 NVP-BVU972 Preclinical MET inhibitor MET NVP-DPP728 Phase 2 dipeptidyl peptidase inhibitor DPP4 NVP-HSP990 Phase 1 HSP inhibitor HSP90AA1 | HSP90AB1 NVP-TAE226 Preclinical protein tyrosine kinase inhibitor IGF1R | PTK2 NVP-TAE684 Preclinical ALK tyrosine kinase receptor inhibitor ALK | INSR NVP-TNKS656 Preclinical tankyrase inhibitor TNKS | TNKS2 NVS-PAK1-1 Preclinical p21 activated kinase inhibitor PAK1 NXY-059 Phase 3 free radical scavenger nystatin Launched fungal ergosterol inhibitor infectious disease | infectious disease | infectious disease | infectious disease "esophageal candidiasis | esophageal candidiasis, skin infections, yeast infection | skin infections | yeast infection" nystatin (fungicidin) Launched fungal ergosterol inhibitor infectious disease "esophageal candidiasis, skin infections, yeast infection" O-1918 Preclinical cannabinoid receptor antagonist O-304 Preclinical AMPK activator PRKAA2 o-3M3FBS Preclinical phospholipase activator O4I1 Preclinical Oct inducer POU5F1 O6-benzylguanine Phase 3 O6-alkylguanine-DNA alkyltransferase inhibitor MGMT OAC1 Preclinical Oct activator OAC2 Preclinical Oct activator POU5F1 O-acetyl-L-serine Preclinical PTGS1 obatoclax Phase 3 BCL inhibitor BCL2 | BCL2L1 | MCL1 obeticholic-acid Launched FXR agonist NR1H4 gastroenterology primary biliary cholangitis obidoxime Launched cholinesterase reactivator ACHE critical care | neurology/psychiatry nerve gas poisoning | poison antidote OC000459 Phase 2 CRTH receptor antagonist PTGDR2 ocaperidone Preclinical serotonin receptor antagonist DRD2 | HTR1A | HTR1B | HTR1D | HTR2A ochromycinone Phase 1 STAT inhibitor STAT3 ocinaplon Phase 3 GABA receptor modulator GABRA1 | GABRA2 | GABRA3 | GABRA5 oclacitinib Launched jak inhibitor JAK2 dermatology dermatitis OCO-1112 Phase 2 cholesterol inhibitor octadecan-1-ol Preclinical octamethyltrisiloxane Preclinical octenidine Launched membrane integrity inhibitor infectious disease | infectious disease gram-negative bacterial infections | gram-positive bacterial infections octinoxate Launched dermatology sunscreen lotion octisalate Launched dermatology sunscreen lotion octocrylene Launched dermatology sunscreen lotion octodrine Preclinical antitumor agent octopamine Preclinical neurotransmitter | trace amine associated receptor agonist ADRA2A | ADRA2B | ADRA2C | F10 | TAAR1 octreotide Launched somatostatin receptor agonist GH1 | SST | SSTR2 | SSTR3 | SSTR5 endocrinology | gastroenterology | oncology acromegaly | carcinoid tumors | diarrhea odanacatib Phase 3 cathepsin inhibitor CTSK odm-203 Phase 1 fgfr inhibitor FGFR1 | FLT1 oncology breast cancer ODQ Preclinical guanylyl cyclase inhibitor GUCY1A2 | GUCY1A3 | GUCY1B3 OF-1 Preclinical bromodomain inhibitor BRD1 ofloxacin Launched bacterial DNA gyrase inhibitor endocrinology | gastroenterology | infectious disease | infectious disease | infectious disease | infectious disease | infectious disease | otolaryngology bone and joint infections | diarrhea | fever | intra-abdominal infections | respiratory tract infections | sinusitis | skin infections | urinary tract infections ofloxacin (floxin) Launched bacterial dna gyrase inhibitor "infectious disease, otolaryngology, gastroenterology, endocrinology" "respiratory tract infections, sinusitis, skin infections, bone and joint infections, intra-abdominal infections, diarrhea, fever, urinary tract infections" ogerin Preclinical G protein-coupled receptor modulator ADORA2A | GPR68 | HTR2B OG-L002 Preclinical histone lysine demethylase inhibitor KDM1A oglemilast Phase 2 phosphodiesterase inhibitor oglufanide Phase 2 VEGF antagonist VEGFA OICR-9429 Preclinical WDR5/MLL interaction inhibitor WDR5 olanexidine Launched bacterial cell wall synthesis inhibitor infectious disease gram-negative bacterial infections olanzapine Launched dopamine receptor antagonist | serotonin receptor antagonist ADRA1A | ADRA1B | ADRA2A | ADRA2B | ADRA2C | ADRB1 | ADRB2 | ADRB3 | CHRM1 | CHRM2 | CHRM3 | CHRM4 | CHRM5 | CYP2C8 | DRD1 | DRD2 | DRD3 | DRD4 | DRD5 | GABRA1 | GABRA2 | GABRA3 | GABRA4 | GABRA5 | GABRA6 | GABRB1 | GABRB2 | GABRB3 | GABRD | GABRE | GABRG1 | GABRG2 | GABRG3 | GABRP | GABRQ | HRH1 | HRH2 | HRH4 | HTR1A | HTR1B | HTR1D | HTR1E | HTR1F | HTR2A | HTR2B | HTR2C | HTR3A | HTR5A | HTR6 | HTR7 neurology/psychiatry | neurology/psychiatry bipolar disorder | schizophrenia olaparib Launched PARP inhibitor PARP1 | PARP2 | PARP3 oncology ovarian cancer OLDA Preclinical TRPV agonist GPR119 oleamide Preclinical cannabinoid receptor agonist CNR1 | HTR7 | PLA2G2A oleandrin Phase 1 Na/K-ATPase inhibitor oleanolic-acid Preclinical G protein-coupled receptor agonist GPBAR1 oleoylethanolamide Preclinical cannabinoid receptor agonist | glucose dependent insulinotropic receptor agonist | potassium channel blocker | PPAR receptor agonist CNR1 | GPR119 | GPR55 | KCND3 | PPARA olesoxime Phase 2/Phase 3 apoptosis stimulant oleuropein Preclinical antioxidant | estrogen receptor agonist GPER1 fungal infection oligomycin-A Preclinical ATPase inhibitor | ATP synthase inhibitor ATP5A1 olinciguat Phase 2 guanylyl cyclase activator GUCY1A1 | GUCY1A2 hematology anemia olmesartan Launched angiotensin receptor antagonist AGTR1 cardiology hypertension olmesartan-medoxomil Launched angiotensin receptor antagonist AGTR1 cardiology hypertension olmutinib Launched Bruton's tyrosine kinase (BTK) inhibitor | EGFR inhibitor BTK | EGFR | ITK | JAK3 oncology non-small cell lung cancer (NSCLC) olodanrigan Phase 2 angiotensin antagonist AGTR2 | MTUS1 olomoucine Preclinical CDK inhibitor CDK1 | CDK2 | CDK5 | MAPK1 olopatadine Launched histamine receptor antagonist HRH1 | S100A1 | S100A12 | S100A13 | S100A2 | S100B ophthalmology conjunctivitis olprinone Launched phosphodiesterase inhibitor PDE3A | PDE4A | PDE4B | PDE4C | PDE4D cardiology congestive heart failure olsalazine Launched cyclooxygenase inhibitor IFNG | PTGS1 | PTGS2 | TPMT gastroenterology ulcerative colitis oltipraz Phase 3 "nuclear factor erythroid derived, like (NRF2) activator" ANG | CYP2B6 | NFE2L2 olumacostat-glasaretil Phase 3 acetyl-CoA carboxylase inhibitor ACACA olutasidenib Phase 1/Phase 2 isocitrate dehydrogenase inhibitor IDH1 oncology glioma olvanil Preclinical TRPV agonist CNR1 | GPR119 | TRPV1 omaciclovir Preclinical dna polymerase inhibitor infectious disease virus herpes simplex (hsv) omadacycline Launched bacterial 30S ribosomal subunit inhibitor infectious disease pneumonia omadacycline (mesylate) Launched bacterial 30s ribosomal subunit inhibitor infectious disease pneumonia omapatrilat Preclinical metalloproteinase inhibitor ACE | MME omarigliptin Launched dipeptidyl peptidase inhibitor DPP4 endocrinology diabetes mellitus ombitasvir Launched HCV inhibitor infectious disease hepatitis C ombrabulin Phase 3 tubulin polymerization inhibitor TUBA1A | TUBB | TUBD1 | TUBE1 | TUBG1 OMDM-2 Preclinical FAAH inhibitor GPR119 omecamtiv-mecarbil Phase 3 cardiac myosin activator MYBPC3 omega-3-acid-esters Launched cholesterol inhibitor omega-(4-iodophenyl)pentadecanoic-acid Preclinical omeprazole Launched ATPase inhibitor ATP4A | CLCN2 | CYP1A2 | CYP2C19 gastroenterology heartburn omeprazole-magnesium Launched proton pump inhibitor ATP4A | ATP4B gastroenterology | gastroenterology gastroesophageal reflux disease (GERD) | heartburn omeprazole-sulfide Phase 1 ATPase inhibitor o-mercapto-benzoic-acid Preclinical omidenepag Launched prostanoid receptor agonist PTGER2 ophthalmology intraocular pressure omtriptolide Preclinical ERK1 and ERK2 phosphorylation inhibitor ON-01500 Preclinical apoptosis stimulant ON123300 Preclinical CDK inhibitor CCNT1 | CDK4 | CDK6 | CDK9 | FGFR1 | FGFR2 | FLT3 | FLT4 | FYN | LCK | LYN | NUAK1 | PDGFRB | RET ONC201 Phase 2 AKT inhibitor | MAP kinase inhibitor TNFRSF10A | TNFSF10 onc206 Phase 1 dopamine receptor antagonist DRD2 oncology glioblastoma oncrasin-1 Preclinical apoptosis stimulant ondansetron Launched 5-ht3 receptor antagonist | serotonin receptor antagonist CYP2D6 | CYP3A5 | HTR3A | HTR3B | HTR3C | HTR3D | HTR3E Alcoholism | gastroenterology | gastroenterology abstinence from alcohol | nausea | vomiting ondansetron (zofran) Launched "serotonin receptor antagonist, 5-ht3 receptor antagonist" HTR3A | HTR3B | HTR3C | HTR3D | HTR3E "Alcoholism, gastroenterology" "abstinence from alcohol, nausea, vomiting" ono-4059 Phase 1 bruton's tyrosine kinase (btk) inhibitor BTK ONO-4059 Phase 1 Bruton's tyrosine kinase (BTK) inhibitor BTK ONO-4817 Phase 1 matrix metalloprotease inhibitor MMP8 ONO-8130 Preclinical prostanoid receptor antagonist PTGER1 ONO-AE3-208 Preclinical prostanoid receptor antagonist PTGER4 ONX-0914 Preclinical proteasome inhibitor OP-0595 Preclinical beta lactamase inhibitor LACTB opaganib Phase 2/Phase 3 angiogenesis inhibitor DEGS1 | DEGS2 | SPHK2 Cardiology atherosclerosis OPC-21268 Phase 1 vasopressin receptor antagonist AVPR1A | AVPR1B | AVPR2 | OXTR opicapone Phase 3 catechol O methyltransferase inhibitor COMT opipramol Launched sigma receptor agonist neurology/psychiatry generalized anxiety disorder (GAD) oprozomib Phase 1/Phase 2 proteasome inhibitor oprozomib (onx 0912) Phase 1/Phase 2 proteasome inhibitor or-1896 Phase 1 phosphodiesterase inhibitor PDE3A | SMPD1 cardiology congestive heart failure OR-486 Preclinical catechol O methyltransferase inhibitor COMT orantinib Phase 3 FGFR inhibitor | PDGFR tyrosine kinase receptor inhibitor | VEGFR inhibitor AURKA | AURKB | EGFR | FGFR1 | FGFR2 | KDR | PDGFRA | PDGFRB | TBK1 orbifloxacin Launched bacterial DNA gyrase inhibitor infectious disease urinary tract infections ORE1001 Phase 1/Phase 2 angiotensin converting enzyme inhibitor ACE2 orelabrutinib Phase 3 ORG-12962 Phase 2 serotonin receptor agonist HTR2A | HTR2B | HTR2C ORG-25543 Preclinical glycine transporter inhibitor GLRB | SLC6A5 ORG-26576 Phase 2 glutamate receptor modulator ORG-27569 Preclinical cannabinoid receptor modulator CNR1 ORG-9768 Phase 1 adrenergic receptor antagonist ADRA2A | SLC6A2 oridonin Preclinical BCL inhibitor BCL2 | NFE2L2 oridonin (isodonol) Preclinical bcl inhibitor BCL2 oritavancin Launched bacterial cell wall synthesis inhibitor infectious disease skin infections oritavancin (diphosphate) orlistat Launched lipase inhibitor CNR1 | DAGLA | DAGLB | FASN | LIPF | PNLIP endocrinology weight-loss aid ormeloxifene Launched selective estrogen receptor modulator (SERM) ESR1 | ESR2 endocrinology contraceptive ormetoprim Launched folic acid antagonist infectious disease coccidiosis ornidazole Launched antiprotozoal agent infectious disease protozoan infection ornipressin Preclinical vasoconstrictor ornithine Launched NFkB pathway modulator GPRC6A orotic-acid Phase 2 DHODH orphanin-fq Phase 1 opioid receptor agonist OPRL1 | OPRM1 orphenadrine Launched acetylcholine receptor antagonist CYP2B6 neurology/psychiatry muscle pain orteronel Phase 3 androgen biosynthesis inhibitor | androgen receptor antagonist | cytochrome P450 inhibitor CYP17A1 ORY-1001 Phase 1/Phase 2 histone lysine demethylase inhibitor KDM1A oseltamivir-carboxylate Launched neuraminidase inhibitor infectious disease influenza A virus infection oseltamivir-phosphate Launched neuraminidase inhibitor CES1 | NEU1 | NEU2 infectious disease influenza A virus infection osemozotan Phase 2/Phase 3 serotonin receptor agonist HTR1A OSI-027 Phase 1 mTOR inhibitor MTOR OSI-420 Preclinical EGFR inhibitor EGFR OSI-930 Phase 1 KIT inhibitor | VEGFR inhibitor FLT1 | KDR | KIT | PDGFB | PDGFRB osilodrostat Launched cytochrome P450 inhibitor CYP11B1 | CYP11B2 osimertinib Launched EGFR inhibitor EGFR oncology non-small cell lung cancer (NSCLC) ospemifene Launched selective estrogen receptor modulator (SERM) CYP2B6 | CYP2C19 | ESR1 | ESR2 endocrinology | obstetrics/gynecology | obstetrics/gynecology dyspareunia | menopause | vaginal atrophy ostarine Phase 3 androgen receptor modulator AR osthol Preclinical calcium channel blocker otamixaban Phase 3 coagulation factor inhibitor F10 otenzepad Phase 3 acetylcholine receptor antagonist CHRM1 | CHRM2 | CHRM3 | CHRM4 | CHRM5 oteseconazole Phase 3 other antifungal infectious disease vulvovaginal candidiasis otilonium Launched acetylcholine receptor antagonist CACNA1C gastroenterology irritable bowel syndrome OT-R-antagonist-1 Preclinical oxytocin receptor antagonist AVPR1A | OXT | OXTR OTS167 Phase 1/Phase 2 maternal embryonic leucine zipper kinase inhibitor MELK OTS514 Preclinical TOPK inhibitor PBK OTX015 Phase 1/Phase 2 bromodomain inhibitor BRD2 | BRD3 | BRD4 | SELE | VCAM1 ouabain Launched ATPase inhibitor ATP1A1 | ATP1A2 | ATP1A3 | ATP1A4 | ATP1B1 | ATP1B2 | ATP1B3 | ATP1B4 | FXYD2 cardiology | cardiology cardiac arrythmia | hypertension OXA-06 Preclinical rho associated kinase inhibitor ROCK1 | ROCK2 oxaceprol Preclinical anti-inflammatory agent oxacillin Launched bacterial cell wall synthesis inhibitor infectious disease staphylococcal infections oxacyclohexadecan-2-one Preclinical protein kinase inhibitor oxaliplatin Launched DNA inhibitor oncology colorectal cancer oxaloacetate Phase 2/Phase 3 glutamate release inhibitor oxamniquine Withdrawn dna inhibitor infectious disease schistosomiasis oxantel Launched anthelmintic agent infectious disease gastrointestinal parasites oxaprozin Launched cyclooxygenase inhibitor PTGS1 | PTGS2 rheumatology | rheumatology osteoarthritis | rheumatoid arthritis oxatomide Launched histamine receptor antagonist HRH1 allergy allergic rhinitis oxcarbazepine Launched sodium channel blocker CYP2C19 | CYP3A4 | CYP3A5 | SCN10A | SCN11A | SCN1A | SCN2A | SCN3A | SCN4A | SCN5A | SCN7A | SCN8A | SCN9A neurology/psychiatry seizures oxelaidin Launched antitussive pulmonary cough suppressant oxethazaine Launched local anesthetic neurology/psychiatry local anesthetic OXF-BD-02 Preclinical bromodomain inhibitor BRD4 | CREB1 oxfendazole Launched anthelmintic agent infectious disease | infectious disease | infectious disease gastrointestinal roundworms | lungworms | tapeworm oxfenicine Phase 1 carnitine palmitoyltransferase inhibitor CPT1A | CPT1B oxibendazole Launched tubulin polymerization inhibitor TUBB | TUBB4B infectious disease strongyles oxiconazole Launched bacterial cell wall synthesis inhibitor infectious disease | infectious disease | infectious disease tinea corporis | tinea cruris | tinea pedis oxidopamine Preclinical neurotoxin oxiniacic-acid Preclinical oxiperomide Phase 2 dopamine receptor antagonist oxiracetam Launched acetylcholine receptor agonist neurology/psychiatry senile dementia oxolamine Launched antitussive pulmonary cough suppressant oxolinic-acid Preclinical bacterial DNA gyrase inhibitor oxonic-acid Preclinical uricase inhibitor oxotremorine-M Preclinical acetylcholine receptor agonist CHRM1 | CHRM2 | CHRM3 | CHRM4 oxotremorine-sesquifumarate Preclinical cholinergic receptor agonist CHRM1 | CHRM2 | CHRM3 | CHRM4 oxprenolol Launched adrenergic receptor antagonist ADRB1 cardiology | cardiology | cardiology angina pectoris | cardiac arrythmia | hypertension oxybenzone Launched lipase inhibitor LIPE dermatology sunscreen lotion oxybuprocaine Launched local anesthetic SCN10A neurology/psychiatry local anesthetic oxybutynin Launched acetylcholine receptor antagonist CHRM1 | CHRM2 | CHRM3 | CHRM4 urology urinary incontinence oxybutynin chloride Launched acetylcholine receptor antagonist CHRM1 | CHRM2 | CHRM3 urology urinary incontinence oxyclozanide Launched infectious disease fascioliasis oxyfedrine Launched adrenergic receptor agonist cardiology angina pectoris oxymatrine Launched oxymetazoline Launched adrenergic receptor agonist ADRA1A | ADRA1B | ADRA1D | ADRA2A | ADRA2B | ADRA2C | CYP2C19 | HTR1B | HTR1D | HTR2C otolaryngology nasal congestion oxymetholone oxyphenbutazone Withdrawn cyclooxygenase inhibitor oxyphencyclimine Launched cholinergic receptor antagonist gastroenterology peptic ulcer disease (PUD) oxyphenonium Launched cholinergic receptor antagonist CHRM1 | CHRM3 gastroenterology peptic ulcer disease (PUD) oxypurinol Phase 2/Phase 3 xanthine oxidase inhibitor XDH oxyquinoline Launched chelating agent METAP2 dermatology cosmetic oxytetracycline Launched bacterial 30S ribosomal subunit inhibitor 30S-RIBOSOMAL SUBUNIT "infectious disease | infectious disease | infectious disease | infectious disease | infectious disease | infectious disease | Infectious disease | Infectious disease, infectious disease, urology | urology" "chlamydia | ear infections | first-aid antibiotic | first-aid antibiotic, chlamydia, urinary tract infections, skin infections, ear infections, gonorrhea, urethritis, lyme disease | gonorrhea | Lyme disease | skin infections | urethritis | urinary tract infections" oxytetracycline dihydrate oxytocin Launched oxytocin receptor agonist AVPR1A | AVPR1B | AVPR2 | OXTR obstetrics/gynecology labor induction ozagrel Launched thromboxane synthase inhibitor TBXAS1 neurology/psychiatry stroke ozanimod Phase 3 sphingosine 1-phosphate receptor agonist S1PR1 ozenoxacin Phase 3 antiinfective drug ozolinone Phase 3 diuretic "p1,p4-di(adenosine-5')tetraphosphate ammonium" Phase 1 adenosine kinase inhibitor P2RY13 | P2RY2 P22077 Preclinical ubiquitin specific protease inhibitor USP7 P276-00 Phase 2 CDK inhibitor CDK1 | CDK4 | CDK9 P5091 Preclinical ubiquitin specific protease inhibitor USP7 P7C3 Preclinical NAMPT inhibitor NAMPT PA-452 Preclinical retinoid receptor antagonist RXRA PAC-1 Phase 1 caspase activator CASP3 paclitaxel Launched tubulin polymerization inhibitor ABCB1 | BCL2 | CYP2C8 | MAP2 | MAP4 | MAPT | NR1I2 | TLR4 | TUBA1A | TUBA1B | TUBA1C | TUBA3C | TUBA3D | TUBA3E | TUBA4A | TUBB | TUBB1 | TUBB2A | TUBB2B | TUBB3 | TUBB4A | TUBB4B | TUBB6 | TUBB8 oncology | oncology | oncology breast cancer | non-small cell lung cancer (NSCLC) | ovarian cancer PACOCF3 Preclinical phospholipase inhibitor PLA2G4A pacritinib Phase 3 FLT3 inhibitor | JAK inhibitor CDK2 | FLT3 | JAK1 | JAK2 | JAK3 padimate o Launched dermatology sunscreen lotion padsevonil Phase 3 antiepileptic paeoniflorin Preclinical anticonvulsant paeonol Preclinical anti-inflammatory agent pafuramidine Phase 3 DNA synthesis inhibitor pagoclone Phase 2/Phase 3 GABA receptor agonist GABRA1 | GABRA2 | GABRA3 | GABRA4 | GABRA5 | GABRA6 palbociclib Launched CDK inhibitor CCND3 | CDK4 | CDK6 oncology breast cancer palifosfamide Phase 3 DNA alkylating agent paliperidone Launched dopamine receptor antagonist | serotonin receptor antagonist DRD2 | HTR2A | HTR7 neurology/psychiatry schizophrenia paliperidone palmitate Launched dopamine receptor antagonist DRD2 neurology/psychiatry schizophrenia palmatine-chloride Preclinical dopamine synthesis inhibitor ACHE | CYP3A4 palmitoleic-acid Preclinical ACE2 palmitoylcarnitine Preclinical protein kinase inhibitor palmitoylethanolamide Launched cannabinoid receptor agonist CNR2 | GPR119 | GPR55 palomid-529 Phase 1 AKT inhibitor | mTOR inhibitor FGF2 | MTOR palonosetron Launched serotonin receptor antagonist HTR3A gastroenterology | gastroenterology nausea | vomiting palosuran Phase 2 urotensin receptor antagonist UTS2R palovarotene Phase 3 retinoid receptor agonist RARG pamabrom Launched diuretic gastroenterology bloating pamapimod Phase 2 p38 mapk inhibitor MAPK10 | MAPK11 | MAPK14 | MAPK8 | MAPK9 rheumatology rheumatoid arthritis pamicogrel Preclinical cyclooxygenase inhibitor PTGS2 hematology thrombosis pamidronate Launched bone resorption inhibitor FDPS endocrinology | endocrinology | hematologic malignancy | oncology breast cancer | hypercalcemia | multiple myeloma | Paget's disease pamiparib Phase 3 PARP inhibitor PARP1 | PARP2 pamufetinib Phase 1 pancuronium Launched acetylcholine receptor antagonist CHRM2 | CHRM3 | CHRNA1 | CHRNA2 critical care | neurology/psychiatry endotracheal intubation | muscle relaxant panipenem Preclinical antibacterial panobinostat Launched HDAC inhibitor HDAC1 | HDAC2 | HDAC3 | HDAC4 | HDAC6 | HDAC7 | HDAC8 | HDAC9 hematologic malignancy multiple myeloma pantethine Launched coenzyme A precursor panthenol (dl) Launched gastroenterology paralytic ileus pantoprazole Launched ATPase inhibitor ATP4A | CYP2C19 | CYP3A4 | DDAH1 gastroenterology | gastroenterology | gastroenterology | gastroenterology "erosive esophagitis (EE) | gastroesophageal reflux disease (GERD) | gastroesophageal reflux disease (gerd), erosive esophagitis (ee), zollinger-ellison syndrome | Zollinger-Ellison syndrome" pantoprazole (sodium) Launched h+/k+-atpase inhibitor A1BG Infectious disease tuberculosis pantothenic-acid Launched coenzyme A precursor PAOPA Preclinical dopamine receptor modulator DRD2 papaverine Launched phosphodiesterase inhibitor PDE10A | PDE4B | PDE5A cardiology | cardiology | cardiology | gastroenterology | hematology angina pectoris | colitis | myocardial infarction | pulmonary embolism (PE) | vascular spasm paquinimod Phase 2 S100A9 inhibitor S100A9 paracetamol Launched cyclooxygenase inhibitor CYP2E1 | FAAH | PTGS1 | PTGS2 | TRPV1 endocrinology | neurology/psychiatry fever | pain relief parachlorophenol Launched antiinfective drug infectious disease first-aid antiseptic paramethadione Launched anticonvulsant CACNA1G neurology/psychiatry seizures para-toluenesulfonamide Phase 3 CA12 | CA2 | CA3 | CA6 | CA9 paraxanthine Phase 1 adenosine receptor antagonist parbendazole Preclinical tubulin polymerization inhibitor TUBB parcetasal Preclinical anti-inflammatory agent MT-CO1 | MT-CO2 pardoprunox Phase 3 dopamine receptor agonist | serotonin receptor agonist DRD2 | DRD3 | DRD4 | HTR1A | HTR7 parecoxib Launched cyclooxygenase inhibitor LTF | PTGS2 neurology/psychiatry pain relief parethoxycaine Preclinical local anesthetic pargyline Launched monoamine oxidase inhibitor MAOA | MAOB cardiology hypertension paricalcitol Launched vitamin D receptor agonist PTH | VDR endocrinology | nephrology chronic kidney disease (CKD) | hyperthyroidism paritaprevir Launched HCV inhibitor infectious disease hepatitis C paromomycin Launched bacterial 30S ribosomal subunit inhibitor infectious disease amebiasis paroxetine Launched selective serotonin reuptake inhibitor (SSRI) CHRM1 | CHRM2 | CHRM3 | CHRM4 | CHRM5 | HTR2A | SLC6A2 | SLC6A4 neurology/psychiatry | neurology/psychiatry | neurology/psychiatry | neurology/psychiatry | neurology/psychiatry | neurology/psychiatry depression | generalized anxiety disorder (GAD) | obsessive compulsive disorder (OCD) | panic disorders | posttraumatic stress disorder | social anxiety disorder paroxypropione Launched gonadotropin inhibitor parsaclisib Phase 2 PI3K inhibitor PIK3CD parthenolide Phase 1 NFkB pathway inhibitor parthenolide-(-) Preclinical NFkB pathway inhibitor HDAC1 parthenolide-(alternate-stereo) Preclinical NFkB pathway inhibitor ADIPOR2 | IKBKB | RELA pasireotide Launched somatostatin receptor agonist GH1 | SSTR1 | SSTR2 | SSTR3 | SSTR5 endocrinology | endocrinology acromegaly | Cushing's syndrome PAT-1251 Phase 1 lysyl oxidase inhibitor LOXL2 pavinetant Phase 2 neurokinin receptor antagonist TACR3 pazopanib Launched KIT inhibitor | PDGFR tyrosine kinase receptor inhibitor | VEGFR inhibitor BRAF | CSF1R | CYP2B6 | CYP2C8 | CYP2E1 | DDR2 | FGF1 | FGFR1 | FGFR3 | FLT1 | FLT4 | ITK | KDR | KIT | PDGFRA | PDGFRB | SH2B3 oncology | oncology renal cell carcinoma (RCC) | soft tissue sarcoma (STS) pazufloxacin Launched topoisomerase inhibitor infectious disease | infectious disease | infectious disease bacterial septicemia | peritonitis | pneumonia PBI-4050 Phase 2/Phase 3 free fatty acid receptor agonist FFAR1 PBT-1033 Preclinical chelating agent PCA-4248 Phase 1 platelet activating factor receptor antagonist PTAFR PCI-24781 Phase 3 HDAC inhibitor HDAC1 | HDAC10 | HDAC2 | HDAC3 | HDAC6 | HDAC8 PCI-27483 Phase 2 ERK1 and ERK2 phosphorylation inhibitor F7 | MAPK1 | MAPK3 PCI-29732 Preclinical Bruton's tyrosine kinase (BTK) inhibitor BTK PCI-34051 Preclinical HDAC inhibitor HDAC1 | HDAC10 | HDAC6 | HDAC8 | IL1B pco371 Phase 1 PTH1R endocrinology hypoparathyroidism PCO-400 Phase 1 potassium channel activator ABCC9 | KCNJ8 PD-0325901 Phase 2 MEK inhibitor MAP2K1 | MAP2K2 PD-102807 Preclinical acetylcholine receptor antagonist CHRM4 PD-118057 Preclinical potassium channel activator KCNH2 PD-123319 Phase 1 angiotensin antagonist AGTR2 PD-128907 Preclinical dopamine receptor agonist DRD2 | DRD3 PD-153035 Phase 1 EGFR inhibitor EGFR | KDR PD-156707 Preclinical endothelin receptor antagonist EDNRA | EDNRB PD-158780 Preclinical EGFR inhibitor EGFR PD-160170 Preclinical neuropeptide receptor antagonist NPY1R PD-161570 Preclinical FGFR inhibitor FGFR1 PD-166285 Preclinical SRC inhibitor EGFR | FGFR1 | PDGFRB | PKMYT1 | SRC | WEE1 PD-166793 Preclinical collagenase inhibitor | metalloproteinase inhibitor MMP13 | MMP2 | MMP3 PD-168077 Preclinical dopamine receptor agonist DRD2 | DRD4 PD-168393 Preclinical EGFR inhibitor EGFR | ERBB2 | SRC PD-168568 Preclinical dopamine receptor antagonist DRD2 | DRD4 PD-173074 Preclinical FGFR inhibitor | VEGFR inhibitor FGFR1 | FGFR2 | FGFR3 | FGFR4 | FLT1 | FLT4 | KDR | PDGFRA | PDGFRB PD-173212 Preclinical calcium channel blocker CACNA1B PD-184352 Phase 2 MEK inhibitor MAP2K1 | MAP2K2 | MAP3K1 | MAP3K2 PD-198306 Preclinical MAP kinase inhibitor | MEK inhibitor MAP2K1 | MAP2K2 | MAPK1 | MAPK3 PD1-PDL-inhibitor-1 Preclinical programmed death ligand inhibitor CD274 PD-318088 Preclinical MEK inhibitor PD-407824 Preclinical PKC inhibitor WEE1 PD-81723 Preclinical adenosine receptor agonist ADORA1 PD-98059 Preclinical MEK inhibitor AKT1 | CHEK1 | GSK3B | LCK | MAP2K1 | MAP2K2 | MAPK1 | MAPK11 | MAPK12 | MAPK14 | MAPK3 | MAPK8 | PRKCA | RAF1 | ROCK1 | RPS6KB1 | SGK1 PDD-00017273 Preclinical PARG inhibitor PARG PDE10-IN-1 Preclinical phosphodiesterase inhibitor PDE10A p-dimethylinamyl-benzoate Preclinical PDP-EA Preclinical FAAH activator FAAH peficitinib Launched JAK inhibitor JAK1 | JAK2 | JAK3 rheumatology rheumatoid arthritis pefloxacin Launched bacterial DNA gyrase inhibitor TOP2A infectious disease | infectious disease | infectious disease | urology gastrointestinal infections | gonorrhea | urethritis | urinary tract infections pelanserin Phase 2 serotonin receptor antagonist HTR2A pelitinib Phase 2 EGFR inhibitor EGFR | ERBB2 pelrinone Phase 2 phosphodiesterase inhibitor PDE3A pemafibrate Phase 3 PPAR receptor agonist PPARA pemetrexed Launched dihydrofolate reductase inhibitor | thymidylate synthase inhibitor ATIC | DHFR | GART | SLC22A8 | TYMS oncology | oncology mesothelioma | non-small cell lung cancer (NSCLC) pemigatinib Launched fgfr inhibitor FGFR1 | FGFR2 | FGFR3 oncology colorectal cancer pemirolast Launched mediator release inhibitor HRH1 pulmonary asthma pempidine Launched ganglionic blocker cardiology hypertension penbutolol Launched adrenergic receptor antagonist ADRB1 | ADRB2 | HTR1A | HTR1B cardiology hypertension penciclovir Launched DNA directed DNA polymerase inhibitor dental cold sore penfluridol Launched T-type calcium channel blocker CACNA1G | DRD1 | DRD2 neurology/psychiatry schizophrenia penicillamine-(D) Launched chelating agent metabolism | nephrology | rheumatology cystinuria | rheumatoid arthritis | Wilson's disease penicillamine-(racemic) Launched penicillin-v-potassium Launched bacterial cell wall synthesis inhibitor infectious disease | infectious disease | infectious disease | infectious disease | infectious disease | infectious disease cholera | ear infections | pneumonia | scarlet fever | skin infections | throat infections pentacosanoic-acid Preclinical pentagastrin Launched CCK receptor agonist CCKBR gastroenterology | gastroenterology anacidity diagnostic | gastric hypersecretion diagnostic pentamidine Launched anti-pneumocystis agent TRDMT1 infectious disease pneumonia pentetic-acid Phase 2 chelating agent pentolinium Launched cholinergic receptor antagonist CHRNA10 | CHRNA3 | CHRNA4 | CHRNB4 cardiology hypertension pentostatin Launched "adenosine deaminase inhibitor | adenosine deaminase inhibitor, ribonucleotide reductase inhibitor | ribonucleotide reductase inhibitor" ADA hematologic malignancy hairy cell leukemia pentoxifylline Launched phosphodiesterase inhibitor ACHE | ADORA1 | ADORA2A | ADORA2B | ADRA2B | CHIA | NT5E | PDE10A | PDE1A | PDE1B | PDE1C | PDE2A | PDE3A | PDE3B | PDE4A | PDE4B | PDE4C | PDE4D | PDE5A | PDE6A | PDE6B | PDE6C | PDE6D | PDE6G | PDE6H | PDE7A | PDE7B | PDE8A | PDE8B | PDE9A | TNF cardiology claudication pentylenetetrazol Withdrawn GABA receptor antagonist peposertib Phase 1/Phase 2 DNA dependent protein kinase inhibitor PRKDC pepstatin Preclinical aspartic protease inhibitor CTSB | CTSD | CTSL | REN peramivir Launched neuraminidase inhibitor infectious disease influenza A virus infection perchlozone Launched infectious disease tuberculosis peretinoin Phase 3 retinoid receptor agonist RXRA perfluamine Launched perflubron Launched contrast agent radiology contrast agent perfluorodecalin Launched dermatology cosmetic perfluorohexyloctane Launched pergolide Withdrawn dopamine receptor agonist ADRA1A | ADRA1B | ADRA1D | ADRA2A | ADRA2B | ADRA2C | DRD1 | DRD2 | DRD3 | DRD4 | DRD5 | HTR1A | HTR1B | HTR1D | HTR2A | HTR2B | HTR2C | KCNA5 perhexiline Launched carnitine palmitoyltransferase inhibitor CPT1A | CPT2 cardiology angina pectoris perhexiline maleate Launched potassium channel blocker A1BG | KCNH2 | SCN5A Cardiology angina pectoris periciazine Launched adrenergic receptor antagonist ADRA1B | ADRA2A | AR | DRD1 neurology/psychiatry psychosis perifosine Phase 3 AKT inhibitor AKT1 | PIK3CA perillyl-alcohol Phase 2 apoptosis stimulant | farnesyltransferase inhibitor FNTA perindopril Launched angiotensin converting enzyme inhibitor ACE cardiology | cardiology | cardiology coronary artery disease (CAD) | hypertension | myocardial infarction perindoprilat Phase 2 angiotensin converting enzyme inhibitor ACE permethrin Launched infectious disease lice perospirone Launched dopamine receptor antagonist | serotonin receptor antagonist DRD2 | DRD3 | DRD4 | HTR2A | HTR2C neurology/psychiatry | neurology/psychiatry bipolar disorder | schizophrenia perphenazine Launched dopamine receptor antagonist CALM1 | DRD1 | DRD2 | HRH1 | HTR2A | HTR2C | HTR6 | HTR7 gastroenterology | gastroenterology | neurology/psychiatry nausea | schizophrenia | vomiting peruvoside Phase 1 cardiac glycoside perzinfotel Phase 2 glutamate receptor antagonist GRIN1 | GRIN2A | GRIN2B pesampator Phase 2 neurology/psychiatry schizophrenia PETCM Preclinical caspase activator CASP3 petesicatib Phase 2 cathepsin inhibitor CTSS | CTSV rheumatology sjogren's syndrome pevonedistat Phase 3 nedd activating enzyme inhibitor NAE1 | UBA3 pexacerfont Phase 2/Phase 3 crf receptor antagonist CRHR1 | PLXNA2 neurology/psychiatry generalized anxiety disorder (gad) pexidartinib Launched tyrosine kinase inhibitor CSF1R | FLT3 | KIT pexmetinib Phase 1 MAP kinase inhibitor | TIE tyrosine kinase inhibitor MAPK14 | TEK pf-00446687 Phase 2 melanocortin receptor agonist MC4R neurology/psychiatry hypoactive sexual desire disorder PF-02413873 Phase 1 progesterone receptor antagonist PGR PF-02545920 Phase 2 phosphodiesterase inhibitor PDE10A PF-03049423 Phase 2 phosphodiesterase inhibitor PDE5A PF-03084014 Phase 3 gamma secretase inhibitor pf-03463275 Phase 2 glycine transporter inhibitor SLC6A9 neurology/psychiatry schizophrenia pf 03716556 Preclinical h+/k+-atpase inhibitor ATP4A gastroenterology gastroesophageal reflux disease (gerd) PF-03758309 Phase 1 p21 activated kinase inhibitor PAK4 PF-03814735 Phase 1 Aurora kinase inhibitor AURKA | AURKB PF-03882845 Phase 1 mineralocorticoid receptor antagonist NR3C2 PF-04136309 Phase 2 CC chemokine receptor antagonist PF-04217903 Phase 1 c-Met inhibitor MET PF-04418948 Phase 1 prostaglandin inhibitor PTGER2 PF-04447943 Phase 2 phosphodiesterase inhibitor PDE9A PF-04457845 Phase 2 FAAH inhibitor FAAH pf 04531083 Phase 2 voltage-gated sodium channel modulator SCN10A neurology/psychiatry chronic pain PF-04620110 Phase 1 diacylglycerol O acyltransferase inhibitor DGAT1 PF-04691502 Phase 2 mTOR inhibitor | PI3K inhibitor MTOR | PIK3CA | PIK3CB | PIK3CD | PIK3CG PF-04885614 Preclinical voltage-gated sodium channel blocker SCN10A PF-04937319 Phase 2 glucokinase activator GCK pf-04971729 Launched sodium/glucose cotransporter inhibitor SLC5A2 endocrinology diabetes mellitus PF-04995274 Phase 1 serotonin receptor agonist HTR4 PF-05089771 Preclinical sodium channel blocker SCN9A PF-05175157 Phase 2 acetyl-CoA carboxylase inhibitor ACACA PF-05180999 Phase 1 phosphodiesterase inhibitor PDE2A PF-05190457 Phase 2 growth hormone secretagogue receptor inverse agonist GHSR PF-05212384 Phase 2 mTOR inhibitor | PI3K inhibitor MTOR | PIK3CA | PIK3CG PF-06260414 Phase 1 androgen receptor modulator AR PF-06273340 Phase 1 tyrosine kinase receptor inhibitor NTRK1 | NTRK2 | NTRK3 PF-06282999 Phase 1 myeloperoxidase inhibitor MPO PF-06305591 Phase 1 sodium channel blocker SCN10A pf-06380101 Preclinical tubulin inhibitor TUBB oncology breast cancer PF-06409577 Phase 1 protein kinase activator PRKAA1 | PRKAB1 | PRKAG1 PF-06412562 Phase 1 dopamine receptor partial agonist DRD1 | DRD5 PF-06447475 Preclinical serine/threonine kinase inhibitor LRRK2 PF-06459988 Phase 2 receptor tyrosine protein kinase inhibitor EGFR PF-06463922 Launched ALK tyrosine kinase receptor inhibitor ALK | FES | ROS1 oncology non-small cell lung cancer (NSCLC) PF-06650833 Phase 1 kinase inhibitor IRAK4 PF-06651600 Phase 2/Phase 3 JAK inhibitor JAK3 PF-06747775 Phase 2 EGFR inhibitor EGFR PF-06751979 Phase 1 beta secretase inhibitor BACE1 PF-06840003 Phase 1 "indoleamine 2,3-dioxygenase inhibitor" IDO1 PF-06873600 Phase 2 CDK inhibitor CDK2 | CDK4 | CDK6 PF-06928215 Preclinical cyclic GMP-AMP synthase inhibitor CGAS pf-06952229 Phase 1 antineoplastic agent TGFBR1 oncology breast cancer PF-3274167 Phase 2 oxytocin receptor antagonist AVPR1A | OXT | OXTR PF-3845 Preclinical FAAH inhibitor FAAH PF-4191834 Preclinical lipoxygenase inhibitor ALOX5 PF-429242 Preclinical SREBP inhibitor MBTPS1 PF-431396 Preclinical focal adhesion kinase inhibitor PTK2 | PTK2B PF-4708671 Preclinical ribosomal protein inhibitor RPS6KB1 PF-477736 Phase 1 CHK inhibitor CHEK1 | CHEK2 PF-4800567 Preclinical casein kinase inhibitor CSNK1D | CSNK1E PF-4981517 Preclinical cytochrome P450 inhibitor CYP3A4 | CYP3A5 | PDE2A PF-514273 Preclinical cannabinoid receptor antagonist CNR1 PF-5274857 Preclinical smoothened receptor antagonist PTCH1 | SMO PF-562271 Phase 1 focal adhesion kinase inhibitor PTK2 | PTK2B PF-573228 Preclinical focal adhesion kinase inhibitor CDK1 | CDK2 | CDK7 | GSK3B | IKBKB PF-670462 Preclinical casein kinase inhibitor CSNK1D | CSNK1E PF-750 Preclinical FAAH inhibitor FAAH PF-8380 Preclinical autotaxin inhibitor ENPP2 PF-915275 Phase 1 11-beta hydroxysteroid dehydrogenase inhibitor HSD11B1 PFI-1 Preclinical bromodomain inhibitor BRD4 PFI-3 Preclinical bromodomain inhibitor PBRM1 | SMARCA4 PFI-4 Preclinical bromodomain inhibitor BRPF1 PFK-015 Phase 1 phosphofructokinase inhibitor PFKFB3 PFK-158 Phase 1 phosphofructokinase inhibitor PFKFB3 PG-9 Preclinical acetylcholine receptor agonist pg-9 maleate Preclinical cholinergic receptor modulator PGL5001 Phase 2 JNK inhibitor MAPK10 | MAPK8 | MAPK9 PH-797804 Phase 2 p38 MAPK inhibitor MAPK11 | MAPK14 PHA-543613 Preclinical nicotinic receptor agonist CHRNA7 PHA-568487 Preclinical nicotinic receptor agonist CHRNA7 PHA-665752 Preclinical c-Met inhibitor MET PHA-680632 Preclinical Aurora kinase inhibitor AURKA | AURKB | AURKC PHA-767491 Preclinical CDC inhibitor CDK1 | RPS6KB1 PHA-793887 Phase 1 CDK inhibitor CCND1 | CCNE1 | CDK1 | CDK2 | CDK4 | CDK5 | CDK7 | CDK9 PHA-848125 Phase 2 CDK inhibitor | growth factor receptor inhibitor CDK1 | CDK2 | CDK4 | CDK5 | CDK7 | NTRK1 PHCCC Preclinical glutamate receptor agonist GRM1 | GRM4 phenacaine Launched local anesthetic neurology/psychiatry local anesthetic phenacemide Launched sodium channel blocker SCN10A | SCN11A | SCN1A | SCN2A | SCN3A | SCN4A | SCN5A | SCN7A | SCN8A | SCN9A neurology/psychiatry | neurology/psychiatry epilepsy | seizures phenacetin Withdrawn cyclooxygenase inhibitor PTGS1 phenazone Launched cyclooxygenase inhibitor PTGS1 | PTGS2 neurology/psychiatry pain relief phenazopyridine Launched local anesthetic SCN1A infectious disease urinary tract infections phenelzine Launched monoamine oxidase inhibitor ABAT | AOC3 | GAD2 | GPT | GPT2 | MAOA | MAOB | SLC6A2 | SLC6A3 | SLC6A4 neurology/psychiatry depression phenethicillin Launched bacterial cell wall synthesis inhibitor phenethyl-isothiocyanate Phase 2 anticancer agent CYP2E1 phenformin Withdrawn AMPK activator KCNJ8 | PRKAA1 phenindamine Launched histamine receptor antagonist HRH1 allergy | otolaryngology allergic rhinitis | common cold phenindione Launched vitamin K antagonist VKORC1 hematology deep vein thrombosis (DVT) pheniramine Launched histamine receptor antagonist HRH1 allergy | allergy allergic rhinitis | urticaria phenol Preclinical CA1 | CA12 | CA14 | CA2 | CA4 | CA9 otolaryngology pharyngitis phenolphthalein Withdrawn indicator dye UGT1A9 phenolsulfonphthalein Launched phenothiazine Preclinical dopamine receptor antagonist phenothrin Launched infectious disease lice phenoxybenzamine Launched adrenergic receptor antagonist ADRA1A | ADRA1B | ADRA1D | ADRA2A | ADRA2B | ADRA2C cardiology | endocrinology hypertension | pheochromocytoma phenprobamate Launched muscle relaxant neurology/psychiatry | neurology/psychiatry anxiety | muscle relaxant phenprocoumon Launched vitamin K antagonist VKORC1 hematology | hematology pulmonary embolism (PE) | thrombosis phenserine Phase 3 acetylcholinesterase inhibitor | beta amyloid synthesis inhibitor ACHE | APP | BCHE phensuximide Launched succinimide antiepileptic neurology/psychiatry seizures phentolamine Launched adrenergic receptor antagonist ADRA1A | ADRA1B | ADRA1D | ADRA2A | ADRA2B | ADRA2C cardiology | endocrinology hypertension | pheochromocytoma phenylacetylglutamine Phase 2 DNA methylase inhibitor | protein synthesis inhibitor phenyl-aminosalicylate Launched infectious disease tuberculosis phenylbenzimidazole-sulfonic-acid Launched dermatology sunscreen lotion phenylbutazone Withdrawn cyclooxygenase inhibitor | prostanoid receptor antagonist PTGIS | PTGS1 | PTGS2 phenylbutyrate Launched HDAC inhibitor CYP3A5 | HDAC1 metabolism urea cycle disorders phenylephrine Launched adrenergic receptor agonist ADRA1A | ADRA1B | ADRA1D cardiology | gastroenterology | otolaryngology hemorrhoids | hypotension | nasal congestion phenylethyl-alcohol Preclinical phenylmercuric-acetate Preclinical other antifungal phenylmethylsulfonyl-fluoride Preclinical serine protease inhibitor phenylpiracetam Launched noradrenaline uptake inhibitor neurology/psychiatry | neurology/psychiatry | neurology/psychiatry anxiety | depression | fatigue phenyl-salicylate Launched antiseptic urology interstitial cystitis (IC) phenytoin Launched hydantoin antiepileptic ABCB1 | CYP2B6 | CYP2C19 | CYP3A4 | SCN10A | SCN11A | SCN1A | SCN2A | SCN3A | SCN4A | SCN5A | SCN7A | SCN8A | SCN9A neurology/psychiatry seizures PhiKan-083 Preclinical p53 stabilizing agent TP53 phloretin Launched sodium/glucose cotransporter inhibitor AQP9 | CLCN3 | SLC23A1 phlorizin Preclinical sodium/glucose cotransporter inhibitor SLC5A1 | SLC5A11 | SLC5A2 | SLC5A3 phloroglucin Launched neurology/psychiatry spasms phortress Phase 1 aryl hydrocarbon receptor ligand AHR phosphatidylcholine Launched "cardiology | dermatology | gastroenterology | infectious disease | infectious disease | infectious disease, dermatology, gastroenterology, cardiology, obstetrics/gynecology | obstetrics/gynecology" "cholesterol | eczema | gallbladder disease | hepatitis B | hepatitis b, hepatitis c, eczema, gallbladder disease, cholesterol, premenstrual syndrome | hepatitis C | premenstrual syndrome" PHP-501 Preclinical GABA receptor antagonist GABRA1 | GABRB2 | GABRG2 PHT-427 Preclinical AKT inhibitor | pyruvate dehydrogenase inhibitor AKT2 | PDPK1 phthalylsulfacetamide Preclinical phthalylsulfathiazole Launched dihydropteroate synthetase inhibitor gastroenterology | infectious disease colitis | dysentry PHTPP Preclinical estrogen receptor antagonist ESR2 physostigmine Launched acetylcholinesterase inhibitor | cholinesterase inhibitor ACHE | BCHE cardiology | gastroenterology | neurology/psychiatry | ophthalmology Alzheimer's disease | gastroparesis | glaucoma | hypotension phytonadione Launched BGLAP | GGCX hematology | hematology anticoagulation reversal | vitamin K deficiency phytosphingosine Phase 1 PI-103 Preclinical mTOR inhibitor | PI3K inhibitor MTOR | PIK3CA | PIK3CB | PIK3CD | PIK3CG | PRKDC PI3Kd-IN-2 Preclinical PI3K inhibitor PI3K-IN-2 Phase 2 PI3K inhibitor MTOR PI4KIII-beta-inhibitor-1 Preclinical PI4K inhibitor PI4K2B PI-828 Preclinical PI3K inhibitor pibenzimol Phase 2 DNA inhibitor piboserod Phase 2 serotonin receptor antagonist HTR2B | HTR4 pibrentasvir Launched antiviral NS5A infectious disease hepatitis c picartamide Phase 2 H+/K+-ATPase inhibitor ATP4A piceatannol Preclinical SYK inhibitor ATP5A1 | ATP5B | ATP5C1 | IRF3 | PTGS2 | SIRT1 | SYK | TYR piclamilast Phase 2 phosphodiesterase inhibitor PDE4A | PDE4B | PDE4C | PDE4D picolamine Preclinical picolinic-acid Phase 2 chelating agent piconol Preclinical picotamide Launched thromboxane receptor antagonist | thromboxane synthase inhibitor TBXA2R | TBXAS1 hematology thrombosis picrotin Phase 2 GABA receptor antagonist GABRA1 | GABRR1 | GLRA1 | GLRA2 | GLRA3 | GLRB Pulmonology respiratory distress syndrome (rds) picrotoxin Preclinical picrotoxinin Preclinical GABA receptor antagonist GLRA1 | GLRA2 | GLRA3 | GLRB | HTR3A | HTR3B pidolic-acid Launched ADAM28 | AMY1A | AMY2A | AMY2B | ANG | CCL8 | HCRT | IGLC1 | KRTAP5-2 | TFF2 | VEGFA dermatology xerosis cutis pidotimod Launched interferon receptor agonist | interleukin receptor agonist infectious disease immune adjuvant pifithrin-alpha Preclinical TP53 inhibitor TP53 pifithrin-cyclic Preclinical TP53 inhibitor TP53 pifithrin-mu Preclinical HSP inhibitor HSPA1A | TP53 PIK-293 Preclinical PI3K inhibitor PIK3CA | PIK3CB | PIK3CD | PIK3CG PIK-294 Preclinical PI3K inhibitor PIK3CB | PIK3CD | PIK3CG PIK-75 Preclinical DNA protein kinase inhibitor | PI3K inhibitor PIK3CA | PIK3CB | PIK3CD | PIK3CG | PRKDC PIK-93 Preclinical PI3K inhibitor PI4KB | PIK3C3 | PIK3CG pikamilone Phase 1 piketoprofen Launched cyclooxygenase inhibitor neurology/psychiatry pain relief pilaralisib Phase 2 PI3K inhibitor pilocarpine Launched acetylcholine receptor agonist CHRM1 | CHRM2 | CHRM3 | CHRM4 | CHRM5 cardiology | ophthalmology glaucoma | hypertension pilsicainide Launched sodium channel blocker SCN5A cardiology cardiac arrythmia PIM-1-Inhibitor-2 Preclinical Pim kinase inhibitor PIM1 PIM-447 Phase 1 Pim kinase inhibitor PIM1 | PIM2 | PIM3 pimavanserin Launched serotonin receptor inverse agonist DRD2 | HTR2A neurology/psychiatry Parkinson's Disease pimecrolimus Launched calcineurin inhibitor CYP3A5 | FKBP1A dermatology eczema pimethixene Launched antihistamine allergy | neurology/psychiatry | neurology/psychiatry | neurology/psychiatry allergic rhinitis | anxiety | attention-deficit/hyperactivity disorder (ADHD) | sleep cycle support pimitespib Phase 1 hsp90 inhibitor HSP90AB1 oncology gastrointestinal stromal tumors (gist) pimobendan Launched "calcium sensitizer | calcium sensitizer, phosphodiesterase inhibitor | phosphodiesterase inhibitor" PDE3A cardiology congestive heart failure pimodivir Phase 3 antiviral pimonidazole Phase 3 pimozide Launched dopamine receptor antagonist CACNA1I | CALM1 | DRD1 | DRD2 | DRD3 | DRD4 | DRD5 | HRH1 | HTR1A | HTR2A | KCNA10 | KCNH2 neurology/psychiatry Tourette's disorder pinacidil Launched ATP channel activator | potassium channel activator ABCC8 | ABCC9 | KCNJ8 cardiology hypertension pinanediol Preclinical pinaverium Launched T-type calcium channel blocker CACNA1C gastroenterology irritable bowel syndrome pinaverium bromide Launched t-type calcium channel blocker CACNA1C gastroenterology irritable bowel syndrome pincainide Phase 1 antiarrhythmic SCN5A pindolol Launched adrenergic receptor antagonist ADRB1 | ADRB2 | HTR1A | HTR2A | HTR2B cardiology hypertension pindolol-(-) Phase 2 adrenergic receptor antagonist | serotonin receptor antagonist HTR1A pinitol Phase 2 gamma secretase inhibitor pinocembrin Phase 2 cytochrome P450 inhibitor AR | CYP1B1 | SRD5A1 | SRD5A2 pioglitazone Launched insulin sensitizer | PPAR receptor agonist INS | PPARG | TRPM3 endocrinology diabetes mellitus pioglitazone hydrochloride Launched "insulin sensitizer, ppar receptor agonist" PPARG | TRPM3 endocrinology diabetes mellitus pipamperone Launched dopamine receptor antagonist DRD2 | HRH1 | HTR1A | HTR1B | HTR1D | HTR2A neurology/psychiatry schizophrenia pipecuronium Launched neuromuscular blocker CHRM2 | CHRM3 | CHRNA2 neurology/psychiatry anesthetic pipemidic-acid Launched topoisomerase inhibitor infectious disease gram-negative bacterial infections pipenzolate Launched cholinergic receptor antagonist CHRM1 neurology/psychiatry spasms pipequaline Preclinical benzodiazepine receptor agonist ALB | GABRA1 neurology/psychiatry drowsiness piperacetazine Launched dopamine receptor antagonist neurology/psychiatry schizophrenia piperacillin Launched bacterial cell wall synthesis inhibitor infectious disease | infectious disease | infectious disease | infectious disease intra-abdominal infections | pelvic inflammatory disease | pneumonia | skin infections piperacillin sodium Launched bacterial cell wall synthesis inhibitor infectious disease "intra-abdominal infections, skin infections, pelvic inflammatory disease, pneumonia" piperaquine-phosphate Launched antimalarial agent infectious disease malaria piperazine Launched benzodiazepine receptor agonist GABRB3 infectious disease gastrointestinal roundworms piperazinedione Phase 2 DNA synthesis inhibitor piperidolate Launched acetylcholine receptor antagonist CHRM1 neurology/psychiatry spasms piperine Phase 1 monoamine oxidase inhibitor MAOA | MAOB | TRPV1 piperonyl-butoxide Launched cytochrome P450 inhibitor infectious disease lice pipobroman Launched DNA alkylating agent hematology | hematology polycythemia vera | thrombocythemia pipofezine Preclinical selective serotonin reuptake inhibitor (SSRI) SLC6A4 pipotiazine Launched dopamine receptor antagonist DRD1 | DRD2 | HTR1A | HTR2A neurology/psychiatry schizophrenia pipotiazine-palmitate Launched dopamine receptor antagonist | serotonin receptor antagonist DRD1 | DRD2 | HTR1A | HTR2A neurology/psychiatry schizophrenia piracetam Launched acetylcholine receptor agonist GRIA1 | GRIA2 | GRIA3 | GRIA4 neurology/psychiatry senile dementia pirarubicin Launched topoisomerase inhibitor TOP2A oncology breast cancer pirbuterol Withdrawn adrenergic receptor agonist ADRB1 | ADRB2 pulmonary bronchospasm pirenoxine Launched AGE inhibitor ophthalmology cataracts pirenperone Preclinical serotonin receptor antagonist HTR2A | HTR7 pirenzepine Launched acetylcholine receptor antagonist CHRM1 | CHRM2 | CHRM3 | CHRM4 | CHRM5 gastroenterology peptic ulcer disease (PUD) piretanide Launched glucocorticoid receptor agonist SLC12A1 | SLC12A2 cardiology | cardiology edema | hypertension pirfenidone Launched TGF beta receptor inhibitor FURIN | MAPK14 | TNF | TNFRSF1A pulmonary idiopathic pulmonary fibrosis (IPF) piribedil Launched dopamine receptor agonist ADRA1A | ADRA2A | ADRA2C | DRD2 | DRD3 | DRD4 | HTR1A | HTR2B neurology/psychiatry | neurology/psychiatry dizziness | Parkinson's Disease piricapiron Phase 2 "dopamine receptor antagonist | dopamine receptor antagonist, serotonin receptor antagonist | serotonin receptor antagonist" DRD2 | HTR1A | HTR2A pirinixic-acid Preclinical PPAR receptor agonist PPARA pirlindole Launched monoamine oxidase inhibitor MAOA | SLC6A2 | SLC6A4 neurology/psychiatry depression pirlindole mesylate Launched monoamine oxidase inhibitor MAOA neurology/psychiatry depression pirmenol Preclinical acetylcholine receptor inhibitor CHRM1 | CHRM2 | CHRM4 piroctone-olamine Launched infectious disease fungal infection pirodavir Phase 2 piromidic-acid Phase 2 bacterial DNA gyrase inhibitor piroxicam Launched cyclooxygenase inhibitor PTGS1 | PTGS2 rheumatology | rheumatology | rheumatology "osteoarthritis | osteoarthritis, rheumatoid arthritis | rheumatoid arthritis" piroximone Phase 2 phosphodiesterase inhibitor PDE3A pirozadil Preclinical hypolipidemic pirquinozol Phase 1 histamine release inhibitor PIT Preclinical purinergic receptor antagonist P2RY1 pitavastatin Launched HMGCR inhibitor APOA1 | CYP2C8 | HMGCR endocrinology hyperlipidemia pitolisant Launched histamine receptor antagonist HRH3 pivagabine Launched corticotropin releasing factor receptor antagonist CRHR1 | CRHR2 | UCN neurology/psychiatry depression pivampicillin Launched bacterial cell wall synthesis inhibitor infectious disease | infectious disease | pulmonary bronchitis | gynecologic infections | pneumonia pivanex Phase 2 HDAC inhibitor HDAC1 | HDAC2 | HDAC3 | HDAC8 pivmecillinam Launched bacterial cell wall synthesis inhibitor infectious disease | infectious disease gram-negative bacterial infections | urinary tract infections pixantrone Launched topoisomerase inhibitor TOP2A hematologic malignancy non-Hodgkin lymphoma (NHL) pizotifen Launched serotonin receptor antagonist HTR1A | HTR2A | HTR2C neurology/psychiatry migraine headache PJ-34 Preclinical PARP inhibitor EEF2 | PARP1 | PARP15 | PARP3 PK-11195 Phase 1 benzodiazepine receptor antagonist NR1I2 | NR1I3 | TSPO PK-44 Preclinical dipeptidyl peptidase inhibitor DPP4 PKI-166 Phase 1 EGFR inhibitor EGFR | ERBB2 PKI-179 Phase 1 mTOR inhibitor | PI3K inhibitor MTOR PK-THPP Preclinical potassium channel blocker KCNK3 | KCNK9 pleconaril Phase 3 plerixafor Launched CC chemokine receptor antagonist ACKR3 | CCR4 | CXCR4 hematologic malignancy | hematologic malignancy multiple myeloma | non-Hodgkin lymphoma (NHL) plicamycin Launched alcohol dehydrogenase inhibitor endocrinology | endocrinology | oncology hypercalcemia | Paget's disease | testicular carcinoma plinabulin Phase 3 tubulin polymerization inhibitor plovamer-acetate Phase 2 TAT | TH | YARS | YARS2 plumbagin Preclinical anticancer agent plurisin-1 Preclinical stearoyl-CoA desaturase inhibitor SCD PLX4720 Preclinical RAF inhibitor BRAF | KDR PLX51107 Phase 1 bromodomain inhibitor BRD2 | BRD3 | BRD4 | BRDT PLX647 Preclinical receptor tyrosine protein kinase inhibitor CSF1R | KIT PLX8394 Phase 1/Phase 2 serine/threonine kinase inhibitor BRAF PMPA Preclinical glutamate receptor antagonist FOLH1 PNU-120596 Preclinical acetylcholine receptor agonist CHRNA7 PNU-142633 Phase 2 serotonin receptor agonist HTR1D PNU-177864 Preclinical dopamine receptor antagonist DRD3 PNU-22394 Phase 2 serotonin receptor agonist HTR2A | HTR2B | HTR2C | MAOA | MAOB PNU-282987 Preclinical cholinergic receptor agonist CHRNA7 PNU-37883 Preclinical ATP-sensitive potassium channel antagonist PNU-74654 Preclinical beta-catenin inhibitor CTNNB1 | TCF4 PNU-89843 Preclinical benzodiazepine receptor agonist GABBR1 pocapavir Preclinical Enterovirus capsid inhibitor podophyllotoxin Launched microtubule inhibitor | tubulin polymerization inhibitor IGF1R | TOP2A | TUBA4A | TUBB infectious disease genital warts polaprezinc Preclinical chelating agent polidocanol Launched local anesthetic dermatology varicose veins polydatin Phase 2 ICAM1 expression inhibitor ICAM1 | XDH polyinosine Preclinical immunostimulant HPRT1 | IMPDH2 | PYGM polymyxin b nonapeptide (tfa) bacterial permeability inducer infectious disease gram-negative bacterial infections polymyxin-B-sulfate Launched bacterial permeability inducer ophthalmology eye infection polythiazide Launched sodium/chloride cotransporter inhibitor SLC12A3 cardiology | cardiology | cardiology | gastroenterology | nephrology | nephrology | rheumatology acute glomerulonephritis (AGN) | chronic renal failure | congestive heart failure | edema | hepatic cirrhosis | hypertension | nephrotic syndrome pomalidomide Launched angiogenesis inhibitor | tumor necrosis factor production inhibitor CRBN | CYP2C19 | TNF hematologic malignancy multiple myeloma ponatinib Launched Bcr-Abl kinase inhibitor | FLT3 inhibitor | PDGFR tyrosine kinase receptor inhibitor ABL1 | BCR | CYP2C8 | CYP3A5 | FGF2 | FGFR1 | FGFR2 | FGFR3 | FGFR4 | FLT1 | FLT3 | KDR | KIT | LCK | LYN | PDGFRA | RET | SRC | TEK hematologic malignancy | hematologic malignancy acute lymphoblastic leukemia (ALL) | chronic myeloid leukemia (CML) ponazuril Launched infectious disease encephalomyelitis ponesimod Phase 3 sphingosine 1-phosphate receptor agonist S1PR1 posaconazole Launched sterol demethylase inhibitor CYP3A4 | CYP51A1 infectious disease oropharyngeal candidiasis potassium-canrenoate Launched mineralocorticoid receptor antagonist NR3C2 cardiology edema potassium-iodide Launched pulmonary | pulmonary | pulmonary asthma | bronchitis | emphysema potassium-p-aminobenzoate Launched rheumatology | rheumatology | urology dermatomyositis | Peyronie's disease | scleroderma pozanicline Phase 2 acetylcholine receptor antagonist CHRNA4 | CHRNB2 poziotinib Phase 2 EGFR inhibitor EGFR | ERBB2 | ERBB4 PP-1 Preclinical SRC inhibitor HCK | RET | SRC PP-121 Preclinical protein tyrosine kinase inhibitor ABL1 | EGFR | HCK | KDR | MTOR | PDGFRA | PIK3CA | PIK3CB | PIK3CD | PIK3CG | PRKDC | SRC PP-2 Preclinical SRC inhibitor ABL1 | LCK | RIPK2 | SRC PP242 Preclinical mTOR inhibitor MTOR | PASK PPT Preclinical estrogen receptor agonist ESR1 PPY-A Preclinical Abl kinase inhibitor ABL1 | BCR PQ-401 Preclinical IGF-1 inhibitor IGF1R PR-619 Preclinical DUB inhibitor practolol Withdrawn adrenergic receptor antagonist ADRB1 pradefovir Phase 2 cytochrome P450 activator CYP3A4 prajmalium bitartrate Launched voltage-gated sodium channel blocker Cardiology cardiac arrythmia pralatrexate Launched dihydrofolate reductase inhibitor DHFR | SLC19A1 hematologic malignancy peripheral T-cell lymphoma (PTCL) pralidoxime Launched acetylcholinesterase inhibitor ACHE | BCHE critical care organophosphate poisoning pralidoxime-chloride Launched acetylcholinesterase inhibitor ACHE | BCHE pulmonary respiratory depression pralmorelin Launched growth hormone releasing peptide ligand agonist GH1 | GH2 | GHRHR | GHSR pramipexole Launched dopamine receptor agonist ADRA2A | ADRA2B | ADRA2C | DRD1 | DRD2 | DRD3 | DRD4 | DRD5 | HTR1A | HTR1B | HTR1D | HTR2A | HTR2B | HTR2C neurology/psychiatry Parkinson's Disease pramiracetam Launched acetylcholine receptor agonist neurology/psychiatry senile dementia pramoxine Launched topical anesthetic dermatology corticosteroid-responsive dermatoses pranidipine Phase 2 calcium channel blocker CACNA1C pranlukast Launched leukotriene receptor antagonist CYSLTR1 | CYSLTR2 | IL5 | MUC2 | NFKB1 | RNASE3 | TNF pulmonary | pulmonary asthma | bronchospasm pranoprofen Launched cyclooxygenase inhibitor neurology/psychiatry pain relief prasterone-acetate Preclinical prasugrel Launched purinergic receptor antagonist CYP2B6 | CYP2C19 | CYP3A5 | P2RY12 cardiology | cardiology acute coronary syndrome (ACS) | myocardial infarction pravadoline Preclinical cyclooxygenase inhibitor CNR1 | CNR2 pravastatin Launched HMGCR inhibitor HMGCR | SLCO1B1 cardiology | endocrinology | endocrinology hypercholesterolemia | hyperlipidemia | myocardial infarction pravastatin sodium Launched hmgcr inhibitor HMGCR | SLCO1B1 "endocrinology, cardiology" "hypercholesterolemia, myocardial infarction, hyperlipidemia" praziquantel Launched anthelmintic agent infectious disease | infectious disease | infectious disease cystic hydatid disease | gastrointestinal parasites | schistosomiasis prazosin Launched adrenergic receptor antagonist ADRA1A | ADRA1B | ADRA1D | ADRA2A | ADRA2B | ADRA2C | CDK1 | KCNH2 | KCNH6 | KCNH7 cardiology hypertension PRE-084 Preclinical sigma receptor agonist SIGMAR1 preclamol Phase 2 dopamine receptor agonist DRD2 prednicarbate Launched glucocorticoid receptor agonist | phospholipase activator NR3C1 | PLA2G1B dermatology | Dermatology | neurology/psychiatry | ophthalmology contact dermatitis | dermatitis | eczema | itching prednisolone Launched glucocorticoid receptor agonist NR3C1 | NR3C2 | SERPINA6 dermatology | infectious disease | ophthalmology | ophthalmology | ophthalmology | ophthalmology conjunctivitis | cyclitis | iritis | punctate keratitis | rosacea | shingles prednisolone acetate Launched glucocorticoid receptor agonist NR3C1 "ophthalmology, dermatology, infectious disease" "conjunctivitis, rosacea, punctate keratitis, shingles, iritis, cyclitis" prednisolone-acetate Launched glucocorticoid receptor agonist NR3C1 dermatology | infectious disease | ophthalmology | ophthalmology | ophthalmology | ophthalmology conjunctivitis | cyclitis | iritis | punctate keratitis | rosacea | shingles prednisolone-hemisuccinate Preclinical glucocorticoid receptor agonist NR3C1 prednisolone sodium phosphate Launched glucocorticoid receptor agonist NR3C1 "allergy, pulmonary, ophthalmology, infectious disease, rheumatology, endocrinology, neurology/psychiatry, gastroenterology, hematology" "allergic rhinitis, asthma, contact dermatitis, mycosis, lupus, hypercalcemia, thyroiditis, congenital adrenal hyperplasia, multiple sclerosis, ulcerative colitis, enteritis, thrombocythemia, pneumonia, meningitis, psoriatic arthritis, rheumatoid arthritis" prednisolone-sodium-phosphate Launched glucocorticoid receptor agonist NR3C1 allergy | endocrinology | endocrinology | endocrinology | gastroenterology | gastroenterology | hematology | infectious disease | infectious disease | infectious disease | neurology/psychiatry | ophthalmology | pulmonary | rheumatology | rheumatology | rheumatology allergic rhinitis | asthma | congenital adrenal hyperplasia | contact dermatitis | enteritis | hypercalcemia | lupus | meningitis | multiple sclerosis | mycosis | pneumonia | psoriatic arthritis | rheumatoid arthritis | thrombocythemia | thyroiditis | ulcerative colitis prednisolone tebutate Withdrawn glucocorticoid receptor agonist NR3C1 General surgery hemorrhoids prednisolone-tebutate Launched anti-inflammatory agent prednisone Launched glucocorticoid receptor agonist HSD11B1 | NR3C1 dermatology | endocrinology | endocrinology | gastroenterology | gastroenterology | hematology | infectious disease | infectious disease | infectious disease | neurology/psychiatry | ophthalmology | rheumatology | rheumatology | rheumatology | rheumatology | rheumatology | rheumatology anemia | ankylosing spondylitis | bursitis | congenital adrenal hyperplasia | conjunctivitis | dermatomyositis | enteritis | epicondylitis | hypercalcemia | meningitis | multiple sclerosis | mycosis | osteoarthritis | psoriasis | psoriatic arthritis | rheumatoid arthritis | ulcerative colitis pregnenolone Launched glutamate receptor modulator PGR | SULT2B1 rheumatology rheumatoid arthritis pregnenolone-succinate Preclinical GABA receptor negative allosteric modulator CYP17A1 preladenant Phase 3 adenosine receptor antagonist ADORA1 | ADORA2A | ADORA2B | ADORA3 prenylamine Withdrawn calcium channel blocker presatovir Phase 2 RSV fusion inhibitor pretomanid Launched nitric oxide donor FASN pridinol Launched muscle relaxant neurology/psychiatry muscle relaxant pridopidine Phase 2 dopamine receptor antagonist DRD2 prilocaine Launched local anesthetic SCN5A neurology/psychiatry anesthetic prilocaine hydrochloride Launched local anesthetic SCN5A neurology/psychiatry anesthetic PRIMA1 Preclinical TP53 inhibitor ACHE primaquine Launched antimalarial agent | DNA inhibitor infectious disease malaria primaquine phosphate Launched "antimalarial agent, dna inhibitor" infectious disease malaria primidone Launched GABA receptor antagonist CHRNA4 | CHRNA7 | GABRA1 | GABRA2 | GABRA3 | GABRA4 | GABRA5 | GABRA6 | GABRB1 | GABRB2 | GABRB3 | GABRD | GABRE | GABRG1 | GABRG2 | GABRG3 | GABRP | GABRQ | GRIA2 | GRIK2 | SCN10A | SCN11A | SCN1A | SCN2A | SCN3A | SCN4A | SCN5A | SCN7A | SCN8A | SCN9A neurology/psychiatry seizures prinaberel Phase 2 estrogen receptor agonist ESR2 | NCOA1 prinomastat Phase 3 matrix metalloprotease inhibitor MMP1 | MMP2 | MMP3 | MMP9 priralfinamide Phase 3 sodium channel blocker CACNA1B prisotinol Phase 2 pristinamycin Launched other antibiotic infectious disease staphylococcal infections pritelivir Phase 2 helicase primase inhibitor PRLX-93936 Phase 1/Phase 2 voltage-dependent anion selective channel protein inhibitor VDAC2 | VDAC3 PRN1008 Preclinical Bruton's tyrosine kinase (BTK) inhibitor BTK PRN1371 Phase 1 protein tyrosine kinase inhibitor FGFR1 | FGFR2 | FGFR3 | FGFR4 proacipimox Phase 1 cholesterol inhibitor proadifen Preclinical nitric oxide synthase inhibitor NOS1 probenecid Launched uricosuric blocker ABCC1 | PANX1 | SLC22A11 | SLC22A6 | SLC22A8 | SLCO1C1 | TRPV2 nephrology | rheumatology gout | hyperuricemia probucol Launched atherogenesis inhibitor ABCA1 | ABCB11 | CES1 cardiology coronary artery disease (CAD) procainamide Launched sodium channel blocker DNMT1 | SCN5A cardiology | cardiology ventricular arrhythmias | ventricular tachycardia (VT) procaine Launched HMGCR inhibitor CHRNA2 | GRIN3A | HMGCR | HTR3A | KCNMA1 | KCNMB1 | KCNMB2 | KCNMB3 | KCNMB4 | KCNN1 | KCNN2 | KCNN3 | KCNN4 | MAOA | MAOB | RYR1 | RYR2 | SCN10A | SLC6A3 neurology/psychiatry anesthetic procarbazine Launched monoamine oxidase inhibitor hematologic malignancy Hodgkin's lymphoma procaterol Launched adrenergic receptor agonist ADRB2 pulmonary asthma prochlorperazine Launched dopamine receptor antagonist DRD1 | DRD2 | DRD3 | DRD4 gastroenterology | gastroenterology nausea | vomiting procodazole Preclinical immunostimulant procyanidin-B-2 Phase 2 procyclidine Withdrawn acetylcholine receptor antagonist | antispasmodic CHRM1 neurology/psychiatry | neurology/psychiatry | neurology/psychiatry | neurology/psychiatry akathisia | dystonia | parkinsonism | Parkinson's Disease procyclidine (hydrochloride) procysteine Phase 3 glutathione synthase stimulant profenamine Launched butyrylcholinesterase inhibitor | cholinergic receptor antagonist BCHE | CHRM1 neurology/psychiatry Parkinson's Disease proflavine-hemisulfate Phase 2 topical anesthetic F2 progesterone Launched progesterone receptor agonist CATSPER1 | CATSPER2 | CATSPER3 | CATSPER4 | CYP17A1 | CYP2C19 | ESR1 | NR3C2 | OPRK1 | PGR | TRPC5 endocrinology | obstetrics/gynecology amenorrhea | infertility proglumetacin Launched cyclooxygenase inhibitor PTGS1 | PTGS2 neurology/psychiatry pain relief proglumide Withdrawn CCK receptor antagonist CCKAR | CCKBR proguanil Launched dihydrofolate reductase inhibitor CYP2C19 | DHFR infectious disease malaria prolylleucylglycinamide Phase 2 melanocyte-stimulating hormone release inhibitor promazine Launched dopamine receptor antagonist ADRA1A | ADRA1B | ADRA1D | CHRM1 | CHRM2 | CHRM3 | CHRM4 | CHRM5 | DRD1 | DRD2 | DRD3 | DRD4 | HRH1 | HTR2A | HTR2C neurology/psychiatry schizophrenia promestriene Launched estrogen receptor agonist ESR1 endocrinology androgenetic alopecia promethazine Launched histamine receptor antagonist HRH1 allergy | neurology/psychiatry allergic rhinitis | sedative pronethalol Withdrawn adrenergic receptor antagonist pronethalol hydrochloride Withdrawn adrenergic receptor antagonist propacetamol Launched cyclooxygenase inhibitor PTGS1 | PTGS2 endocrinology | neurology/psychiatry fever | pain relief propafenone Launched antiarrhythmic ADRB1 | ADRB2 | KCNA5 | KCNH2 | KCNK2 | KCNK3 | SCN5A cardiology | cardiology | cardiology atrial fibrillation (AF) | ventricular arrhythmias | ventricular tachycardia (VT) propafenone hydrochloride Launched antiarrhythmic ADRB1 | ADRB2 | KCNA5 | KCNH2 cardiology "atrial fibrillation (af), ventricular tachycardia (vt), ventricular arrhythmias" propagermanium Launched CCR agonist | interferon receptor agonist CCR2 infectious disease hepatitis B propantheline Launched acetylcholine receptor antagonist CHRM1 | CHRM2 | CHRM3 | CHRM4 gastroenterology peptic ulcer disease (PUD) propatylnitrate Launched cardiology angina pectoris propentofylline Launched adenosine reuptake inhibitor | phosphodiesterase inhibitor ACHE | PDE1A neurology/psychiatry stroke propidium-iodide Preclinical ACHE propiolactone Launched infectious disease antiseptic propiverine Launched acetylcholine receptor antagonist CACNA1C | CHRM1 | CHRM2 | CHRM3 | CHRM4 urology urinary incontinence propofol Launched benzodiazepine receptor agonist CYP2B6 | FAAH | GABRA1 | GABRA2 | GABRA3 | GABRA4 | GABRA5 | GABRA6 | GABRB1 | GABRB2 | GABRB3 | GABRD | GABRE | GABRG1 | GABRG2 | GABRG3 | GABRP | GABRQ | SCN2A | SCN4A | TRPV1 neurology/psychiatry anesthetic propoxur Launched infectious disease flea control propoxycaine Launched local anesthetic neurology/psychiatry anesthetic propranolol Launched adrenergic receptor antagonist ADRB1 | ADRB2 cardiology | cardiology | neurology/psychiatry angina pectoris | hypertension | migraine headache propranolol hydrochloride Launched adrenergic receptor antagonist ADRB1 | ADRB2 | ADRB3 Cardiology angina pectoris propranolol-(R) Preclinical adrenergic receptor antagonist ADRB2 | ADRB3 propranolol-(S) Preclinical adrenergic receptor antagonist ADRB1 | CYP2C19 | HTR1A | HTR5A | SLC10A1 propyl-benzoate Launched propylene-glycol Launched propylhexedrine Launched adrenergic receptor agonist allergy | endocrinology | otolaryngology allergic rhinitis | fever | nasal congestion propylparaben Launched propylthiouracil Launched thyroid peroxidase inhibitor DIO1 | TPO endocrinology | endocrinology | endocrinology goiter | Grave's disease | hyperthyroidism propyphenazone Preclinical anti-inflammatory agent proquazone Launched cyclooxygenase inhibitor PTGS1 | PTGS2 neurology/psychiatry pain relief proscillaridin a Launched cardiology "congestive heart failure, cardiac arrythmia" proscillaridin-A Launched cardiology | cardiology cardiac arrythmia | congestive heart failure protionamide Launched infectious disease tuberculosis protirelin Launched thyrotropin releasing hormone receptor agonist TRHR radiology thyroid function diagnostic protokylol Withdrawn adrenergic receptor agonist ADRB2 infectious disease respiratory tract infections protoporphyrin-IX Preclinical heme oxygenase inhibitor HMOX1 protriptyline Launched tricyclic antidepressant SLC6A2 | SLC6A4 neurology/psychiatry depression proxodolol Launched adrenergic receptor antagonist proxyfan Preclinical histamine receptor modulator HRH3 proxymetacaine Launched sodium channel blocker SCN10A | SCN5A | SCN9A neurology/psychiatry anesthetic Proxyphylline Launched pulmonary asthma PRT062070 Phase 2/Phase 3 JAK inhibitor | SYK inhibitor SYK PRT062607 Phase 2 SYK inhibitor FGR | MAP3K9 | SYK PRT4165 Preclinical polycomb repressive complex inhibitor PRC1 prucalopride Launched serotonin receptor agonist HTR4 gastroenterology constipation prulifloxacin Launched bacterial DNA gyrase inhibitor gastroenterology | infectious disease | pulmonary bronchitis | diarrhea | urinary tract infections pruvanserin Phase 2 serotonin receptor antagonist HTR2A | HTR2C PRX-07034 Phase 1 serotonin receptor antagonist HTR6 PRX-08066 Phase 2 serotonin receptor antagonist HTR2B PS178990 Phase 1 androgen receptor modulator AR PSB-06126 Preclinical NTPDase inhibitor ENTPD3 PSB-11 Preclinical adenosine receptor antagonist ADORA1 | ADORA2A | ADORA3 PSB-1115 Preclinical adenosine receptor antagonist ADORA1 | ADORA2B | ADORA3 PSB-36 Preclinical adenosine receptor antagonist ADORA1 | ADORA2A | ADORA2B | ADORA3 PSB-603 Preclinical adenosine receptor antagonist ADORA1 | ADORA2A | ADORA2B | ADORA3 PSI-6130 Phase 1 RNA polymerase inhibitor PSI-697 Phase 1 P selectin inhibitor SELP PSI-7976 Preclinical HCV inhibitor PSN-375963 Preclinical glucose dependent insulinotropic receptor agonist GPR119 PSNCBAM-1 Preclinical cannabinoid receptor modulator CNR1 psoralen Launched MAOA | MAOB dermatology | dermatology | dermatology eczema | psoriasis | vitiligo PT-2385 Phase 1 hypoxia inducible factor inhibitor EPAS1 pt2399 Preclinical hif modulator EPAS1 oncology renal cell carcinoma (rcc) PTC-028 Preclinical BMI-1 inhibitor BMI1 PTC-209 Preclinical BMI-1 inhibitor BMI1 ptc596 Phase 1 polycomb protein inhibitor BMI1 oncology glioma pterostilbene Phase 2/Phase 3 "cyclooxygenase inhibitor | cyclooxygenase inhibitor, ppar receptor agonist | PPAR receptor agonist" FAAH | PPARA | PTGS1 | PTGS2 pti-428 Phase 2 cftr channel potentiator CFTR pulmonary cystic fibrosis puerarin Phase 2 serotonin receptor antagonist PU-H71 Phase 1 HSP inhibitor HSP90AA1 pulrodemstat Phase 2 histone lysine demethylase inhibitor KDM1A | MBD2 hematologic malignancy acute myeloid leukemia (aml) pumosetrag Phase 2 serotonin receptor agonist HTR3A | HTR4 purmorphamine Preclinical smoothened receptor agonist DHH | IHH | PTCH1 | SMO puromycin Preclinical protein synthesis inhibitor NHP2L1 | RPL10L | RPL11 | RPL13A | RPL15 | RPL19 | RPL23 | RPL23A | RPL26L1 | RPL3 | RPL37 | RPL8 | RSL24D1 puromycin dihydrochloride Preclinical ribosomal protein inhibitor purvalanol-A Preclinical CDK inhibitor CCND1 | CCNE1 | CDK1 | CDK2 | CDK4 | CDK5 | CSNK1G3 | RPS6KA1 | SRC purvalanol-B Preclinical tyrosine kinase inhibitor CDK2 | CDK4 | CDK5 | MAPK1 | MAPK3 | SRPK2 putrescine Phase 2 tissue transglutaminase inhibitor AMD1 | KCNJ4 | ODC1 PX-12 Phase 2 thioredoxin inhibitor CNR1 | TXN | TXNRD1 | TXNRD2 PX-478 Phase 1 hypoxia inducible factor inhibitor HIF1A PYM50028 Phase 2 neurotrophic agent PYR-41 Preclinical ubiquitin activating enzyme inhibitor pyrantel Launched acetylcholine receptor agonist | nicotinic receptor agonist infectious disease gastrointestinal roundworms pyrantel-pamoate Launched neuromuscular blocker infectious disease | infectious disease hookworm | tapeworm pyrazinamide Launched fatty acid synthase inhibitor FASN infectious disease tuberculosis pyrazinoylguanidine Phase 1 diuretic pyrazolanthrone Preclinical JNK inhibitor LRRK2 | MAPK10 | MAPK8 | MAPK8IP1 | MAPK9 | TTK pyrazoloacridine Phase 2 rna synthesis inhibitor | topoisomerase inhibitor TOP1 | TOP2A oncology melanoma pyrethrins Launched infectious disease flea control pyridoxal Launched PDXK neurology/psychiatry epilepsy pyridoxal-isonicotinoyl-hydrazone Phase 2 apoptosis stimulant pyridoxamine Phase 3 AGE inhibitor pyridoxine Launched vitamin B DDC | PDXK metabolism vitamin B6 deficiency pyrimethamine Launched dihydrofolate reductase inhibitor DHFR | DHFRP1 | HEXA | SLC47A1 | STAT3 infectious disease malaria pyrintegrin Preclinical integrin signaling activator pyriproxyfen Launched pyrithione-zinc Launched ATP synthase inhibitor KCNQ1 | KCNQ2 | KCNQ4 | KCNQ5 dermatology | dermatology cosmetic | dandruff pyrithyldione Withdrawn psychoactive drug pyritinol Launched neurology/psychiatry | rheumatology rheumatoid arthritis | senile dementia pyronaridine Phase 3 antimalarial agent pyrotinib Phase 3 kinase inhibitor EGFR | ERBB2 pyroxamide Phase 1 HDAC inhibitor HDAC1 pyrrolidine-dithiocarbamate Preclinical NFkB pathway inhibitor HSD11B1 | RELA pyrvinium-pamoate Launched androgen receptor antagonist AR infectious disease pinworm PZ-2891 Preclinical pantothenate kinase activator PANK3 Q-203 Phase 2 ATP synthase inhibitor quazinone Phase 2 phosphodiesterase inhibitor PDE3A | PDE3B quercetin Launched polar auxin transport inhibitor AKR1B1 | ATP5A1 | ATP5B | ATP5C1 | CYP2C8 | EGFR | GAA | HCK | HIBCH | MAOA | PIK3CG | PIM1 | PTPN1 | SCN5A | SIRT1 | STK17B | UGT3A1 | XDH allergy | neurology/psychiatry | neurology/psychiatry allergic rhinitis | drowsiness | fatigue quetiapine Launched dopamine receptor antagonist | serotonin receptor antagonist ADRA1A | ADRA1B | ADRA1D | ADRA2A | ADRA2B | ADRA2C | CHRM1 | CHRM2 | CHRM3 | CHRM4 | CHRM5 | DRD1 | DRD2 | DRD3 | DRD4 | DRD5 | HRH1 | HTR1A | HTR1B | HTR1D | HTR1E | HTR1F | HTR2A | HTR2C | HTR3A | HTR6 | HTR7 | SLC6A2 neurology/psychiatry | neurology/psychiatry bipolar disorder | schizophrenia quiflapon Phase 2 leukotriene synthesis inhibitor ALOX5 | ALOX5AP quinagolide Launched dopamine receptor agonist DRD2 | PRL endocrinology hyperprolactinemia quinapril Launched angiotensin converting enzyme inhibitor ACE cardiology | cardiology | cardiology angioedema | congestive heart failure | hypertension quinaprilat Launched angiotensin converting enzyme inhibitor ACE cardiology | cardiology angioedema | hypertension quinelorane Phase 3 dopamine receptor agonist DRD2 | DRD3 quinestrol Launched estrogen receptor agonist ESR1 | ESR2 endocrinology menopause quinethazone Launched thiazide diuretic cardiology hypertension quinidine Launched sodium channel blocker ABCB1 | CYP2D6 | KCNA5 | KCNA7 | KCNH1 | KCNH2 | KCNH5 | KCNK1 | KCNK6 | SCN5A | SLC29A4 cardiology | cardiology | infectious disease atrial fibrillation (AF) | malaria | ventricular arrhythmias quinine Launched hemozoin biocrystallization inhibitor GP9 | KCNB2 | KCNN4 | SLC29A4 infectious disease malaria quinine-ethyl-carbonate Launched infectious disease malaria quinolinic-acid Preclinical glutamate receptor agonist quinpirol-(-) Phase 2 dopamine receptor agonist DRD1 | DRD2 | DRD3 | DRD4 | HTR1A | HTR2A | HTR2B | HTR2C quinupristin Launched bacterial 50s ribosomal subunit inhibitor infectious disease gram-negative bacterial infections quipazine Preclinical serotonin receptor agonist HTR1A | HTR1D | HTR2A | HTR2B | HTR2C | HTR3A | HTR3B | HTR6 | SLC6A4 quizartinib Phase 3 FLT3 inhibitor CSF1R | FLT3 | KIT | PDGFRA | PDGFRB | RET QX-222 Preclinical sodium channel blocker QX-314 Preclinical sodium channel blocker MAPK14 | TGFBR1 R112 Phase 1 SYK inhibitor SYK R-121919 Preclinical CRF receptor antagonist CRHR1 R-1479 Phase 1 HCV inhibitor R-1485 Phase 1 serotonin receptor antagonist HTR6 R-1487 Phase 1 p38 MAPK inhibitor MAPK14 R-268712 Preclinical serine/threonine kinase inhibitor TGFBR1 R306465 Phase 1 HDAC inhibitor R406 Phase 1 SYK inhibitor FLT3 | IL2 | IL6 | RET | SYK | TNF R-428 Phase 2 AXL kinase inhibitor AXL R547 Phase 1 CDK inhibitor CCND1 | CCNE1 | CDK1 | CDK2 | CDK4 | CDK7 R-59022 Preclinical diacylglycerol kinase inhibitor | protein kinase inhibitor DGKA R-96544 Preclinical serotonin receptor antagonist HTR2A rabeprazole Launched ATPase inhibitor | gastrin inhibitor ATP4A | CYP2C19 gastroenterology | gastroenterology | gastroenterology duodenal ulcer disease | gastroesophageal reflux disease (GERD) | Zollinger-Ellison syndrome rac-BHFF Preclinical GABA receptor positive allosteric modulator GABBR1 racecadotril Launched enkephalinase inhibitor MME gastroenterology diarrhea racepinephrine Launched adrenergic receptor agonist ADRA1A | ADRA1B | ADRA1D | ADRA2A Immunology anaphylactic shock raclopride Launched dopamine receptor antagonist DRD2 | DRD3 | HTR1A ractopamine Launched adrenergic receptor agonist endocrinology weight-gain aid ractopamine hcl Launched adrenergic receptor agonist endocrinology weight-gain aid RAD140 Phase 1 androgen receptor modulator AR radafaxine Phase 2 dopamine-norepinephrine reuptake inhibitor CHRNA4 | CHRNB2 | SLC6A2 | SLC6A3 radezolid Phase 2 bacterial 30S ribosomal subunit inhibitor | bacterial 50S ribosomal subunit inhibitor radiprodil Phase 2 acetylcholine receptor antagonist GRIN2B radotinib Phase 3 Bcr-Abl kinase inhibitor ABL1 | BCR RAF265 Phase 2 RAF inhibitor | VEGFR inhibitor BRAF | KDR | KIT | PDGFRB | RAF1 RAF709 Preclinical RAF inhibitor BRAF | RAF1 ralinepag Phase 3 IP1 prostacyclin receptor agonist PTGIR raloxifene Launched estrogen receptor antagonist | selective estrogen receptor modulator (SERM) ACVRL1 | ENG | ESR1 | ESR2 oncology | orthopedics breast cancer | osteoporosis raltegravir Launched HIV integrase inhibitor infectious disease human immunodeficiency virus (HIV-1) raltitrexed Launched thymidylate synthase inhibitor FPGS | TYMS oncology mesothelioma ramatroban Launched prostanoid receptor antagonist CCL2 | PTGDR2 | TBXA2R cardiology | pulmonary asthma | coronary artery disease (CAD) ramelteon Launched melatonin receptor agonist MTNR1A | MTNR1B neurology/psychiatry insomnia ramifenazone Launched cyclooxygenase inhibitor endocrinology | neurology/psychiatry fever | pain relief ramipril Launched angiotensin converting enzyme inhibitor ACE cardiology hypertension ramosetron Launched serotonin receptor antagonist HTR3A gastroenterology | gastroenterology | gastroenterology irritable bowel syndrome | nausea | vomiting ranirestat Phase 3 aldose reductase inhibitor AKR1B1 ranitidine Launched histamine receptor antagonist HRH2 | SLC22A2 gastroenterology heartburn ranitidine (zantac) Launched histamine receptor antagonist HRH2 gastroenterology heartburn ranolazine Launched sodium channel blocker SCN10A | SCN9A | SLC22A2 cardiology chronic stable angina rapacuronium bromide Withdrawn acetylcholine receptor antagonist CHRM2 neurology/psychiatry general anaesthetic rapastinel Phase 2 glutamate receptor agonist (R)-(-)-apomorphine Launched dopamine receptor agonist ADRA2A | ADRA2B | ADRA2C | CALY | DRD1 | DRD2 | DRD3 | DRD4 | DRD5 | HTR1A | HTR1B | HTR1D | HTR2A | HTR2B | HTR2C | HTR5A | TRPA1 neurology/psychiatry Parkinson's Disease rasagiline Launched monoamine oxidase inhibitor BCL2 | MAOB neurology/psychiatry Parkinson's Disease rauwolscine Preclinical adrenergic receptor antagonist ADRA2A | ADRA2B | ADRA2C | HTR1B | HTR1D | HTR1E | HTR2B ravoxertinib Phase 1 ERK1 and ERK2 phosphorylation inhibitor MAPK1 | MAPK3 ravuconazole Phase 2 sterol demethylase inhibitor (R)-baclofen Phase 3 benzodiazepine receptor agonist GABBR1 | GABBR2 RBC8 Preclinical Ral GTPase inhibitor RALA | RALB rebamipide Launched free radical scavenger FPR1 gastroenterology | gastroenterology gastritis | peptic ulcer disease (PUD) rebastinib Phase 1/Phase 2 Bcr-Abl kinase inhibitor | TIE tyrosine kinase inhibitor | VEGFR inhibitor ABL1 | BCR | FGR | FLT3 | HCK | KDR | LYN | SRC | TEK reboxetine Launched adrenergic receptor antagonist SLC6A2 neurology/psychiatry depression reboxetine mesylate Launched adrenergic receptor antagonist SLC6A2 neurology/psychiatry depression Rec-15/2615 Phase 2 adrenergic receptor antagonist ADRA1A | ADRA1B recilisib Phase 1 free radical scavenger refametinib Phase 2 MEK inhibitor MAP2K1 | MAP2K2 regadenoson Launched adenosine receptor agonist ADORA1 | ADORA2A | ADORA2B | ADORA3 radiology myocardial perfusion imaging (MPI) regorafenib Launched FGFR inhibitor | KIT inhibitor | PDGFR tyrosine kinase receptor inhibitor | RAF inhibitor | RET tyrosine kinase inhibitor | VEGFR inhibitor ABL1 | BRAF | CYP2B6 | CYP2C19 | CYP2C8 | DDR2 | EPHA2 | FGF2 | FGFR1 | FGFR2 | FLT1 | FLT4 | FRK | KDR | KIT | MAPK11 | NTRK1 | PDGFRA | PDGFRB | RAF1 | RET | TEK oncology | oncology colorectal cancer | gastrointestinal stromal tumors (GIST) relcovaptan Phase 2 vasopressin receptor antagonist AVPR1A | AVPR1B | AVPR2 | OXTR relebactam Launched beta lactamase inhibitor relugolix Phase 3 gonadotropin releasing factor hormone receptor antagonist GNRH1 | GNRHR remacemide Phase 3 glutamate receptor antagonist GRIN1 remdesivir Launched rna polymerase inhibitor remetinostat Phase 2 HDAC inhibitor HDAC1 | HDAC2 | HDAC3 | HDAC6 remimazolam Phase 3 benzodiazepine receptor agonist GABBR1 remodelin Preclinical transferase inhibitor NAT10 remogliflozin etabonate Phase 2 sodium/glucose cotransporter inhibitor SLC5A2 endocrinology diabetes mellitus remoxipride Withdrawn dopamine receptor antagonist DRD2 | DRD3 | DRD4 | HTR2A | SIGMAR1 rentiapril Preclinical angiotensin converting enzyme inhibitor ACE cardiology hypertension repaglinide Launched insulin secretagogue ABCC8 | CYP2C8 | CYP3A5 | INS | KCNJ11 | PPARG endocrinology diabetes mellitus reparixin Phase 3 CC chemokine receptor antagonist CXCR1 | CXCR2 repotrectinib Phase 1/Phase 2 receptor tyrosine protein kinase inhibitor ALK | ROS1 | SRC | TRK repsox Preclinical TGF beta receptor inhibitor TGFBR1 resatorvid Phase 3 toll-like receptor inhibitor TLR4 reserpine Launched vesicular monoamine transporter inhibitor SLC18A1 | SLC18A2 cardiology hypertension resibufogenin Phase 2 Na/K-ATPase inhibitor resiquimod Phase 3 toll-like receptor agonist TLR7 | TLR8 resmetirom Phase 3 thyroid hormone receptor agonist THRB resminostat Phase 2 HDAC inhibitor HDAC1 | HDAC2 | HDAC3 | HDAC6 | HDAC8 resorcinol Launched phosphodiesterase inhibitor CA12 | CA14 | CA2 | PTGS1 dermatology | dermatology | dermatology | dermatology acne vulgaris (AV) | eczema | psoriasis | seborrheic dermatitis resorcinol-monoacetate Launched antiseptic resveratrol Launched cytochrome P450 inhibitor | SIRT activator APOA1 | BACE1 | CSNK2A1 | MAOA | NQO2 | PTGS1 | PTGS2 | SCN5A | SIRT1 | TXNRD1 | TXNRD2 | XDH retagliptin Phase 1 dipeptidyl peptidase inhibitor DPP4 retapamulin Launched protein synthesis inhibitor infectious disease impetigo retaspimycin Phase 3 HSP inhibitor HSP90AA1 retinaldehyde Launched dermatology cosmetic retinol Launched retinoid receptor ligand ALDH1A1 | ALDH1A2 | ALDH1A3 | DHRS3 | DHRS4 | LRAT | NR2C2 | RBP1 | RBP3 | RDH11 | RDH12 | RDH13 | RDH14 | RDH5 | RDH8 | RETSAT | RHO | RLBP1 | RXRA | RXRB | RXRG dermatology | dermatology | dermatology acne vulgaris (AV) | cosmetic | keratosis retinyl-acetate Launched retinyl-palmitate Launched REV-5901 Phase 2 leukotriene receptor antagonist | lipoxygenase inhibitor ALOX5 revaprazan Launched potassium-competitive acid antagonist ATP4A gastroenterology gastritis revefenacin Launched cholinergic receptor antagonist CHRM3 reversan Preclinical MRP inhibitor ABCC1 reversine Preclinical Aurora kinase inhibitor ADORA3 | AURKA | AURKB | INCENP | MAP2K1 reynoutrin Preclinical antioxidant rezafungin Phase 3 rezafungin (acetate) Phase 3 other antifungal infectious disease candidemia RG108 Preclinical DNA methyltransferase inhibitor DNMT1 | DNMT3B RG1530 Phase 1 FGFR inhibitor | PDGFR tyrosine kinase receptor inhibitor | VEGFR inhibitor CDK2 | FGFR1 | FGFR2 | FLT1 | FLT3 | FLT4 | KDR | PDGFRB RG2833 Phase 1 HDAC inhibitor HDAC1 | HDAC3 RG4733 Phase 2 gamma secretase inhibitor NOTCH1 | PSEN1 rg-7112 Phase 1 mdm inhibitor MDM2 RG7112 Phase 1 MDM inhibitor MDM2 RG7800 Preclinical RNA splicing modifier RG7834 Preclinical antiviral RGB-286638 Phase 1 CDK inhibitor CDK1 | CDK2 | CDK3 | CDK4 | CDK5 | CDK6 | CDK7 | CDK9 | FLT3 | GSK3B | JAK2 | MAP3K7 | MAPK9 RGFP966 Preclinical HDAC inhibitor HDAC1 | HDAC2 | HDAC3 RGX-104 Phase 1 LXR agonist NR1H2 | NR1H3 RHC-80267 Preclinical triacylglycerol lipase inhibitor DAGLA | DAGLB | LIPC | LIPE | LIPG rhein Phase 1 HSP90AA1 rheochrysidin Preclinical protein tyrosine kinase inhibitor IL6 | PTPN1 rhodamine-123 Phase 1 RI-1 Preclinical BCL2 | RAD51 riamilovir Phase 2/Phase 3 antiviral infectious disease influenza a virus infection ribavirin Launched antiviral ADK | ENPP1 | IMPDH1 | IMPDH2 | NT5C2 infectious disease hepatitis C ribitol Preclinical ribociclib Launched CDK inhibitor CDK4 | CDK6 | JAK3 oncology breast cancer riboflavin Launched vitamin B BLVRB | RFK gastroenterology jaundice riboflavin 5-phosphate sodium Launched BLVRB | DHODH | DPYD | HAO1 | HAO2 | MT-ND1 | NOS1 | PNPO | POR | PPCDC | RFK | RPS6KA4 | SGK1 riboflavin-5-phosphate-sodium Launched BLVRB | DHODH | DPYD | HAO1 | HAO2 | MT-ND1 | NOS1 | PNPO | POR | PPCDC | RFK | RPS6KA4 | SGK1 riboflavin-tetrabutyrate Preclinical antioxidant ribostamycin Launched bacterial 30S ribosomal subunit inhibitor P4HB infectious disease human immunodeficiency virus (HIV-1) ribostamycin-sulfate Launched bacterial 30S ribosomal subunit inhibitor infectious disease gram-negative bacterial infections ricinoleic-acid Launched prostanoid receptor agonist PTGER3 ridinilazole Phase 3 antibacterial rifabutin Launched protein synthesis inhibitor CYP3A4 infectious disease human immunodeficiency virus (HIV-1) rifampin Launched RNA polymerase inhibitor ABCB1 | CYP2B6 | CYP2C19 | CYP2C8 | CYP3A4 | CYP3A5 | NR1I2 | SLCO1A2 | SLCO1B1 | SLCO1B3 infectious disease | infectious disease | infectious disease "meningitis | tuberculosis | tuberculosis, meningitis" rifamycin Launched DNA directed RNA polymerase inhibitor SLCO1A2 | SLCO1B1 | SLCO1B3 | SLCO2B1 infectious disease | infectious disease leprosy | tuberculosis rifamycin-sv Phase 3 RNA synthesis inhibitor rifamycin sv na Phase 3 rna synthesis inhibitor rifapentine Launched RNA polymerase inhibitor CYP2C8 | CYP2C9 | CYP3A4 infectious disease tuberculosis rifaximin Launched RNA synthesis inhibitor CYP3A4 | NR1I2 gastroenterology | gastroenterology | gastroenterology | gastroenterology "diarrhea | diarrhea, irritable bowel syndrome, hepatic encephalopathy (he) | hepatic encephalopathy (HE) | irritable bowel syndrome" rigosertib Phase 3 cell cycle inhibitor | PLK inhibitor MCL1 | PLK1 rilapladib Phase 2 phospholipase inhibitor PLA2G7 rilmenidine Launched adrenergic receptor agonist | imidazoline receptor agonist ADRA2A | NISCH cardiology hypertension rilpivirine Launched non-nucleoside reverse transcriptase inhibitor CYP2C19 | CYP3A5 | NR1I2 | SCN10A infectious disease human immunodeficiency virus (HIV-1) riluzole Launched glutamate inhibitor KCND3 | KCNK10 | KCNK2 | KCNK4 | KCNN4 | SCN10A | SCN11A | SCN1A | SCN2A | SCN3A | SCN4A | SCN5A | SCN7A | SCN8A | SCN9A | SLC7A11 neurology/psychiatry amyotrophic lateral sclerosis (ALS) rimacalib Phase 2 calcium/calmodulin dependent protein kinase inhibitor CAMK2A rheumatology rheumatoid arthritis rimantadine Launched antiviral | RNA synthesis inhibitor infectious disease influenza A virus infection rimantadine hydrochloride Launched "antiviral, rna synthesis inhibitor" infectious disease influenza a virus infection rimcazole Phase 1 sigma receptor antagonist SIGMAR1 rimegepant Launched calcitonin antagonist CALCA | CALCRL rimeporide Phase 1 sodium/hydrogen exchanger inhibitor SLC9A1 rimexolone Launched glucocorticoid receptor agonist NR3C1 | SERPINA6 ophthalmology anterior uveitis rimonabant Withdrawn cannabinoid receptor antagonist CNR1 | GPR55 | IL6 riociguat Launched guanylate cyclase stimulant GUCY1A2 | GUCY1A3 | GUCY1B2 | GUCY1B3 cardiology hypertension riodipine Phase 2 calcium channel blocker CACNA1C riodoxol Launched other antibiotic ripasudil Launched rho associated kinase inhibitor ROCK1 | ROCK2 ophthalmology | ophthalmology glaucoma | ocular hypertension ripazepam Phase 2 benzodiazepine receptor agonist GABRA1 | GABRA2 | GABRA3 | GABRA5 ripretinib Phase 3 receptor tyrosine protein kinase inhibitor KIT | PDGFRA risdiplam Phase 2/Phase 3 RNA splicing inhibitor SMN2 risedronate Launched osteoclast inhibitor FDPS endocrinology | orthopedics osteoporosis | Paget's disease rislenemdaz Preclinical ionotropic glutamate receptor antagonist GRIN2B risperidone Launched dopamine receptor antagonist | serotonin receptor antagonist ADRA1A | ADRA1B | ADRA1D | ADRA2A | ADRA2B | ADRA2C | CYP3A5 | DRD1 | DRD2 | DRD3 | DRD4 | HRH1 | HTR1A | HTR1B | HTR1D | HTR1E | HTR1F | HTR2A | HTR2C | HTR6 | HTR7 neurology/psychiatry | neurology/psychiatry | neurology/psychiatry bipolar disorder | irritability | schizophrenia RITA Preclinical MDM inhibitor MDM2 | TXNRD1 | TXNRD2 ritanserin Phase 3 serotonin receptor antagonist ADRA1A | ADRA1B | ADRA1D | HTR1A | HTR1B | HTR1D | HTR2A | HTR2B | HTR2C | HTR5A | HTR6 | HTR7 ritodrine Withdrawn adrenergic receptor agonist ADRB2 obstetrics/gynecology premature labor ritodrine hydrochloride Withdrawn adrenergic receptor agonist obstetrics/gynecology premature labor ritonavir Launched HIV protease inhibitor CYP1A2 | CYP2B6 | CYP2C19 | CYP2C8 | CYP2C9 | CYP2D6 | CYP2E1 | CYP3A4 | CYP3A5 | CYP3A7 infectious disease human immunodeficiency virus (HIV-1) rivanicline Phase 2 acetylcholine receptor agonist CHRNA4 | CHRNB2 | CXCL8 rivaroxaban Launched coagulation factor inhibitor CYP2J2 | CYP3A5 | F10 cardiology | hematology | hematology | hematology | neurology/psychiatry atrial fibrillation (AF) | deep vein thrombosis (DVT) | pulmonary embolism (PE) | stroke | systemic embolism rivastigmine Launched acetylcholinesterase inhibitor ACHE | BCHE neurology/psychiatry | neurology/psychiatry | neurology/psychiatry Alzheimer's disease | Parkinson's Disease | senile dementia rizatriptan Launched serotonin receptor agonist HTR1A | HTR1B | HTR1D | HTR1E | HTR1F neurology/psychiatry migraine headache (r)-ketorolac Phase 3 cyclooxygenase inhibitor CDC42 | RAC1 RKI-1447 Preclinical rho associated kinase inhibitor CDC42BPA | DMPK | LIMK1 | MYLK | PAK1 | PKN1 | ROCK1 | ROCK2 RLX Preclinical RMC-4550 Preclinical SHIP2 phosphatase inhibitor PTPN11 RN-1 Preclinical histone demethylase inhibitor KDM1A RN-1734 Preclinical TRPV antagonist TRPV4 RN-1747 Preclinical TRPV agonist TRPV4 Ro-04-5595 Preclinical glutamate receptor antagonist GRIN2B Ro-08-2750 Preclinical NGF binding inhibitor NGF | NGFR Ro-10-5824 Preclinical dopamine receptor agonist DRD4 Ro-106-9920 Preclinical NFkB pathway inhibitor Ro-1138452 Preclinical prostanoid receptor antagonist PTGIR Ro-15-4513 Preclinical GABA benzodiazepine site receptor inverse agonist GABRA1 | GABRA2 | GABRA3 | GABRA4 | GABRA5 | GABRA6 | GABRB2 | GABRG2 Ro-19-4605 Preclinical GABA benzodiazepine site receptor inverse agonist GABRA1 | GABRA2 | GABRA3 | GABRA5 Ro-20-1724 Preclinical phosphodiesterase inhibitor PDE3A | PDE4A | PDE4B | PDE4C | PDE4D Ro-25-6981 Preclinical glutamate receptor antagonist | monamine transporter modulator GRIN2B | SLC18A2 Ro-28-1675 Preclinical glucokinase activator GCK Ro-3 Preclinical purinergic receptor antagonist P2RX3 Ro-3306 Preclinical CDK inhibitor CDK1 Ro-48-6791 Preclinical GABA receptor modulator Ro-48-8071 Preclinical oxidosqualene cyclase inhibitor LSS Ro-4987655 Phase 1 MEK inhibitor MAP2K1 Ro-5028442 Phase 1 vasopressin receptor antagonist AVPR1A Ro-5126766 Phase 1 MEK inhibitor | RAF inhibitor BRAF | MAP2K1 | MAP2K2 | RAF1 Ro-5263397 Preclinical trace amine associated receptor agonist TAAR1 Ro-60-0175 Preclinical serotonin receptor agonist HTR2A | HTR2B | HTR2C Ro-61-8048 Preclinical kynurenine 3-monooxygenase inhibitor KMO Ro-67-7476 Preclinical glutamate receptor positive allosteric modulator GRM1 Ro-90-7501 Preclinical beta amyloid protein neurotoxicity inhibitor APP Ro-9187 Preclinical HCV inhibitor robalzotan Phase 2 serotonin receptor antagonist HTR1A robenidine Launched other antibiotic infectious disease coccidiosis roblitinib Preclinical FGFR inhibitor FGFR4 rociletinib Phase 3 EGFR inhibitor EGFR rocuronium Launched acetylcholine receptor antagonist CHRM2 | CHRNA2 | HTR3A neurology/psychiatry anesthetic rofecoxib Withdrawn cyclooxygenase inhibitor CYP3A4 | ELN | PTGS2 roflumilast Launched phosphodiesterase inhibitor CYP2B6 | CYP2C19 | PDE4A | PDE4B | PDE4C | PDE4D pulmonary | pulmonary bronchitis | chronic obstructive pulmonary disease (COPD) rogaratinib Phase 2/Phase 3 FGFR inhibitor FGFR1 | FGFR2 | FGFR3 | FGFR4 rolapitant Phase 3 neurokinin receptor antagonist TACR1 rolipram Phase 3 phosphodiesterase inhibitor rolitetracycline Launched bacterial 30S ribosomal subunit inhibitor infectious disease | infectious disease gram-negative bacterial infections | gram-positive bacterial infections roluperidone Phase 2 HTR2A rolziracetam Phase 2 romidepsin Launched HDAC inhibitor CYP2B6 | CYP2C19 | CYP3A5 | HDAC1 | HDAC2 | HDAC3 | HDAC4 | HDAC5 | HDAC6 | HDAC7 | HDAC8 | HDAC9 hematologic malignancy cutaneous T-cell lymphoma (CTCL) romifidine Launched adrenergic receptor agonist ADRA1A neurology/psychiatry sedative ronidazole Launched antiprotozoal agent infectious disease | infectious disease dysentry | histomoniasis ropinirole Launched dopamine receptor agonist ADRA2A | ADRA2B | ADRA2C | DRD1 | DRD2 | DRD3 | DRD4 | DRD5 | HTR1A | HTR1B | HTR1D | HTR2A | HTR2B | HTR2C neurology/psychiatry | neurology/psychiatry Parkinson's Disease | restless leg syndrome ropivacaine Launched sodium channel blocker SCN10A | SCN9A neurology/psychiatry anesthetic roquinimex Phase 3 angiogenesis inhibitor | tumor necrosis factor production inhibitor rosamicin Phase 2 protein synthesis inhibitor roscovitine Phase 2 CDK inhibitor CDK1 | CDK2 | CDK5 | CDK7 | CDK9 rose-bengal Launched contrast agent | immunostimulant radiology diagnostic agent rose-bengal-lactone Launched coloring agent ophthalmology staining agent rosiglitazone Withdrawn "insulin sensitizer | insulin sensitizer, ppar receptor agonist | PPAR receptor agonist" CYP2C8 | FFAR1 | INS | PPARG | TRPC5 | TRPM3 Insulin sensitizer diabetes mellitus rosiglitazone maleate Launched rosiptor Phase 2 SHIP1 phosphatase activator INPP5D rosmarinic-acid Launched GABA transaminase inhibitor MCL1 | TYR rosoxacin Launched topoisomerase inhibitor infectious disease urinary tract infections rostafuroxine Phase 2 ATPase inhibitor ATP1A1 rosuvastatin Launched HMGCR inhibitor HMGCR cardiology | cardiology | endocrinology | endocrinology | endocrinology atherosclerosis | dyslipidemia | hypercholesterolemia | hyperlipidemia | hypertriglyceridemia rotigotine Launched dopamine receptor agonist ADRA2B | DRD1 | DRD2 | DRD3 | DRD4 | DRD5 | HTR1A neurology/psychiatry | neurology/psychiatry Parkinson's Disease | restless leg syndrome rotundine Launched serotonin receptor agonist DRD1 | DRD2 | DRD3 | HTR1A | HTR1D | HTR4 | HTR7 neurology/psychiatry | neurology/psychiatry anxiety | sedative rovazolac Preclinical LXR agonist NR1H2 roxarsone Launched antiprotozoal agent endocrinology weight-gain aid roxatidine-acetate Launched histamine receptor antagonist HRH2 gastroenterology | gastroenterology | gastroenterology | gastroenterology erosive esophagitis (EE) | gastritis | gastroesophageal reflux disease (GERD) | Zollinger-Ellison syndrome roxithromycin Launched bacterial 50S ribosomal subunit inhibitor MLNR infectious disease | infectious disease | infectious disease respiratory tract infections | skin infections | urinary tract infections RP-001 Preclinical sphingosine 1-phosphate receptor agonist S1PR1 rp-54745 interleukin inhibitor IL6 rheumatology rheumatoid arthritis RP67580 Preclinical RQ-00203078 Preclinical transient receptor potential channel antagonist TRPM8 (R)-(-)-rolipram Phase 1 phosphodiesterase inhibitor PDE4A | PDE4B | PDE4C | PDE4D | PDE5A RRx-001 Phase 3 glucose 6-phosphate dehydrogenase inhibitor G6PD rs0481 Phase 2 immunostimulant RS-0481 Phase 2 immunostimulant RS-100329 Preclinical adrenergic receptor antagonist ADRA1A | ADRA1D RS-102221 Preclinical serotonin receptor antagonist HTR2A | HTR2B | HTR2C RS-102895 Preclinical CCR antagonist CCR2 RS-127445 Phase 1 serotonin receptor antagonist HTR2A | HTR2B | HTR2C RS-16566 Preclinical serotonin receptor antagonist RS-17053 Preclinical adrenergic receptor antagonist ADRA1A | ADRA1D RS-23597-190 Preclinical serotonin receptor antagonist HTR4 RS-39604 Preclinical serotonin receptor antagonist HTR4 RS-45041-190 Preclinical imidazoline receptor agonist RS-504393 Preclinical CC chemokine receptor antagonist CCL2 | CCR2 RS-56812 Preclinical serotonin receptor partial agonist HTR3A RS-67333 Preclinical serotonin receptor partial agonist HTR4 RS-67506 Preclinical serotonin receptor partial agonist HTR4 RS-79948 Preclinical adrenergic receptor antagonist ADRA2A RSV604 Phase 2 RSV replication inhibitor RTA-408 Phase 2 nitric oxide production inhibitor NFE2L2 RU-24969 Phase 1 serotonin receptor agonist HTR1A | HTR1B | HTR1D | HTR2A | HTR2B | HTR2C | HTR5A | HTR6 RU-28318 Phase 2 cytochrome P450 inhibitor NR3C2 RU-42173 Phase 2 adrenergic receptor agonist ADRB2 RU-58841 Phase 2 androgen receptor antagonist AR rubitecan Phase 3 topoisomerase inhibitor TOP1 ruboxistaurin Phase 3 PKC inhibitor PRKCB rucaparib Phase 3 PARP inhibitor PARP1 | PARP2 rucinol Phase 1 tyrosinase inhibitor TYR rufinamide Launched voltage-gated sodium channel blocker CYP2E1 | CYP3A4 | GRM5 | SCN10A | SCN11A | SCN1A | SCN2A | SCN3A | SCN4A | SCN5A | SCN7A | SCN8A | SCN9A neurology/psychiatry seizures rufloxacin Launched bacterial DNA gyrase inhibitor infectious disease gram-negative bacterial infections rupatadine Launched histamine receptor antagonist | platelet activating factor receptor antagonist HRH1 | PTAFR allergy | allergy allergic rhinitis | urticaria rupintrivir Phase 2/Phase 3 antiviral otolaryngology common cold RU-SKI-43 Preclinical hedgehog pathway inhibitor HHAT rutaecarpine Preclinical cyclooxygenase inhibitor PTGS2 rutin Launched antioxidant | capillary stabilizing agent | nitric oxide scavenger AKR1B1 | AKR1C3 allergy | gastroenterology | neurology/psychiatry | otolaryngology | rheumatology allergic rhinitis | constipation | irritability | joint pain | nasal congestion ruxolitinib Launched JAK inhibitor JAK1 | JAK2 | JAK3 | TYK2 hematologic malignancy | hematology myelofibrosis | polycythemia vera ruxolitinib-(S) Preclinical JAK inhibitor JAK1 | JAK2 | JAK3 RV1729 Phase 1 PI3K inhibitor PIK3CD RWJ-21757 Phase 2 toll-like receptor agonist TLR7 RWJ-50271 Preclinical integrin inhibitor ICAM1 RWJ-67657 Phase 1 MAP kinase inhibitor IL1B | MAPK14 | PTGS2 | TNF RX-3117 Phase 1/Phase 2 CDK inhibitor | DNA synthesis inhibitor CDK2 | DNMT1 RX-821002 Preclinical adrenergic receptor antagonist ADRA1A | ADRA1B | ADRA1D | ADRA2A | ADRA2B | ADRA2C ryuvidine Preclinical histone lysine methyltransferase inhibitor CDK2 | CDK4 S-07662 Preclinical CAR antagonist NR1I3 S-111 Phase 2 PARP inhibitor PARP1 | SLC6A2 | SLC6A4 S-14506 Preclinical serotonin receptor agonist DRD2 | HTR1A | HTR2C S15535 Preclinical serotonin receptor agonist HTR1A S-17092 Preclinical prolyl endopeptidase inhibitor PREP S18986 Phase 2 glutamate receptor modulator GRIA1 | GRIA2 | GRIA3 | GRIA4 S1P1-agonist-III Preclinical sphingosine kinase inhibitor S1PR1 S26948 Preclinical PPAR receptor agonist INS | PPARG S-3304 Phase 1/Phase 2 matrix metalloprotease inhibitor MMP2 | MMP9 S-38093 Preclinical histamine receptor antagonist HRH3 S4 Preclinical carbonic anhydrase inhibitor CA12 | CA9 S49076 Preclinical tyrosine kinase inhibitor AXL | FGFR1 | FGFR2 | FGFR3 | MET s55746 Phase 1 bcl inhibitor BCL2 hematologic malignancy chronic lymphocytic leukemia (cll) S63845 Preclinical MCL1 inhibitor MCL1 SA-47 Preclinical FAAH inhibitor FAAH saccharin Launched DNA polymerase inhibitor CA1 | CA12 | CA2 | CA9 saclofen Preclinical GABA receptor antagonist GABBR1 | GABBR2 | KCTD12 | KCTD16 | KCTD8 sacubitril Launched neprilysin inhibitor MME cardiology congestive heart failure sacubitrilat Preclinical neprilysin inhibitor MME sacubitril valsartan cocrystal Launched neprilysin inhibitor AGTR1 | MME Cardiovascular hypertension safflower-yellow Preclinical anti-inflammatory agent safinamide Launched dopamine reuptake inhibitor | glutamate inhibitor | monoamine oxidase inhibitor MAOB | SLC6A3 neurology/psychiatry Parkinson's Disease safingol Phase 1 PKC inhibitor PRKCA | TRPM3 safranal Phase 2 benzodiazepine receptor agonist GABBR1 SAG Preclinical smoothened receptor agonist DHH | IHH | PTCH1 | SMO | TRPC6 sal003 Preclinical eukaryotic translation initiation factor inhibitor EIF2A salazodine Phase 2 ulcerative colitis salicin Phase 1 anti-inflammatory agent salicyl-alcohol Preclinical salicylamide Launched analgesic agent endocrinology | neurology/psychiatry fever | pain relief salicylanilide Preclinical other antibiotic salicylic-acid Launched cyclooxygenase inhibitor | prostanoid receptor antagonist AKR1C1 | ASIC3 | PTGS1 | PTGS2 dermatology | endocrinology | neurology/psychiatry acne vulgaris (AV) | fever | pain relief salidroside Preclinical beta amyloid protein neurotoxicity inhibitor APP salinomycin Launched infectious disease coccidiosis "salinomycin, sodium" Launched infectious disease coccidiosis salirasib Phase 2 mTOR inhibitor MTOR | TRPA1 salmeterol Launched adrenergic receptor agonist ADRB2 pulmonary | pulmonary | pulmonary asthma | bronchospasm | chronic obstructive pulmonary disease (COPD) salsolinol-1-carboxylic-acid Preclinical salubrinal Preclinical eukaryotic translation initiation factor inhibitor EIF2S1 | SLC6A9 salvianolic-acid-A Phase 1 matrix metalloprotease inhibitor salvianolic-acid-B Phase 2 EGFR inhibitor | metalloproteinase inhibitor APP | MMP9 salvinorin-A Phase 1 opioid receptor agonist OPRD1 | OPRK1 | OPRM1 SAM-315 Preclinical serotonin receptor antagonist HTR6 sameridine Preclinical opioid receptor modulator OPRM1 sanazole Phase 1 sancycline Preclinical antitumor agent sangivamycin Phase 1 DNA inhibitor sanguinarium-chloride Phase 1 apoptosis stimulant ACHE | CASP3 SANT-1 Preclinical smoothened receptor antagonist DHH | IHH | PTCH1 | SHH | SMO SANT-2 Preclinical smoothened receptor antagonist DHH | IHH | PTCH1 | SHH | SMO sapacitabine Phase 3 DNA synthesis inhibitor POLA1 sapropterin Launched phenylalanine 4-hydroxylase stimulant DBH | NOS3 | PAH | TH | TPH1 metabolism hyperphenylalaninemia (HPA) saquinavir Launched HIV protease inhibitor CYP3A4 | CYP3A5 infectious disease human immunodeficiency virus (HIV-1) saquinavir mesylate Launched hiv protease inhibitor CYP3A4 infectious disease human immunodeficiency virus (hiv-1) sar125844 Phase 2 c-met inhibitor MET oncology gastric adenocarcinoma SAR131675 Preclinical VEGFR inhibitor FLT4 SAR-245409 Phase 1/Phase 2 PI3K inhibitor MTOR | PIK3CG sar-260301 Phase 1 pi3k inhibitor PIK3C2G | PIK3C3 | PIK3CA | PIK3CB | PIK3CD oncology melanoma SAR405 Preclinical PI3K inhibitor PIK3C3 SAR405838 Phase 1 MDM inhibitor MDM2 SAR407899 Phase 2 rho associated kinase inhibitor ROCK1 | ROCK2 "[sar9,met(o2)11]-substance-p" Preclinical tachykinin antagonist TACR1 saracatinib Phase 2/Phase 3 SRC inhibitor ABL1 | LCK | SRC | YES1 sarafloxacin Launched bacterial DNA gyrase inhibitor infectious disease | infectious disease gram-negative bacterial infections | gram-positive bacterial infections saralasin Withdrawn angiotensin receptor antagonist AGTR1 cardiology hypertension sarcosine Phase 2 glycine transporter inhibitor SLC6A9 sardomozide Preclinical S-adenosylmethionine decarboxylase inhibitor AMD1 sarecycline Launched bacterial 50s ribosomal subunit inhibitor dermatology acne vulgaris (av) saredutant Phase 3 neurokinin receptor antagonist TACR2 neurology/psychiatry depression sari-59-801 Phase 1 saroglitazar Launched PPAR receptor agonist ANGPTL4 | PPARA | PPARG cardiology | endocrinology | gastroenterology diabetes mellitus | dyslipidemia | non-alcoholic steatohepatitis (NASH) sarolaner Launched gaba gated chloride channel blocker GABRD infectious disease flea control sarpogrelate Launched serotonin receptor antagonist HTR2A | HTR2B | HTR2C cardiology | cardiology | endocrinology | rheumatology | rheumatology angina pectoris | atherosclerosis | Buerger's disease | diabetes mellitus | Raynaud's disease sasapyrine Launched NFkB pathway inhibitor PTGS1 | PTGS2 rheumatology | rheumatology osteoarthritis | rheumatoid arthritis satraplatin Phase 3 DNA alkylating agent savolitinib Phase 3 c-Met inhibitor MET saxagliptin Launched dipeptidyl peptidase inhibitor CYP3A5 | DPP4 endocrinology diabetes mellitus SB-200646 Preclinical serotonin receptor antagonist HTR2B | HTR2C SB-202190 Preclinical p38 MAPK inhibitor AKT1 | ALOX5 | CHEK1 | GSK3B | LCK | MAPK1 | MAPK11 | MAPK12 | MAPK14 | MAPK8 | PRKCA | ROCK1 | RPS6KB1 | SGK1 SB-203186 Preclinical serotonin receptor antagonist HTR4 SB-203580 Preclinical p38 MAPK inhibitor AKT1 | ALOX5 | CHEK1 | CYP2D6 | CYP3A4 | GAK | GSK3B | LCK | MAPK1 | MAPK10 | MAPK11 | MAPK12 | MAPK14 | MAPK8 | MAPK9 | PRKCA | RAF1 | RIPK2 | ROCK1 | RPS6KB1 | SGK1 | SRC | TNF SB-205384 Preclinical GABA receptor modulator GABRA3 | GABRA5 | GABRA6 SB-206553 Preclinical serotonin receptor antagonist HTR1A | HTR2A | HTR2B | HTR2C SB-216641 Preclinical serotonin receptor antagonist HTR1A | HTR1B | HTR1D | HTR2A | HTR2B | HTR2C SB-216763 Preclinical glycogen synthase kinase inhibitor CCNA2 | CDK2 | GSK3A | GSK3B sb-218078 Preclinical chk inhibitor CHEK1 SB-218078 Preclinical CHK inhibitor CHEK1 SB-218795 Preclinical tachykinin antagonist TACR3 SB-221284 Preclinical serotonin receptor antagonist HTR2A | HTR2B | HTR2C SB-222200 Preclinical tachykinin antagonist TACR3 SB-225002 Preclinical CC chemokine receptor antagonist CXCR2 SB-228357 Preclinical serotonin receptor antagonist HTR2A | HTR2B | HTR2C SB-2343 Phase 1 mTOR inhibitor | PI3K inhibitor MTOR | PIK3CA | PIK3CB | PIK3CD | PIK3CG SB-239063 Preclinical p38 MAPK inhibitor MAPK11 | MAPK14 | PTGS2 | TNF SB-242235 Phase 1 p38 MAPK inhibitor HSPB1 | MAPK14 SB-243213 Phase 1 serotonin receptor inverse agonist HTR2A | HTR2B | HTR2C | HTR6 SB-258585 Preclinical serotonin receptor antagonist HTR6 SB-268262 Preclinical calcitonin antagonist CALCA | CALCRL SB-269970 Preclinical serotonin receptor antagonist HTR7 SB-271046 Phase 1 serotonin receptor antagonist HTR6 SB-297006 Preclinical CC chemokine receptor antagonist CCR3 SB-328437 Preclinical CCR antagonist SB-334867 Preclinical orexin receptor antagonist HCRTR1 | HCRTR2 SB-366791 Preclinical TRPV antagonist TRPV1 SB-399885 Preclinical serotonin receptor antagonist HTR6 SB-408124 Preclinical orexin receptor antagonist HCRTR1 | HCRTR2 SB-415286 Preclinical glycogen synthase kinase inhibitor GSK3A | GSK3B | RPS6KB1 sb-431542 Preclinical activin receptor inhibitor A1BG | ACVR1B | ACVR1C | TGFBR1 Oncology brain tumors SB-431542 Preclinical TGF beta receptor inhibitor ACVR1B | ACVR1C | TGFBR1 SB-452533 Preclinical TRPV antagonist TRPV1 SB-505124 Preclinical ALK tyrosine kinase receptor inhibitor ACVR1B | ACVR1C | TGFBR1 SB-525334 Preclinical TGF beta receptor inhibitor TGFBR1 SB-590885 Preclinical RAF inhibitor BRAF SB-612111 Preclinical nociceptin/orphanin FQ receptor antagonist OPRL1 SB-649868 Phase 2 orexin receptor antagonist HCRTR1 | HCRTR2 SB-657510 Preclinical urotensin receptor antagonist UTS2R SB-683698 Phase 1 integrin antagonist ITGA4 | ITGAV | ITGB1 | ITGB7 SB-705498 Phase 2 TRPV antagonist TRPV1 SB-706375 Preclinical urotensin receptor antagonist UTS2R SB-742457 Phase 3 serotonin receptor antagonist HTR6 SB-743921 Phase 1/Phase 2 kinesin-like spindle protein inhibitor KIF11 SB-747651A Preclinical kinase inhibitor AKT1 | AKT3 | ROCK1 | RPS6KA4 | RPS6KA5 | RPS6KB1 SB-756050 Phase 1 G protein-coupled receptor agonist GPBAR1 SB-772077B Preclinical rho associated kinase inhibitor ROCK1 | ROCK2 SB-939 Phase 3 HDAC inhibitor HDAC1 | HDAC10 | HDAC2 | HDAC3 | HDAC4 | HDAC5 | HDAC6 | HDAC9 SBE-13 Preclinical PLK inhibitor PLK1 SBHA Preclinical HDAC inhibitor HDAC1 | HDAC3 SBI-115 Preclinical G protein-coupled receptor antagonist GPBAR1 SC-10 Preclinical protein kinase activator PRKCA SC-12267 Phase 2 dihydroorotate dehydrogenase inhibitor DHODH | IFNG | IL17A SC-144 Preclinical P glycoprotein inhibitor SC-19220 Preclinical prostanoid receptor antagonist PTGER1 SC-236 Preclinical cyclooxygenase inhibitor PTGS2 SC-51089 Preclinical prostanoid receptor antagonist PTGER1 SC-560 Preclinical cyclooxygenase inhibitor PTGS1 SC-9 Preclinical protein tyrosine kinase activator PRKCA scabertopin Preclinical anticancer agent SCH-202676 Preclinical G protein-coupled receptor modulator CHRM1 | CHRM2 | CHRM4 | DRD1 | DRD2 SCH-221510 Preclinical nociceptin/orphanin FQ receptor agonist OPRL1 SCH-23390 Preclinical dopamine receptor antagonist DRD1 | DRD5 | HTR2C | KCNJ4 | KCNJ6 SCH-28080 Phase 1 ATPase inhibitor ATP4A SCH-51344 Preclinical MTH1 inhibitor NUDT1 SCH-58261 Preclinical adenosine receptor antagonist ADORA1 | ADORA2A | ADORA2B | ADORA3 SCH-900776 Phase 2 CHK inhibitor CDK2 | CHEK1 schisandrin-B Preclinical antioxidant ABCB1 | ABCC1 | ATR | GSR schisandrol-B Phase 3 lipid peroxidase inhibitor sclareol Preclinical sclareolide Launched other antifungal SCMC-Lys Launched mucolytic agent GSTP1 pulmonary chronic obstructive pulmonary disease (COPD) scopine Launched scopolamine Launched acetylcholine receptor antagonist CHRM1 | CHRM2 | CHRM3 | CHRM4 | CHRM5 | SI gastroenterology | gastroenterology | neurology/psychiatry motion sickness | nausea | vomiting scopolamine hydrobromide Launched acetylcholine receptor antagonist CHRM1 | CHRM2 | CHRM3 | CHRM4 | CHRM5 | SI "neurology/psychiatry, gastroenterology" "motion sickness, vomiting, nausea" scopolamine-N-oxide Preclinical acetylcholine receptor antagonist CHRM1 | CHRM2 | CHRM3 | CHRM4 SCP-1 Phase 1 analgesic agent scriptaid Preclinical HDAC inhibitor HDAC1 | HDAC2 | HDAC3 | HDAC4 | HDAC5 | HDAC6 | HDAC7 | HDAC8 | HDAC9 SCS Preclinical SD-0006 Phase 2 p38 MAPK inhibitor MAPK14 SD-169 Preclinical p38 MAPK inhibitor MAPK14 SD-208 Preclinical TGF beta receptor inhibitor TGFBR1 SD-2590 Preclinical matrix metalloprotease inhibitor MMP1 | MMP13 | MMP14 | MMP2 | MMP3 | MMP8 | MMP9 SDM25N Preclinical opioid receptor antagonist OPRD1 SDZ-205-557 Preclinical serotonin receptor antagonist HTR3A | HTR3B | HTR4 SDZ-21009 Preclinical adrenergic receptor antagonist | serotonin receptor antagonist HTR1A | HTR1B SDZ-220-040 Preclinical glutamate receptor antagonist GRIN1 SDZ-220-581 Preclinical glutamate receptor antagonist GRIN1 sdz-mks 492 phosphodiesterase inhibitor PDE3A pulmonary asthma SDZ-NKT-343 Phase 1 tachykinin antagonist TACR1 SDZ-SER-082 Preclinical serotonin receptor antagonist HTR2A | HTR2B | HTR2C SDZ-WAG-994 Phase 2 adenosine receptor agonist ADORA1 secalciferol Launched vitamin D receptor agonist VDR critical care bone fracture seclazone Phase 1 anti-inflammatory agent seclidemstat Phase 1 histone demethylase inhibitor KDM1A secnidazole Launched acetylcholinesterase inhibitor | microtubule inhibitor infectious disease protozoan infection secoisolariciresinol-(-) Phase 2 secoisolariciresinol-diglucoside Phase 2 antioxidant securinine Preclinical GABA receptor antagonist | TP53 activator GABRA1 segesterone Launched progesterone receptor agonist PGR obstetrics/gynecology endometriosis segesterone-acetate Launched progesterone receptor agonist PGR sel120-34a (monohydrochloride) Phase 1 cdk inhibitor CDK19 | CDK8 hematologic malignancy acute myeloid leukemia (aml) seladelpar Phase 3 PPAR receptor agonist PPARD selamectin Launched nematocide infectious disease flea control selegiline Launched monoamine oxidase inhibitor CYP2B6 | CYP2C19 | MAOA | MAOB neurology/psychiatry Parkinson's Disease selegiline hydrochloride Launched monoamine oxidase inhibitor MAOA | MAOB neurology/psychiatry parkinson's disease selenomethionine Launched seletalisib Preclinical PI3K inhibitor PIK3CD selexipag Launched IP1 prostacyclin receptor agonist | platelet aggregation inhibitor PTGIR pulmonary pulmonary arterial hypertension (PAH) selfotel Phase 3 glutamate receptor antagonist GRIN1 | GRIN2A | GRIN2B | GRIN2C | GRIN2D selinexor Launched exportin antagonist XPO1 hematologic malignancy multiple myeloma selitrectinib Phase 1/Phase 2 protein tyrosine kinase inhibitor NTRK1 selonsertib Phase 2 MAP kinase activator MAP3K5 selpercatinib Launched ret tyrosine kinase inhibitor RET oncology medullary thyroid cancer (mtc) seltorexant Phase 3 orexin receptor antagonist HCRTR2 neurology/psychiatry depression selumetinib Phase 3 MEK inhibitor MAP2K1 | MAP2K2 semagacestat Phase 3 gamma secretase inhibitor PSEN1 semagacestat (ly450139) Phase 3 gamma secretase inhibitor PSEN1 semapimod Phase 2 cytokine production inhibitor | p38 MAPK inhibitor DHPS | MAPK14 | RAF1 semaxanib Phase 3 VEGFR inhibitor FGFR1 | FLT1 | FLT3 | KDR | KIT | MET | PDGFRA | PDGFRB | RET Se-methylselenocysteine Phase 2 semustine Phase 3 DNA alkylating agent SEN-1269 Preclinical beta amyloid inhibitor APP senaparib Phase 1 parp inhibitor PARP1 oncology breast cancer senicapoc Phase 3 intermediate conductance potassium channel blocker KCNN4 sennoside a Preclinical antiviral Infectious disease human immunodeficiency virus (hiv-1) sennoside-A Launched glycoside agonist gastroenterology constipation sennoside-protonated Preclinical seocalcitol Phase 3 vitamin D receptor agonist VDR SEP-227900 Phase 1 D-amino acid oxidase Inhibitor DAO sep-363856 Phase 2 trace amine associated receptor agonist HTR1A | TAAR1 neurology/psychiatry schizophrenia seratrodast Launched prostanoid receptor antagonist TBXA2R pulmonary asthma serdemetan Phase 1 MDM inhibitor MDM2 serotonin Launched growth factor receptor activator DRD1 | DRD5 | HTR1A | HTR1B | HTR1D | HTR1E | HTR1F | HTR2A | HTR2B | HTR2C | HTR3A | HTR3B | HTR4 | HTR5A | HTR6 | HTR7 | SLC36A1 neurology/psychiatry | neurology/psychiatry | neurology/psychiatry anxiety | depression | sleeplessness sertaconazole Launched sterol demethylase inhibitor infectious disease tinea pedis sertindole Withdrawn dopamine receptor antagonist | serotonin receptor antagonist ADRA1A | ADRA1B | ADRA1D | DRD2 | DRD3 | DRD4 | HRH1 | HTR1A | HTR1B | HTR1D | HTR1E | HTR1F | HTR2A | HTR2C | HTR6 | KCNH2 sertraline Launched selective serotonin reuptake inhibitor (SSRI) CYP2C19 | SLC6A3 | SLC6A4 neurology/psychiatry | neurology/psychiatry | neurology/psychiatry | neurology/psychiatry | neurology/psychiatry | obstetrics/gynecology depression | obsessive compulsive disorder (OCD) | panic disorders | posttraumatic stress disorder | premenstrual syndrome | social anxiety disorder sesamin Preclinical NFkB pathway inhibitor setipiprant Phase 3 prostaglandin inhibitor PTGDR2 setiptiline Launched adrenergic receptor antagonist HRH1 | HTR2A | HTR2C neurology/psychiatry depression setmelanotide Phase 3 melanocortin receptor agonist MC1R | MC3R | MC4R sevelamer hcl sevoflurane Launched membrane integrity inhibitor ATP2C1 | ATP5D | CYP2E1 | GABRA1 | GABRA2 | GABRA3 | GABRA4 | GABRA5 | GABRA6 | GABRB1 | GABRB2 | GABRB3 | GABRD | GABRE | GABRG1 | GABRG2 | GABRG3 | GABRP | GABRQ | GLRA1 | GLRB | GRIA1 | KCNA1 | KCNK10 | KCNK18 | KCNK2 | KCNK3 | KCNK9 | MT-ND1 neurology/psychiatry anesthetic SEW-2871 Preclinical lysophospholipid receptor agonist S1PR1 SF-11 Preclinical neuropeptide receptor antagonist MCOLN3 | NPY2R SGC-0946 Preclinical histone lysine methyltransferase inhibitor SGC-707 Preclinical protein arginine N-methyltransferase inhibitor PRMT3 SGC-CBP30 Preclinical bromodomain inhibitor CREBBP | EP300 SGI-1027 Preclinical DNA methyltransferase inhibitor DNMT1 | DNMT3A | DNMT3B SGI-1776 Phase 1 Pim kinase inhibitor FLT3 | PIM1 | PIM2 | PIM3 SGS-742 Preclinical GABA receptor antagonist GABBR1 | GABBR2 SGX523 Phase 1 hepatocyte growth factor receptor inhibitor MET SHA-68 Preclinical neuropeptide receptor antagonist NPSR1 shikimic-acid Preclinical SHP099 Preclinical protein tyrosine kinase inhibitor PTPN11 SIB-1553A Phase 2 acetylcholine receptor agonist CHRNB4 SIB-1757 Preclinical glutamate receptor antagonist GRM5 SIB-1893 Preclinical glutamate receptor antagonist GRM4 | GRM5 sibofimloc Phase 2 gastroenterology crohn's disease SID-7969543 Preclinical steroidogenic factor antagonist NR5A1 sigma-2 receptor antagonist 1 Phase 2 sigma receptor antagonist PGRMC1 | TMEM97 neurology/psychiatry alzheimer's disease siguazodan Phase 1 phosphodiesterase inhibitor PDE3A | PDE3B Cardiology heart failure therapy sildenafil Launched phosphodiesterase inhibitor PDE5A | PDE6G | PDE6H | SLCO1B1 | SLCO1B3 urology erectile dysfunction silibinin Launched cytochrome P450 inhibitor ALOX5 gastroenterology hepatic cirrhosis silodosin Launched adrenergic receptor antagonist ADRA1A | ADRA1B | ADRA1D urology benign prostatic hyperplasia (BPH) silver-sulfadiazine Launched PABA antagonist critical care sepsis silymarin Launched simeprevir Launched HCV inhibitor CYP1A2 | CYP2C19 | CYP2C8 | CYP3A4 | SLCO1B3 infectious disease hepatitis C simurosertib Preclinical kinase inhibitor CDC7 simvastatin Launched HMGCR inhibitor CYP2C8 | CYP3A4 | CYP3A5 | HMGCR | ITGB2 cardiology | cardiology | endocrinology | endocrinology | neurology/psychiatry coronary heart disease | hypercholesterolemia | hyperlipidemia | myocardial infarction | stroke sincalide Preclinical cholecystokinin agonist CCKAR | CCKBR sinefungin Preclinical DNA methyltransferase inhibitor | RNA synthesis inhibitor CARM1 sinomenine Preclinical angiogenesis inhibitor sipatrigine Phase 2 voltage-gated sodium channel blocker CACNA1B | CACNA1D | SCN10A | SCN1A | SCN2A | SCN3A | SCN4A | SCN5A | SCN9A siponimod Launched sphingosine 1-phosphate receptor modulator S1PR1 | S1PR5 neurology/psychiatry multiple sclerosis siramesine Phase 2 sigma receptor antagonist ADRA1A | ADRA1B | ADRA1D | PGRMC1 | SIGMAR1 siremadlin Preclinical MDM inhibitor MDM2 sirolimus Launched mTOR inhibitor CCR5 | FKBP1A | MTOR "pulmonary | transplant | transplant, pulmonary" "lymphangioleiomyomatosis | organ rejection | organ rejection, lymphangioleiomyomatosis" SirReal-2 Preclinical SIRT inhibitor SIRT2 sirtinol Preclinical SIRT inhibitor SIRT1 | SIRT2 SIS3 Preclinical serine/threonine kinase inhibitor SMAD3 | TGFBR1 sisomicin Launched protein synthesis inhibitor ophthalmology | ophthalmology conjunctivitis | punctate keratitis sisomicin-sulfate Launched bacterial 30S ribosomal subunit inhibitor infectious disease gram-negative bacterial infections S-isopropylisothiourea Preclinical nitric oxide synthase inhibitor NOS3 sitafloxacin Launched bacterial DNA gyrase inhibitor infectious disease buruli ulcer sitagliptin Launched dipeptidyl peptidase inhibitor CYP2C8 | DPP4 | FASLG | HMGCR | SLC22A8 endocrinology diabetes mellitus sitaxentan Withdrawn endothelin receptor antagonist EDNRA | EDNRB sitosterol Preclinical sitravatinib Phase 3 receptor tyrosine protein kinase inhibitor AXL | DDR1 | DDR2 | EPHA2 | EPHA4 | EPHB2 | EPHB4 | EPHB6 | FLT1 | FLT3 | FLT4 | KDR | KIT | MERTK | MET | NTRK1 | RET | TEK sivelestat Launched elastase inhibitor CELA1 | ELANE pulmonary acute lung injury SJ-172550 Preclinical MDM inhibitor MDM4 SJ-733 Phase 1 ATPase inhibitor ATP1A4 SJG-136 Phase 2 DNA intercalating agent CASP3 SKA-31 Preclinical potassium channel activator KCNN4 skepinone-L Preclinical p38 MAPK inhibitor MAPK14 | TNF SK&F-10047-(+) Phase 1 sigma receptor agonist OPRM1 | SIGMAR1 (+)-sk&f 10047 hydrochloride Phase 1 sigma receptor agonist SIGMAR1 SKF-38393 Preclinical dopamine receptor agonist CALY | DRD1 | DRD5 SKF-77434 Preclinical dopamine receptor agonist DRD1 SKF-81297 Preclinical dopamine receptor agonist DRD1 | DRD5 SKF-83566 Preclinical dopamine receptor antagonist DRD1 | DRD5 SKF-86002 Preclinical p38 MAPK inhibitor ALOX5 | MAPK14 SKF-89976A Preclinical GABA uptake inhibitor SLC6A1 SKF-91488 Preclinical histamine N-methyltransferase inhibitor HNMT SKF-96365 Preclinical calcium channel blocker CYP3A4 | PKD2 | TRPC1 | TRPC3 | TRPC4 | TRPC5 | TRPV2 SKI-II Preclinical sphingosine kinase inhibitor SPHK1 | VCP SKLB1002 Preclinical VEGFR inhibitor KDR SKLB-1028 Preclinical Abl kinase inhibitor | EGFR inhibitor | FLT3 inhibitor EGFR | FLT3 SLV-319-(+/-) Phase 2 cannabinoid receptor antagonist CNR1 | DRD2 | HTR1A SLV-320 Phase 2 adenosine receptor antagonist ADORA1 | ADORA2A | ADORA2B | ADORA3 SM-108 Phase 2 SM-164 Preclinical XIAP inhibitor BIRC2 | BIRC3 | CASP3 | CASP9 | XIAP SM-21 Preclinical sigma receptor antagonist PGRMC1 sm-21 maleate Preclinical cholinergic receptor antagonist SMER-28 Preclinical autophagy inducer SNCA S-methylcysteine Phase 1 CTSD | MGMT SMI-4a Preclinical Pim kinase inhibitor AKR1B1 | PIM1 | PIM2 smn-c3 Preclinical cell splicing inhibitor SMN2 SN-2 Preclinical transient receptor potential channel agonist MCOLN3 SN-38 Launched topoisomerase inhibitor TOP1 oncology colorectal cancer SN-6 Preclinical sodium/calcium exchange inhibitor SNAP Phase 2 nitric oxide donor PTPN1 SNAP-5089 Preclinical adrenergic receptor antagonist ADRA1A | ADRA1B | ADRA1D | ADRA2A | ADRA2B | ADRA2C | CACNA1C | CACNA1D SNAP-94847 Preclinical ADRA1A | DRD2 | MCHR1 SNC-80 Preclinical OPRD1 sndx-5613 Phase 1 KMT2A | MEN1 hematologic malignancy acute myeloid leukemia (aml) SNG-1153 Preclinical selective estrogen receptor modulator (SERM) ESR1 S-nitrosoglutathione Phase 1 nitric oxide stimulant PTPN1 snog SNS-314 Phase 1 Aurora kinase inhibitor AURKA | AURKB | AURKC SNX-2112 Phase 1 HSP inhibitor SNX-5422 Phase 1/Phase 2 HSP inhibitor HSP90AA1 | HSP90AB1 sobetirome Phase 1/Phase 2 thyroid hormone receptor agonist THRA | THRB soblidotin Phase 2 microtubule inhibitor sobrepin Launched mucolytic agent pulmonary chest congestion sobuzoxane Launched topoisomerase inhibitor TOP2A hematologic malignancy peripheral T-cell lymphoma (PTCL) sodium-ascorbate Launched sodium-butyrate Phase 2 HDAC inhibitor BCHE | FFAR2 | FFAR3 | HDAC1 | HDAC2 | HDAC3 | HDAC8 sodium-danshensu Preclinical sodium-dodecyl-sulfate Launched ALB sodium gluconate Launched sodium-gluconate Launched sodium-gualenate Launched antacid gastroenterology | otolaryngology peptic ulcer disease (PUD) | pharyngitis sodium monensin Launched bacterial permeability inducer infectious disease gastrointestinal parasites sodium-monofluorophosphate Launched PYGM dental cavities sodium-nitrite Launched nitric oxide donor critical care | critical care cyanide poisoning | poison antidote sodium nitroprusside Launched nitric oxide donor cardiology "hypertension, congestive heart failure" sodium-nitroprusside Launched nitric oxide donor cardiology | cardiology congestive heart failure | hypertension sodium-orthovanadate Preclinical sodium oxybate sodium-picosulfate Launched gastroenterology constipation sodium stibogluconate Launched tyrosine phosphatase inhibitor PTPN6 infectious disease leishmaniasis sodium-stibogluconate Launched tyrosine phosphatase inhibitor PTPN6 infectious disease leishmaniasis sodium-tanshinone-II-A-sulfonate Phase 2 potassium channel activator sodium-tetradecyl-sulfate Launched PROC dermatology varicose veins sofalcone Launched mucus protecting agent CBR1 | HPGD gastroenterology peptic ulcer disease (PUD) sofosbuvir Launched HCV inhibitor infectious disease hepatitis C sofosbuvir-impurity-m Preclinical antiviral sograzepide Phase 2 gastrin inhibitor CCKBR solamargine Launched apoptosis inhibitor | apoptosis stimulant solasonine Launched hedgehog pathway inhibitor CYCS | MAPK14 | MAPK8 dermatology actinic keratosis (ak) solcitinib Phase 1 JAK inhibitor JAK1 solifenacin succinate Launched acetylcholine receptor antagonist CHRM1 | CHRM2 | CHRM3 | CHRM4 | CHRM5 urology "urinary incontinence, urinary frequency" solifenacin-succinate Launched acetylcholine receptor antagonist CHRM1 | CHRM2 | CHRM3 | CHRM4 | CHRM5 urology | urology urinary frequency | urinary incontinence solithromycin Phase 3 protein synthesis inhibitor solriamfetol Launched dopamine reuptake inhibitor SLC6A2 | SLC6A3 neurology/psychiatry narcolepsy somantadine Phase 1 antiviral somatostatin Launched somatostatin receptor agonist GH1 | GHR | OPRD1 | OPRM1 | SSTR1 | SSTR2 | SSTR3 | SSTR4 | SSTR5 hematology hemorrhage sonepiprazole Phase 2 dopamine receptor antagonist DRD4 sonidegib Launched smoothened receptor antagonist SMO oncology basal cell carcinoma (BCC) sophocarpine Phase 3 sorafenib Launched FLT3 inhibitor | KIT inhibitor | PDGFR tyrosine kinase receptor inhibitor | RAF inhibitor | RET tyrosine kinase inhibitor | VEGFR inhibitor BRAF | CYP2B6 | CYP2C8 | CYP3A5 | DDR2 | FGFR1 | FLT1 | FLT3 | FLT4 | KDR | KIT | PDGFB | PDGFRB | RAF1 | RET | SLCO1B3 oncology | oncology | oncology hepatocellular carcinoma (HCC) | renal cell carcinoma (RCC) | thyroid cancer soraprazan Preclinical proton pump inhibitor ATP4A | ATP4B sorbic-acid Launched sorbinil Phase 3 aldose reductase inhibitor AKR1B1 sorbitan-monostearate Preclinical sorbitol Launched mucolytic agent gastroenterology constipation sorivudine Phase 3 dna polymerase inhibitor DPYD infectious disease virus herpes simplex (hsv) sotagliflozin Phase 3 sodium/glucose cotransporter inhibitor SLC5A1 | SLC5A2 sotalol Launched adrenergic receptor antagonist ADRB1 | ADRB2 | ADRB3 | KCNH2 cardiology | cardiology | Cardiology angina pectoris | atrial fibrillation (AF) | ventricular arrhythmias sotorasib Launched ras gtpase inhibitor KRAS oncology non-small cell lung cancer (nsclc) sotrastaurin Phase 2 PKC inhibitor PRKCA | PRKCB | PRKCD | PRKCE | PRKCH | PRKCQ SP-100030 Preclinical NFkB pathway inhibitor JUN | NFKB1 SP-141 Preclinical ubiquitin ligase inhibitor MDM2 SP-420 Phase 1 spaglumic-acid Launched glutamate receptor antagonist GRM3 allergy | allergy allergic conjunctivitis | allergic rhinitis sparfloxacin Withdrawn bacterial DNA gyrase inhibitor TOP2A sparfosate Phase 3 aspartate carbamoyltransferase inhibitor CA2 | CA4 | CAD sparsentan Phase 3 angiotensin receptor antagonist AGTR1 | EDNRA sparteine-(-) Launched sparteine-(+) Launched sparteine-sulfate Launched spautin-1 Preclinical deubiquitinase inhibitor USP10 | USP13 spectinomycin Launched bacterial 30S ribosomal subunit inhibitor pulmonary | pulmonary airsacculitis | chronic respiratory disease spermidine Preclinical glutamate receptor modulator KCNJ4 | TXNRD1 spermine Preclinical CA14 | CA4 | CA6 | CA9 | CASR | GRIN1 | GRIN2A | KCNJ4 | NOS2 | ODC1 | SMOX | SMS | TRPM4 | TRPM5 sphingosylphosphorylcholine Preclinical gene expression stimulant GPR12 spinosad Launched acetylcholine receptor agonist CHRNA7 infectious disease lice spiperone Launched dopamine receptor antagonist ADRA1A | ADRA1B | ADRA1D | DRD1 | DRD2 | DRD3 | DRD4 | DRD5 | HTR1A | HTR1D | HTR2A | HTR2B | HTR2C | HTR6 | HTR7 neurology/psychiatry schizophrenia spiradoline Phase 2 opioid receptor agonist OPRK1 spiramycin Launched bacterial 50S ribosomal subunit inhibitor infectious disease | infectious disease | infectious disease "soft tissue infection | toxoplasmosis | toxoplasmosis, soft tissue infection" spirapril Withdrawn angiotensin converting enzyme inhibitor ACE cardiology hypertension spirobromin Phase 1 spironolactone Launched mineralocorticoid receptor antagonist AR | CACNA1A | CACNA1B | CACNA1C | CACNA1D | CACNA1F | CACNA1G | CACNA1H | CACNA1I | CACNA1S | CACNA2D1 | CACNA2D2 | CACNA2D3 | CACNB1 | CACNB2 | CACNB3 | CACNB4 | CACNG1 | CYP11B2 | KCNA5 | KCND3 | NR3C1 | NR3C2 | PGR | SCNN1A | SHBG cardiology | cardiology | endocrinology | endocrinology | gastroenterology | rheumatology congestive heart failure | hepatic cirrhosis | hyperaldosteronism | hypertension | hypokalemia | nephrotic syndrome spiroxatrine Preclinical serotonin receptor antagonist ADRA1A | ADRA1B | ADRA1D | ADRA2A | ADRA2B | ADRA2C | HTR1A | HTR2B spizofurone Withdrawn GAST splitomycin Preclinical SIRT inhibitor SIRT1 | SIRT2 SPP301 Phase 3 endothelin receptor antagonist EDNRA SPP86 Preclinical receptor tyrosine protein kinase inhibitor RET spr741 (acetate) other antibiotic infectious disease gram-negative bacterial infections sq109 Phase 2/Phase 3 bacterial cell wall synthesis inhibitor Infectious disease tuberculosis SQ-109 Phase 3 bacterial cell wall synthesis inhibitor FDFT1 SQ-22536 Preclinical adenylyl cyclase inhibitor ADCY1 | ADCY5 squalamine Phase 3 antiviral squaric-acid-dibutyl-ester Preclinical oxidative stress inducer SR-1078 Preclinical retinoid receptor agonist RORA | RORC SR-11302 Preclinical SR-140333 Phase 2 neurokinin receptor antagonist TACR1 sr 146131 Preclinical cck receptor agonist CCKAR oncology neuroblastoma SR-1664 Preclinical PPAR receptor ligand PPARG sr 202 Phase 2 ppar receptor antagonist PPARG SR-2211 Preclinical retinoid receptor inverse agonist RORC SR-2640 Phase 2 leukotriene receptor antagonist CYSLTR1 SR-27897 Phase 2 CCK receptor antagonist CCKAR sr-31747 Preclinical immunosuppressant SIGMAR1 oncology prostate cancer SR-3306 Preclinical JNK inhibitor MAPK10 | MAPK8 | MAPK9 SR-33805 Phase 1 calcium channel blocker SR-3576 Preclinical JNK inhibitor MAPK10 SR-3677 Preclinical rho associated kinase inhibitor ROCK2 SR-57227A Phase 2 serotonin receptor agonist HTR3A SR-59230A Preclinical adrenergic receptor antagonist ADRB1 | ADRB2 | ADRB3 SR-95639A Preclinical acetylcholine receptor agonist CHRM1 SRC-kinase-inhibitor-I Preclinical SRC inhibitor CSK | LCK | RIPK2 (S)-(+)-rolipram Phase 1 phosphodiesterase inhibitor PDE4B | PDE4D SRPIN340 Preclinical serine arginine protein kinase inhibitor SRPK1 | SRPK2 SRT1720 Preclinical SIRT activator SIRT1 SRT2104 Phase 2 SIRT activator SIRT1 SRT3190 Preclinical CC chemokine receptor antagonist CXCR2 SSR128129E Preclinical SSR180711 Phase 2 acetylcholine receptor agonist CHRNA7 SSR240612 Preclinical bradykinin receptor antagonist BDKRB1 sstr5 antagonist 1 SSTR5 endocrinology diabetes mellitus S-sulfo-L-cysteine Preclinical glutamate receptor agonist ST-1535 Preclinical adenosine receptor antagonist ADORA1 | ADORA2A ST-1859 Phase 1 antiamyloidogenic agent ST-2825 Preclinical myeloid differentiation primary response inhibitor MYD88 ST-91 Preclinical adrenergic receptor agonist STA-5326 Phase 2 interleukin synthesis inhibitor IL12A | IL12B | IL12RB1 | IL12RB2 | IL23A stanozolol Launched androgen receptor agonist AR Oncology breast cancer STAT3-inhibitor-VI Preclinical STAT inhibitor STAT3 statil Preclinical aldose reductase inhibitor AKR1B10 stattic Preclinical stavudine Launched DNA directed DNA polymerase inhibitor | nucleoside reverse transcriptase inhibitor infectious disease human immunodeficiency virus (HIV-1) stemregenin-1 Preclinical aryl hydrocarbon receptor antagonist AHR stepronin Launched mucolytic agent stetaderm Launched AR STF-083010 Preclinical serine/threonine kinase inhibitor ERN1 STF-118804 Preclinical NAMPT inhibitor NAMPT STF-31 Preclinical NAMPT inhibitor NAMPT | SLC2A1 STF-62247 Preclinical autophagy inducer stigmasterol Preclinical stiripentol Launched GABA uptake inhibitor ABAT | GABRA3 | SCN1A | SCN3A neurology/psychiatry epilepsy stobadine Phase 2 adrenergic receptor antagonist ADRA1A streptomycin Launched bacterial 30S ribosomal subunit inhibitor infectious disease tuberculosis streptomycin sulfate [5mm; 10% aq dmso + 5mm ethanolamine] Launched bacterial 30s ribosomal subunit inhibitor infectious disease tuberculosis streptozocin dna alkylating drug Oncology pancreatic cancer streptozotocin Launched DNA alkylating agent oncology pancreatic cancer S-trityl-L-cysteine Preclinical mitotic kinesin inhibitor strontium-ranelate Launched bone formation stimulant | bone resorption inhibitor CASR orthopedics | rheumatology osteoarthritis | osteoporosis strophanthidin acetate Phase 2 atpase inhibitor ATP1A1 strychnine Preclinical acetylcholine receptor antagonist CHRM1 | CHRM2 | CHRM3 | CHRM4 | CHRM5 | CHRNA10 | CHRNA9 | GLRA1 | GLRA2 | GLRA3 | GLRB SU014813 Phase 2 PDGFR tyrosine kinase receptor inhibitor | VEGFR inhibitor FLT3 | KDR | PDGFRA | PDGFRB SU11274 Preclinical hepatocyte growth factor receptor inhibitor | tyrosine kinase inhibitor MET su14813 Phase 2 "pdgfr tyrosine kinase receptor inhibitor, vegfr inhibitor" KDR SU16f Preclinical PDGFR tyrosine kinase receptor inhibitor PDGFRB SU3327 Preclinical JNK inhibitor MAPK8 SU4312 Preclinical PDGFR tyrosine kinase receptor inhibitor | tyrosine kinase inhibitor | VEGFR inhibitor KDR | PDGFRB SU9516 Preclinical CDK inhibitor CCND1 | CDK1 | CDK2 | CDK4 | CDK5 subasumstat Phase 1 SAE1 hematologic malignancy myeloproliferative neoplasms substance-P Phase 1 neurokinin receptor antagonist TACR1 | TACR2 | TACR3 succinic-acid Launched ALDH5A1 | ASPH | BBOX1 | HSD17B6 | OXCT1 | OXCT2 | P3H1 | P3H2 | P3H3 | P4HA1 | P4HA2 | PLOD1 | PLOD3 | SDHA | SDHB | SDHC | SDHD | SLC13A1 | SLC13A2 | SLC13A3 | SLC25A10 | SUCLA2 | SUCLG1 | SUCLG2 | SUCNR1 | TMLHE succinobucol Phase 2/Phase 3 antioxidant CCL2 | MAPK1 | MAPK11 | MAPK3 | VCAM1 succinylcholine-chloride Launched CHRFAM7A | CHRM1 | CHRM2 | CHRM3 | CHRNA1 | CHRNA10 neurology/psychiatry muscle relaxant succinylsulfathiazole Phase 2 dihydrofolate reductase inhibitor DHFR sucralfate Launched antacid gastroenterology duodenal ulcer disease sucralose Launched sucrose Launched ACTA1 | ATOX1 | C22orf28 | LYZ sucrose-octaacetate Preclinical sudan-IV Preclinical sufugolix Preclinical gonadotropin releasing factor hormone receptor antagonist GNRH1 | GNRHR sugammadex Launched neuromuscular blockade reversal agent sulbactam Launched beta lactamase inhibitor infectious disease | infectious disease | infectious disease | infectious disease "gynecologic infections | intra-abdominal infections | skin infections | skin infections, intra-abdominal infections, gynecologic infections" sulbactam-pivoxil Launched beta lactamase inhibitor infectious disease skin infections sulbentine Preclinical other antifungal sulbutiamine Launched acetylcholine receptor antagonist neurology/psychiatry asthenia sulconazole Launched sterol demethylase inhibitor infectious disease | infectious disease | infectious disease tinea corporis | tinea cruris | tinea pedis sulfabenzamide Launched bacterial antifolate infectious disease | infectious disease gram-negative bacterial infections | gram-positive bacterial infections sulfacarbamide Withdrawn sulfacetamide Launched PABA antagonist ophthalmology conjunctivitis sulfachlorpyridazine Launched bacterial antifolate infectious disease urinary tract infections sulfadiazine Launched bacterial antifolate infectious disease | infectious disease | infectious disease | infectious disease | infectious disease | ophthalmology chancroid | conjunctivitis | malaria | meningitis | trachoma | urinary tract infections sulfadoxine Launched dihydropteroate synthase inhibitor infectious disease malaria sulfafurazole Launched bacterial antifolate infectious disease urinary tract infections sulfaguanidine Launched bacterial antifolate infectious disease urinary tract infections sulfamerazine Launched bacterial antifolate infectious disease | infectious disease cholera | coccidiosis sulfameter Launched dihydrofolate reductase inhibitor DHFR infectious disease urinary tract infections sulfamethazine Launched PABA antagonist gastroenterology enteritis sulfamethizole Launched bacterial antifolate infectious disease urinary tract infections sulfamethoxazole Launched PABA antagonist gastroenterology | infectious disease | infectious disease enteritis | pneumonia | urinary tract infections sulfamethoxypyridazine Withdrawn bacterial antifolate sulfametopyrazine Launched PABA antagonist infectious disease | infectious disease | infectious disease malaria | respiratory tract infections | urinary tract infections sulfamonomethoxine Launched bacterial antifolate infectious disease urinary tract infections sulfamoxole Launched PABA antagonist infectious disease urinary tract infections sulfanilamide Launched carbonic anhydrase inhibitor CA1 | CA2 | CA9 | CYP2C19 | CYP2C9 | CYP2D6 | CYP2E1 | CYP3A4 infectious disease vulvovaginal candidiasis sulfanilate-zinc Preclinical sulfanitran Launched infectious disease coccidiosis sulfaphenazole Launched dihydropteroate synthetase inhibitor DHPS infectious disease urinary tract infections sulfapyridine Launched PABA antagonist infectious disease | infectious disease gram-negative bacterial infections | gram-positive bacterial infections sulfaquinoxaline Launched vitamin K antagonist infectious disease coccidiosis sulfasalazine Launched cyclooxygenase inhibitor ACAT1 | ALOX5 | CHUK | IKBKB | PLA2G1B | PPARG | PTGS1 | PTGS2 | SLC46A1 | SLC7A11 | TBXAS1 gastroenterology ulcerative colitis sulfathiazole Launched dihydropteroate synthase inhibitor infectious disease | infectious disease gram-negative bacterial infections | gram-positive bacterial infections sulfatinib Phase 1 tyrosine kinase inhibitor CSF1R | FGFR1 | KDR sulfinpyrazone Launched uricosuric blocker ABCC1 | FPR1 | SLC22A12 rheumatology gout sulfisomidin Preclinical antibacterial sulfisoxazole-acetyl Launched folic acid antagonist infectious disease | infectious disease | infectious disease | otolaryngology meningitis | otitis | trachoma | urinary tract infections sulforaphane Phase 2 anticancer agent | aryl hydrocarbon receptor antagonist NFE2L2 "sulfuric acid compound with (2r,3r,4r,5r)-2-((1s,2s,3r,4s,6r)-4,6-diamino-3-((2r,3r,6s)-3-amino-6-((r)-1-(met hylamino)ethyl)tetrahydro-2h-pyran-2-yloxy)-2-h" sulindac Launched cyclooxygenase inhibitor AKR1B1 | PTGS1 | PTGS2 rheumatology | rheumatology | rheumatology ankylosing spondylitis | osteoarthritis | rheumatoid arthritis sulisobenzone Launched dermatology sunscreen lotion sulmazole Phase 1 adenosine receptor antagonist sulmetozine Launched gastrin inhibitor GAST gastroenterology peptic ulcer disease (PUD) suloctidil Withdrawn adrenergic receptor antagonist sulopenem Phase 3 antibacterial sulphadimethoxine Launched dihydropteroate synthetase inhibitor infectious disease | infectious disease gram-negative bacterial infections | gram-positive bacterial infections sulpiride Launched dopamine receptor antagonist CA7 | DRD2 neurology/psychiatry schizophrenia sultamicillin Launched antibacterial infectious disease | infectious disease gram-negative bacterial infections | gram-positive bacterial infections sultiame Phase 3 carbonic anhydrase inhibitor CA12 | CA2 | CA7 | CA9 sultopride Preclinical dopamine receptor antagonist DRD2 sumanirole Phase 3 dopamine receptor agonist DRD2 | HTR1A | HTR1D sumatriptan Launched serotonin receptor agonist HTR1A | HTR1B | HTR1D | HTR1E | HTR1F | HTR5A | HTR6 | HTR7 neurology/psychiatry migraine headache SUN-11602 Preclinical fibroblast growth factor mimetic FGFR1 SUN-B-8155 Preclinical calcitonin agonist CALCA | CALCR sunitinib Launched FLT3 inhibitor | KIT inhibitor | PDGFR tyrosine kinase receptor inhibitor | RET tyrosine kinase inhibitor | VEGFR inhibitor CSF1R | FGFR1 | FLT1 | FLT3 | FLT4 | KDR | KIT | PDGFRA | PDGFRB | RET oncology | oncology | oncology gastrointestinal stromal tumors (GIST) | neuroendocrine tumors of pancreatic origin (PNET) | renal cell carcinoma (RCC) suplatast Launched histamine release inhibitor | immunoglobulin inhibitor rheumatology Kimura's disease suprofen Withdrawn cyclooxygenase inhibitor PTGS1 | PTGS2 suramin Launched DNA synthesis inhibitor F2 | FSHR | HPSE | P2RY1 | P2RY11 | P2RY13 | P2RY2 | PLA2G2A | RYR1 | RYR2 | SIRT5 infectious disease | infectious disease African trypanosomiasis | onchocerciasis suritozole Phase 2 GABA receptor inverse agonist ADORA1 | GABBR1 sutezolid Phase 2 protein synthesis inhibitor suxibuzone Launched cyclooxygenase inhibitor neurology/psychiatry | rheumatology joint pain | muscle pain swainsonine Phase 2 alpha mannosidase inhibitor MAN2A1 SX-011 Preclinical MAP kinase inhibitor MAPK14 sx-682 Phase 1/Phase 2 antitumor agent CXCL11 | CXCR1 | CXCR2 hematologic malignancy myeloproliferative neoplasms SY-640 Phase 2 SYM-2081 Preclinical kainate receptor antagonist GRIK1 | GRIK2 | GRIK3 | GRIK4 | GRIK5 | SLC1A2 SYM-2206 Preclinical glutamate receptor antagonist GRIA1 | GRIA2 | GRIA3 | GRIA4 symclosene Preclinical synephrine Launched adrenergic receptor agonist ADRA1A otolaryngology sinusitis synephrine (oxedrine) Launched adrenergic receptor agonist ADRA1A otolaryngology sinusitis T-0070907 Preclinical PPAR receptor antagonist PPARG T-0156 Preclinical phosphodiesterase inhibitor PDE5A t-025 Preclinical clk inhibitor T-025 Preclinical CLK inhibitor CLK2 T-0901317 Preclinical LXR agonist ABCA1 | NCOA1 | NCOA2 | NR1H2 | NR1H3 | NR1I2 | RORA | RORC | RXRB T-1095 Preclinical sodium/glucose cotransporter inhibitor SLC5A2 t-1101 (tosylate) Phase 1 hec1 inhibitor NDC80 | NEK2 oncology prostate cancer T-5224 Phase 2 AP inhibitor JUN T-5601640 Preclinical LIM kinase inhibitor LIMK2 T-62 Phase 2 adenosine receptor modulator ADORA2A T-807 Phase 2 PET radiotracer TA-01 Preclinical casein kinase inhibitor | MAP kinase inhibitor CSNK1D | CSNK1E | MAPK14 tabimorelin Phase 2 growth hormone secretagogue receptor agonist GH1 | GHRHR | GHSR tacalcitol Launched vitamin D receptor agonist VDR dermatology | dermatology chapped lips | psoriasis tacedinaline Phase 3 HDAC inhibitor HDAC1 tacrine Launched acetylcholinesterase inhibitor ACHE | BCHE neurology/psychiatry Alzheimer's disease tacrolimus Launched calcineurin inhibitor CYP3A5 | CYP3A7 | FKBP1A transplant organ rejection tadalafil Launched phosphodiesterase inhibitor PDE11A | PDE5A urology erectile dysfunction tafamidis-meglumine Launched transthyretin amyloid inhibitor TTR neurology/psychiatry familial amyloid polyneuropathy (FAP) tafenoquine Launched antimalarial agent infectious disease malaria tafluprost Launched prostaglandin inhibitor PTGDR | PTGDR2 | PTGFR ophthalmology | ophthalmology glaucoma | ocular hypertension tagatose Launched phosphorylase inhibitor PYGL TAK-063 Phase 2 phosphodiesterase inhibitor PDE10A tak-071 Phase 2 mitotic inhibitor FOS | SNCA neurology/psychiatry parkinson's disease TAK-220 Phase 1 CC chemokine receptor antagonist CCR5 TAK-243 Phase 1 ubiquitin activating enzyme inhibitor UBA1 TAK-285 Phase 1 EGFR inhibitor EGFR | ERBB2 TAK-593 Phase 1 VEGFR inhibitor FLT1 | KDR | PDGFRA TAK-632 Preclinical RAF inhibitor BRAF | RAF1 TAK-659 Phase 2 spleen associated tyrosine kinase inhibitor SYK TAK-715 Phase 2 p38 MAPK inhibitor MAPK14 | TNF TAK-733 Phase 1 MEK inhibitor MAP2K1 TAK-779 Preclinical CC chemokine receptor antagonist CCR2 | CCR5 | CXCR3 TAK-875 Phase 3 insulin secretagogue FFAR1 | INS TAK-901 Phase 1 Aurora kinase inhibitor AURKA | AURKB TAK-960 Phase 1 PLK inhibitor PLK1 talabostat Phase 3 dipeptidyl peptidase inhibitor | fibroblast activation protein inhibitor DPP4 | DPP7 | DPP8 | DPP9 | FAP taladegib Phase 2 smoothened receptor antagonist DHH | IHH | PTCH1 | SMO talampanel Phase 2 glutamate receptor antagonist GRIA1 | GRIA2 | GRIA3 | GRIA4 talaporfin Launched photosensitizing agent oncology glioma talarozole Phase 2 cytochrome P450 inhibitor CYP26A1 talazoparib Launched PARP inhibitor PARP1 | PARP2 oncology breast cancer talc taletrectinib Phase 2 proto-oncogene tyrosine protein kinase inhibitor ROS1 oncology non-small cell lung cancer (nsclc) talinolol Launched adrenergic receptor antagonist ADRB1 cardiology hypertension talipexole Launched adrenergic receptor agonist | dopamine receptor agonist ADRA2A | DRD2 | HTR3A infectious disease genitial herpes talmapimod Phase 2 p38 MAPK inhibitor IL1B | MAPK11 | MAPK14 | MT-CO2 | TNF talnetant Phase 2 tachykinin antagonist TACR2 | TACR3 talniflumate Launched cyclooxygenase inhibitor CLCA1 neurology/psychiatry pain relief talopram Phase 2 adrenergic inhibitor SLC6A2 talsaclidine Phase 2/Phase 3 acetylcholine receptor agonist CHRM1 | CHRM2 | CHRM3 | CHRM4 | CHRM5 taltirelin Launched thyrotropin releasing hormone receptor agonist TRHR neurology/psychiatry spinocerebellar ataxia taltobulin Phase 1 tubulin polymerization inhibitor TAME Preclinical tamibarotene Launched retinoid receptor agonist RARA | RARB hematologic malignancy acute promyelocytic leukemia (APL) taminadenant Phase 1/Phase 2 adenosine receptor antagonist ADORA2A tamoxifen Launched estrogen receptor antagonist | selective estrogen receptor modulator (SERM) CYP3A5 | EBP | ESR1 | ESR2 | GPER1 | PRKCA | PRKCB | PRKCD | PRKCE | PRKCG | PRKCI | PRKCQ | PRKCZ oncology breast cancer tamsulosin Launched adrenergic receptor antagonist ADRA1A | ADRA1B | ADRA1D urology benign prostatic hyperplasia (BPH) tanaproget Phase 2 progesterone receptor agonist PGR tandospirone Launched serotonin receptor agonist HTR1A neurology/psychiatry | neurology/psychiatry dysthymic disorder | generalized anxiety disorder (GAD) tandutinib Phase 2 FLT3 inhibitor | KIT inhibitor | PDGFR tyrosine kinase receptor inhibitor CSF1R | FLT3 | KIT | PDGFD | PDGFRA | PDGFRB tanespimycin Phase 3 HSP inhibitor CHEK1 | HSP90AA1 tangeritin Preclinical cell cycle inhibitor tannic acid Launched parg inhibitor ANO1 gastroenterology constipation tannic-acid Launched PARG inhibitor ANO1 | PARG gastroenterology constipation tanshinone-I Phase 2 AP inhibitor AHR | IFNG tanshinone-IIA Phase 2/Phase 3 anti-inflammatory agent | interleukin inhibitor IL1B | NR1I2 | TNF tapentadol hydrochloride tapinarof Phase 3 aryl hydrocarbon receptor agonist AHR | CSNK2A1 | CSNK2B | LCK taprenepag Phase 2 prostaglandin receptor agonist PTGER2 tarafenacin Phase 2 acetylcholine receptor antagonist CHRM3 tarafenacin (d-tartrate) Phase 2 acetylcholine receptor antagonist CHRM3 taranabant Phase 3 cannabinoid receptor inverse agonist CNR1 targinine Phase 3 nitric oxide synthase inhibitor NOS2 | NOS3 tariquidar Phase 3 P glycoprotein inhibitor ABCB1 tartaric-acid Launched antioxidant TAS-103 Phase 1 topoisomerase inhibitor TOP1 | TOP2A tas-115 mesylate Phase 1 protein tyrosine kinase inhibitor HGF | PDGFRA | TNK1 oncology osteosarcoma tas4464 Phase 1 nedd activating enzyme inhibitor NAE1 hematologic malignancy multiple myeloma taselisib Phase 3 PI3K inhibitor PIK3CA | PIK3CB | PIK3CD | PIK3CG tasimelteon Launched melatonin receptor agonist MTNR1A | MTNR1B neurology/psychiatry Non-24-Hour Sleep-Wake Disorder tasisulam Phase 3 apoptosis stimulant tasquinimod Phase 3 angiogenesis inhibitor | S100A9 inhibitor HDAC4 | S100A9 tasuldine Phase 3 mucolytic agent taurine Launched antioxidant neurology/psychiatry | neurology/psychiatry | neurology/psychiatry anxiety | irritability | sleeplessness taurocholate Phase 1 G protein-coupled receptor agonist CEL | FABP6 | SLCO1C1 tauroglycocholate Preclinical membrane permeability enhancer taurolidine Launched apoptosis stimulant infectious disease catheter-related bloodstream infection tavaborole Launched leucyl-tRNA synthetase inhibitor infectious disease onychomycosis tavapadon Phase 2 dopamine agonist DRD1 | DRD5 neurology/psychiatry parkinson's disease tavilermide Phase 3 tyrosine kinase partial agonist NGF | NTRK1 taxifolin Phase 2 opioid receptor antagonist ADIPOR2 | APOB | APP | HMGCR tazarotene Launched retinoid receptor agonist ODC1 | RARA | RARB | RARG | RXRB dermatology | dermatology cosmetic | sunscreen lotion tazemetostat Launched histone lysine methyltransferase inhibitor EZH2 tazobactam Launched beta lactamase inhibitor infectious disease pneumonia TBA-354 Phase 1 tbaj-587 Phase 1 atp synthase inhibitor infectious disease tuberculosis TBOA-(DL) Preclinical excitatory amino acid transporter inhibitor SLC1A1 | SLC1A2 | SLC1A3 | SLC1A6 | SLC1A7 TC1 Preclinical beta-secretase inhibitor BACE1 TC2559 Preclinical acetylcholine receptor agonist CHRNA4 TC-A-2317 Preclinical Aurora kinase inhibitor AURKA | AURKB TC-ASK-10 Preclinical MAP kinase inhibitor MAP3K5 | MAP3K6 TC-E-5002 Preclinical histone demethylase inhibitor KDM2A | KDM4A | KDM4C | KDM5A | KDM6A | KDM7A | PHF8 TC-E-5006 Preclinical gamma secretase modulator APP TC-F-2 Preclinical FAAH inhibitor FAAH TC-FPR-43 Preclinical formyl peptide receptor agonist FPR2 TC-G-1000 Preclinical adrenergic receptor agonist ADRA2A | ADRA2B | ADRA2C TC-G-1004 Preclinical adenosine receptor antagonist ADORA2A TC-G-1005 Preclinical G protein-coupled receptor agonist GPBAR1 TC-G-1008 Preclinical G protein-coupled receptor agonist GPR39 TC-H-106 Preclinical HDAC inhibitor HDAC1 | HDAC2 | HDAC3 | HDAC8 TC-I-15 Preclinical integrin inhibitor ITGA2 | ITGB1 TC-I-2000 Preclinical transient receptor potential channel antagonist TRPM8 TC-I-2014 Preclinical transient receptor potential channel antagonist TRPM8 TCID Preclinical TC-LPA5-4 Preclinical lysophosphatidic acid receptor antagonist LPAR5 TC-Mps1-12 Preclinical monopolar spindle 1 kinase inhibitor TTK TC-N-1752 Preclinical sodium channel blocker SCN9A TCN201 Preclinical glutamate receptor antagonist GRIN2A TCN238 Preclinical glutamate receptor positive allosteric modulator GRM4 TC-NTR1-17 Preclinical neurotensin agonist NTSR1 TC-O-9311 Preclinical G protein-coupled receptor agonist GPR139 TC-OT-39 Preclinical oxytocin receptor agonist | vasopressin receptor agonist AVPR1A | OXT | OXTR TCS-2002 Preclinical glycogen synthase kinase inhibitor GSK3B TCS-21311 Preclinical JAK inhibitor JAK3 TCS-2210 Preclinical neural stem cell inducer TCS-2314 Preclinical integrin inhibitor ITGA4 | ITGB1 TCS-3035 Preclinical G protein-coupled receptor agonist GPR35 TCS-359 Preclinical FLT3 inhibitor FLT3 TCS-5861528 Preclinical transient receptor potential channel antagonist TRPA1 TC-S-7003 Preclinical SRC inhibitor LCK TC-S-7004 Preclinical DYRK inhibitor DYRK1A | DYRK1B TC-S-7005 Preclinical PLK inhibitor PLK2 TC-S-7006 Preclinical MAP kinase inhibitor MAP3K8 TC-S-7009 Preclinical hypoxia inducible factor inhibitor EPAS1 TCS-HDAC6-20b Preclinical HDAC inhibitor HDAC6 TCS-OX2-29 Preclinical orexin receptor antagonist HCRTR2 TC-SP-14 Preclinical sphingosine 1-phosphate receptor agonist S1PR1 TCS-PIM-1-1 Preclinical Pim kinase inhibitor PIM1 TCV-309 Preclinical platelet activating factor receptor antagonist PAFAH1B1 | PAFAH1B2 | PAFAH1B3 | PTAFR TD139 Phase 2 anti-inflammatory agent LGALS3 tebanicline (dihydrochloride) Preclinical acetylcholine receptor agonist CHRNA4 | CHRNB2 neurology/psychiatry chronic pain tebipenem Launched bacterial cell wall synthesis inhibitor CNR1 infectious disease | otolaryngology otitis | pneumonia tebipenem pivoxil Launched bacterial cell wall synthesis inhibitor CNR1 "infectious disease, otolaryngology" "pneumonia, otitis" tecadenoson Phase 2 adenosine receptor agonist ADORA1 tecalcet Phase 2 calcium-sensing receptor agonist CASR tecarfarin Phase 3 vitamin k antagonist VKORC1 hematology thrombosis tecastemizole Phase 3 histamine receptor antagonist HRH1 | KCNH2 tecovirimat Launched orthopoxvirus egress inhibitor infectious disease smallpox tedizolid Launched bacterial 50S ribosomal subunit inhibitor infectious disease skin infections tedizolid-phosphate Launched protein synthesis inhibitor infectious disease skin infections tefinostat Phase 1/Phase 2 hdac inhibitor HDAC1 oncology hepatocellular carcinoma (hcc) tegafur Launched tegaserod Withdrawn serotonin receptor partial agonist HTR2A | HTR2B | HTR2C | HTR4 teglicar Phase 2 carnitine palmitoyltransferase inhibitor CPT1A endocrinology diabetes mellitus tegobuvir Phase 3 HCV inhibitor | protease inhibitor teicoplanin Launched bacterial cell wall synthesis inhibitor infectious disease gram-positive bacterial infections teicoplanin-A2-1 Launched bacterial cell wall synthesis inhibitor infectious disease gram-positive bacterial infections teicoplanin-A2-3 Launched bacterial cell wall synthesis inhibitor infectious disease gram-positive bacterial infections teijin-compound-1 Preclinical CC chemokine receptor antagonist CCR2 telaprevir Launched HCV inhibitor CTSA | PGR infectious disease hepatitis C telatinib Phase 2 KIT inhibitor | PDGFR tyrosine kinase receptor inhibitor | VEGFR inhibitor FLT4 | KDR | KIT | PDGFRB telavancin Launched bacterial cell wall synthesis inhibitor infectious disease gram-positive bacterial infections telbivudine Launched DNA polymerase inhibitor infectious disease hepatitis B telcagepant Phase 3 calcitonin antagonist CALCA | CALCRL | RAMP1 telenzepine Phase 3 acetylcholine receptor antagonist CHRM1 telithromycin Launched "bacterial 30S ribosomal subunit inhibitor | bacterial 30s ribosomal subunit inhibitor, bacterial 50s ribosomal subunit inhibitor | bacterial 50S ribosomal subunit inhibitor" CYP1A2 | CYP2D6 | CYP3A4 | CYP3A5 | CYP3A7 | SLCO1B3 infectious disease pneumonia telmesteine Launched mucolytic agent pulmonary cough suppressant telmisartan Launched angiotensin receptor antagonist AGTR1 | CYP2C19 | CYP2J2 | PPARA | PPARG cardiology hypertension telotristat Launched tryptophan hydroxylase inhibitor TPH1 gastroenterology diarrhea telotristat-ethyl Launched tryptophan hydroxylase inhibitor TPH1 gastroenterology diarrhea telratolimod Preclinical toll-like receptor agonist TLR7 | TLR8 temanogrel Preclinical serotonin receptor antagonist HTR2A temefos Launched cholinesterase inhibitor temocapril Launched angiotensin converting enzyme inhibitor ACE cardiology | cardiology | cardiology | nephrology congestive heart failure | coronary artery disease (CAD) | diabetic nephropathy | hypertension temoporfin Launched radical formation stimulant oncology head and neck squamous cell carcinoma (HNSCC) temozolomide Launched DNA alkylating agent MGMT | TOP2A oncology | oncology astrocytoma | glioblastoma tempol Phase 2 free radical scavenger temsirolimus Launched mTOR inhibitor MTOR | PTEN oncology renal cell carcinoma (RCC) TEN-010 Preclinical bromodomain inhibitor BRD2 | BRD3 | BRD4 | BRDT tenalisib Phase 2 PI3K inhibitor PIK3CD | PIK3CG tenapanor Launched sodium/hydrogen exchanger inhibitor SLC9A3 tenatoprazole Phase 2 ATPase inhibitor ATP4A | IDO1 teneligliptin Launched dipeptidyl peptidase inhibitor DPP4 endocrinology diabetes mellitus tenidap Phase 3 cyclooxygenase inhibitor ALOX5 | KCNJ4 | PTGS1 tenilsetam Phase 3 AGE inhibitor teniposide Launched topoisomerase inhibitor CYP3A5 | TOP2A | TOP2B hematologic malignancy acute lymphoblastic leukemia (ALL) tenofovir Launched HIV integrase inhibitor | nucleoside reverse transcriptase inhibitor infectious disease | infectious disease hepatitis B | human immunodeficiency virus (HIV-1) tenofovir alafenamide Launched hiv gag inhibitor GAG-POL Infectious disease human immunodeficiency virus (hiv-1) tenofovir-alafenamide Launched nucleoside reverse transcriptase inhibitor infectious disease hepatitis B tenofovir-disoproxil Launched nucleoside reverse transcriptase inhibitor CYP1A2 | CYP3A4 infectious disease | infectious disease hepatitis B | human immunodeficiency virus (HIV-1) tenovin-1 Preclinical SIRT inhibitor | TP53 activator SIRT1 | SIRT2 tenovin-6 Preclinical SIRT inhibitor SIRT1 | SIRT2 | SIRT3 tenoxicam Launched cyclooxygenase inhibitor PTGS1 | PTGS2 orthopedics | rheumatology | rheumatology | rheumatology | rheumatology | rheumatology ankylosing spondylitis | bursitis | osteoarthritis | periarthritis | rheumatoid arthritis | tendinitis tenylidone Preclinical tepilamide fumarate Launched "nuclear factor erythroid derived, like (nrf2) activator" GSTP1 | HCAR2 | NFE2L2 neurology/psychiatry multiple sclerosis tepoxalin Launched cyclooxygenase inhibitor | lipoxygenase inhibitor ALOX5 orthopedics | rheumatology hip dysplasia | rheumatoid arthritis TEPP-46 Preclinical pyruvate kinase isozyme activator PKM teprenone Launched mucus protecting agent dermatology cosmetic terameprocol Phase 1/Phase 2 lipoxygenase inhibitor BIRC5 | CDK1 terazosin Launched adrenergic receptor antagonist ADRA1A | ADRA1B | ADRA1D cardiology | urology benign prostatic hyperplasia (BPH) | hypertension terazosin hydrochloride Launched adrenergic receptor antagonist ADRA1A | ADRA1B | ADRA1D "urology, cardiology" "benign prostatic hyperplasia (bph), hypertension" terbinafine Launched fungal squalene epoxidase inhibitor CYP2C19 | CYP2C8 | SQLE infectious disease | infectious disease | infectious disease tinea corporis | tinea cruris | tinea pedis terbutaline Launched adrenergic receptor agonist ADRB2 pulmonary | pulmonary | pulmonary bronchitis | bronchospasm | emphysema terciprazine Phase 1 terconazole Launched sterol demethylase inhibitor infectious disease vulvovaginal candidiasis terfenadine Withdrawn histamine receptor antagonist HRH1 | KCNH1 | KCNH2 terguride Launched dopamine receptor agonist | serotonin receptor antagonist ADRA1A | ADRA2A | ADRA2B | ADRA2C | DRD2 | DRD3 | DRD4 | HTR1A | HTR1B | HTR1D | HTR2A | HTR2B | HTR2C | PRL neurology/psychiatry Parkinson's Disease teriflunomide Launched dihydroorotate dehydrogenase inhibitor CYP1A2 | CYP2C8 | DHODH | MMP2 | MMP9 neurology/psychiatry multiple sclerosis terlipressin Launched vasopressin receptor agonist AVPR1A | AVPR1B | AVPR2 cardiology hypotension terodiline Withdrawn cholinergic receptor antagonist CHRM1 | CHRM2 | CHRM3 | CHRM4 teroxirone Phase 1 DNA inhibitor terpene Preclinical terpinen-4-ol Launched anti-inflammatory agent BCL2 | BIRC5 | XIAP oncology melanoma terreic-acid-(-) Preclinical Bruton's tyrosine kinase (BTK) inhibitor BTK terutroban Phase 3 prostanoid receptor antagonist TBXA2R tesaglitazar Phase 3 insulin sensitizer | PPAR receptor agonist INS | PPARA | PPARG testosterone propionate tetomilast Phase 2 phosphodiesterase inhibitor PDE4A | PDE4B | PDE4C | PDE4D tetrabenazine Launched vesicular monoamine transporter inhibitor SLC18A1 | SLC18A2 infectious disease | neurology/psychiatry cholera | Huntington's disease tetracaine Launched membrane integrity inhibitor SCN10A | SCN11A | SCN1A | SCN2A | SCN3A | SCN4A | SCN5A | SCN7A | SCN8A | SCN9A neurology/psychiatry anesthetic tetracycline Launched bacterial 30S ribosomal subunit inhibitor dermatology | infectious disease | infectious disease | infectious disease | infectious disease | infectious disease | infectious disease acne vulgaris (AV) | plague | pneumonia | psittacosis | respiratory tract infections | skin infections | urinary tract infections tetracycline hcl Launched bacterial 30s ribosomal subunit inhibitor "infectious disease, dermatology" "respiratory tract infections, pneumonia, skin infections, urinary tract infections, acne vulgaris (av), plague, psittacosis" tetradecylthioacetic-acid Phase 2 lipid peroxidase inhibitor tetraethylenepentamine Phase 2/Phase 3 superoxide dismutase inhibitor SOD1 | SOD2 tetrahydrofolic-acid Launched FOLR2 tetrahydropapaverine Preclinical tetrahydrouridine Phase 2 cytidine deaminase inhibitor CDA tetrahydrozoline Launched adrenergic receptor agonist ophthalmology eye irritation tetramethylthiuram-monosulfide Preclinical tetramisole Launched immunostimulant ALPPL2 | CHRNA3 infectious disease gastrointestinal parasites tetrandrine Preclinical calcium channel blocker SLC6A3 tetrazol-5-yl-glycine-(RS) Preclinical glutamate receptor agonist GRIN1 | GRIN2A | GRIN2B | GRIN2C | GRIN2D tetrindole Phase 3 monoamine oxidase inhibitor MAOA tetroquinone Preclinical tezacaftor Launched CFTR channel agonist CFTR pulmonary cystic fibrosis TFC-007 Preclinical prostaglandin inhibitor HPGDS TG-003 Preclinical CLK inhibitor CLK1 | CLK4 | DYRK1A | DYRK1B TG-02 Phase 1/Phase 2 CDK inhibitor | FLT3 inhibitor | JAK inhibitor CCNT1 | CDK1 | CDK2 | CDK7 | CDK9 | FLT3 | JAK2 | MAPK7 TG100-115 Phase 1/Phase 2 PI3K inhibitor PIK3CA | PIK3CB | PIK3CD | PIK3CG TG-100572 Preclinical SRC inhibitor | VEGFR inhibitor EPHB4 | KDR | SRC TG-100713 Preclinical PI3K inhibitor TG-100801 Phase 2 SRC inhibitor | VEGFR inhibitor CSK | EPHB4 | FGFR1 | FLT1 | FLT4 | KDR | SRC TG-101209 Preclinical JAK inhibitor JAK2 | JAK3 TGR-1202 Phase 3 PI3K inhibitor PIK3CD TGX-221 Preclinical PI3K inhibitor PIK3CB | PIK3CD TH-302 Phase 3 DNA alkylating agent TH-588 Preclinical MTH1 inhibitor NUDT1 thaliblastine Phase 2 DNA inhibitor thalidomide Launched tumor necrosis factor production inhibitor CRBN | CYP1A2 | CYP2B6 | CYP2C19 | CYP3A5 | TNF oncology myeloma theaflavin Preclinical antiviral CYP19A1 | FASN | LIPC | LIPE | LIPG theobromine Launched phosphodiesterase inhibitor ADORA1 | ADORA2A | PDE4B thiamet-g Preclinical GLCNAC phosphotransferase inhibitor MGEA5 thiamine Launched vitamin B SLC19A2 | SLC19A3 | TPK1 metabolism thiamine deficiency thiamine-pyrophosphate Launched hematology anemia thiamphenicol Launched bacterial 50S ribosomal subunit inhibitor infectious disease pelvic inflammatory disease thiamylal Launched glutamate receptor antagonist GABRA1 neurology/psychiatry sedative thiazovivin Preclinical rho associated kinase inhibitor thiethylperazine Launched dopamine receptor antagonist DRD1 | DRD2 | DRD4 gastroenterology nausea thiocolchicoside Launched GABA receptor antagonist GABRA1 | GABRB2 | GABRG2 | GLRA1 | GLRB neurology/psychiatry muscle relaxant thioctic-acid Launched reducing agent ACHE | ALDH2 | PTGS2 nephrology diabetic nephropathy thiodiglycol Preclinical thioguanine Launched purine antagonist IMPDH1 | IMPDH2 hematologic malignancy acute myeloid leukemia (AML) thiomersal Launched other antibiotic OXCT1 infectious disease preservative thiopental Launched GABA receptor antagonist FAAH neurology/psychiatry anesthetic thioperamide Preclinical histamine receptor antagonist HRH3 | HRH4 thiophanate Preclinical thioproperazine Launched dopamine receptor antagonist ADRA1A | ADRA1B | DRD1 | DRD2 | HTR1A | HTR2A neurology/psychiatry schizophrenia thioridazine Launched dopamine receptor antagonist CHRNA7 | DRD1 | DRD2 | DRD3 | DRD4 | DRD5 | HRH1 | HTR1A | HTR2A | HTR2C | HTR6 | HTR7 | MALT1 Neurology psychosis thiorphan Phase 1 membrane metalloendopeptidase inhibitor MME thiostrepton Launched "FOXM1 inhibitor | foxm1 inhibitor, protein synthesis inhibitor | protein synthesis inhibitor" FOXM1 obstetrics/gynecology mastitis thiotepa Launched cytochrome P450 inhibitor CYP2B6 | CYP3A4 oncology | oncology | oncology bladder cancer | breast cancer | ovarian cancer thiothixene Launched dopamine receptor antagonist DRD1 | DRD2 | HRH1 | HTR2A neurology/psychiatry schizophrenia thiram Launched JAK2 ophthalmology contact dermatitis THK5351 Phase 2 PET radiotracer thonzonium Launched ATPase inhibitor infectious disease ear infections thonzylamine Launched antihistamine neurology/psychiatry itching threo-2-methylisocitrate-(DL) Preclinical isocitrate lyase substrate thymalfasin Launched immune response modulator infectious disease | infectious disease hepatitis B | hepatitis C thymol Launched GABA receptor positive allosteric modulator TRPA1 infectious disease | infectious disease antiseptic | ringworm thymol-iodide Preclinical thymopentin Launched immune response stimulator THZ1 Preclinical CDK inhibitor CDK7 THZ1-R Preclinical CDK inhibitor CDK7 THZ2 Preclinical CDK inhibitor CDK7 tiabendazole Launched angiogenesis inhibitor infectious disease | infectious disease gastrointestinal roundworms | hookworm tiagabine Launched GABA uptake inhibitor CYP2C19 | SLC6A1 neurology/psychiatry seizures tiamulin Launched bacterial 50s ribosomal subunit inhibitor infectious disease dysentry tianeptine Launched selective serotonin reuptake enhancer (SSRE) OPRD1 | OPRK1 | OPRM1 | SLC6A4 gastroenterology | neurology/psychiatry | pulmonary asthma | depression | irritable bowel syndrome tianeptine (sodium salt) tiapride Launched dopamine receptor antagonist DRD2 | DRD3 neurology/psychiatry | neurology/psychiatry | neurology/psychiatry abstinence from alcohol | dyskinesia | psychosis tiaprofenic-acid Launched cyclooxygenase inhibitor PTGS1 | PTGS2 rheumatology rheumatoid arthritis tiaramide Launched anti-inflammatory agent ADRB2 pulmonary asthma tibolone Launched androgen receptor agonist | estrogen receptor agonist | progesterone receptor agonist AR | ESR1 | PGR | STS obstetrics/gynecology | Oncology breast cancer | endometriosis TIC10 Phase 2 AKT inhibitor | TRAIL modulator AKT1 | MAPK1 ticagrelor Launched purinergic receptor antagonist CYP3A5 | P2RY12 cardiology | cardiology | cardiology "acute coronary syndrome (ACS) | acute coronary syndrome (acs), myocardial infarction | myocardial infarction" ticarcillin Launched lactamase inhibitor infectious disease gram-negative bacterial infections ticlopidine Launched purinergic receptor antagonist CYP2B6 | CYP2C19 | P2RY12 hematology | neurology/psychiatry stroke | thrombosis tideglusib Phase 2 glycogen synthase kinase inhibitor GSK3B tie2-kinase-inhibitor Preclinical TIE tyrosine kinase inhibitor KDR | MAPK14 | TEK tienilic-acid Withdrawn cytochrome P450 inhibitor | sodium/potassium/chloride transporter inhibitor CYP2C9 | SLC12A1 | SLC22A12 tifenazoxide Phase 1 ATP-sensitive potassium channel agonist ABCC8 | KCNJ11 tigecycline Launched "bacterial 30S ribosomal subunit inhibitor | bacterial 30s ribosomal subunit inhibitor, bacterial dna inhibitor | bacterial dna inhibitor" "infectious disease | infectious disease | infectious disease | Infectious disease | infectious disease, Infectious disease" "gram-negative bacterial infections | intra-abdominal infections | pneumonia | skin infections | skin infections, pneumonia, intra-abdominal infections, gram-negative bacterial infections" tildipirosin Launched bacterial 50s ribosomal subunit inhibitor infectious disease respiratory tract infections tilmicosin Launched bacterial 50S ribosomal subunit inhibitor pulmonary bovine respiratory disease (BRD) tilorone Launched interferon inducer gastroenterology | infectious disease | infectious disease | infectious disease | infectious disease | infectious disease | neurology/psychiatry diarrhea | hepatitis B | hepatitis C | influenza A virus infection | multiple sclerosis | urinary tract infections | virus herpes simplex (HSV) tiludronate Launched bone resorption inhibitor | osteoclast inhibitor ATP6V1A | MMP2 | PTPN1 orthopedics navicular syndrome timofibrate Phase 2 cholesterol inhibitor | lipase clearing factor inhibitor LPL timolol Launched adrenergic receptor antagonist ADRB1 | ADRB2 ophthalmology | ophthalmology glaucoma | ocular hypertension timolol maleate Launched adrenergic receptor antagonist ADRB1 | ADRB2 ophthalmology "ocular hypertension, glaucoma" timonacic Launched antioxidant tinazoline Launched adrenergic receptor agonist ADRA1A | ADRA1B | ADRA1D | ADRB1 tinidazole Launched antiprotozoal agent infectious disease | infectious disease | infectious disease | obstetrics/gynecology amebiasis | bacterial vaginosis | giardiasis | trichomoniasis tinoridine Launched anti-inflammatory agent neurology/psychiatry pain relief tioconazole Launched sterol demethylase inhibitor infectious disease yeast infection tioguanine Launched purine antagonist hematologic malignancy | hematologic malignancy | hematologic malignancy acute lymphoblastic leukemia (ALL) | acute myeloid leukemia (AML) | chronic myeloid leukemia (CML) tiopronin Launched chelating agent | reducing agent urology kidney stones tiotidine Phase 2 histamine receptor antagonist HRH2 tiotropium Launched acetylcholine receptor antagonist CHRM1 | CHRM2 | CHRM3 pulmonary | pulmonary | pulmonary bronchitis | chronic obstructive pulmonary disease (COPD) | emphysema tioxolone Preclinical carbonic anhydrase inhibitor CA1 | CA2 tipelukast Phase 2 leukotriene receptor antagonist ALOX5 | CYSLTR1 | CYSLTR2 | LTB4R | LTB4R2 tipepidine Phase 2 g protein signaling inhibitor KCNJ3 neurology/psychiatry attention-deficit/hyperactivity disorder (adhd) tipifarnib Phase 3 farnesyltransferase inhibitor FNTA | FNTB tipiracil Launched thymidine phosphorylase inhibitor TYMP oncology colorectal cancer tiplaxtinin Phase 1 plasminogen activator inhibitor SERPINE1 tipranavir Launched HIV protease inhibitor infectious disease human immunodeficiency virus (HIV-1) tiprenolol Phase 2 adrenergic receptor antagonist ADRB1 | ADRB2 | ADRB3 tiquizium Launched acetylcholine receptor antagonist neurology/psychiatry spasms tirabrutinib Launched bruton's tyrosine kinase (btk) inhibitor BTK hematologic malignancy small lymphocytic lymphoma (sll) tiracizine Withdrawn sodium channel blocker SCN5A tirapazamine Phase 3 DNA inhibitor tirasemtiv Phase 2 troponin activator tiratricol Launched thyroid hormone stimulant THRA | THRB endocrinology Refetoff syndrome tirbanibulin Launched protein tyrosine kinase inhibitor SRC | TUBB dermatology actinic keratosis (ak) tirofiban Launched platelet aggregation inhibitor | structural glycoprotein antagonist ITGA2B | ITGB3 cardiology | cardiology myocardial infarction | refactory angina titanocene-dichloride Phase 2 apoptosis stimulant tivantinib Phase 3 tyrosine kinase inhibitor MET tivozanib Launched VEGFR inhibitor FLT1 | FLT4 | KDR | KIT | PDGFRA | PDGFRB oncology renal cell carcinoma (RCC) tizanidine Launched adrenergic receptor agonist ADRA2A | ADRA2B | ADRA2C | CYP1A2 | NISCH neurology/psychiatry spasms tk216 Phase 1 binding of rna helicase a to the transcription factor ews-fli1 inhibitor EWSR1 | FLI1 oncology ewing's sarcoma TMC-353121 Phase 2 RSV fusion inhibitor TMC647055 Phase 2 RNA polymerase inhibitor TMN-355 Preclinical cyclophilin inhibitor PPIA TMPH Preclinical TMS Preclinical tno155 Phase 1/Phase 2 tyrosine phosphatase inhibitor PTPN11 oncology colorectal cancer TNP-470 Phase 2 methionine aminopeptidase inhibitor METAP2 tobramycin Launched bacterial 30S ribosomal subunit inhibitor infectious disease | infectious disease | infectious disease | infectious disease | infectious disease bacterial septicemia | meningitis | respiratory tract infections | skin infections | urinary tract infections tocainide Launched sodium channel blocker SCN5A cardiology cardiac arrythmia tocainide hydrochloride Launched sodium channel blocker SCN5A cardiology cardiac arrythmia toceranib Launched protein tyrosine kinase inhibitor FGF2 | FLT1 | FLT3 | KDR | PDGFRA | PDGFRB oncology cutaneous mast cell tumors tocofersolan Launched antioxidant cardiology cerebral cholesterosis todralazine Launched antihypertensive agent cardiology hypertension tofacitinib Launched JAK inhibitor CYP2C19 | JAK1 | JAK2 | JAK3 rheumatology rheumatoid arthritis tofisopam Launched cytochrome P450 inhibitor | phosphodiesterase inhibitor CYP3A4 | GABRA1 | GABRA2 | GABRA3 | GABRA5 neurology/psychiatry | neurology/psychiatry abstinence from alcohol | anxiety tofogliflozin Launched sodium/glucose cotransporter inhibitor GCK | SLC5A2 endocrinology diabetes mellitus tolamolol Phase 3 adrenergic receptor antagonist ADRB1 | ADRB2 | ADRB3 tolazamide Launched ATP channel blocker ABCC8 | KCNJ1 | KCNJ10 | KCNJ11 endocrinology diabetes mellitus tolazoline Launched adrenergic receptor antagonist ADRA1A | ADRA2A | ADRA2B | ADRA2C | HRH1 | HRH2 neurology/psychiatry reverse sedative tolbutamide Launched ATP channel blocker ABCC8 | CYP2B6 | CYP2C19 | CYP2C8 | KCNJ1 | KCNJ11 | KCNJ8 endocrinology diabetes mellitus tolcapone Withdrawn catechol O methyltransferase inhibitor COMT | TTR tolebrutinib Phase 3 bruton's tyrosine kinase (btk) inhibitor BTK neurology/psychiatry multiple sclerosis tolfenamic-acid Launched cyclooxygenase inhibitor | prostanoid receptor antagonist neurology/psychiatry migraine headache tolimidone Phase 2 SRC activator LYN | SRC tolmetin Launched cyclooxygenase inhibitor PTGS1 | PTGS2 rheumatology | rheumatology osteoarthritis | rheumatoid arthritis tolnaftate Launched fungal squalene epoxidase inhibitor infectious disease | infectious disease tinea corporis | tinea pedis tolonidine Launched adrenergic receptor antagonist ADRA2A tolonium Launched hematology methemoglobinemia toloxatone Launched monoamine oxidase inhibitor MAOA | MAOB neurology/psychiatry depression tolperisone Launched voltage-gated sodium channel blocker CYP2B6 | CYP2C19 | CYP2D6 cardiology | infectious disease | neurology/psychiatry | neurology/psychiatry | rheumatology | rheumatology ankylosing spondylitis | atherosclerosis | encephalomyelitis | multiple sclerosis | muscle relaxant | Raynaud's disease tolrestat Withdrawn aldose reductase inhibitor AKR1A1 | AKR1B1 | AKR1B10 tolterodine Launched acetylcholine receptor antagonist CHRM1 | CHRM2 | CHRM3 | CHRM4 | CHRM5 urology | urology urinary frequency | urinary incontinence toltrazuril Launched antiprotozoal agent infectious disease coccidiosis tolvaptan Launched vasopressin receptor antagonist AVPR1A | AVPR2 cardiology | endocrinology | gastroenterology congestive heart failure | hepatic cirrhosis | hyponatremia tomeglovir Preclinical antiviral tomelukast Phase 3 leukotriene receptor antagonist CYSLTR1 tomivosertib Phase 2 MAPK-interacting kinase inhibitor MKNK1 | MKNK2 tonabersat Phase 2 gap junction modulator | nitric oxide production inhibitor topilutamide Preclinical androgen receptor antagonist AR topiramate Launched carbonic anhydrase inhibitor | glutamate receptor antagonist | kainate receptor antagonist CA1 | CA12 | CA2 | CA4 | CA7 | CYP2C19 | CYP3A4 | GABRA1 | GABRA2 | GABRA3 | GABRA4 | GABRA5 | GABRA6 | GABRB1 | GABRB2 | GABRB3 | GABRD | GABRE | GABRG1 | GABRG2 | GABRG3 | GABRP | GABRQ | GRIA1 | GRIA2 | GRIA3 | GRIA4 | GRIK1 | GRIK2 | GRIK3 | GRIK4 | GRIK5 | SCN10A | SCN11A | SCN1A | SCN2A | SCN3A | SCN4A | SCN5A | SCN7A | SCN8A | SCN9A neurology/psychiatry | neurology/psychiatry epilepsy | migraine headache topiroxostat Launched xanthine oxidase inhibitor XDH nephrology | rheumatology gout | hyperuricemia topotecan Launched topoisomerase inhibitor TOP1 | TOP1MT oncology | oncology cervical cancer | small cell lung cancer torasemide Launched electrolyte reabsorption inhibitor | thromboxane receptor antagonist CYP2C8 | SLC12A1 | SLC12A2 cardiology | cardiology | cardiology congestive heart failure | edema | hypertension torcetrapib Phase 3 cholesteryl ester transfer protein inhibitor CETP torcitabine Phase 2 DNA polymerase inhibitor DCK | TK2 toremifene Launched estrogen receptor antagonist | selective estrogen receptor modulator (SERM) CYP3A5 | ESR1 oncology breast cancer torin-1 Preclinical mTOR inhibitor MTOR | PIK3CA torin-2 Preclinical mTOR inhibitor MTOR tosedostat Phase 2 peptidase inhibitor ANPEP | LAP3 | NPEPPS tosufloxacin Launched bacterial DNA gyrase inhibitor infectious disease gram-negative bacterial infections toyocamycin Phase 1 serine/threonine kinase inhibitor ERN1 tozadenant Phase 3 adenosine receptor antagonist ADORA2A tozasertib Phase 2 Aurora kinase inhibitor | Bcr-Abl kinase inhibitor | FLT3 inhibitor | JAK inhibitor ABL1 | AURKA | AURKB | AURKC | BCR | DDR2 | FLT3 | JAK2 | LCK TP-003 Preclinical GABA receptor inverse agonist GABRA1 | GABRA2 | GABRA3 | GABRA5 | GABRB3 | GABRG2 TP-0903 Phase 1/Phase 2 AXL kinase inhibitor AURKA | AURKB | AXL TP-3654 Phase 1 "1,4,5-trisphosphate inhibitor" PIM1 | PIM3 TPCA-1 Preclinical IKK inhibitor IKBKB tpps4 Phase 1 TPPS4 Phase 1 trabectedin Phase 3 antitumor agent IL6 trabodenoson Phase 3 adenosine receptor agonist ADORA1 tracazolate Phase 2 GABA receptor modulator GABRA1 tradipitant Phase 3 neurokinin receptor antagonist TAC1 | TACR1 TRAM-34 Preclinical potassium channel antagonist KCNN4 TRAM-39 Preclinical calcium-activated potassium channel activator KCNN4 tramadol hydrochloride trametinib Launched MEK inhibitor CYP2C8 | CYP3A4 | MAP2K1 | MAP2K2 oncology melanoma tramiprosate Phase 3 beta amyloid protein neurotoxicity inhibitor APP trandolapril Launched angiotensin converting enzyme inhibitor ACE cardiology | cardiology | cardiology "hypertension | hypertension, myocardial infarction | myocardial infarction" tranexamic-acid Launched antifibrinolytic | plasminogen activator inhibitor FGA | FGB | FGG | PLAT | PLG hematology hemophilia tranilast Launched angiogenesis inhibitor HPGDS | HRH1 | IDO1 | IFNG | IL10 | IL2 | IL4 | SLC22A12 | TGFB1 | TNF | TRPV2 pulmonary asthma "trans-10,cis-12-conjugated-linoleic-acid" Launched trans-2-undecenoic-acid Preclinical "trans-4-[8-(3-fluorophenyl)-1,7-naphthyridin-6-yl]cyclohexanecarboxylic-acid" Preclinical trans-4-hydroxycrotonic-acid Preclinical gamma hydroxybutyric acid ligand trans-4-methoxycinnamic-acid Preclinical transcrocetinate Preclinical glutamate receptor antagonist GRIN1 | GRIN2A tranylcypromine Launched monoamine oxidase inhibitor CYP2A6 | KDM1A | MAOA | MAOB neurology/psychiatry depression tranylcypromine (2-pcpa) hcl tranylcypromine hydrochloride Launched monoamine oxidase inhibitor KDM1A | MAOA | MAOB neurology/psychiatry depression tranylcypromine sulfate Launched monoamine oxidase inhibitor KDM1A | MAOA | MAOB neurology/psychiatry depression trap-101 Preclinical nociceptin/orphanin FQ receptor antagonist | opioid receptor antagonist OPRL1 trapidil Launched PDGFR tyrosine kinase receptor inhibitor PDGFRA cardiology coronary artery disease (CAD) travoprost Launched prostanoid receptor agonist PTGFR ophthalmology | ophthalmology glaucoma | ocular hypertension traxoprodil Phase 2 glutamate receptor antagonist GRIN2B trazodone Launched adrenergic receptor antagonist | serotonin receptor antagonist | serotonin reuptake inhibitor ADRA1A | ADRA2A | HRH1 | HTR1A | HTR2A | HTR2B | HTR2C | SLC6A4 neurology/psychiatry depression trebenzomine Phase 2 trelagliptin Launched dipeptidyl peptidase inhibitor DPP4 endocrinology diabetes mellitus tremorine Preclinical acetylcholine receptor agonist treosulfan Launched DNA synthesis inhibitor oncology ovarian cancer trepibutone Launched cholinergic receptor antagonist CHRM1 | CHRM2 | CHRM3 | CHRM4 gastroenterology irritable bowel syndrome treprostinil Launched prostanoid receptor agonist P2RY12 | PPARD | PTGDR | PTGER2 | PTGIR pulmonary pulmonary arterial hypertension (PAH) trequinsin Phase 1 phosphodiesterase inhibitor PDE4A | PDE4B | PDE4C | PDE4D | PDE5A | PTGIR tretazicar Phase 2 DNA replication inhibitor NQO2 tretinoin Launched retinoid receptor agonist | retinoid receptor ligand ALDH1A1 | ALDH1A2 | GPRC5A | NR0B1 | NR2C2 | PPARD | RARA | RARB | RARG | RARRES1 | RORB | RORC | RXRB | RXRG hematologic malignancy acute promyelocytic leukemia (APL) triacetin Launched triamcinolone Launched glucocorticoid receptor agonist NR3C1 dermatology corticosteroid-responsive dermatoses triamcinolone acetonide Launched "glucocorticoid receptor agonist, immunosuppressant" NR3C1 | SERPINA6 dermatology corticosteroid-responsive dermatoses triamcinolone-acetonide Launched glucocorticoid receptor agonist | immunosuppressant CYP3A5 | CYP3A7 | NR3C1 | SERPINA6 dermatology corticosteroid-responsive dermatoses triamcinolone-hexacetonide Launched anti-inflammatory agent triamterene Launched sodium channel blocker SCNN1A | SCNN1B | SCNN1D | SCNN1G cardiology | cardiology | endocrinology edema | hypertension | hypokalemia triapine Phase 2 ribonucleotide reductase inhibitor RRM1 | RRM2 tribenoside Launched anti-inflammatory agent | capillary stabilizing agent tribomsalan Preclinical tribromoethanol Preclinical analgesic agent tributyrin Phase 1 HDAC inhibitor tricaine Withdrawn sodium channel blocker SCN1A neurology/psychiatry anesthetic tricaprylin Launched dermatology cosmetic trichlormethiazide Launched chloride channel blocker PTGS1 | PTGS2 | SLC12A1 cardiology | cardiology edema | hypertension trichloroacetic-acid Launched dermatology warts trichloroethylene Preclinical trichostatin-a Phase 1 HDAC inhibitor HDAC1 | HDAC10 | HDAC2 | HDAC3 | HDAC4 | HDAC5 | HDAC6 | HDAC7 | HDAC8 | HDAC9 triciribine Phase 1/Phase 2 AKT inhibitor AKT1 | AKT2 | AKT3 triciribine-phosphate Phase 1/Phase 2 AKT inhibitor AKT1 | AKT2 | AKT3 triclabendazole Launched microtubule inhibitor DNMT1 infectious disease tapeworm triclocarban Launched other antibiotic infectious disease first-aid antiseptic triclosan Launched antibacterial agent DNMT1 infectious disease first-aid antiseptic tridihexethyl Launched acetylcholine receptor antagonist gastroenterology | ophthalmology nystagmus | peptic ulcer disease (PUD) trientine Launched chelating agent CA14 metabolism Wilson's disease trifarotene Launched retinoid receptor agonist RARA | RARB | RARG dermatology acne vulgaris (av) trifloxystrobin Preclinical mitochondrial electron transport inhibitor trifluoperazine Launched dopamine receptor antagonist ABCG2 | ADRA1A | CALM1 | CALY | CAMK2A | DRD2 | DRD4 | HRH1 | HTR2A | HTR2C | S100A4 | SCN4A | SCN9A | TNNC1 neurology/psychiatry schizophrenia triflupromazine Launched dopamine receptor antagonist CHRM1 | CHRM2 | CHRNA7 | DRD1 | DRD2 | HTR2B gastroenterology | gastroenterology | neurology/psychiatry nausea | psychosis | vomiting trifluridine Launched DNA directed DNA polymerase inhibitor | thymidylate synthase inhibitor TYMS infectious disease virus herpes simplex (HSV) triflusal Launched cyclooxygenase inhibitor | platelet aggregation inhibitor | thromboxane synthase inhibitor NFKB1 | NOS2 | PDE10A | PDE4A | PDE4B | PDE4C | PDE4D | PTGS1 | PTGS2 cardiology | cardiology | neurology/psychiatry atrial fibrillation (AF) | myocardial infarction | stroke trigonelline Phase 1 triheptanoin Launched anticonvulsant cardiology cardiomyopathy trihexyphenidyl Launched acetylcholine receptor antagonist CHRM1 neurology/psychiatry parkinsonism trihexyphenidyl hydrochloride Launched acetylcholine receptor antagonist CHRM1 neurology/psychiatry parkinsonism trilaciclib Phase 2 CDK inhibitor CDK4 | CDK6 trilostane Launched 3beta-hydroxy-delta5-steroid dehydrogenase inhibitor ESR1 | ESR2 | HSD3B2 | JUN | NR3C1 endocrinology Cushing's syndrome TRIM Preclinical trimebutine Launched opioid receptor agonist CHRM1 | CHRM2 | CHRM3 | CHRM4 | OPRD1 | OPRK1 | OPRM1 gastroenterology irritable bowel syndrome trimebutine maleate Launched opioid receptor agonist OPRD1 | OPRK1 | OPRM1 gastroenterology irritable bowel syndrome trimetaphan camsilate Withdrawn acetylcholine receptor antagonist CHRNA10 cardiology hypertension trimetazidine Launched 3-ketoacyl CoA thiolase inhibitor ACAA2 cardiology angina pectoris trimethadione Launched oxazolidine antiepileptic CACNA1G | CACNA1H | CACNA1I neurology/psychiatry seizures trimethobenzamide Launched histamine receptor antagonist DRD2 gastroenterology | gastroenterology | gastroenterology gastroenteritis | nausea | vomiting trimethoprim Launched dihydrofolate reductase inhibitor CYP2C8 | DHFR | SLC22A2 | TYMS gastroenterology | infectious disease | infectious disease diarrhea | ear infections | urinary tract infections trimethoquinol Launched adrenergic receptor antagonist ADRB2 | ADRB3 pulmonary asthma trimethylolpropane-triacrylate Preclinical trimetozine Launched sedative neurology/psychiatry sedative trimetrexate Phase 3 dihydrofolate reductase inhibitor DHFR trimipramine Launched norepinephrine reputake inhibitor | tricyclic antidepressant SLC6A2 | SLC6A3 | SLC6A4 neurology/psychiatry depression trimipramine maleate Launched "norepinephrine reputake inhibitor, tricyclic antidepressant" SLC6A2 | SLC6A3 | SLC6A4 neurology/psychiatry depression trioxsalen Launched DNA synthesis inhibitor dermatology | dermatology eczema | vitiligo tripelennamine Launched histamine receptor antagonist HRH1 allergy | allergy | pulmonary allergic rhinitis | asthma | urticaria triprolidine Launched histamine receptor antagonist HRH1 allergy allergic rhinitis triptan Phase 1 serotonin receptor agonist HTR1B | HTR1D triptolide Phase 3 RNA polymerase inhibitor CYP2C19 | RELA triptorelin Launched gonadotropin releasing factor hormone receptor agonist GNRH1 | GNRHR endocrinology | endocrinology | obstetrics/gynecology | obstetrics/gynecology | oncology | oncology breast cancer | endometriosis | gender dysphoria | myoma | precocious puberty | prostate cancer tro 19622 troclosene Launched trodusquemine Phase 1 tyrosine phosphatase inhibitor PTPN1 trofinetide Phase 3 anti-inflammatory agent | cytokine production inhibitor ATF3 | IFNG | IL6 | TNF trofosfamide Launched DNA alkylating agent oncology medulloblastoma troglitazone Withdrawn insulin sensitizer | PPAR receptor agonist AKR1B1 | CCL2 | CYP2C8 | CYP3A4 | INS | PPARG | TRPM3 troleandomycin Launched protein synthesis inhibitor | ribosomal protein inhibitor "infectious disease | infectious disease, pulmonary, otolaryngology | otolaryngology | otolaryngology | pulmonary" "bronchitis | pneumonia | pneumonia, bronchitis, tonsillitis, sinusitis | sinusitis | tonsillitis" trolox Launched antioxidant tromaril Launched prostanoid receptor antagonist ophthalmology eye inflammation trometamol Launched AMD1 | CANT1 | DCN | NEIL1 | VEGFA "tropanyl-3,5-dimethylbenzoate" Preclinical serotonin receptor antagonist HTR3A | HTR3B tropesin Launched cyclooxygenase inhibitor PTGS1 | PTGS2 tropicamide Launched acetylcholine receptor antagonist CHRM3 | CHRM4 ophthalmology | ophthalmology cycloplegia diagnostic | mydriasis diagnostic tropifexor Phase 2 FXR agonist NR1H4 tropisetron Launched serotonin receptor antagonist GLRA1 | GLRA2 | GLRB | HTR3A | HTR4 gastroenterology | gastroenterology nausea | vomiting trospium Launched acetylcholine receptor antagonist CHRM1 urology | urology urinary frequency | urinary incontinence trospium chloride Launched acetylcholine receptor antagonist CHRM1 urology "urinary incontinence, urinary frequency" trovafloxacin Withdrawn bacterial DNA gyrase inhibitor TOP2A troventol Phase 1 trovirdine Phase 1 non-nucleoside reverse transcriptase inhibitor troxerutin Launched antioxidant troxipide Launched glucosamine synthetase stimulant gastroenterology gastroesophageal reflux disease (GERD) TRV130 Phase 3 opioid receptor agonist OPRM1 tryptanthrin Preclinical cyclooxygenase inhibitor ALOX5 | HGF | IDO1 | PTGS2 tryptophan Launched serotonin receptor partial agonist CASR | IDO1 | SLC36A1 | WARS | WARS2 gastroenterology | gastroenterology | neurology/psychiatry | neurology/psychiatry | neurology/psychiatry anxiety | bloating | constipation | fatigue | sleeplessness TS-011 Preclinical delayed vasospasm antagonist TTNPB Phase 1 retinoid receptor agonist RARA | RARB | RARG TTP-22 Preclinical casein kinase inhibitor CSNK2A1 TU-2100 Phase 2 tuaminoheptane Launched otolaryngology nasal congestion tubastatin-A Preclinical HDAC inhibitor HDAC6 tubocurarine Launched acetylcholine receptor antagonist ACHE | CHRNA2 | HTR3A | HTR3B | KCNN1 | KCNN2 | KCNN3 | ZACN neurology/psychiatry anesthetic tucatinib Phase 3 EGFR inhibitor ERBB2 tucidinostat Phase 3 HDAC inhibitor HDAC1 | HDAC10 | HDAC2 | HDAC3 tuftsin Preclinical macrophage activator TUG-770 Preclinical free fatty acid receptor agonist FFAR1 TUG-891 Preclinical free fatty acid receptor agonist FFAR4 tulathromycin Launched bacterial 50s ribosomal subunit inhibitor pulmonary bovine respiratory disease (brd) tulobuterol Launched adrenergic receptor agonist ADRB2 pulmonary asthma tulobuterol hydrochloride Launched adrenergic receptor agonist ADRB2 pulmonary asthma tulrampator Phase 2 antidepressant CNIH1 | CNIH2 | CNIH3 | CNIH4 TW-37 Preclinical BCL inhibitor BCL2 | BCL2L1 | MCL1 TWS-119 Preclinical glycogen synthase kinase inhibitor GSK3B | JUN | MYC TXA127 Phase 2 angiotensin receptor agonist TY-52156 Preclinical sphingosine 1-phosphate receptor antagonist S1PR3 tylosin Launched protein synthesis inhibitor gastroenterology | infectious disease colitis | gram-positive bacterial infections tyloxapol tylvalosin Launched bacterial 50s ribosomal subunit inhibitor infectious disease gram-negative bacterial infections tymazoline Launched allergy allergic rhinitis tyroserleutide Phase 3 antitumor agent PIK3CA oncology hepatocellular carcinoma (hcc) tyrphostin-A9 Preclinical protein tyrosine kinase inhibitor | tyrosine kinase inhibitor tyrphostin-AG-1296 Preclinical FLT3 inhibitor FLT3 tyrphostin-AG-1478 Preclinical EGFR inhibitor EGFR | MAPK14 tyrphostin-AG-18 Preclinical EGFR inhibitor | tyrosine kinase inhibitor EGFR tyrphostin-AG-494 Preclinical EGFR inhibitor EGFR tyrphostin-AG-825 Preclinical protein tyrosine kinase inhibitor ERBB2 tyrphostin-AG-835 Preclinical protein tyrosine kinase inhibitor EGFR tyrphostin-AG-879 Preclinical tyrosine kinase inhibitor ERBB2 | KDR | NTRK1 tyrphostin-AG-99 Preclinical tyrosine kinase inhibitor EGFR U-0124 Preclinical MEK inhibitor U-0126 Preclinical MEK inhibitor AKT1 | CHEK1 | GSK3B | JAK2 | LCK | MAP2K1 | MAP2K2 | MAP2K7 | MAPK1 | MAPK11 | MAPK12 | MAPK14 | MAPK8 | PRKCA | RAF1 | ROCK1 | RPS6KB1 | SGK1 U-0521 Preclinical catechol O methyltransferase inhibitor COMT U-104 Phase 1/Phase 2 carbonic anhydrase inhibitor CA1 | CA12 | CA2 | CA9 U-18666A Preclinical oxidosqualene cyclase inhibitor U-50488-(-) Preclinical opioid receptor agonist OPRK1 U-54494A Preclinical opioid receptor agonist OPRK1 U-75799E Phase 1 growth hormone releasing factor agonist GH1 | GHSR U-99194 Preclinical dopamine receptor antagonist DRD3 UAMC-00039 Preclinical dipeptidyl peptidase inhibitor DPP4 | DPP7 UB-165 Preclinical acetylcholine receptor agonist CHRNA3 | CHRNA4 | CHRNB2 ubenimex Launched leukotriene synthesis inhibitor ANPEP | LTA4H | RNPEP hematologic malignancy acute myeloid leukemia (AML) UBP-296 Preclinical glutamate receptor antagonist GRIK1 UBP-302 Preclinical glutamate receptor antagonist GRIK1 UBP-310 Preclinical glutamate receptor antagonist GRIK1 | GRIK5 ubrogepant Launched calcitonin antagonist CALCRL neurology/psychiatry migraine headache UC-112 Preclinical XIAP inhibitor XIAP UCL-2077 Preclinical slow afterhyperpolarization channel blocker udenafil Launched phosphodiesterase inhibitor PDE5A urology erectile dysfunction UF-010 Preclinical HDAC inhibitor HDAC1 | HDAC2 | HDAC3 | HDAC8 ufenamate Launched cyclooxygenase inhibitor PTGS1 | PTGS2 dermatology | dermatology dermatitis | eczema UH-232-(+) Preclinical dopamine receptor antagonist DRD2 | DRD3 | DRD4 | HTR1A UK-356618 Preclinical metalloproteinase inhibitor MMP13 | MMP14 | MMP2 | MMP3 | MMP9 UK-383367 Phase 1 procollagen C-endopeptidase inhibitor BMP1 UK-5099 Preclinical monocarboxylate transporter inhibitor SLC16A1 uki-1 Preclinical urokinase inhibitor PLAU ulifloxacin Launched infectious disease | infectious disease gram-negative bacterial infections | gram-positive bacterial infections ulipristal Launched progesterone receptor antagonist PGR endocrinology contraceptive umbralisib Launched casein kinase inhibitor ABL1 | CSNK1E | PIK3CD hematologic malignancy non-hodgkin lymphoma (nhl) umeclidinium Launched acetylcholine receptor antagonist CHRM1 | CHRM2 | CHRM3 pulmonary | pulmonary | pulmonary bronchitis | chronic obstructive pulmonary disease (COPD) | emphysema unbs-5162 Phase 1 CC chemokine receptor antagonist UNC0224 Preclinical histone lysine methyltransferase inhibitor EHMT1 | EHMT2 UNC0321 Preclinical histone lysine methyltransferase inhibitor EHMT2 UNC0631 Preclinical histone lysine methyltransferase inhibitor EHMT2 UNC0638 Preclinical histone lysine methyltransferase inhibitor EHMT1 | EHMT2 UNC0642 Preclinical histone lysine methyltransferase inhibitor EHMT1 | EHMT2 UNC0646 Preclinical histone lysine methyltransferase inhibitor EHMT2 UNC0737 Preclinical histone lysine methyltransferase inhibitor EHMT1 | EHMT2 UNC1215 Preclinical L3MBTL antagonist L3MBTL3 UNC1999 Preclinical histone lysine methyltransferase inhibitor EZH1 | EZH2 UNC2025 Preclinical FLT3 inhibitor | MER tyrosine kinase inhibitor AXL | FLT3 | MERTK | TYRO3 UNC2250 Preclinical MER tyrosine kinase inhibitor MERTK UNC2327 Preclinical protein arginine N-methyltransferase inhibitor PRMT3 UNC3230 Preclinical phosphatidyl-inositol activator PIP5K1C UNC669 Preclinical L3MBTL antagonist L3MBTL1 | L3MBTL3 UNC926 Preclinical MBT inhibitor L3MBTL1 | L3MBTL3 undecylenic-acid Launched other antifungal infectious disease | infectious disease tinea corporis | tinea pedis upadacitinib Launched JAK inhibitor JAK1 upamostat Phase 2 serine protease inhibitor PLAU UPF-1069 Preclinical PARP inhibitor PARP2 uprifosbuvir Preclinical antiviral uprosertib Phase 2 AKT inhibitor AKT1 | AKT2 | AKT3 uracil Launched DPYD | UCKL1 uracil-mustard Launched DNA synthesis inhibitor hematologic malignancy non-Hodgkin lymphoma (NHL) urapidil Launched adrenergic receptor antagonist HTR1A cardiology hypertension URB597 Phase 1 FAAH inhibitor FAAH | FAAH2 | TRPA1 urea Launched hydroxy radical formation stimulant ARG1 | CA2 | CTNNB1 dermatology | dermatology | dermatology | dermatology | dermatology | dermatology dermatitis | eczema | ichthyosis vulgaris | keratosis | psoriasis | xerosis cutis urethane Preclinical local anesthetic uric-acid Phase 3 PYGL uridine Phase 2 dopamine receptor agonist LSM6 | TYMP uridine-5'-triphosphate Launched purinergic receptor activator P2RY11 | P2RY2 | P2RY4 | P2RY6 | UCK2 uridine-triacetate Launched nephrology orotic aciduria URMC-099 Preclinical mixed lineage kinase inhibitor CDKL2 | DAPK3 | FLT3 | LRRK2 | MAP3K10 | MAP3K11 | MAP3K2 | MAP3K9 | SRPK2 urolithin-A Phase 3 antioxidant ursodeoxycholyltaurine Phase 3 cholesterol inhibitor ursodiol Launched "nuclear factor erythroid derived, like (NRF2) activator" AKR1C2 | NFE2L2 | NR1H4 gastroenterology gallstones ursolic-acid Phase 2/Phase 3 ATPase inhibitor | NFkB pathway inhibitor | STAT inhibitor ACHE | CASP3 | HSD11B1 | PLA2G1B | PTPN1 | PYGM | STS usl311 Phase 1/Phase 2 cc chemokine receptor antagonist CXCR4 oncology glioblastoma usniacin-(+) Preclinical MAP kinase activator PTPN1 V-51 Phase 1 adrenergic receptor antagonist vabicaserin hydrochloride Phase 2 serotonin receptor agonist HTR2A | HTR2B | HTR2C neurology/psychiatry schizophrenia vaborbactam Launched beta lactamase inhibitor LACTB vadadustat Phase 3 hypoxia inducible factor prolyl hydroxylase inhibitor EGLN1 | EGLN2 | EGLN3 valaciclovir Launched DNA polymerase inhibitor infectious disease | infectious disease shingles | virus herpes simplex (HSV) valbenazine Launched vesicular monoamine transporter inhibitor SLC18A2 neurology/psychiatry dyskinesia valdecoxib Withdrawn cyclooxygenase inhibitor CA12 | CYP2C19 | PTGS2 valethamate Launched acetylcholine receptor antagonist CHRM1 | CHRM4 | CHRM5 obstetrics/gynecology labor induction valganciclovir Launched DNA synthesis inhibitor infectious disease cytomegalovirus (CMV) valganciclovir hydrochloride Launched dna synthesis inhibitor infectious disease cytomegalovirus (cmv) valnemulin Launched bacterial 50S ribosomal subunit inhibitor gastroenterology | infectious disease | infectious disease colitis | dysentry | pneumonia valnemulin hcl Launched bacterial 50s ribosomal subunit inhibitor "infectious disease, gastroenterology" "dysentry, colitis, pneumonia" valnivudine Phase 3 antiviral infectious disease varicella-zoster virus (vzv) valnoctamide Launched arachidonic acid acylation inhibitor | benzodiazepine receptor agonist neurology/psychiatry sleeplessness valproic-acid Launched benzodiazepine receptor agonist | HDAC inhibitor ABAT | ACADSB | ALDH5A1 | HDAC1 | HDAC2 | HDAC9 | OGDH | SCN10A | SCN11A | SCN1A | SCN1B | SCN2A | SCN2B | SCN3A | SCN3B | SCN4A | SCN4B | SCN5A | SCN7A | SCN8A | SCN9A neurology/psychiatry | neurology/psychiatry epilepsy | seizures valpromide Launched epoxide hydolase inhibitor neurology/psychiatry epilepsy valrocemide Phase 2 valrubicin Launched DNA inhibitor | topoisomerase inhibitor TOP2A oncology bladder cancer valsartan Launched angiotensin receptor antagonist AGTR1 cardiology | cardiology congestive heart failure | hypertension valspodar Phase 3 P glycoprotein inhibitor ABCB1 val-tyr Preclinical angiotensin converting enzyme inhibitor ACE | ACE2 vamorolone Phase 2 glucocorticoid receptor agonist DMD | NFKB1 | NR3C1 genetics duchenne muscular dystrophy (dmd) vancomycin Launched bacterial cell wall synthesis inhibitor infectious disease endocarditis vandetanib Launched EGFR inhibitor | RET tyrosine kinase inhibitor | VEGFR inhibitor EGFR | EPHA1 | EPHA10 | EPHA2 | EPHA3 | EPHA4 | EPHA5 | EPHA6 | EPHA7 | EPHA8 | EPHB1 | EPHB2 | EPHB3 | EPHB4 | EPHB6 | ERBB2 | ERBB3 | ERBB4 | FLT1 | FLT3 | FLT4 | KDR | KIT | PTK6 | RET | SRC | TEK | VEGFA oncology medullary thyroid cancer (MTC) vanillin Preclinical ABAT | ALDH5A1 vanillylacetone Preclinical vaniprevir Phase 3 serine protease inhibitor NS3/4A vanitiolide Preclinical vanoxerine Phase 3 dopamine reuptake inhibitor MAOA | MAOB | SLC6A3 vapendavir Phase 2 antiviral vardenafil Launched phosphodiesterase inhibitor CYP2C19 | CYP2C8 | CYP3A5 | PDE5A | PDE6G | PDE6H urology erectile dysfunction varenicline Launched acetylcholine receptor agonist CHRNA3 | CHRNA4 | CHRNA6 | CHRNA7 | CHRNB2 neurology/psychiatry smoking cessation varenicline tartrate Launched acetylcholine receptor agonist CHRNA3 | CHRNA4 | CHRNA6 | CHRNA7 neurology/psychiatry smoking cessation varespladib Phase 3 secretory phospholipase inhibitor PLA2G2A | PLA2G2D vasopressin Launched vasopressin receptor agonist AVPR1A | AVPR1B | AVPR2 | OXTR gastroenterology abdominal distension vatalanib Phase 3 KIT inhibitor | PDGFR tyrosine kinase receptor inhibitor | VEGFR inhibitor CYP19A1 | EGFR | FLT1 | FLT4 | KDR | KIT | PDGFRA | PDGFRB vatinoxan Preclinical adrenergic receptor antagonist ADRA2A VBY-825 Preclinical cathepsin inhibitor CTSB | CTSL | CTSS VCH-916 Phase 1 HCV inhibitor VE-821 Preclinical ATR kinase inhibitor ATR VE-822 Phase 2 ATR kinase inhibitor ATM | ATR | MTOR | PIK3CG vecabrutinib Phase 1/Phase 2 Bruton's tyrosine kinase (BTK) inhibitor BTK | ITK vecuronium Launched acetylcholine receptor antagonist CHRNA2 neurology/psychiatry muscle relaxant vedaprofen Launched anti-inflammatory agent PTGS1 | PTGS2 endocrinology | neurology/psychiatry fever | pain relief vedotin Phase 2 antimitotic agent TNFRSF10B | TPPP hematologic malignancy acute lymphoblastic leukemia (all) velaresol Preclinical HBB veledimex Phase 2 cytochrome P450 inhibitor CYP3A4 | CYP3A5 veliflapon Phase 3 leukotriene synthesis inhibitor ALOX5AP veliparib Phase 3 PARP inhibitor PARP1 | PARP2 velneperit Phase 2 neuropeptide receptor antagonist NPY5R velpatasvir Launched antiviral infectious disease hepatitis C vemurafenib Launched RAF inhibitor BRAF | CYP2C19 | CYP3A4 | CYP3A5 | RAF1 oncology melanoma venetoclax Launched BCL inhibitor BCL2 hematologic malignancy chronic lymphocytic leukemia (CLL) venlafaxine Launched adrenergic inhibitor | norepinephrine reuptake inhibitor | serotonin–norepinephrine reuptake inhibitor (SNRI) CYP2C19 | SLC6A2 | SLC6A4 neurology/psychiatry | neurology/psychiatry | neurology/psychiatry | neurology/psychiatry depression | generalized anxiety disorder (GAD) | panic disorders | social anxiety disorder VER-155008 Preclinical HSP inhibitor HSPA1A VER-49009 Preclinical HSP inhibitor HSP90AA1 veralipride Preclinical dopamine receptor antagonist DRD2 verapamil Launched calcium channel blocker CACNA1A | CACNA1B | CACNA1C | CACNA1D | CACNA1F | CACNA1G | CACNA1I | CACNA1S | CACNB1 | CACNB2 | CACNB3 | CACNB4 | CYP2C8 | CYP2E1 | CYP3A4 | CYP3A5 | CYP3A7 | DRD2 | KCNA10 | KCNA7 | KCNH2 | KCNJ11 | NALCN | SCN5A | SLC29A4 | SLC6A4 cardiology hypertension verbascoside Phase 2/Phase 3 NFkB pathway inhibitor | PKC inhibitor vercirnon Phase 3 CC chemokine receptor antagonist CCR9 verdinexor Preclinical exportin antagonist XPO1 verdiperstat Phase 3 myeloperoxidase inhibitor MPO vericiguat Phase 3 guanylate cyclase stimulant verinurad Phase 2 urate transporter inhibitor SLC22A12 vernakalant Launched potassium channel blocker KCNA5 | KCNJ3 | KCNJ5 | SCN5A cardiology atrial fibrillation (AF) verteporfin Launched photosensitizing agent ophthalmology macular degeneration verubecestat Phase 3 beta secretase inhibitor BACE1 verubulin Phase 2 tubulin polymerization inhibitor TUBB verucerfont Phase 2 corticotropin releasing factor receptor antagonist CRHR1 vesamicol Preclinical acetylcholinesterase inhibitor SLC18A3 vesnarinone Launched phosphodiesterase inhibitor IL6R | KCNA3 | KCNH2 | PDE3A | VCP cardiology congestive heart failure VGX-1027 Phase 1 tumor necrosis factor receptor antagonist TLR4 | TNF vicagrel Phase 2 platelet aggregation inhibitor P2RY12 cardiology coronary artery disease (cad) vicriviroc Phase 3 CC chemokine receptor antagonist CCR5 vidarabine Launched antiviral ADA | ADCY5 infectious disease | infectious disease varicella-zoster virus (VZV) | virus herpes simplex (HSV) vigabatrin Launched GABA aminotransferase inhibitor ABAT | SLC32A1 neurology/psychiatry | neurology/psychiatry seizures | spasms vilanterol Launched adrenergic receptor agonist ADRB2 pulmonary chronic obstructive pulmonary disease (COPD) vilanterol trifenatate Phase 3 adrenergic receptor agonist ADRB2 Lung diseases chronic obstructive pulmonary disease (copd) vilazodone Launched serotonin reuptake inhibitor CYP2C19 | CYP2E1 | DRD2 | DRD3 | HRH1 | HTR1A | HTR4 | SLC6A4 neurology/psychiatry depression vildagliptin Launched dipeptidyl peptidase inhibitor DPP4 endocrinology diabetes mellitus vildagliptin (laf-237) Launched dipeptidyl peptidase inhibitor DPP4 endocrinology diabetes mellitus viloxazine Launched norepinephrine reuptake inhibitor SLC6A2 | SLC6A4 neurology/psychiatry depression vimirogant Preclinical ror antagonist RORC neurology/psychiatry multiple sclerosis vimseltinib Launched csf1r inhibitor CSF1R vinblastine Launched microtubule inhibitor | tubulin polymerization inhibitor JUN | TUBA1A | TUBB | TUBD1 | TUBE1 | TUBG1 hematologic malignancy | hematologic malignancy | hematologic malignancy | infectious disease | oncology | oncology Hodgkin's lymphoma | Kaposi sarcoma | mycosis | small lymphocytic lymphoma (SLL) | testicular carcinoma | true histiocytic lymphoma (THL) vinblastine (sulfate) vinburnine Launched adrenergic receptor antagonist CHRM1 | CHRM2 | CHRM3 | CHRM4 neurology/psychiatry stroke vincamine Withdrawn adrenergic receptor antagonist CHRM1 | CHRM2 | CHRM3 | CHRM4 vincristine Launched tubulin polymerization inhibitor TUBA4A | TUBB hematologic malignancy acute lymphoblastic leukemia (ALL) vincristine (sulfate) vindesine Launched tubulin polymerization inhibitor TUBB | TUBB1 oncology | oncology | oncology breast cancer | melanoma | non-small cell lung cancer (NSCLC) vinflunine Launched microtubule inhibitor oncology bladder cancer vinorelbine Launched tubulin polymerization inhibitor TUBA1A | TUBA1B | TUBA1C | TUBA3C | TUBA3D | TUBA3E | TUBA4A | TUBB | TUBB1 | TUBB2A | TUBB2B | TUBB3 | TUBB4A | TUBB4B | TUBB6 | TUBB8 oncology non-small cell lung cancer (NSCLC) vinpocetine Launched phosphodiesterase inhibitor | sodium channel blocker PDE1A | PDE1C | SCN10A neurology/psychiatry | neurology/psychiatry senile dementia | stroke viomycin Launched protein synthesis inhibitor infectious disease tuberculosis vipadenant Phase 1 adenosine receptor antagonist ADORA1 | ADORA2A | ADORA2B | ADORA3 vipivotide tetraxetan Phase 3 glutamate carboxypeptidase inhibitor FOLH1 oncology prostate cancer vismodegib Launched hedgehog pathway inhibitor | smoothened receptor antagonist ABCB1 | ABCG2 | CYP2C19 | CYP2C8 | DHH | IHH | PTCH1 | SMO oncology basal cell carcinoma (BCC) visomitin Preclinical antioxidant vitamin-b12 Launched hematology megaloblastic anemia vitamin-B12 Launched hematology megaloblastic anemia vitamin-E Launched LDL oxidation inhibitor | PKC inhibitor ALOX5 | DGKA | NR1I2 | PPP2CA | PPP2CB | PRKCA | PRKCB | SEC14L2 | SEC14L3 | SEC14L4 vixotrigine Phase 2 sodium channel blocker MAOB | SCN3A | SCN9A VL285 Preclinical PROTAC VLX1570 Phase 1/Phase 2 deubiquitinase inhibitor USP14 VLX600 Phase 1 antitumor agent | ubiquitin C-terminal hydrolase inhibitor TP53 | USP14 voclosporin Phase 3 calcineurin inhibitor CALN1 voglibose Launched glucosidase inhibitor GAA | MGAM endocrinology | endocrinology diabetes mellitus | hyperglycemia volasertib Phase 3 PLK inhibitor PLK1 volinanserin Phase 3 serotonin receptor antagonist HTR2A | HTR2B | HTR2C | KCNH2 vonoprazan Launched potassium-competitive acid antagonist ATP4A gastroenterology peptic ulcer disease (PUD) vorapaxar Launched thrombin inhibitor F2R cardiology | cardiology myocardial infarction | peripheral artery disease (PAD) vorasidenib Preclinical isocitrate dehydrogenase inhibitor IDH1 voreloxin Phase 3 topoisomerase inhibitor PRKDC | TOP2A voriconazole Launched cytochrome P450 inhibitor CYP2C19 | CYP2C9 | CYP3A4 | CYP3A5 | CYP51A1 | PTGS1 infectious disease | infectious disease | infectious disease aspergillosis | esophageal candidiasis | skin infections vorinostat Launched HDAC inhibitor HDAC1 | HDAC10 | HDAC11 | HDAC2 | HDAC3 | HDAC5 | HDAC6 | HDAC8 | HDAC9 hematologic malignancy cutaneous T-cell lymphoma (CTCL) vortioxetine Launched serotonin receptor agonist | serotonin receptor antagonist CYP2B6 | CYP2C19 | CYP2C8 | CYP3A5 | HTR1A | HTR1B | HTR1D | HTR2A | HTR2C | HTR3A | HTR5A | HTR6 | HTR7 | SLC6A4 neurology/psychiatry depression voruciclib Phase 1 CDK9 inhibitor CCND1 | CCNE1 | CCNT1 | CDK1 | CDK2 | CDK4 | CDK9 voxelotor Launched hemoglobin modulator voxtalisib Phase 2 mTOR inhibitor | PI3K inhibitor MTOR | PIK3CA VP-20629 Phase 1 beta amyloid antagonist APP | PLA2G2E | SLC36A1 VS-4718 Phase 1 focal adhesion kinase inhibitor VT-464 Phase 2 cytochrome P450 inhibitor CYP17A1 VTP-27999 Phase 1 renin inhibitor REN VU0155069 Preclinical phospholipase inhibitor PLD1 VU0238429 Preclinical acetylcholine receptor allosteric modulator CHRM5 VU0240551 Preclinical potassium/chloride cotransporter inhibitor SLC12A5 VU0357121 Preclinical glutamate receptor positive allosteric modulator GRM5 VU0360172 Preclinical glutamate receptor positive allosteric modulator GRM5 VU0361737 Preclinical glutamate receptor positive allosteric modulator GRM4 VU0364439 Preclinical glutamate receptor positive allosteric modulator GRM4 VU0364739 Preclinical phospholipase inhibitor PLD2 VU0364770 Preclinical glutamate receptor positive allosteric modulator GRM4 VU0422288 Preclinical glutamate receptor positive allosteric modulator GRM3 VU10010 Preclinical acetylcholine receptor allosteric modulator CHRM4 VU152100 Preclinical acetylcholine receptor allosteric modulator CHRM4 VU1545 Preclinical glutamate receptor positive allosteric modulator GRM5 VU29 Preclinical glutamate receptor potentiator GRM5 VU591 Preclinical potassium channel blocker KCNJ1 VUF10166 Preclinical serotonin receptor antagonist HTR3A | HTR3B VUF10460 Preclinical histamine receptor agonist HRH4 VUF11207 Preclinical CC chemokine receptor agonist ACKR3 VX-11e Preclinical MAP kinase inhibitor MAPK1 VX-222 Phase 2 HCV inhibitor VX-702 Phase 2 p38 MAPK inhibitor IL1B | IL6 | MAPK11 | MAPK12 | MAPK14 | TNF VX-745 Phase 2 p38 MAPK inhibitor MAPK11 | MAPK12 | MAPK14 vx-765 Phase 2 caspase inhibitor CASP1 VX-765 Phase 2 caspase inhibitor CASP1 | IL18R1 vx-984 Phase 1 dna repair enzyme inhibitor oncology breast cancer W-54011 Preclinical anaphylatoxin chemotactic receptor antagonist C5AR1 walrycin-B Preclinical transcriptional regulatory protein WalR warfarin Launched vitamin K antagonist CYP2C19 | CYP2C8 | CYP4F2 | VKORC1 "cardiology | cardiology | hematology | hematology | hematology, cardiology" "atrial fibrillation (AF) | deep vein thrombosis (DVT) | deep vein thrombosis (dvt), pulmonary embolism (pe), atrial fibrillation (af), myocardial infarction | myocardial infarction | pulmonary embolism (PE)" WAY-100635 Phase 1 serotonin receptor antagonist HTR1A WAY-161503 Preclinical serotonin receptor agonist HTR2C WAY-170523 Preclinical metalloproteinase inhibitor MMP13 way-181187 Preclinical serotonin receptor agonist HTR2A neurology/psychiatry depression WAY-200070 Preclinical estrogen receptor agonist ERBB2 | ERBB3 | ERBB4 | ESR2 WAY-207024 Preclinical gonadotropin releasing factor hormone receptor antagonist GNRHR | HRH2 | TACR2 WAY-208466 Preclinical serotonin receptor agonist DRD2 | HTR2A | HTR2C | HTR6 | HTR7 WAY-213613 Preclinical glutamate inhibitor SLC1A2 WAY-255348 Preclinical progesterone receptor antagonist PGR WAY-316606 Preclinical secreted frizzled related protein inhibitor SFRP1 WAY-362450 Phase 1 FXR agonist NR1H4 WAY-600 Preclinical mTOR inhibitor MTOR WAY-629 Preclinical serotonin receptor agonist HTR2C WB-4101 Preclinical adrenergic receptor antagonist ADRA1A | ADRA1B | ADRA1D | ADRA2A | ADRA2B | ADRA2C | HTR1A WDR5-0103 Preclinical histone lysine methyltransferase inhibitor WDR5 WEHI-345-analog Preclinical SRC inhibitor WH-4-023 Preclinical SRC inhibitor LCK | SRC WHI-P154 Preclinical JAK inhibitor ALK | EGFR | JAK1 | JAK2 | JAK3 WIKI4 Preclinical tankyrase inhibitor | WNT pathway inhibitor TNKS2 WIN-18446 Preclinical aldehyde dehydrogenase inhibitor ALDH1A2 WIN-64338 Preclinical bradykinin receptor antagonist BDKRB2 wiskostatin Preclinical actin related protein inhibitor | neural Wiskott-Aldrich syndrome protein inhibitor WASL wnt-c59 Preclinical porcupine inhibitor PORCN wortmannin Preclinical PI3K inhibitor ATM | ATR | MTOR | PI4KA | PI4KB | PIK3CA | PIK3CD | PIK3CG | PIK3R1 | PLK1 | PLK3 | PRKDC WP1066 Phase 1 STAT inhibitor STAT3 WP1130 Preclinical deubiquitinase inhibitor JAK2 | STAT3 | SYK | UCHL5 | USP14 | USP9X WP921 Preclinical AKR1B1 WR99210 Preclinical dihydrofolate reductase inhibitor TYMS infectious disease malaria WWL-113 Preclinical carboxylesterase inhibitor CES3 WWL-123 Preclinical monoacylglycerol lipase inhibitor ABHD6 WY-16922 Phase 1 histamine release inhibitor WYE-125132 Preclinical mTOR inhibitor MTOR | PIK3CA WYE-354 Preclinical mTOR inhibitor MTOR WYE-687 Preclinical mTOR inhibitor MTOR WZ-3146 Preclinical EGFR inhibitor EGFR WZ-4002 Preclinical EGFR inhibitor EGFR | ERBB2 WZ4003 Preclinical AMPK inhibitor NUAK1 | NUAK2 WZ8040 Preclinical EGFR inhibitor EGFR WZ811 Preclinical CC chemokine receptor antagonist CXCR4 xaliproden Phase 3 serotonin receptor agonist HTR1A xamoterol Phase 3 adrenergic receptor agonist ADRB1 xanomeline Phase 3 acetylcholine receptor agonist CHRM1 | CHRM2 | CHRM3 | CHRM4 | CHRM5 | HTR1A | HTR1B | HTR1D | HTR1E | HTR1F | HTR2A | HTR2B | HTR2C | HTR6 | HTR7 xanthone Preclinical antimalarial agent XAV-939 Preclinical tankyrase inhibitor TNKS | TNKS2 XBD173 Phase 2 benzodiazepine receptor ligand TSPO XD-14 Preclinical bromodomain inhibitor BRD2 | BRD3 | BRD4 | BRDT XE-991 Preclinical potassium channel blocker KCNQ1 | KCNQ2 | KCNQ3 | KCNQ4 | KCNQ5 xenalipin Phase 2 xibenolol Phase 3 adrenergic receptor antagonist xiliertinib Phase 1 egfr inhibitor EGFR | ERBB4 oncology esophageal cancer xilobam Phase 1 xipamide Launched carbonic anhydrase inhibitor SLC12A3 cardiology | cardiology edema | hypertension XL019 Phase 1 JAK inhibitor JAK1 | JAK2 | JAK3 XL041 Preclinical LXR agonist NR1H2 XL147 Phase 2 PI3K inhibitor PIK3CA | PIK3CD | PIK3CG XL228 Phase 1 Abl kinase inhibitor | insulin growth factor receptor inhibitor | SRC inhibitor AURKA | FGF2 | IGF1R | SRC XL388 Preclinical mTOR inhibitor MTOR XL647 Phase 3 EGFR inhibitor | VEGFR inhibitor EGFR | EPHB4 | ERBB2 | FLT4 | KDR | SRC XL888 Phase 1 HSP inhibitor XMD17-109 Preclinical MAP kinase inhibitor LRRK2 | MAPK7 XMD8-92 Preclinical MAP kinase inhibitor DCLK2 | LRRK2 | MAPK7 | PLK4 | TNK1 xylazine Launched adrenergic receptor agonist ADRA2A | ADRA2B | ADRA2C neurology/psychiatry anesthetic xylometazoline Launched adrenergic receptor agonist ADRA1A | ADRA1B | ADRA1D | ADRA2A | ADRA2B | ADRA2C allergy | otolaryngology allergic rhinitis | nasal congestion xylose Launched Y-11 Preclinical focal adhesion kinase inhibitor PTK2 Y-134 Preclinical estrogen receptor antagonist ESR1 | ESR2 Y16 Preclinical rho associated kinase inhibitor ARHGEF12 | NR1H4 | RHOA Y-26763 Phase 1 potassium channel activator KCNJ8 Y-27152 Phase 1 potassium channel activator ABCC9 | KCNJ8 Y-27632 Preclinical rho associated kinase inhibitor LRRK2 | PKIA | PKN2 | PRKACA | PRKCE | ROCK1 | ROCK2 Y-29794 Preclinical prolyl endopeptidase inhibitor PREP Y-320 Preclinical interleukin inhibitor IL17A | TNF Y-39983 Phase 2 rho associated kinase inhibitor ROCK1 | ROCK2 YC-1 Preclinical guanylyl cyclase activator GUCY1A2 | GUCY1A3 | GUCY1B3 | HIF1A YIL-781 Preclinical ghrelin receptor antagonist GHSR YK-4-279 Preclinical apoptosis inhibitor EWSR1 | FLI1 YL0919 Preclinical selective serotonin reuptake inhibitor (SSRI) HTR1A YM-022 Phase 2 CCK receptor antagonist CCKBR YM-155 Phase 2 survivin inhibitor BIRC5 YM-201636 Preclinical PI3K inhibitor YM-244769 Preclinical sodium/calcium exchange inhibitor YM-298198 Preclinical glutamate receptor antagonist GRM1 YM-298198-desmethyl Preclinical glutamate receptor antagonist GRM1 YM-511 Phase 2 aromatase inhibitor CYP19A1 YM-58483 Preclinical calcium channel blocker IL2 | IL4 | IL5 | TRPC3 | TRPC5 | TRPM4 YM-750 Phase 1 ACAT inhibitor SOAT1 YM-90709 Preclinical IL5 inhibitor CSF2RB | IL5RA YM-976 Phase 1 phosphodiesterase inhibitor PDE4A | PDE4B | PDE4C | PDE4D | TNF YO-01027 Preclinical gamma secretase inhibitor yoda-1 Preclinical piezo channel activator PIEZO1 | SLC6A5 yohimbine Launched adrenergic receptor antagonist ADRA2A | ADRA2B | ADRA2C | DRD2 | DRD3 | HTR1A | HTR1B | HTR1D | HTR1E | HTR1F | HTR2A | HTR2B | HTR2C | HTR5A | HTR7 | KCNJ1 | KCNJ10 | KCNJ11 | KCNJ12 | KCNJ14 | KCNJ15 | KCNJ8 cardiology | cardiology bradycardia | cardiac arrythmia YS-035 Preclinical calcium channel blocker YS-201 Preclinical calcium receptor antagonist YZ9 Preclinical phosphofructokinase inhibitor MIF | PFKFB3 Z160 Phase 2 N-type calcium channel blocker CACNA1B | CACNA2D1 zacopride Phase 2 serotonin receptor antagonist HTR3A | HTR3B | HTR4 | HTR5A zafirlukast Launched leukotriene receptor antagonist CYSLTR1 | CYSLTR2 pulmonary asthma zalcitabine Launched nucleoside reverse transcriptase inhibitor infectious disease human immunodeficiency virus (HIV-1) zaldaride Phase 3 calmodulin antagonist CALM1 zaltidine Phase 3 histamine receptor antagonist HRH2 zaltoprofen Launched cyclooxygenase inhibitor endocrinology | neurology/psychiatry fever | pain relief ZAMI-633 Phase 3 urease inhibitor zamicastat Phase 2 dopamine beta hydroxylase inhibitor DBH pulmonary pulmonary arterial hypertension (pah) zamifenacin Phase 3 acetylcholine receptor antagonist CHRM3 zanamivir Launched neuraminidase inhibitor NEU2 infectious disease influenza A virus infection zandelisib Phase 2 pi3k inhibitor PIK3CD oncology non-hodgkin lymphoma (nhl) zanubrutinib Launched Bruton's tyrosine kinase (BTK) inhibitor BTK ZAPA Preclinical zaprinast Phase 2 phosphodiesterase inhibitor GPR35 | PDE1A | PDE4D | PDE5A | PDE9A zardaverine Phase 2 phosphodiesterase inhibitor PDE3A | PDE4A | PDE4B | PDE4C | PDE4D zatebradine Phase 3 HCN channel blocker HCN1 | HCN2 | HCN3 | HCN4 zaurategrast ethyl ester Phase 2 integrin antagonist ITGA4 | ITGB7 neurology/psychiatry multiple sclerosis ZCL-278 Preclinical CDC inhibitor CDC42 ZD-0947 Preclinical potassium channel activator KCNJ8 ZD-2079 Phase 2 adrenergic receptor agonist ADRB3 zd-4190 Phase 1 antitumor agent EGFR | KDR oncology gastric adenocarcinoma ZD-7114 Phase 1 adrenergic receptor agonist ADRB3 ZD-7155 Preclinical angiotensin receptor antagonist AGTR1 ZD-7288 Phase 2 HCN channel blocker HCN1 | HCN2 | HCN3 | HCN4 zeatin Phase 1 zebularine Preclinical DNA methyltransferase inhibitor CDA | DNMT1 zeranol Launched estrogen receptor agonist ACTA2 | ESR1 | NR1I2 | SHBG zibotentan Phase 3 endothelin receptor antagonist EDNRA zidebactam Phase 1 beta lactamase inhibitor infectious disease gram-negative bacterial infections zidovudine Launched nucleoside reverse transcriptase inhibitor TERT infectious disease | infectious disease acquired immunodeficiency syndrome (AIDS) | human immunodeficiency virus (HIV-1) zileuton Launched leukotriene synthesis inhibitor | lipoxygenase inhibitor ALOX5 pulmonary asthma zilpaterol Launched adrenergic receptor agonist ADRB2 endocrinology weight-gain aid zimelidine Withdrawn selective serotonin reuptake inhibitor (SSRI) MAOA | MAOB | SLC6A4 zinc-undecylenate Launched other antifungal infectious disease tinea pedis zindotrine Phase 2 phosphodiesterase inhibitor ziprasidone Launched dopamine receptor antagonist | serotonin receptor antagonist ADRA1A | ADRA1B | ADRA2A | ADRA2B | ADRA2C | CHRM1 | CHRM2 | CHRM3 | CHRM4 | CHRM5 | DRD1 | DRD2 | DRD3 | DRD4 | DRD5 | HRH1 | HTR1A | HTR1B | HTR1D | HTR1E | HTR2A | HTR2C | HTR3A | HTR6 | HTR7 | SLC6A4 neurology/psychiatry | neurology/psychiatry bipolar disorder | schizophrenia ziritaxestat Phase 3 autotaxin inhibitor ENPP2 ZK-164015 Preclinical estrogen receptor antagonist ESR1 | ESR2 ZK-200775 Phase 2 kainate receptor antagonist ZK-811752 Phase 2 CC chemokine receptor antagonist CCR1 ZK-93423 Phase 3 benzodiazepine receptor agonist GABRA1 | GABRA2 | GABRA3 | GABRA5 | GABRB2 | GABRG2 ZK-93426 Phase 1 benzodiazepine receptor antagonist GABRA1 | GABRA2 | GABRA3 | GABRA5 ZLN005 Preclinical ZLN024 Preclinical AMPK activator PRKAA1 | PRKAB1 | PRKAG1 ZM-226600 Preclinical Kir6 channel (KATP) activator ZM-241385 Preclinical adenosine receptor antagonist ADORA1 | ADORA2A | ADORA2B | ADORA3 ZM-306416 Preclinical Abl kinase inhibitor | SRC inhibitor | VEGFR inhibitor EGFR | FLT1 | FLT4 | KDR ZM-323881 Preclinical VEGFR inhibitor KDR ZM-336372 Preclinical RAF inhibitor BRAF | LCK | MAPK14 | RAF1 ZM-39923 Preclinical JAK inhibitor JAK1 | JAK3 ZM-447439 Preclinical Aurora kinase inhibitor AURKA | AURKB zofenopril-calcium Launched angiotensin converting enzyme inhibitor ACE cardiology hypertension zolantidine Preclinical histamine receptor antagonist zoledronic-acid Launched bone resorption inhibitor FDPS | GGPS1 endocrinology Paget's disease zoliflodacin Phase 3 antibacterial zolimidine Launched mucus protecting agent gastroenterology | gastroenterology gastroesophageal reflux disease (GERD) | peptic ulcer disease (PUD) zolmitriptan Launched serotonin receptor agonist HTR1A | HTR1B | HTR1D | HTR1E | HTR1F neurology/psychiatry migraine headache zomepirac Withdrawn prostaglandin synthesis inhibitor PTGDR2 zometapine Phase 2 zoniporide Phase 3 sodium/hydrogen exchanger inhibitor AOX1 | SLC9A1 zonisamide Launched sodium channel blocker | T-type calcium channel blocker CA1 | CA10 | CA11 | CA12 | CA13 | CA14 | CA2 | CA3 | CA4 | CA5A | CA5B | CA6 | CA7 | CA8 | CA9 | CACNA1G | CACNA1H | CACNA1I | MAOA | MAOB | SCN10A | SCN11A | SCN1A | SCN1B | SCN2A | SCN2B | SCN3A | SCN3B | SCN4A | SCN4B | SCN5A | SCN7A | SCN8A | SCN9A neurology/psychiatry | neurology/psychiatry epilepsy | seizures zopolrestat Phase 2 AKR1B1 | AKR1B10 zosuquidar Phase 3 P glycoprotein inhibitor ABCB1 | ABCB4 zotarolimus Launched mTOR inhibitor FKBP1A | MTOR cardiology coronary artery restenosis zotatifin Phase 1 eukaryotic translation initiation factor inhibitor EIF4A1 zotepine Launched dopamine receptor antagonist | serotonin receptor antagonist ADRA2B | DRD2 | DRD3 | DRD4 | HRH1 | HTR1A | HTR1B | HTR1D | HTR1E | HTR2A | HTR2C | HTR6 | HTR7 | SLC6A2 | SLC6A4 neurology/psychiatry schizophrenia zoxazolamine Phase 2 myorelaxant ZSET1446 Preclinical nicotinic receptor agonist CACNA1G | CHAT ZSTK-474 Phase 1/Phase 2 PI3K inhibitor PIK3CA | PIK3CB | PIK3CD | PIK3CG zuclopenthixol Launched dopamine receptor antagonist ADRA1A | ADRA2A | DRD1 | DRD2 | DRD5 | HRH1 | HTR2A neurology/psychiatry | neurology/psychiatry bipolar disorder | schizophrenia zuranolone Phase 3 GABA receptor agonist GABRA1 | GABRA4